Entry | Database: PDB / ID: 5elq |
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Title | Crystal structure of the SNX27 PDZ domain bound to the C-terminal DGKzeta PDZ binding motif |
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Components | - GLU-ASP-GLN-GLU-THR-ALA-VAL
- Sorting nexin-27
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Keywords | PROTEIN TRANSPORT / Endosome / PDZ domain / sorting nexin |
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Function / homology | Function and homology information
: / lipid phosphorylation / response to methamphetamine hydrochloride / glycerolipid metabolic process / diacylglycerol metabolic process / lipid kinase activity / diacylglycerol kinase (ATP) / ATP-dependent diacylglycerol kinase activity / phosphatidic acid biosynthetic process / establishment of protein localization to plasma membrane ...: / lipid phosphorylation / response to methamphetamine hydrochloride / glycerolipid metabolic process / diacylglycerol metabolic process / lipid kinase activity / diacylglycerol kinase (ATP) / ATP-dependent diacylglycerol kinase activity / phosphatidic acid biosynthetic process / establishment of protein localization to plasma membrane / positive regulation of AMPA glutamate receptor clustering / neurotransmitter receptor transport to plasma membrane / WASH complex / : / NAD+ kinase activity / endosome to plasma membrane protein transport / retromer complex / Effects of PIP2 hydrolysis / phosphatidylinositol-3-phosphate binding / : / endocytic recycling / endosomal transport / negative regulation of T cell receptor signaling pathway / regulation of postsynaptic membrane neurotransmitter receptor levels / immunological synapse / negative regulation of mitotic cell cycle / regulation of synaptic transmission, glutamatergic / mitotic G1 DNA damage checkpoint signaling / phosphatidylinositol binding / cellular response to nerve growth factor stimulus / intracellular protein transport / ionotropic glutamate receptor binding / Schaffer collateral - CA1 synapse / platelet activation / calcium-dependent protein binding / cell migration / lamellipodium / kinase activity / nervous system development / early endosome membrane / early endosome / intracellular signal transduction / endosome / nuclear speck / glutamatergic synapse / signal transduction / ATP binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosolSimilarity search - Function Diacylglycerol kinase / Diacylglycerol kinase, accessory domain / Diacylglycerol kinase accessory domain / Diacylglycerol kinase accessory domain (presumed) / SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / SNX17/27/31 / Diacylglycerol kinase, catalytic domain / Diacylglycerol kinase catalytic domain ...Diacylglycerol kinase / Diacylglycerol kinase, accessory domain / Diacylglycerol kinase accessory domain / Diacylglycerol kinase accessory domain (presumed) / SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / SNX17/27/31 / Diacylglycerol kinase, catalytic domain / Diacylglycerol kinase catalytic domain / DAG-kinase catalytic (DAGKc) domain profile. / Diacylglycerol kinase catalytic domain (presumed) / Domain of unknown function DUF3447 / Ras-associating (RA) domain profile. / Inorganic polyphosphate/ATP-NAD kinase, N-terminal / NAD kinase/diacylglycerol kinase-like domain superfamily / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / Phorbol esters/diacylglycerol binding domain (C1 domain) / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / Ankyrin repeats (3 copies) / PDZ superfamily / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Ubiquitin-like domain superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Rattus norvegicus (Norway rat)
Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.1 Å |
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Authors | Collins, B.M. / Clairfeuille, T. |
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Funding support | Australia, 1items Organization | Grant number | Country |
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National Health and Medical Research Council (NHMRC, Australia) | APP1058734 | Australia |
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Citation | Journal: Nat.Struct.Mol.Biol. / Year: 2016 Title: A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. Authors: Clairfeuille, T. / Mas, C. / Chan, A.S. / Yang, Z. / Tello-Lafoz, M. / Chandra, M. / Widagdo, J. / Kerr, M.C. / Paul, B. / Merida, I. / Teasdale, R.D. / Pavlos, N.J. / Anggono, V. / Collins, B.M. |
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History | Deposition | Nov 5, 2015 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Sep 7, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 21, 2016 | Group: Database references |
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Revision 1.2 | Oct 19, 2016 | Group: Database references |
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Revision 1.3 | Sep 27, 2017 | Group: Author supporting evidence / Data collection / Derived calculations Category: diffrn_source / pdbx_audit_support / pdbx_struct_oper_list Item: _diffrn_source.pdbx_synchrotron_site / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.4 | Jan 8, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.5 | Sep 27, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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