Entry | Database: PDB / ID: 3qgl |
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Title | Crystal Structure of PDZ domain of sorting nexin 27 (SNX27) in complex with the ESESKV peptide corresponding to the C-terminal tail of GIRK3 |
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Components | - G protein-activated inward rectifier potassium channel 3
- Sorting nexin-27
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Keywords | PROTEIN BINDING / PDZ domain / PDZ binding / GIRK3 regulation / early endosomes / brain / neurons |
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Function / homology | Function and homology information
regulation of presynaptic membrane potential / response to methamphetamine hydrochloride / G-protein activated inward rectifier potassium channel activity / establishment of protein localization to plasma membrane / positive regulation of AMPA glutamate receptor clustering / neurotransmitter receptor transport to plasma membrane / WASH complex / retromer complex / endosome to plasma membrane protein transport / inward rectifier potassium channel activity ...regulation of presynaptic membrane potential / response to methamphetamine hydrochloride / G-protein activated inward rectifier potassium channel activity / establishment of protein localization to plasma membrane / positive regulation of AMPA glutamate receptor clustering / neurotransmitter receptor transport to plasma membrane / WASH complex / retromer complex / endosome to plasma membrane protein transport / inward rectifier potassium channel activity / endocytic recycling / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / phosphatidylinositol-3-phosphate binding / regulation of monoatomic ion transmembrane transport / parallel fiber to Purkinje cell synapse / monoatomic ion channel complex / endosomal transport / potassium ion import across plasma membrane / regulation of postsynaptic membrane neurotransmitter receptor levels / immunological synapse / ionotropic glutamate receptor binding / phosphatidylinositol binding / cellular response to nerve growth factor stimulus / PDZ domain binding / intracellular protein transport / Schaffer collateral - CA1 synapse / calcium-dependent protein binding / nervous system development / presynaptic membrane / early endosome membrane / early endosome / endosome / glutamatergic synapse / signal transduction / plasma membrane / cytosolSimilarity search - Function Potassium channel, inwardly rectifying, Kir3.3 / SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / SNX17/27/31 / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / Potassium channel, inwardly rectifying, transmembrane domain / Inward rectifier potassium channel transmembrane domain ...Potassium channel, inwardly rectifying, Kir3.3 / SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / SNX17/27/31 / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / Potassium channel, inwardly rectifying, transmembrane domain / Inward rectifier potassium channel transmembrane domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / Potassium channel, inwardly rectifying, Kir, cytoplasmic / Potassium channel, inwardly rectifying, Kir / Inward rectifier potassium channel, C-terminal / Inward rectifier potassium channel C-terminal domain / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Immunoglobulin E-set / Ubiquitin-like domain superfamily / Roll / Mainly BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Rattus norvegicus (Norway rat) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.31 Å |
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Authors | Balana, B. / Kwiatkowski, W. / Choe, S. |
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2011 Title: Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Authors: Balana, B. / Maslennikov, I. / Kwiatkowski, W. / Stern, K.M. / Bahima, L. / Choe, S. / Slesinger, P.A. |
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History | Deposition | Jan 24, 2011 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Mar 16, 2011 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Version format compliance |
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Revision 1.2 | Sep 13, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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