PDB-4u3m: Crystal structure of Anisomycin bound to the yeast 80S ribosome

基本情報

• 登録情報: データベース: PDB / ID: 4u3m
• タイトル: Crystal structure of Anisomycin bound to the yeast 80S ribosome

要素

• (40S ribosomal protein ...) x 32
• (5.8s rRNA) x 2
• (60S ribosomal protein ...) x 40
• (UNKNOWN PROTEIN ...) x 3
• (Ubiquitin-40S ribosomal protein ...) x 2
• 18S rRNA
• 25s rRNA
• 60S acidic ribosomal protein P0
• Guanine nucleotide-binding protein subunit beta-like protein
• Suppressor protein STM1
• Ubiquitin-60S ribosomal protein L40

• キーワード: RIBOSOME / translation / 40S / 60S / 80S / eukaryote / RNA-protein complex / inhibitor / antibiotic

機能・相同性

分子機能:

: / triplex DNA binding / ribosome hibernation / translation elongation factor binding / regulation of translational initiation in response to stress / Platelet degranulation / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) / negative regulation of glucose mediated signaling pathway / negative regulation of translational frameshifting / Negative regulators of DDX58/IFIH1 signaling / positive regulation of translational fidelity / Protein methylation / RMTs methylate histone arginines / mTORC1-mediated signalling / Protein hydroxylation / ribosome-associated ubiquitin-dependent protein catabolic process / GDP-dissociation inhibitor activity / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / pre-mRNA 5'-splice site binding / Formation of the ternary complex, and subsequently, the 43S complex / Translation initiation complex formation / Ribosomal scanning and start codon recognition / translational elongation / cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / preribosome, small subunit precursor / response to cycloheximide / telomeric DNA binding / mRNA destabilization / Major pathway of rRNA processing in the nucleolus and cytosol / SRP-dependent cotranslational protein targeting to membrane / GTP hydrolysis and joining of the 60S ribosomal subunit / Formation of a pool of free 40S subunits / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / negative regulation of mRNA splicing, via spliceosome / L13a-mediated translational silencing of Ceruloplasmin expression / preribosome, large subunit precursor / ribosomal large subunit export from nucleus / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / G-protein alpha-subunit binding / TOR signaling / positive regulation of protein kinase activity / protein-RNA complex assembly / regulation of translational fidelity / Ub-specific processing proteases / ribosomal small subunit export from nucleus / translation regulator activity / ribosomal subunit export from nucleus / translational termination / endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / translation repressor activity / DNA-(apurinic or apyrimidinic site) endonuclease activity / cellular response to amino acid starvation / telomere maintenance / ribosome assembly / rescue of stalled ribosome / maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / 90S preribosome / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / maturation of LSU-rRNA / ribosomal large subunit biogenesis / maturation of SSU-rRNA / macroautophagy / small-subunit processome / positive regulation of apoptotic signaling pathway / protein kinase C binding / maintenance of translational fidelity / ribosomal large subunit assembly / cytoplasmic stress granule / modification-dependent protein catabolic process / rRNA processing / protein tag activity / ribosome biogenesis / ribosome binding / ribosomal small subunit biogenesis / ribosomal small subunit assembly / small ribosomal subunit / small ribosomal subunit rRNA binding / 5S rRNA binding / large ribosomal subunit rRNA binding / cytosolic small ribosomal subunit / cytosolic large ribosomal subunit / cytoplasmic translation / rRNA binding / negative regulation of translation / ribosome / protein ubiquitination / structural constituent of ribosome / translation / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / negative regulation of gene expression / response to antibiotic / mRNA binding / ubiquitin protein ligase binding / nucleolus / negative regulation of apoptotic process / perinuclear region of cytoplasm / mitochondrion / DNA binding

ドメイン・相同性:

Stm1-like, N-terminal / Stm1 / Hyaluronan/mRNA-binding protein / Hyaluronan / mRNA binding family / 60s Acidic ribosomal protein / 60S acidic ribosomal protein P0 / 50S ribosomal protein L10, insertion domain superfamily / 60S ribosomal protein L10P, insertion domain / Insertion domain in 60S ribosomal protein L10P / : / Ribosomal protein S26e signature. / : / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S26e / Ribosomal protein S21e, conserved site / Ribosomal protein S21e signature. / Ribosomal protein S12e signature. / Ribosomal protein S12e / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / Small (40S) ribosomal subunit Asc1/RACK1 / Ribosomal protein S2, eukaryotic / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal protein L29e / Ribosomal L29e protein family / 40S Ribosomal protein S10 / S27a-like superfamily / Ribosomal protein S10, eukaryotic/archaeal / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Plectin/S10, N-terminal / Plectin/S10 domain / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein S25 / S25 ribosomal protein / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal L38e protein family / Ribosomal protein S2, eukaryotic/archaeal / : / Ribosomal protein S17e, conserved site / Ribosomal protein S17e signature. / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S8e subdomain, eukaryotes / Ribosomal protein S30 / Ribosomal protein S30 / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal protein L27e, conserved site / Ribosomal protein L27e signature. / Ribosomal protein S7e signature. / Ribosomal protein L44e signature. / Ribosomal protein L10e, conserved site / Ribosomal protein L10e signature. / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal protein L10e / Ribosomal protein L13e / Ribosomal protein L13e / Ribosomal protein L19, eukaryotic / Ribosomal protein S19e / Ribosomal protein S3Ae, conserved site / Ribosomal protein S19e / Ribosomal protein S3Ae signature. / Ribosomal_S19e / Ribosomal protein S27e signature. / 60S ribosomal protein L18a/ L20, eukaryotes / Ribosomal protein S4e, N-terminal, conserved site / Ribosomal protein S4e signature. / 40S ribosomal protein S4, C-terminal domain / 40S ribosomal protein S4 C-terminus / : / Ribosomal protein S19A/S15e / Ribosomal protein S8e, conserved site / Ribosomal protein S8e signature. / Ribosomal protein L24e, conserved site / Ribosomal protein L24e signature. / Ribosomal protein L44e / Ribosomal protein L19/L19e conserved site / Ribosomal protein L44 / Ribosomal protein L19e signature. / Ribosomal protein L34e, conserved site / Ribosomal protein L34e signature. / Ribosomal protein L5 eukaryotic, C-terminal / Ribosomal L18 C-terminal region / Ribosomal protein S17e / Ribosomal protein S17e-like superfamily / Ribosomal S17 / Ribosomal protein L6e signature. / 50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a / Ribosomal L40e family / Ribosomal protein L30e signature 1.

構成要素:

ANISOMYCIN / osmium (III) hexammine / : / : / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / : / Small ribosomal subunit protein uS4A / Large ribosomal subunit protein uL15 / Small ribosomal subunit protein eS17A / Large ribosomal subunit protein eL24A / Large ribosomal subunit protein uL23 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein uL10 / Large ribosomal subunit protein uL30A / Large ribosomal subunit protein uL6A / Large ribosomal subunit protein uL22A / Large ribosomal subunit protein uL24A / Large ribosomal subunit protein eL33A / Large ribosomal subunit protein eL36A / Large ribosomal subunit protein eL29 / Large ribosomal subunit protein eL15A / Large ribosomal subunit protein eL22A / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein uS15 / Ubiquitin-ribosomal protein eS31 fusion protein / Small ribosomal subunit protein uS11A / Small ribosomal subunit protein eS19A / Small ribosomal subunit protein eS21A / Small ribosomal subunit protein uS8A / Large ribosomal subunit protein eL27A / Large ribosomal subunit protein eL31A / Ubiquitin-ribosomal protein eL40A fusion protein / Large ribosomal subunit protein eL20A / Large ribosomal subunit protein eL43A / Large ribosomal subunit protein eL42A / Small ribosomal subunit protein uS12A / Small ribosomal subunit protein eS24A / Small ribosomal subunit protein eS30A / Small ribosomal subunit protein eS4A / Small ribosomal subunit protein eS6A / Small ribosomal subunit protein eS8A / Large ribosomal subunit protein uL14A / Large ribosomal subunit protein uL2A / Small ribosomal subunit protein uS17A / Large ribosomal subunit protein eL18A / Small ribosomal subunit protein uS9A / Small ribosomal subunit protein uS13A / Large ribosomal subunit protein eL19A / Large ribosomal subunit protein uL29A / Small ribosomal subunit protein eS32A / Large ribosomal subunit protein uL4A / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein eL8A / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein uL18 / Small ribosomal subunit protein uS7 / Large ribosomal subunit protein uL13A / Small ribosomal subunit protein eS7A / Small ribosomal subunit protein uS2A / Small ribosomal subunit protein eS1A / Small ribosomal subunit protein eS27A / Large ribosomal subunit protein eL14A / Small ribosomal subunit protein RACK1 / Large ribosomal subunit protein eL32 / Small ribosomal subunit protein uS10 / Suppressor protein STM1 / Small ribosomal subunit protein eS26B / Small ribosomal subunit protein uS14A / Large ribosomal subunit protein uL16 / 40S ribosomal protein S10-B / Small ribosomal subunit protein eS12 / Large ribosomal subunit protein eL37A / Large ribosomal subunit protein eL38 / Large ribosomal subunit protein eL34A / Small ribosomal subunit protein uS19 / Large ribosomal subunit protein eL6A / Large ribosomal subunit protein eL21A / Small ribosomal subunit protein eS10A / Large ribosomal subunit protein eL13A / Large ribosomal subunit protein uL5B / Small ribosomal subunit protein eS25A / Small ribosomal subunit protein eS28A

• 生物種: Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
• 手法: X線回折 / シンクロトロン / 分子置換 / 解像度: 3 Å
• データ登録者: Garreau de Loubresse, N. / Prokhorova, I. / Yusupova, G. / Yusupov, M.
• 引用: ジャーナル: Nature / 年: 2014; タイトル: Structural basis for the inhibition of the eukaryotic ribosome.; 著者: Garreau de Loubresse, N. / Prokhorova, I. / Holtkamp, W. / Rodnina, M.V. / Yusupova, G. / Yusupov, M.

履歴

登録	2014年7月22日	登録サイト: RCSB / 処理サイト: PDBE
改定 1.0	2014年10月22日	Provider: repository / タイプ: Initial release
置き換え	2014年12月10日	ID: 4ujz, 4uk0, 4uk1, 4uk2, 4uk3
改定 1.1	2014年12月10日	Group: Other
改定 1.2	2014年12月17日	Group: Other
改定 1.3	2015年1月14日	Group: Database references / Derived calculations
改定 1.4	2015年7月29日	Group: Derived calculations
改定 1.5	2017年10月11日	Group: Data collection / カテゴリ: reflns_shell / Item: _reflns_shell.percent_possible_all
改定 1.6	2023年12月20日	Group: Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id

集合体

登録構造単位

2: 18S rRNA

S0: 40S ribosomal protein S0-A

S1: 40S ribosomal protein S1-A

S2: 40S ribosomal protein S2

S3: 40S ribosomal protein S3

S4: 40S ribosomal protein S4-A

S5: 40S ribosomal protein S5

S6: 40S ribosomal protein S6-A

S7: 40S ribosomal protein S7-A

S8: 40S ribosomal protein S8-A

S9: 40S ribosomal protein S9-A

C0: 40S ribosomal protein S10-B

C1: 40S ribosomal protein S11-A

C2: 40S ribosomal protein S12

C3: 40S ribosomal protein S13

C4: 40S ribosomal protein S14-A

C5: 40S ribosomal protein S15

C6: 40S ribosomal protein S16-A

C7: 40S ribosomal protein S17-A

C8: 40S ribosomal protein S18-A

C9: 40S ribosomal protein S19-A

D0: 40S ribosomal protein S20

D1: 40S ribosomal protein S21-A

D2: 40S ribosomal protein S22-A

D3: 40S ribosomal protein S23-A

D4: 40S ribosomal protein S24-A

D5: 40S ribosomal protein S25-A

D6: 40S ribosomal protein S26-B

D7: 40S ribosomal protein S27-A

D8: 40S ribosomal protein S28-A

D9: 40S ribosomal protein S29-A

E0: 40S ribosomal protein S30-A

E1: Ubiquitin-40S ribosomal protein S31

SR: Guanine nucleotide-binding protein subunit beta-like protein

SM: Suppressor protein STM1

1: 25s rRNA

3: 5.8s rRNA

4: 5.8s rRNA

L2: 60S ribosomal protein L2-A

L3: 60S ribosomal protein L3

L4: 60S ribosomal protein L4-A

L5: 60S ribosomal protein L5

L6: 60S ribosomal protein L6-A

L7: 60S ribosomal protein L7-A

L8: 60S ribosomal protein L8-A

L9: 60S ribosomal protein L9-A

M0: 60S ribosomal protein L10

M1: 60S ribosomal protein L11-B

M3: 60S ribosomal protein L13-A

M4: 60S ribosomal protein L14-A

M5: 60S ribosomal protein L15-A

M6: 60S ribosomal protein L16-A

M7: 60S ribosomal protein L17-A

M8: 60S ribosomal protein L18-A

M9: 60S ribosomal protein L19-A

N0: 60S ribosomal protein L20-A

N1: 60S ribosomal protein L21-A

N2: 60S ribosomal protein L22-A

N3: 60S ribosomal protein L23-A

N4: 60S ribosomal protein L24-A

N5: 60S ribosomal protein L25

N6: 60S ribosomal protein L26-A

N7: 60S ribosomal protein L27-A

N8: 60S ribosomal protein L28

N9: 60S ribosomal protein L29

O0: 60S ribosomal protein L30

O1: 60S ribosomal protein L31-A

O2: 60S ribosomal protein L32

O3: 60S ribosomal protein L33-A

O4: 60S ribosomal protein L34-A

O5: 60S ribosomal protein L35-A

O6: 60S ribosomal protein L36-A

O7: 60S ribosomal protein L37-A

O8: 60S ribosomal protein L38

O9: 60S ribosomal protein L39

Q0: Ubiquitin-60S ribosomal protein L40

Q1: 60S ribosomal protein L41-A

Q2: 60S ribosomal protein L42-A

Q3: 60S ribosomal protein L43-A

6: 18S rRNA

s0: 40S ribosomal protein S0-A

s1: 40S ribosomal protein S1-A

s2: 40S ribosomal protein S2

s3: 40S ribosomal protein S3

s4: 40S ribosomal protein S4-A

s5: 40S ribosomal protein S5

s6: 40S ribosomal protein S6-A

s7: 40S ribosomal protein S7-A

s8: 40S ribosomal protein S8-A

s9: 40S ribosomal protein S9-A

c0: 40S ribosomal protein S10-B

c1: 40S ribosomal protein S11-A

c2: 40S ribosomal protein S12

c3: 40S ribosomal protein S13

c4: 40S ribosomal protein S14-A

c5: 40S ribosomal protein S15

c6: 40S ribosomal protein S16-A

c7: 40S ribosomal protein S17-A

c8: 40S ribosomal protein S18-A

c9: 40S ribosomal protein S19-A

d0: 40S ribosomal protein S20

d1: 40S ribosomal protein S21-A

d2: 40S ribosomal protein S22-A

d3: 40S ribosomal protein S23-A

d4: 40S ribosomal protein S24-A

d5: 40S ribosomal protein S25-A

d6: 40S ribosomal protein S26-B

d7: 40S ribosomal protein S27-A

d8: 40S ribosomal protein S28-A

d9: 40S ribosomal protein S29-A

e0: 40S ribosomal protein S30-A

e1: Ubiquitin-40S ribosomal protein S31

sR: Guanine nucleotide-binding protein subunit beta-like protein

sM: Suppressor protein STM1

5: 25s rRNA

7: 5.8s rRNA

8: 5.8s rRNA

l2: 60S ribosomal protein L2-A

l3: 60S ribosomal protein L3

l4: 60S ribosomal protein L4-A

l5: 60S ribosomal protein L5

l6: 60S ribosomal protein L6-A

l7: 60S ribosomal protein L7-A

l8: 60S ribosomal protein L8-A

l9: 60S ribosomal protein L9-A

m0: 60S ribosomal protein L10

m1: 60S ribosomal protein L11-B

m2: UNKNOWN PROTEIN m2

m3: 60S ribosomal protein L13-A

m4: 60S ribosomal protein L14-A

m5: 60S ribosomal protein L15-A

m6: 60S ribosomal protein L16-A

m7: 60S ribosomal protein L17-A

m8: 60S ribosomal protein L18-A

m9: 60S ribosomal protein L19-A

n0: 60S ribosomal protein L20-A

n1: 60S ribosomal protein L21-A

n2: 60S ribosomal protein L22-A

n3: 60S ribosomal protein L23-A

n4: 60S ribosomal protein L24-A

n5: 60S ribosomal protein L25

n6: 60S ribosomal protein L26-A

n7: 60S ribosomal protein L27-A

n8: 60S ribosomal protein L28

n9: 60S ribosomal protein L29

o0: 60S ribosomal protein L30

o1: 60S ribosomal protein L31-A

o2: 60S ribosomal protein L32

o3: 60S ribosomal protein L33-A

o4: 60S ribosomal protein L34-A

o5: 60S ribosomal protein L35-A

o6: 60S ribosomal protein L36-A

o7: 60S ribosomal protein L37-A

o8: 60S ribosomal protein L38

o9: 60S ribosomal protein L39

q0: Ubiquitin-60S ribosomal protein L40

q1: 60S ribosomal protein L41-A

q2: 60S ribosomal protein L42-A

q3: 60S ribosomal protein L43-A

p0: 60S acidic ribosomal protein P0

p1: UNKNOWN PROTEIN p1

p2: UNKNOWN PROTEIN p2

ヘテロ分子

概要:

• 6.63 MDa, 162 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	6,631,515	2723
ポリマ－	6,271,217	162
非ポリマー	360,299	2561
水	0	0

1

2: 18S rRNA

S0: 40S ribosomal protein S0-A

S1: 40S ribosomal protein S1-A

S2: 40S ribosomal protein S2

S3: 40S ribosomal protein S3

S4: 40S ribosomal protein S4-A

S5: 40S ribosomal protein S5

S6: 40S ribosomal protein S6-A

S7: 40S ribosomal protein S7-A

S8: 40S ribosomal protein S8-A

S9: 40S ribosomal protein S9-A

C0: 40S ribosomal protein S10-B

C1: 40S ribosomal protein S11-A

C2: 40S ribosomal protein S12

C3: 40S ribosomal protein S13

C4: 40S ribosomal protein S14-A

C5: 40S ribosomal protein S15

C6: 40S ribosomal protein S16-A

C7: 40S ribosomal protein S17-A

C8: 40S ribosomal protein S18-A

C9: 40S ribosomal protein S19-A

D0: 40S ribosomal protein S20

D1: 40S ribosomal protein S21-A

D2: 40S ribosomal protein S22-A

D3: 40S ribosomal protein S23-A

D4: 40S ribosomal protein S24-A

D5: 40S ribosomal protein S25-A

D6: 40S ribosomal protein S26-B

D7: 40S ribosomal protein S27-A

D8: 40S ribosomal protein S28-A

D9: 40S ribosomal protein S29-A

E0: 40S ribosomal protein S30-A

E1: Ubiquitin-40S ribosomal protein S31

SR: Guanine nucleotide-binding protein subunit beta-like protein

SM: Suppressor protein STM1

1: 25s rRNA

3: 5.8s rRNA

4: 5.8s rRNA

L2: 60S ribosomal protein L2-A

L3: 60S ribosomal protein L3

L4: 60S ribosomal protein L4-A

L5: 60S ribosomal protein L5

L6: 60S ribosomal protein L6-A

L7: 60S ribosomal protein L7-A

L8: 60S ribosomal protein L8-A

L9: 60S ribosomal protein L9-A

M0: 60S ribosomal protein L10

M1: 60S ribosomal protein L11-B

M3: 60S ribosomal protein L13-A

M4: 60S ribosomal protein L14-A

M5: 60S ribosomal protein L15-A

M6: 60S ribosomal protein L16-A

M7: 60S ribosomal protein L17-A

M8: 60S ribosomal protein L18-A

M9: 60S ribosomal protein L19-A

N0: 60S ribosomal protein L20-A

N1: 60S ribosomal protein L21-A

N2: 60S ribosomal protein L22-A

N3: 60S ribosomal protein L23-A

N4: 60S ribosomal protein L24-A

N5: 60S ribosomal protein L25

N6: 60S ribosomal protein L26-A

N7: 60S ribosomal protein L27-A

N8: 60S ribosomal protein L28

N9: 60S ribosomal protein L29

O0: 60S ribosomal protein L30

O1: 60S ribosomal protein L31-A

O2: 60S ribosomal protein L32

O3: 60S ribosomal protein L33-A

O4: 60S ribosomal protein L34-A

O5: 60S ribosomal protein L35-A

O6: 60S ribosomal protein L36-A

O7: 60S ribosomal protein L37-A

O8: 60S ribosomal protein L38

O9: 60S ribosomal protein L39

Q0: Ubiquitin-60S ribosomal protein L40

Q1: 60S ribosomal protein L41-A

Q2: 60S ribosomal protein L42-A

Q3: 60S ribosomal protein L43-A

ヘテロ分子

概要:

• ソフトウェアが定義した集合体
• 3.28 MDa, 79 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	3,284,945	1324
ポリマ－	3,107,886	79
非ポリマー	177,059	1245
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

計算値:

手法	PISA

2

6: 18S rRNA

s0: 40S ribosomal protein S0-A

s1: 40S ribosomal protein S1-A

s2: 40S ribosomal protein S2

s3: 40S ribosomal protein S3

s4: 40S ribosomal protein S4-A

s5: 40S ribosomal protein S5

s6: 40S ribosomal protein S6-A

s7: 40S ribosomal protein S7-A

s8: 40S ribosomal protein S8-A

s9: 40S ribosomal protein S9-A

c0: 40S ribosomal protein S10-B

c1: 40S ribosomal protein S11-A

c2: 40S ribosomal protein S12

c3: 40S ribosomal protein S13

c4: 40S ribosomal protein S14-A

c5: 40S ribosomal protein S15

c6: 40S ribosomal protein S16-A

c7: 40S ribosomal protein S17-A

c8: 40S ribosomal protein S18-A

c9: 40S ribosomal protein S19-A

d0: 40S ribosomal protein S20

d1: 40S ribosomal protein S21-A

d2: 40S ribosomal protein S22-A

d3: 40S ribosomal protein S23-A

d4: 40S ribosomal protein S24-A

d5: 40S ribosomal protein S25-A

d6: 40S ribosomal protein S26-B

d7: 40S ribosomal protein S27-A

d8: 40S ribosomal protein S28-A

d9: 40S ribosomal protein S29-A

e0: 40S ribosomal protein S30-A

e1: Ubiquitin-40S ribosomal protein S31

sR: Guanine nucleotide-binding protein subunit beta-like protein

sM: Suppressor protein STM1

5: 25s rRNA

7: 5.8s rRNA

8: 5.8s rRNA

l2: 60S ribosomal protein L2-A

l3: 60S ribosomal protein L3

l4: 60S ribosomal protein L4-A

l5: 60S ribosomal protein L5

l6: 60S ribosomal protein L6-A

l7: 60S ribosomal protein L7-A

l8: 60S ribosomal protein L8-A

l9: 60S ribosomal protein L9-A

m0: 60S ribosomal protein L10

m1: 60S ribosomal protein L11-B

m2: UNKNOWN PROTEIN m2

m3: 60S ribosomal protein L13-A

m4: 60S ribosomal protein L14-A

m5: 60S ribosomal protein L15-A

m6: 60S ribosomal protein L16-A

m7: 60S ribosomal protein L17-A

m8: 60S ribosomal protein L18-A

m9: 60S ribosomal protein L19-A

n0: 60S ribosomal protein L20-A

n1: 60S ribosomal protein L21-A

n2: 60S ribosomal protein L22-A

n3: 60S ribosomal protein L23-A

n4: 60S ribosomal protein L24-A

n5: 60S ribosomal protein L25

n6: 60S ribosomal protein L26-A

n7: 60S ribosomal protein L27-A

n8: 60S ribosomal protein L28

n9: 60S ribosomal protein L29

o0: 60S ribosomal protein L30

o1: 60S ribosomal protein L31-A

o2: 60S ribosomal protein L32

o3: 60S ribosomal protein L33-A

o4: 60S ribosomal protein L34-A

o5: 60S ribosomal protein L35-A

o6: 60S ribosomal protein L36-A

o7: 60S ribosomal protein L37-A

o8: 60S ribosomal protein L38

o9: 60S ribosomal protein L39

q0: Ubiquitin-60S ribosomal protein L40

q1: 60S ribosomal protein L41-A

q2: 60S ribosomal protein L42-A

q3: 60S ribosomal protein L43-A

p0: 60S acidic ribosomal protein P0

p1: UNKNOWN PROTEIN p1

p2: UNKNOWN PROTEIN p2

ヘテロ分子

概要:

• ソフトウェアが定義した集合体
• 3.35 MDa, 83 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	3,346,570	1399
ポリマ－	3,163,331	83
非ポリマー	183,240	1316
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

計算値:

手法	PISA

単位格子

Length a, b, c (Å)	436.680, 287.990, 304.760
Angle α, β, γ (deg.)	90.000, 99.010, 90.000
Int Tables number	4
Space group name H-M	P1211

• 詳細: there are 2 biological units in the asymetric unit (segid *A and segid *B)

要素

RNA鎖 , 4種, 8分子 2 6 1 5 3 7 4 8

#1: RNA鎖

2 6 18S rRNA

詳細:

分子量: 579761.938 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: GenBank: Z75578.1

#36: RNA鎖

1 5 25s rRNA

詳細:

分子量: 1097493.875 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: TPG: 329138943

#37: RNA鎖

3 7 5.8s rRNA

詳細:

分子量: 38951.105 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: TPG: 329138943

#38: RNA鎖

4 8 5.8s rRNA

詳細:

分子量: 50682.922 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: GenBank: 618731124

40S ribosomal protein ... , 32種, 62分子 S0 s0 S1 s1 S2 s2 S3 s3 S4 s4 S5 s5 S6 s6 S7 s7 S8 s8 S9 s9 C0 c0 C1 c1 C2 c2 C3 c3 C4 c4 ...

#2: タンパク質

S0 s0 40S ribosomal protein S0-A / Nucleic acid-binding protein NAB1A

詳細:

分子量: 27920.133 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P32905

#3: タンパク質

S1 s1 40S ribosomal protein S1-A / RP10A

詳細:

分子量: 28667.275 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P33442

#4: タンパク質

S2 s2 40S ribosomal protein S2 / Omnipotent suppressor protein SUP44 / RP12 / S4 / YS5

詳細:

分子量: 27359.629 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P25443

#5: タンパク質

S3 s3 40S ribosomal protein S3 / RP13 / YS3

詳細:

分子量: 26411.596 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05750

#6: タンパク質

S4 s4 40S ribosomal protein S4-A / RP5 / S7 / YS6

詳細:

分子量: 29338.133 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX35

#7: タンパク質

S5 s5 40S ribosomal protein S5 / RP14 / S2 / YS8

詳細:

分子量: 24941.402 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P26783

#8: タンパク質

S6 s6 40S ribosomal protein S6-A / RP9 / S10 / YS4

詳細:

分子量: 27054.486 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX37

#9: タンパク質

S7 s7 40S ribosomal protein S7-A / RP30 / RP40

詳細:

分子量: 21527.014 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P26786

#10: タンパク質

S8 s8 40S ribosomal protein S8-A / RP19 / S14 / YS9

詳細:

分子量: 22537.803 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX39

#11: タンパク質

S9 s9 40S ribosomal protein S9-A / RP21 / S13 / YP28 / YS11

詳細:

分子量: 22356.695 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: O13516

#12: タンパク質

C0 c0 40S ribosomal protein S10-B

詳細:

分子量: 12771.471 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P46784, UniProt: Q08745*PLUS

#13: タンパク質

C1 c1 40S ribosomal protein S11-A / RP41 / S18 / YS12

詳細:

分子量: 17668.766 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX47

#14: タンパク質

C2 c2 40S ribosomal protein S12

詳細:

分子量: 15385.485 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P48589

#15: タンパク質

C3 c3 40S ribosomal protein S13 / S27a / YS15

詳細:

分子量: 16928.748 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05756

#16: タンパク質

C4 c4 40S ribosomal protein S14-A / RP59A

詳細:

分子量: 14431.462 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P06367

#17: タンパク質

C5 c5 40S ribosomal protein S15 / RIG protein / RP52 / S21 / YS21

詳細:

分子量: 15900.712 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: Q01855

#18: タンパク質

C6 c6 40S ribosomal protein S16-A / RP61R

詳細:

分子量: 15746.292 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX51

#19: タンパク質

C7 c7 40S ribosomal protein S17-A / RP51A

詳細:

分子量: 15820.413 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P02407

#20: タンパク質

C8 c8 40S ribosomal protein S18-A

詳細:

分子量: 16940.443 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX55

#21: タンパク質

C9 c9 40S ribosomal protein S19-A / RP55A / S16a / YP45 / YS16A

詳細:

分子量: 15810.930 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P07280

#22: タンパク質

D0 d0 40S ribosomal protein S20

詳細:

分子量: 13797.850 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P38701

#23: タンパク質

D1 d1 40S ribosomal protein S21-A / S26 / YS25

詳細:

分子量: 9758.829 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0C0V8

#24: タンパク質

D2 d2 40S ribosomal protein S22-A / RP50 / S24 / YP58 / YS22

詳細:

分子量: 14518.867 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0C0W1

#25: タンパク質

D3 d3 40S ribosomal protein S23-A / RP37 / S28 / YS14

詳細:

分子量: 15942.699 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX29

#26: タンパク質

D4 d4 40S ribosomal protein S24-A / RP50

詳細:

分子量: 15231.650 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX31

#27: タンパク質

D5 d5 40S ribosomal protein S25-A / RP45 / S31 / YS23

詳細:

分子量: 11936.076 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: Q3E792

#28: タンパク質

D6 d6 40S ribosomal protein S26-B

詳細:

分子量: 11022.989 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P39939

#29: タンパク質

D7 d7 40S ribosomal protein S27-A / RP61 / YS20

詳細:

分子量: 8762.195 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P35997

#30: タンパク質

D8 d8 40S ribosomal protein S28-A / S33 / YS27

詳細:

分子量: 7474.652 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: Q3E7X9

#31: タンパク質

D9 d9 40S ribosomal protein S29-A / S36 / YS29

詳細:

分子量: 6544.527 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P41057

#32: タンパク質

E0 40S ribosomal protein S30-A

詳細:

分子量: 6779.086 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX33

#80: タンパク質

e0 40S ribosomal protein S30-A

詳細:

分子量: 7006.346 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX33

Ubiquitin-40S ribosomal protein ... , 2種, 2分子 E1 e1

#33: タンパク質

E1 Ubiquitin-40S ribosomal protein S31

詳細:

分子量: 8703.462 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05759

#81: タンパク質

e1 Ubiquitin-40S ribosomal protein S31

詳細:

分子量: 8717.488 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05759

タンパク質 , 4種, 7分子 SR sR SM sM Q0 q0 p0

#34: タンパク質

SR sR Guanine nucleotide-binding protein subunit beta-like protein / Receptor for activated C kinase / Receptor of activated protein kinase C 1 / RACK1

詳細:

分子量: 34710.023 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P38011

#35: タンパク質

SM sM Suppressor protein STM1 / 3BP1 / GU4 nucleic-binding protein 2 / G4p2 protein / POP2 multicopy suppressor protein 4 / Ribosomal subunits association factor / AF / TOM1 suppressor protein 1 / Triplex-binding protein 1

詳細:

分子量: 30048.010 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P39015

#76: タンパク質

Q0 q0 Ubiquitin-60S ribosomal protein L40

詳細:

分子量: 6032.321 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CH08

#83: タンパク質

p0 60S acidic ribosomal protein P0 / A0 / L10E

詳細:

分子量: 33617.930 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05317

60S ribosomal protein ... , 40種, 80分子 L2 l2 L3 l3 L4 l4 L5 l5 L6 l6 L7 l7 L8 l8 L9 l9 M0 m0 M1 m1 M3 m3 M4 m4 M5 m5 M6 m6 M7 m7 ...

#39: タンパク質

L2 l2 60S ribosomal protein L2-A / L5 / RP8 / YL6

詳細:

分子量: 27332.377 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX45

#40: タンパク質

L3 l3 60S ribosomal protein L3 / Maintenance of killer protein 8 / RP1 / Trichodermin resistance protein / YL1

詳細:

分子量: 43719.602 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P14126

#41: タンパク質

L4 l4 60S ribosomal protein L4-A / L2 / RP2 / YL2

詳細:

分子量: 39027.926 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P10664

#42: タンパク質

L5 l5 60S ribosomal protein L5 / L1 / L1a / Ribosomal 5S RNA-binding protein / YL3

詳細:

分子量: 33633.633 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P26321

#43: タンパク質

L6 l6 60S ribosomal protein L6-A / L17 / RP18 / YL16

詳細:

分子量: 19869.369 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: Q02326

#44: タンパク質

L7 l7 60S ribosomal protein L7-A / L6 / RP11 / YL8

詳細:

分子量: 27555.084 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05737

#45: タンパク質

L8 l8 60S ribosomal protein L8-A / L4 / L4-2 / L7a-1 / Maintenance of killer protein 7 / RP6 / YL5

詳細:

分子量: 28058.646 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P17076

#46: タンパク質

L9 l9 60S ribosomal protein L9-A / L8 / RP24 / YL11

詳細:

分子量: 21605.061 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05738

#47: タンパク質

M0 m0 60S ribosomal protein L10 / L9 / Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein

詳細:

分子量: 25279.271 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P41805

#48: タンパク質

M1 m1 60S ribosomal protein L11-B / L16 / RP39 / YL22

詳細:

分子量: 19654.520 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: Q3E757

#49: タンパク質

M3 m3 60S ribosomal protein L13-A

詳細:

分子量: 22472.967 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: Q12690

#50: タンパク質

M4 m4 60S ribosomal protein L14-A

詳細:

分子量: 15063.870 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P36105

#51: タンパク質

M5 m5 60S ribosomal protein L15-A / L13 / RP15R / YL10 / YP18

詳細:

分子量: 24351.162 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05748

#52: タンパク質

M6 m6 60S ribosomal protein L16-A / L13a / L21 / RP22 / YL15

詳細:

分子量: 22116.029 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P26784

#53: タンパク質

M7 m7 60S ribosomal protein L17-A / L20A / YL17

詳細:

分子量: 20458.322 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05740

#54: タンパク質

M8 m8 60S ribosomal protein L18-A / RP28

詳細:

分子量: 20478.059 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX49

#55: タンパク質

M9 m9 60S ribosomal protein L19-A / L23 / RP15L / RP33 / YL14

詳細:

分子量: 21631.121 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX82

#56: タンパク質

N0 n0 60S ribosomal protein L20-A / L18a

詳細:

分子量: 20478.852 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX23

#57: タンパク質

N1 n1 60S ribosomal protein L21-A

詳細:

分子量: 18148.066 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: Q02753

#58: タンパク質

N2 n2 60S ribosomal protein L22-A / L1c / RP4 / YL31

詳細:

分子量: 13580.163 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05749

#59: タンパク質

N3 n3 60S ribosomal protein L23-A / L17a / YL32

詳細:

分子量: 14362.755 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX41

#60: タンパク質

N4 n4 60S ribosomal protein L24-A / L30 / RP29 / YL21

詳細:

分子量: 17661.717 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P04449

#61: タンパク質

N5 n5 60S ribosomal protein L25 / RP16L / YL25 / YP42'

詳細:

分子量: 15656.417 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P04456

#62: タンパク質

N6 n6 60S ribosomal protein L26-A / L33 / YL33

詳細:

分子量: 14134.588 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05743

#63: タンパク質

N7 n7 60S ribosomal protein L27-A

詳細:

分子量: 15437.166 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0C2H6

#64: タンパク質

N8 n8 60S ribosomal protein L28 / L27a / L29 / RP44 / RP62 / YL24

詳細:

分子量: 16630.471 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P02406

#65: タンパク質

N9 n9 60S ribosomal protein L29 / YL43

詳細:

分子量: 6560.688 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05747

#66: タンパク質

O0 o0 60S ribosomal protein L30 / L32 / RP73 / YL38

詳細:

分子量: 11299.168 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P14120

#67: タンパク質

O1 o1 60S ribosomal protein L31-A / L34 / YL28

詳細:

分子量: 12848.962 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0C2H8

#68: タンパク質

O2 o2 60S ribosomal protein L32

詳細:

分子量: 14678.246 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P38061

#69: タンパク質

O3 o3 60S ribosomal protein L33-A / L37 / RP47 / YL37

詳細:

分子量: 12045.935 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05744

#70: タンパク質

O4 o4 60S ribosomal protein L34-A

詳細:

分子量: 13412.820 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P87262

#71: タンパク質

O5 o5 60S ribosomal protein L35-A

詳細:

分子量: 13811.444 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX84

#72: タンパク質

O6 o6 60S ribosomal protein L36-A / L39 / YL39

詳細:

分子量: 11020.063 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P05745

#73: タンパク質

O7 o7 60S ribosomal protein L37-A / L43 / YL35 / YP55

詳細:

分子量: 9746.199 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P49166

#74: タンパク質

O8 o8 60S ribosomal protein L38

詳細:

分子量: 8714.363 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P49167

#75: タンパク質・ペプチド

O9 o9 60S ribosomal protein L39 / L46 / YL40

詳細:

分子量: 6227.444 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P04650

#77: タンパク質・ペプチド

Q1 q1 60S ribosomal protein L41-A / L47 / YL41

詳細:

分子量: 3354.243 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX86

#78: タンパク質

Q2 q2 60S ribosomal protein L42-A / L41 / YL27 / YP44

詳細:

分子量: 12115.462 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX27

#79: タンパク質

Q3 q3 60S ribosomal protein L43-A / L37a / YL35

詳細:

分子量: 9981.756 Da / 分子数: 2 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)
参照: UniProt: P0CX25

UNKNOWN PROTEIN ... , 3種, 3分子 m2 p1 p2

#82: タンパク質

m2 UNKNOWN PROTEIN m2

詳細:

分子量: 13634.798 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)

#84: タンパク質・ペプチド

p1 UNKNOWN PROTEIN p1

詳細:

分子量: 4017.944 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)

#85: タンパク質・ペプチド

p2 UNKNOWN PROTEIN p2

詳細:

分子量: 3932.839 Da / 分子数: 1 / 由来タイプ: 天然
由来: (天然) Saccharomyces cerevisiae ATCC 204508 / S288c (パン酵母)

非ポリマー , 4種, 2561分子

#86: 化合物

2-1901 2-1902 2-1903 2-1904 2-1905 2-1906 2-1907 2-1908 2-1909 2-1910 2-1911 2-1912 2-1913 2-1914 2-1915 2-1916 2-1917 2-1918 2-1919 2-1920 ...
ChemComp-MG / MAGNESIUM ION / マグネシウムジカチオン

詳細:

分子量: 24.305 Da / 分子数: 1410 / 由来タイプ: 合成 / 式: Mg

#87: 化合物

2-2023 2-2024 2-2025 2-2026 2-2027 2-2028 2-2029 2-2030 2-2031 2-2032 2-2033 2-2034 2-2035 2-2036 2-2037 2-2038 2-2039 2-2040 2-2041 2-2042 ...
ChemComp-OHX / osmium (III) hexammine / osmium(6+) hexaazanide

詳細:

分子量: 286.365 Da / 分子数: 1133 / 由来タイプ: 合成 / 式: H₁₂N₆Os

#88: 化合物

D6-500 D7-101 D9-101 E1-501 O7-101 Q0-500 Q2-501 Q3-501 d6-101 d7-101 d9-101 e1-501 o7-501 q0-201 q2-501 q3-501
ChemComp-ZN / ZINC ION

詳細:

分子量: 65.409 Da / 分子数: 16 / 由来タイプ: 合成 / 式: Zn

#89: 化合物

1-4218 5-4260 ChemComp-ANM / ANISOMYCIN / アニソマイシン

詳細:

分子量: 265.305 Da / 分子数: 2 / 由来タイプ: 合成 / 式: C₁₄H₁₉NO₄ / コメント: 抗生剤*YM

実験情報

実験

• 実験: 手法: X線回折 / 使用した結晶の数: 1

試料調製

• 結晶: マシュー密度: 3.08 ų/Da / 溶媒含有率: 60.08 %
• 結晶化: 温度: 277 K / 手法: 蒸気拡散法, ハンギングドロップ法 / pH: 7.5 ; 詳細: PEG 20K, KSCN, Mg Acetate, Tris-Acetate, Glycerol, Spermidine

データ収集

• 回折: 平均測定温度: 100 K
• 放射光源: 由来: シンクロトロン / サイト: SOLEIL / ビームライン: PROXIMA 1 / 波長: 1 Å
• 検出器: タイプ: DECTRIS PILATUS 6M / 検出器: PIXEL / 日付: 2013年7月1日
• 放射: プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
• 放射波長: 波長: 1 Å / 相対比: 1
• 反射: 解像度: 3→99.795 Å / Num. obs: 1479440 / % possible obs: 100 % / Observed criterion σ(I): -3 / 冗長度: 12.94 % / B_iso Wilson estimate: 74.79 Ų / R_merge F obs: 0.996 / R_merge(I) obs: 0.3 / R_rim(I) all: 0.311 / Χ²: 0.992 / Net I/σ(I): 8.36 / Num. measured all: 20088881

反射 シェル

Diffraction-ID: 1 / Rejects: _

解像度 (Å)	最高解像度 (Å)	Rmerge F obs	Rmerge(I) obs	Mean I/σ(I) obs	Num. measured obs	Num. possible	Num. unique obs	Rrim(I) all	% possible all
3-3.1		0.453	2.747	1.09	1788791	138239	138204	2.86	100
3.1-3.2		0.621	1.865	1.57	1573500	121575	121558	1.942	100
3.2-3.3		0.745	1.345	2.14	1439633	107182	107174	1.398	100
3.3-3.4		0.814	1.074	2.67	1247266	95074	95060	1.118	100
3.4-3.5		0.864	0.876	3.24	1103460	84585	84574	0.911	100
3.5-4		0.95	0.516	5.48	4075771	307199	307166	0.537	100
4-5		0.986	0.258	10.69	4019642	304581	304553	0.269	100
5-7		0.993	0.166	16.08	2718913	203601	203581	0.173	100
7-10		0.996	0.161	22.76	1300899	77014	76999	0.166	100
10-20		0.998	0.116	31.31	731124	35454	35445	0.119	100
20-30		0.999	0.069	41.46	73574	3649	3645	0.071	99.9
30-40		0.999	0.074	41.53	14073	891	892	0.077	100
40-50		0.998	0.037	24.46	1403	325	322	0.043	99.1
50-100		0.998	0.039	18.63	832	309	267	0.046	86.4
100-150						35
	150					14

解析

ソフトウェア

名称	バージョン	分類
PHENIX	(phenix.refine: dev_1702)	精密化
PDB_EXTRACT	3.14	データ抽出
XDS		データ削減
XSCALE		データスケーリング
HKL		データ削減

精密化

構造決定の手法: 分子置換
開始モデル: 3U5B, 3U5C, 3U5D, 3U5E, 3U5F, 3U5G, 3U5H, 3U5I

3u5b
PDB 未公開エントリ

3u5c
PDB 未公開エントリ

3u5d
PDB 未公開エントリ

3u5e
PDB 未公開エントリ

3u5f
PDB 未公開エントリ

3u5g
PDB 未公開エントリ

3u5h
PDB 未公開エントリ

3u5i
PDB 未公開エントリ

解像度: 3→99.795 Å / SU ML: 0.41 / 交差検証法: FREE R-VALUE / σ(F): 0 / 位相誤差: 24.45 / 立体化学のターゲット値: ML

	Rfactor	反射数	%反射
Rfree	0.2453	29589	2 %
Rwork	0.1985	1449689	-
obs	0.1994	1479278	99.98 %

• 溶媒の処理: 減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL
• 原子変位パラメータ: B_iso max: 276.48 Ų / B_iso mean: 70.0499 Ų / B_iso min: 20 Ų

精密化ステップ

サイクル: final / 解像度: 3→99.795 Å

	タンパク質	核酸	リガンド	溶媒	全体
原子数	179693	222116	10975	0	412784
Biso mean	-	-	110.85	-	-
残基数	-	-	-	-	32990

拘束条件

Refine-ID	タイプ	Dev ideal	数
X-RAY DIFFRACTION	f_bond_d	0.013	438179
X-RAY DIFFRACTION	f_angle_d	1.7	650206
X-RAY DIFFRACTION	f_chiral_restr	0.066	79424
X-RAY DIFFRACTION	f_plane_restr	0.008	41800
X-RAY DIFFRACTION	f_dihedral_angle_d	18.692	194784

LS精密化 シェル

Refine-ID: X-RAY DIFFRACTION / Total num. of bins used: 30 / % reflection obs: 100 %

解像度 (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Num. reflection all
3-3.0341	0.3509	983	0.3082	48185	49168
3.0341-3.0698	0.328	981	0.2913	48037	49018
3.0698-3.1072	0.3362	986	0.2825	48292	49278
3.1072-3.1465	0.329	983	0.2858	48180	49163
3.1465-3.1879	0.3357	983	0.2797	48194	49177
3.1879-3.2316	0.2969	985	0.2517	48276	49261
3.2316-3.2778	0.2872	987	0.2364	48311	49298
3.2778-3.3267	0.2714	982	0.2258	48142	49124
3.3267-3.3787	0.2867	984	0.2263	48230	49214
3.3787-3.4341	0.2666	986	0.2151	48289	49275
3.4341-3.4933	0.2709	985	0.212	48253	49238
3.4933-3.5568	0.2558	984	0.2032	48247	49231
3.5568-3.6253	0.2567	983	0.2041	48183	49166
3.6253-3.6993	0.2486	986	0.1953	48307	49293
3.6993-3.7797	0.244	985	0.1865	48237	49222
3.7797-3.8676	0.2265	984	0.1791	48249	49233
3.8676-3.9643	0.2186	988	0.1689	48390	49378
3.9643-4.0715	0.2296	986	0.1739	48302	49288
4.0715-4.1913	0.2323	984	0.1742	48239	49223
4.1913-4.3266	0.2251	986	0.1742	48304	49290
4.3266-4.4813	0.2195	987	0.1698	48351	49338
4.4813-4.6607	0.2282	986	0.1729	48316	49302
4.6607-4.8728	0.2174	989	0.1699	48433	49422
4.8728-5.1297	0.2164	985	0.1718	48321	49306
5.1297-5.4511	0.2223	988	0.1703	48420	49408
5.4511-5.8719	0.225	989	0.1764	48450	49439
5.8719-6.4627	0.2296	989	0.1872	48448	49437
6.4627-7.3976	0.2375	991	0.1955	48526	49517
7.3976-9.3192	0.2378	992	0.2076	48637	49629
9.3192-99.8499	0.256	1002	0.2298	48940	49942

精密化 TLS

手法: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	1.4902	0.1533	-0.99	0.4871	-0.1466	2.2263	-0.0152	-0.115	-0.4865	0.2655	-0.1338	0.0894	0.2604	-0.069	0.0629	0.8327	-0.3977	0.4806	1.1862	-0.3219	1.1878	-110.8506	-8.0739	110.4932
2	1.0257	-0.6842	0.2719	1.147	0.007	0.6078	-0.0593	-0.5221	-0.5838	0.6562	0.0302	0.0718	0.412	-0.042	0.0014	1.5122	-0.2237	0.1881	0.9281	0.3122	0.8607	-47.0185	-27.5285	139.4976
3	1.2094	0.0786	-0.2981	0.8155	0.249	1.0309	0.0527	0.0951	0.0436	0.0993	-0.052	0.454	0.1345	-0.5069	0.0211	0.4442	-0.1161	0.0748	1.0731	-0.2791	1.0178	-101.2342	9.7954	77.1138
4	1.1164	0.6643	-0.3316	0.779	-0.3162	0.4385	0.0217	0.3043	-0.0369	-0.0279	0.0384	0.1493	-0.093	-0.2924	-0.0058	0.4698	-0.1039	-0.0206	1.1121	-0.2783	0.9035	-99.6887	-29.0722	46.1038
5	0.6414	0.0807	-0.3589	0.9612	0.2544	1.1739	0.0302	0.0111	0.2014	0.0229	0.005	0.4369	-0.1385	-0.3091	-0.0278	0.6264	0.3281	0.0573	0.8963	0.0137	1.0377	-80.0994	81.4642	71.4709
6	1.5765	-0.8944	0.4173	0.6047	0.0092	2.1999	0.0257	-0.3205	-0.1858	0.1677	-0.1019	0.1373	0.2396	-0.0549	0.0653	1.0053	-0.3712	0.0788	0.5613	-0.0818	0.7553	-76.5914	-77.1005	91.0646
7	0.9515	-0.3009	-0.4412	0.9634	0.038	0.8452	0.0788	0.1717	0.3579	-0.3741	-0.2011	-0.1903	-0.289	0.0219	0.1295	0.7849	0.2212	0.0498	0.6459	0.2365	0.8964	-30.1671	98.4777	48.911
8	1.0306	-0.0963	-0.5134	0.2763	-0.2609	0.6138	0.0323	-0.4676	0.3772	0.3267	-0.1233	0.099	-0.1432	-0.1697	-0.1316	0.8433	-0.0855	0.4341	1.2277	-0.4566	0.9423	-97.9068	48.2153	136.6794
9	0.8171	0.243	0.1855	2.3445	0.5139	1.213	0.0921	-0.1395	0.335	0.1963	-0.1796	0.0891	-0.3298	-0.0359	0.0884	0.5755	0.0992	0.1631	0.4859	-0.1152	0.7543	-31.63	89.409	95.104
10	0.812	-0.1294	0.0667	1.1134	0.2437	1.5823	0.0774	0.047	-0.0076	-0.175	-0.0125	0.435	-0.1913	-0.3778	-0.0622	0.4511	0.1109	-0.1187	1.2222	-0.1385	1.1957	-96.7015	41.7609	48.6462
11	0.0624	0.316	-0.2592	2.2496	-0.439	2.2276	0.1695	0.491	-0.1789	-0.2565	0.0731	0.3161	0.0173	-0.5574	-0.2426	0.5621	-0.2139	-0.0066	1.3433	-0.1281	0.9348	-86.6629	-32.7939	14.1374
12	1.5066	1.1646	0.1972	2.2181	0.4759	0.5359	0.2274	-0.5286	0.1095	0.5465	-0.4159	0.2911	0.0114	-0.1441	0.1961	0.6832	0.0349	0.2264	0.7054	-0.0988	0.6164	-52.4305	67.4103	105.2209
13	3.7209	-2.446	-0.9082	3.5307	-0.9537	1.4795	0.1095	0.398	0.1534	-0.3362	-0.0942	0.2973	-0.1	-0.1137	-0.0067	1.2503	-0.0749	-0.1064	1.7179	0.1721	1.0868	-79.4306	-25.5135	-17.9534
14	0.9286	-0.1853	-0.2869	1.2677	-0.0868	1.1727	0.0274	-0.3552	0.0981	0.5839	-0.1205	0.2547	-0.0837	-0.3211	0.0954	0.7362	-0.2214	0.1905	0.8471	-0.1457	0.5121	-60.7279	30.3487	132.1729
15	0.2717	-0.2403	0.1891	1.3209	-0.024	0.1685	-0.0264	-0.21	-0.7249	0.394	-0.1355	0.0488	0.6699	-0.0108	0.1128	1.4241	-0.254	0.1251	0.6619	0.1976	1.4282	-44.8281	-39.3938	116.405
16	1.1769	1.0632	-0.705	3.1395	0.1243	2.8366	-0.1831	0.1049	-0.105	-0.4267	-0.0083	-0.0059	0.2707	-0.0327	0.1709	0.4531	-0.1399	0.0968	0.8966	-0.3196	1.0506	-46.918	-69.9721	21.9258
17	0.7858	0.3875	-0.723	1.5459	-0.8141	0.8892	-0.1226	0.1567	-0.0601	0.2696	-0.0105	0.0651	0.1688	-0.1581	0.1327	1.0396	-0.5083	0.2577	0.9779	-0.4358	1.0046	-98.1771	-77.178	73.6038
18	0.0679	-0.1017	-0.0265	0.6941	0.9219	1.4199	0.0333	0.1176	-0.3007	-0.0805	-0.0208	0.0539	-0.0554	0.0377	0.1058	0.6623	-0.3968	0.3029	0.8846	-0.3212	0.9361	-112.1808	-30.1883	98.6681
19	0.5644	-0.0104	-0.0055	1.5888	-0.4391	0.9298	-0.0269	0.0556	-0.3825	0.0961	0.0209	0.1341	0.4739	-0.0243	0.0222	0.6874	-0.153	0.1323	0.7673	-0.2853	1.1875	-49.3712	-90.162	49.3645
20	1.3714	0.657	0.5281	1.6452	0.354	0.6208	-0.0712	0.1098	-0.4374	0.1812	-0.1444	-0.1083	0.2706	-0.1945	0.1536	1.0511	-0.464	0.3323	0.9122	-0.4436	1.4077	-82.9397	-95.1261	52.0035
21	4.5353	2.0417	1.7365	2.2631	0.7675	1.7631	0.0129	0.2154	0.1949	-0.3166	-0.1631	0.6144	-0.0563	-0.469	0.0936	0.6803	-0.279	0.0359	1.2544	-0.4834	1.0994	-107.5655	-55.6766	43.392
22	1.1243	-0.9002	0.8966	0.7853	-0.4917	1.488	0.0987	-0.0103	0.1205	0.2095	-0.0371	0.3599	0.0456	-0.3631	-0.0981	0.5962	-0.1485	0.3925	1.2941	-0.3775	1.2505	-111.1796	12.1802	101.8296
23	0.9043	0.1472	0.0063	0.9341	0.1616	0.8425	0.1552	0.2679	0.3121	0.3525	-0.0889	0.4708	-0.0066	-0.5263	-0.0644	0.5066	-0.0338	0.2852	0.9905	-0.1868	0.8875	-90.2045	33.4185	102.062
24	0.457	-0.1781	-0.0779	1.1854	0.9456	0.8458	-0.0781	0.0374	-0.0394	-0.0188	-0.0714	0.1891	-0.0088	-0.0285	0.123	0.3003	-0.0312	0.0488	0.556	-0.0567	0.4402	-54.5351	21.6031	56.5568
25	2.4797	0.0972	0.7845	1.3844	-0.0829	0.7918	-0.1563	0.4592	0.3296	-0.3898	0.1247	0.5375	-0.2793	-0.4857	0.0324	0.8577	0.3469	-0.2109	1.0658	0.0648	0.8429	-74.2159	77.1749	33.8302
26	0.5646	-0.8819	0.2934	1.398	-0.4946	0.2135	0.0499	-0.1696	0.0412	0.0645	0.0139	-0.1409	-0.0317	0.2151	-0.0451	1.6577	-0.3046	0.0006	0.8657	-0.056	1.4099	-63.7145	-102.0403	81.5344
27	1.1556	0.0789	0.127	0.2145	0.4191	0.823	-0.1351	-0.4123	-0.6951	0.1926	0.0873	0.5122	0.6362	-0.4921	0.0352	1.0319	-0.3362	0.2499	0.8884	0.0406	1.2482	-61.2447	-22.7309	109.9134
28	2.6575	-0.1212	0.675	0.9898	-0.0472	0.1712	0.1427	-0.5162	0.0821	0.5364	-0.0347	0.0767	-0.1336	-0.4065	-0.1032	0.9362	-0.2842	0.453	1.0598	-0.1097	0.9312	-80.9528	17.5442	141.5718
29	2.2778	-0.2839	-0.7238	3.358	-0.8847	3.4374	0.1258	-0.7344	0.1092	0.9047	-0.1592	-0.2402	-0.5121	0.2956	0.0195	1.6752	-0.4958	0.0838	1.2345	-0.2665	0.7369	-76.1736	-56.92	107.4719
30	1.9292	0.0793	-0.7358	1.1533	0.1323	0.7592	-0.0052	0.3102	0.0094	0.0276	-0.0918	0.2101	0.0918	-0.2983	0.0562	0.4724	-0.2598	0.0909	0.9379	-0.3042	0.8521	-79.8635	-47.5099	36.9461
31	4.1946	-3.1164	-0.3491	2.7672	0.2057	0.4889	-0.2486	-0.338	-0.6397	-0.1741	0.1225	0.7879	-0.0173	-0.4609	0.1573	0.6858	-0.0646	-0.0472	1.2532	-0.1847	0.9155	-80.6392	12.9934	37.7987
32	0.3018	0.2094	-0.0157	0.6848	1.2738	3.046	0.1835	0.3395	-0.0182	-0.1249	0.1588	-0.0839	0.0391	0.2391	-0.2395	1.0835	-0.0281	0.1018	1.6852	-0.1384	0.917	-60.5123	-42.6664	-6.8923
33	1.4152	-0.0251	-0.1289	1.4659	0.0501	0.8482	-0.0675	-0.1061	0.0848	0.3198	0.0033	0.2827	0.1489	-0.2517	0.0534	0.9143	-0.5309	0.3945	1.2564	-0.3914	1.1238	-132.6428	-57.6808	87.14
34	0.3884	-0.3362	-0.0812	0.2484	0.056	-0.0112	0.1408	-0.096	0.0977	0.0747	-0.0791	-0.1184	-0.048	0.034	-0.0743	0.5115	-0.1829	0.0137	0.8488	-0.0643	0.9246	-54.7851	-40.0788	41.1376
35	0.3212	-0.0879	-0.6671	0.5513	-0.0203	1.7784	0.015	-0.088	-0.0788	0.135	-0.0332	0.1464	0.0663	-0.0604	-0.0024	0.3684	-0.126	0.0766	0.4714	-0.0165	0.4274	-2.9662	-3.6427	124.5901
36	0.5111	0.0656	-0.0714	0.8044	-0.1402	0.6204	0.0995	0.1711	0.2673	0.0545	-0.0394	0.0155	-0.2988	-0.0469	-0.0699	0.4608	0.0739	0.1038	0.4631	0.1864	0.6046	32.1077	61.7008	38.9459
37	0.3483	0.022	-0.0357	0.2366	-0.0267	0.4363	-0.0069	-0.0521	-0.0655	0.085	-0.0396	-0.1652	0.0679	0.1764	0.0565	0.2836	-0.0076	-0.0075	0.4085	0.066	0.4164	92.5995	-24.4152	73.5344
38	0.6391	0.1239	0.235	1.4553	-0.3227	0.8748	0.1076	0.1992	-0.305	-0.071	0.0385	-0.0703	0.52	-0.0649	-0.1459	0.7685	-0.1289	-0.0373	0.5467	-0.3316	0.7855	24.3624	-93.0413	30.264
39	0.4025	0.2583	-0.4706	1.1845	-0.9892	1.878	0.0839	0.0229	-0.0298	-0.1389	-0.1818	-0.2913	-0.06	0.2761	0.082	0.2416	0.0128	0.075	0.4891	0.0903	0.4579	105.8806	12.5833	12.462
40	0.7334	-0.1415	-0.321	1.5118	0.3071	1.7182	-0.0949	0.2263	-0.0155	-0.0312	-0.002	-0.1451	0.2008	-0.0468	0.0788	0.2629	-0.0153	0.0145	0.3697	-0.0372	0.2285	75.724	-30.9621	16.863
41	1.0082	-0.7401	-0.3789	1.5321	0.294	0.3407	-0.1199	-0.3089	-0.2439	0.4162	0.034	0.131	0.0312	-0.0454	0.1023	0.7449	-0.1449	0.0979	0.7583	0.1521	0.3571	28.52	-39.5909	161.4664
42	2.0575	-0.7983	-0.589	0.7792	0.1768	0.5124	0.1526	0.4675	0.4016	-0.2548	-0.0587	0.0702	-0.2022	-0.2336	-0.1109	0.4825	0.1169	-0.0179	0.9143	0.286	0.5309	20.3602	33.5766	-8.7185
43	1.4192	-0.2097	0.3181	1.351	-0.309	0.8004	0.0016	0.295	-0.0843	-0.2863	-0.0465	0.2929	0.0411	-0.3462	0.0777	0.361	-0.1339	-0.0796	0.8046	-0.0358	0.419	11.3212	-26.7455	12.4926
44	1.7677	-0.0388	-0.1943	0.8934	-0.0854	1.3571	0.0481	0.2362	-0.3532	-0.155	0.0528	0.3269	0.359	-0.684	-0.1073	0.5436	-0.2493	-0.1245	0.9307	-0.1881	0.957	-12.62	-78.6438	29.8815
45	0.2889	0.1547	0.1555	1.1925	-0.2022	1.1745	0.0162	-0.1213	-0.1767	0.2761	-0.0501	-0.2061	0.1318	0.2423	0.0656	0.3833	0.0048	0.0057	0.5377	0.1794	0.3845	71.2584	-54.8083	111.7924
46	1.0623	0.3764	0.4693	0.2747	0.0875	0.5897	0.0783	0.407	0.1975	-0.0268	-0.001	-0.0866	0.0325	-0.0278	-0.0544	0.3967	-0.016	0.0717	0.6833	0.0781	0.3487	68.4246	14.7023	-15.7233
47	0.2168	-0.0618	-0.1674	0.0633	-0.0259	0.6318	0.0084	-0.1105	-0.1533	0.0992	0.0172	0.0303	0.0845	-0.0443	-0.0238	0.478	-0.1227	0.0059	0.4856	0.1252	0.329	42.2376	-31.8866	127.8634
48	0.2927	-0.0473	0.0243	0.3484	0.1629	0.2921	0.0104	0.2612	0.1852	-0.0547	0.0097	0.0368	-0.0517	-0.1376	-0.0243	0.3425	0.0593	0.0271	0.536	0.1894	0.3945	55.924	30.5552	12.3706
49	0.328	-0.1386	0.2921	1.1968	0.5525	1.071	0.1486	0.0961	0.22	-0.0806	-0.023	-0.1612	-0.0851	0.2726	-0.1549	0.4102	-0.0882	0.0328	0.3831	0.0162	0.4219	73.1946	40.8718	68.0037
50	0.7743	-0.102	-0.0718	0.5065	-0.0503	0.5608	0.0101	-0.0642	-0.1617	0.0521	-0.0507	-0.069	0.1424	0.1256	0.0692	0.3743	0.0197	0.0109	0.3608	0.0407	0.494	80.879	-49.5738	65.6487
51	1.4156	-0.1458	0.4143	0.8364	-0.2203	0.9237	0.0426	-0.2929	0.5034	0.149	-0.0837	-0.1847	-0.2535	-0.0501	0.0745	0.6974	-0.0769	0.0604	0.5258	-0.1552	0.669	36.8691	62.2726	112.1789
52	1.71	0.5879	-1.3101	0.4305	-0.7337	1.4291	0.1222	-0.189	0.1229	0.185	-0.1041	0.1931	-0.2479	-0.0115	-0.0136	0.591	-0.0122	0.17	0.6372	-0.1669	0.6454	-15.2961	52.395	119.0306
53	2.9896	-1.6774	-0.527	1.6058	0.6652	0.7302	-0.3109	-0.1153	-0.3357	0.3556	0.0154	0.4938	0.0741	-0.7498	0.2979	0.8397	0.0754	0.2387	1.1192	-0.2582	0.904	-48.3705	58.7469	133.9093
54	0.5101	0.538	-0.3866	1.4455	-0.1318	0.4999	-0.0468	0.2936	0.0899	-0.1773	0.1031	0.1984	0.1277	-0.1905	-0.0704	0.3396	-0.0092	-0.0369	0.7345	-0.0156	0.2674	48.7279	-13.798	-4.7987
55	0.1945	0.263	-0.4012	0.5773	-0.6841	1.335	-0.1185	0.0724	-0.075	-0.1287	0.054	0.1431	0.3401	-0.1203	0.0438	0.3927	-0.0543	-0.0489	0.4346	-0.1688	0.4071	46.162	-54.6543	29.4966
56	1.1885	0.0557	0.7838	3.2702	0.9947	3.2529	-0.0559	-0.1759	0.511	0.0469	-0.0309	-0.2002	-1.0076	0.0271	0.1348	1.2493	-0.0021	0.0037	0.4943	-0.2523	0.8222	24.0074	90.1862	119.1267
57	1.8211	0.1582	0.4777	2.511	-0.6476	0.4394	0.1662	0.4437	0.4132	-0.1975	-0.0348	0.2964	-0.1103	-0.1283	-0.1534	0.3577	0.1484	0.0717	0.514	0.0404	0.4885	-7.8862	45.9334	48.5361
58	0.9986	-1.162	0.9106	1.3524	-1.0589	0.8292	-0.1402	0.2139	0.8904	-0.0596	0.1697	0.0793	-0.64	-0.516	0.0813	0.7699	0.1392	0.1533	0.6221	0.1973	1.0809	-5.2741	81.6951	57.4079
59	0.7281	-0.173	0.2194	0.6626	-0.0218	0.6912	0.0309	-0.1954	0.1224	0.3477	-0.1034	-0.0652	-0.0534	0.1535	0.0979	0.5322	-0.1272	0.0111	0.6264	-0.1656	0.2998	52.3773	25.2049	143.7316
60	1.5878	0.1384	0.1759	1.3335	0.0568	1.3182	-0.0092	-0.375	0.039	0.2333	0.0447	-0.2954	-0.2139	0.4079	-0.0232	0.4571	-0.1583	-0.1285	0.7131	0.0054	0.4721	100.9714	11.9566	114.4017
61	0.8366	-0.3808	0.1114	0.6253	-0.4199	1.9145	-0.1313	-0.5205	0.0976	0.3359	0.1632	0.1002	-0.1114	-0.1792	-0.0892	0.9506	-0.0442	0.3717	0.9883	-0.1721	0.4555	-7.8921	27.7218	174.238
62	0.376	0.236	-0.0107	1.7835	-0.6807	0.7337	0.0114	0.035	-0.1904	0.0144	-0.0973	-0.1906	0.1459	0.1347	0.1057	0.2855	-0.0068	-0.0411	0.41	0.0374	0.3209	66.5	-53.8763	84.0184
63	0.0219	0.0257	0.1293	4.5573	-0.3707	0.7898	0.0028	0.0127	-0.0964	-0.2563	-0.0978	-0.6303	0.2145	-0.0231	0.0795	0.3753	-0.0563	-0.0266	0.5085	-0.1021	0.5484	56.0638	-56.0112	51.3517
64	1.3337	-0.8714	0.8218	1.6374	-0.5966	3.7814	0.0245	-0.3637	0.0454	0.2275	0.0376	0.5595	0.1678	-0.5585	-0.0473	0.6191	-0.0333	0.3064	0.9548	-0.0784	0.6713	-32.6188	23.661	153.0465
65	3.8108	1.5021	-0.2459	5.2857	0.0806	4.045	0.041	-0.1261	0.5258	0.1216	0.0012	-0.2918	-0.4339	0.3302	-0.0598	0.4114	-0.0288	0.0982	0.2664	0.0029	0.5405	43.9494	72.5187	81.3598
66	3.5378	-0.2616	0.8221	0.2711	-0.1545	1.1445	0.0094	0.3228	0.0905	0.0064	-0.0896	-0.0736	-0.097	0.3131	0.0484	0.2669	-0.0389	-0.008	0.3354	0.1191	0.322	89.7198	0.21	57.8613
67	1.2003	0.2934	-0.2218	2.28	0.5621	2.0908	0.0823	0.1706	-0.0163	0.0554	-0.0224	-0.1834	-0.0181	-0.014	-0.0914	0.2244	-0.0071	0.0387	0.4889	0.0951	0.3249	81.4779	14.7019	22.2703
68	1.6805	0.1005	-1.2707	0.1194	-0.4028	1.8632	-0.1278	-0.184	-0.1455	0.1115	-0.0311	-0.0592	0.1115	-0.169	0.178	0.7365	-0.0856	0.1723	0.7014	-0.2068	0.4356	5.9773	27.7579	144.7844
69	0.3623	-0.2226	-0.0345	2.1614	0.2772	0.4333	-0.0248	-0.3374	0.0336	0.5479	0.0894	-0.2969	0.0336	0.0925	-0.0621	0.5126	-0.0739	-0.126	0.8095	-0.0222	0.3328	73.3323	-0.4578	142.1422
70	1.2294	-1.0627	-0.2686	1.0498	0.5746	1.1576	-0.0948	-0.1915	-0.5408	0.2795	-0.0453	0.2723	0.4362	-0.364	0.2034	0.7365	-0.2833	0.0099	0.5829	0.2391	0.6002	36.4725	-63.5111	127.6949
71	0.4364	-0.8676	0.1917	1.868	-0.8337	1.4863	-0.0947	-0.1733	0.2186	0.1435	0.0297	-0.0643	0.197	0.0166	0.0745	0.4064	-0.1162	0.0014	0.3992	-0.0369	0.3366	53.2757	3.0019	118.1412
72	2.3808	-1.0486	-0.02	4.4488	-0.2727	3.191	-0.0599	-0.4309	0.2969	0.6549	0.0753	0.0364	-0.3947	-0.2259	0.0262	0.8813	-0.1203	0.0564	0.9149	-0.3337	0.4693	28.7591	62.116	155.7604
73	3.0998	0.3226	-0.0745	0.4886	-0.1524	0.0928	0.0618	0.2887	0.0133	0.2014	-0.1012	-0.0826	-0.1245	-0.0366	0.0703	0.5415	-0.1013	0.0035	0.5453	-0.1008	0.4065	59.1296	24.2906	112.4297
74	0.4929	0.7414	0.6349	1.9192	-0.0245	2.014	-0.1349	0.182	0.0678	-0.2602	0.1788	0.335	-0.0958	-0.2029	-0.1054	0.3848	0.0632	-0.07	0.9912	0.1921	0.4857	7.4569	17.7324	3.0592
75	2.7053	1.3313	-3.1394	2.0046	-2.5442	4.4778	0.1539	-0.1879	0.0581	0.2675	-0.1557	0.2894	-0.0704	-0.1353	0.0505	0.5375	-0.0313	0.1178	0.6452	-0.0412	0.704	-35.4572	5.7535	82.6224
76	0.2625	0.4576	0.2189	2.8341	0.8948	2.1414	0.0931	-0.0498	-0.1316	-0.0252	-0.1172	0.2729	0.3735	-0.4188	-0.0171	0.4521	-0.1531	0.0248	0.4359	-0.0063	0.5409	20.2155	-60.746	77.3307
77	0.9257	-0.1886	0.1648	0.9651	-0.0488	1.6423	0.0423	-0.2494	-0.0354	0.2759	0.0305	0.2368	-0.2186	-0.3869	-0.1332	0.3868	-0.0599	0.2179	0.5919	-0.1076	0.4164	-17.8424	14.231	123.8873
78	1.837	-0.2484	-0.7509	0.0308	0.1089	1.1841	-0.1211	-0.1011	-0.2036	-0.16	-0.1859	-0.3053	0.3026	0.3264	0.223	0.5504	0.1849	0.4161	0.7422	0.3685	1.4449	294.9176	-0.8666	218.7758
79	1.2858	0.5447	0.1274	1.5767	0.1188	0.8688	-0.0282	0.419	-0.3271	-0.3522	0.0026	-0.2229	0.2536	0.1725	0.0245	0.6127	0.1931	0.2022	0.7107	-0.1842	0.6922	238.8762	-24.7387	177.779
80	1.8913	-0.7005	0.1377	1.2005	0.1122	2.1611	-0.0218	-0.0579	-0.1127	0.1073	-0.1093	-0.3345	0.0984	0.3451	0.1894	0.4214	-0.0626	-0.1016	0.5325	0.2531	1.0437	277.4241	17.7121	248.3402
81	1.6162	-0.1047	-0.9695	1.1244	0.3201	1.3986	0.431	-0.4142	0.5178	0.2564	-0.0663	-0.2554	-0.3819	0.3229	-0.4002	0.7413	-0.1243	0.037	0.5413	-0.0831	0.8298	273.7792	-22.363	279.5999
82	0.7866	-0.052	-0.6261	1.0324	-0.2465	1.0995	-0.0013	-0.0689	0.2298	0.0489	-0.0136	-0.6034	-0.1922	0.3342	0.036	0.6431	-0.1888	-0.1609	0.4665	0.1095	1.1798	252.794	88.5405	245.0549
83	2.0651	0.6898	0.1158	1.0301	-0.2002	3.2025	-0.2127	0.6363	0.0615	-0.4298	0.0992	-0.1588	0.6258	-0.292	0.0526	0.9897	-0.1462	0.1847	0.5925	0.0273	0.5233	255.0619	-69.4615	232.1423
84	1.9706	0.1077	-0.4748	1.1925	-0.0217	0.7596	0.0007	0.0148	0.3646	0.4112	-0.081	-0.026	-0.2695	-0.0237	0.0775	0.7841	0.0772	-0.1149	0.3034	-0.0394	0.6459	197.2199	104.1363	256.5666
85	2.4848	0.3864	-1.1399	0.7514	0.1762	1.7822	-0.0123	0.3933	0.1932	-0.3781	-0.1585	-0.4473	-0.3542	0.2974	0.0929	0.6196	-0.1191	0.2471	0.9771	0.3461	0.9911	285.8028	53.5804	187.4898
86	0.9397	0.2517	-0.0551	1.6261	0.0429	0.8672	0.0257	0.3533	0.3221	-0.2631	-0.1196	-0.0313	-0.3709	0.025	0.0931	0.6919	0.0554	-0.0047	0.431	0.1985	0.605	210.2589	92.8691	211.3778
87	1.0228	0.2323	-0.125	1.1597	0.0274	2.1772	-0.0747	-0.1033	0.2562	0.2152	-0.0241	-0.4198	-0.1259	0.3865	0.0638	0.5925	-0.0736	-0.3906	0.6057	0.0826	1.1534	265.6205	50.8235	273.2851
88	0.9242	0.1437	0.6915	1.087	0.1239	1.8162	0.1471	-0.729	0.4952	0.4506	-0.1924	-0.0909	-0.2373	0.1117	0.0285	1.4007	-0.304	0.2498	1.0565	-0.2683	1.0093	256.8116	-26.5485	309.443
89	1.6068	-1.4955	0.8853	3.1155	-1.0967	1.1186	-0.0548	0.2892	0.2201	-0.6317	-0.2079	-0.5066	-0.0228	0.1065	0.2317	0.634	-0.0559	0.161	0.5146	0.2205	0.6453	233.3484	72.1051	208.0603
90	0.2098	0.2725	0.4157	0.5135	0.7332	1.0557	-0.04	-0.1575	0.2083	0.2563	-0.1466	-0.1592	-0.0276	-0.1843	0.1591	2.3233	-0.4092	0.408	1.9348	-0.5226	1.4713	245.7535	-19.0235	341.1019
91	0.469	-0.172	0.0401	1.1437	0.0964	0.9515	-0.0536	0.166	-0.0119	-0.2954	-0.0916	-0.3064	-0.1146	0.3117	0.1191	0.4999	0.06	0.1847	0.6125	0.1317	0.5205	248.9898	33.9776	184.8258
92	0.3884	-0.1563	0.1295	1.9418	1.2281	1.3415	0.0119	0.0484	-0.1641	0.3076	0.0329	0.0945	0.5727	0.1442	-0.0892	0.7778	0.1097	0.1036	0.5968	-0.105	0.9732	232.4098	-36.5152	200.0952
93	2.2532	0.1518	-0.1831	1.4859	0.4295	2.4784	0.1223	-0.2255	0.2513	0.3418	0.0653	0.5766	0.1364	-0.6304	-0.2287	0.687	0.0507	0.3289	0.7433	0.2378	0.9537	215.3767	-59.3275	296.0286
94	2.3509	-0.1318	-1.0678	1.9448	0.8571	1.7376	-0.1002	-0.0444	-0.095	-0.1622	0.106	-0.4122	0.5008	0.3435	0.0033	0.8846	0.1573	0.129	0.409	0.0942	0.7514	273.8644	-70.4598	252.5182
95	0.2775	0.4382	-0.428	0.7153	-0.7714	0.9816	0.2136	0.0757	-0.0276	-0.2535	-0.2692	-0.422	0.0051	0.1525	0.1137	0.6261	0.2343	0.2273	0.7246	0.1616	1.147	294.1406	-24.9304	231.0314
96	1.2734	-0.0667	-0.2483	2.6878	0.5118	1.0618	-0.0048	0.3684	0.019	-0.1725	0.0791	0.3642	0.4561	-0.6164	-0.111	0.8354	-0.2669	0.0344	0.9063	0.3248	0.6845	221.2895	-80.4622	269.4675
97	2.1876	-0.3321	0.4326	2.307	-0.4404	1.1074	-0.2225	-0.155	-0.5002	0.0736	0.0758	-0.3405	0.7177	0.027	0.1334	1.0509	0.0874	0.1371	0.4209	0.1581	0.8003	254.6409	-87.2761	271.7074
98	2.0378	-0.0718	0.5017	2.2626	-0.4519	3.1178	0.1379	-0.5394	-0.041	0.641	0.0335	-0.4261	-0.0539	0.6219	-0.1778	0.6336	-0.0235	-0.0795	0.7014	0.0093	0.7225	280.5219	-49.6047	284.4334
99	1.8092	0.214	0.4997	0.1587	0.3137	2.707	-0.1396	0.1127	-0.0041	-0.0954	-0.1911	-0.6163	0.055	0.5409	0.2373	0.4701	-0.0065	0.0893	0.745	0.3565	1.2006	292.2973	19.5471	226.027
100	0.7163	-0.1276	-0.0627	0.5625	-0.0771	1.0702	0.1057	-0.0461	0.2267	-0.0782	-0.077	-0.4676	-0.1158	0.3833	-0.0091	0.4224	-0.0812	0.1298	0.537	0.1662	0.9312	271.0867	39.5694	220.301
101	0.6257	0.1609	-0.3032	0.7236	-0.5769	0.8961	-0.0415	-0.0007	-0.0336	0.074	-0.0319	-0.1265	0.0095	-0.0022	0.1224	0.4416	-0.024	-0.0316	0.3067	0.0682	0.5021	227.0759	28.1612	257.8929
102	2.292	0.1112	0.6853	1.1194	0.1315	0.7677	-0.2577	-0.51	0.5498	0.4034	0.0049	-0.5057	-0.2458	0.1281	0.1838	0.9096	-0.0692	-0.2927	0.4173	-0.0957	0.6407	239.3146	85.9518	280.8504
103	4.8379	1.7438	-0.0435	2.2243	0.2314	3.6528	-0.1145	0.2726	-0.7534	-0.2191	-0.0456	0.1144	0.4909	-0.2062	0.1403	1.7759	-0.3857	0.2361	0.6737	-0.0648	0.7957	239.6955	-93.6767	239.8854
104	0.4079	0.235	0.3724	0.4911	0.2969	1.3198	-0.0965	0.1676	-0.4698	0.0608	0.1063	-0.4094	0.3262	0.4724	-0.0005	0.4839	0.1106	0.1296	0.5911	0.0099	0.9973	246.6128	-18.0769	209.4974
105	2.7207	0.3914	1.02	1.4697	0.7786	0.6631	-0.0356	0.7594	-0.0139	-0.5481	0.0115	-0.2199	-0.2211	0.5139	0.0461	0.6521	0.0297	0.4432	0.9658	0.076	0.8564	270.9948	21.7793	180.4587
106	1.9892	0.0719	-0.232	3.3128	1.1021	4.9751	0.1836	0.6846	0.1618	-1.0186	-0.0159	-0.0107	-0.4762	-0.0033	-0.1623	1.3314	-0.1105	0.2535	1.0135	0.2255	0.7788	258.2392	-49.6303	215.6169
107	2.7416	-0.1213	-0.3943	1.9614	0.1142	0.3836	0.0703	-0.3553	0.3393	0.1985	-0.135	0.0316	-0.1534	0.047	0.0398	0.8913	0.0919	0.0798	0.559	0.022	0.8313	251.9912	-39.6788	286.0807
108	3.8016	3.154	0.3385	3.1392	0.8692	0.7379	-0.0129	-0.1778	-0.8511	0.5123	0.0998	-0.8094	0.0678	0.2781	-0.0587	0.7927	-0.0623	-0.2431	0.6621	0.2776	0.8662	249.0223	21.379	282.2646
109	0.5463	-0.01	-0.0201	1.144	-0.7507	0.4934	0.1026	-0.133	0.2106	-0.0427	-0.0542	-0.1205	0.2348	0.4523	-0.0291	1.6951	-0.2339	0.2333	1.9371	-0.4563	1.2677	227.3777	-34.0116	323.8615
110	1.4217	0.4674	-0.2833	1.2867	0.1883	1.4593	0.0395	0.2059	0.0097	-0.1013	0.112	-0.6808	0.3536	0.6812	-0.1476	0.7038	0.3673	0.2321	0.9935	0.0952	1.4149	310.4667	-52.7324	243.6077
111	1.3572	0.7446	0.4055	0.3965	0.2248	0.1079	-0.0039	-0.1486	0.0112	-0.1392	0.1163	0.0006	-0.026	-0.0395	-0.1373	0.6375	-0.0334	0.0051	0.6286	0.0797	0.8541	217.5166	-38.8512	282.3848
112	1.108	-0.1283	-1.1857	0.8271	0.2322	1.4777	0.0079	0.2844	-0.0854	-0.1228	-0.0212	-0.2127	0.1154	-0.1016	-0.0105	0.385	0.0537	-0.0223	0.5227	-0.103	0.3719	192.6947	-6.2835	184.8395
113	0.5886	0.0359	0.019	0.5053	-0.082	0.5248	0.0227	-0.0103	0.252	0.024	0.009	-0.0251	-0.2191	-0.059	-0.0569	0.4414	0.0433	0.02	0.2235	0.0547	0.4661	137.0304	67.0183	250.9072
114	0.1296	-0.0395	0.0411	0.1567	0.0313	0.4803	0.0637	0.0898	-0.0456	-0.0714	0.0344	0.1351	0.1744	-0.1899	-0.0544	0.4378	-0.0944	-0.1437	0.4624	0.0075	0.4077	88.3786	-25.8097	215.123
115	0.807	-0.1278	0.1368	1.7341	-0.3835	0.6453	0.0452	-0.1233	-0.2617	0.0818	0.1467	0.1263	0.199	-0.131	-0.1771	0.6055	-0.0372	-0.173	0.3065	0.1476	0.5397	145.194	-84.6486	282.1675
116	0.7474	-0.5424	-0.8608	1.3058	1.0291	1.3563	0.1636	0.0219	-0.1472	0.0673	-0.1893	0.3123	-0.0161	-0.4891	0.0743	0.3652	0.0385	0.0416	0.5776	0.1973	0.4879	60.3827	17.441	266.2837
117	0.8949	-0.1166	-0.3645	1.2718	-0.167	1.2865	0.0034	0.0743	-0.0767	0.0527	0.0614	0.2354	0.153	-0.2369	-0.0682	0.3687	-0.0732	0.0073	0.277	0.1131	0.3304	91.7461	-24.5952	274.5422
118	0.564	0.4117	0.0019	1.1526	0.0562	0.4441	-0.0135	0.3156	-0.254	-0.1704	0.0032	-0.1511	0.1926	0.0669	0.0029	0.9044	0.1404	0.0625	0.8861	-0.3235	0.4903	171.1534	-48.2415	146.9633
119	4.4074	1.374	-1.0042	0.8933	-0.0879	0.5912	0.013	-0.2232	0.1888	0.1888	0.047	-0.0217	-0.1864	-0.0292	-0.0873	0.5059	0.0762	-0.0477	0.2348	-0.0093	0.2236	138.3586	45.2904	303.427
120	0.8137	0.0567	-0.1941	0.4714	0.4005	0.4188	-0.2219	-0.1656	-0.0134	0.5394	-0.0502	-0.2997	-0.3514	0.1404	0.001	1.0384	0.1162	-0.407	0.308	-0.0315	0.4767	154.0692	-15.9135	292.1267
121	2.1148	-0.293	-0.1267	0.4754	0.1755	0.9984	-0.2033	0.0167	-0.0569	0.157	0.1616	-0.1776	0.0837	0.238	0.035	0.6011	0.0266	-0.2047	0.2606	-0.0152	0.5775	181.3224	-69.0948	288.7109
122	2.3125	1.9468	-0.3157	4.6867	-0.3113	1.4753	0.0424	-0.2403	-0.4606	0.3863	-0.1805	-0.2153	0.4535	0.1883	0.1406	1.1593	-0.2819	-0.3289	0.6709	0.2551	1.3195	173.3617	22.6194	347.8038
123	0.2339	-0.1728	0.0713	0.7383	-0.0913	1.1988	0.0376	0.1057	-0.1749	-0.2872	0.0121	0.1245	0.188	-0.0607	-0.0566	0.624	-0.1357	-0.1799	0.5639	-0.1641	0.5028	118.7541	-59.5852	187.082
124	1.4733	-0.5676	0.8563	0.2918	-0.4455	1.5106	0.0152	-0.064	0.191	-0.0384	0.1088	0.098	0.0161	-0.207	-0.099	0.3799	0.0515	0.1278	0.4031	0.0816	0.3183	90.417	25.3105	301.8063
125	0.3936	-0.1801	-0.1073	0.0925	-0.0298	0.2824	0.082	0.2365	-0.1513	-0.1479	-0.0185	-0.0191	0.0804	-0.0381	-0.082	0.6758	0.0174	-0.0655	0.6055	-0.2193	0.4419	150.1971	-37.2056	175.2205
126	0.7852	0.137	0.0844	0.5032	-0.1613	0.482	-0.0139	-0.0408	0.0912	0.0678	0.0393	-0.0957	-0.0589	-0.1103	-0.0144	0.2855	0.0227	0.0347	0.1765	0.0275	0.2145	108.6336	38.1815	275.2838
127	2.113	-0.2597	0.8232	1.157	-0.3862	1.0212	0.2048	0.1952	0.2073	-0.1453	-0.1813	0.2555	-0.0303	-0.2459	-0.0452	0.399	0.0626	0.0125	0.3832	0.1331	0.3518	110.1575	41.5967	211.7955
128	0.762	-0.0386	-0.0742	0.5684	0.0848	0.2168	0.0808	0.0281	-0.1923	-0.0746	-0.0818	0.0935	0.137	-0.1328	-0.0179	0.542	-0.137	-0.1276	0.349	0.0291	0.4497	98.4179	-49.1933	228.6884
129	1.6176	0.7729	-0.0902	0.7672	0.2629	0.286	-0.0766	0.2171	0.2128	-0.1582	-0.0226	-0.0667	-0.0741	0.1012	0.1126	0.6118	-0.0098	-0.0123	0.5367	0.178	0.3704	149.3575	58.4066	179.1205
130	1.6925	-1.1334	-0.3409	1.1855	0.6832	0.5557	0.2982	0.3407	0.341	-0.1273	-0.044	-0.1566	-0.338	-0.1529	-0.215	0.4731	-0.0343	0.0662	0.5224	0.1872	0.4499	201.6672	50.8225	185.6057
131	5.1179	2.2374	0.565	1.1974	0.2392	0.0975	-0.2425	0.6693	0.0802	-0.1762	0.1616	-0.3619	-0.0017	0.5711	0.1551	0.6957	-0.0409	0.1225	1.1094	0.2938	0.7134	236.8168	61.2037	178.8225
132	0.6939	-0.0286	-0.4169	1.523	-0.0559	0.5681	-0.0395	-0.1046	-0.0141	0.2044	0.1005	-0.1006	0.0449	-0.0403	-0.0868	0.4241	0.0113	-0.0488	0.2999	0.0765	0.2241	112.6449	-3.3776	299.4424
133	0.3368	-0.2975	-0.312	0.5124	0.7004	0.9428	-0.0358	0.0053	-0.2446	0.2006	0.009	0.0793	0.1671	0.0216	0.0462	0.5667	-0.0177	-0.078	0.2563	0.1201	0.4184	124.0229	-47.7831	272.3114
134	1.0872	-0.4987	-0.0471	2.2726	-0.8514	3.2554	-0.0138	0.3476	0.3712	-0.184	-0.052	-0.0544	-0.6102	-0.0983	0.0516	1.1145	-0.048	-0.0095	0.6456	0.3625	0.5541	162.2502	86.0089	171.9013
135	1.7003	-0.2822	0.4945	2.2481	0.3998	0.5595	0.124	-0.1987	0.3498	0.1401	-0.126	-0.3438	-0.1437	0.0558	-0.0161	0.3964	-0.0638	-0.0083	0.2245	0.0621	0.461	178.4384	52.3091	252.9196
136	0.5194	0.8928	0.2461	1.7023	0.6192	0.3095	-0.0682	0.0038	0.2511	0.1015	0.1264	0.1024	-0.1672	0.1177	0.0057	0.6931	-0.0316	-0.0019	0.3821	0.0003	0.7301	191.4163	101.2781	249.3754
137	0.4894	0.1029	0.1393	0.3911	0.2339	0.5056	0.0554	0.2454	-0.0746	-0.4324	-0.0801	0.1717	-0.0982	-0.1228	0.0468	0.7119	-0.0391	-0.077	0.8019	0.098	0.3274	142.4948	17.1227	150.1045
138	1.4167	-0.6564	0.0297	2.224	-0.4343	1.205	0.0704	0.5934	0.0263	-0.2538	0.0681	0.1138	-0.068	-0.1098	-0.0806	0.5248	-0.0245	-0.2159	0.7961	0.0695	0.4562	89.082	4.674	169.0803
139	0.3766	-0.0082	-0.2259	0.793	0.4457	1.3825	0.0187	0.302	-0.0098	-0.4485	-0.0396	-0.1991	-0.042	0.0898	0.0376	0.8865	-0.0196	0.2875	1.5097	0.0227	0.4746	208.4133	18.7749	134.0318
140	0.1887	-0.0799	0.024	1.401	0.4338	0.3447	-0.022	0.0643	-0.1035	-0.1405	0.0991	0.17	0.1617	-0.0267	-0.0771	0.5532	-0.1182	-0.1637	0.424	-0.0718	0.4289	116.7223	-54.9218	214.8051
141	0.0567	-0.4185	-0.0135	3.2952	-0.2531	0.6404	0.0538	0.0929	-0.1386	0.2016	-0.0209	0.6439	0.2146	-0.1261	-0.0141	0.5323	-0.0526	-0.1732	0.3977	0.0477	0.5014	119.1355	-52.3853	249.2357
142	1.3291	0.6679	-1.1613	1.842	0.9157	3.6444	0.1907	0.1945	-0.0204	-0.1279	0.0477	-0.4534	-0.0583	0.681	-0.2159	0.4775	0.0355	0.2192	1.083	0.0773	0.5197	227.9273	18.9128	161.03
143	3.9173	-1.4869	-0.0694	4.7352	-0.2649	3.4685	0.0308	0.3503	0.1385	-0.3261	0.0257	0.4554	-0.362	-0.3695	-0.0219	0.3842	-0.0084	0.0076	0.327	0.1356	0.3515	134.9767	72.1262	205.9461
144	3.5203	0.2735	1.9327	0.456	0.3028	2.2025	0.0727	-0.0849	0.0473	0.0482	0.0184	0.1597	-0.176	-0.2951	-0.0591	0.3174	-0.0397	-0.0135	0.3176	0.0604	0.3325	86.9716	0.6507	227.714
145	3.0317	-0.4623	-0.6349	2.8318	0.2127	2.8245	-0.1069	0.0728	0.0503	-0.102	0.1082	0.1809	0.0203	-0.3644	-0.0474	0.2673	-0.0191	-0.0108	0.3281	0.0781	0.3359	86.3479	19.9204	262.1078
146	1.6018	-0.1236	-0.9544	0.1723	0.36	1.0511	-0.0979	0.3442	-0.2331	-0.2374	0.0143	0.1086	-0.0433	0.1128	0.0522	0.594	-0.0267	0.079	0.8212	0.0624	0.3215	187.9815	21.8139	159.294
147	0.3293	0.1935	0.2079	1.4586	-0.415	0.6486	-0.0673	0.3151	0.0081	-0.4115	0.1746	0.0723	0.1311	-0.0666	-0.1337	0.6687	-0.0699	-0.1268	0.9451	0.0027	0.3277	122.6994	-9.456	150.0782
148	1.9392	1.2351	-0.2566	0.9246	-0.458	0.9416	-0.1492	0.1836	-0.4021	-0.2888	0.1006	-0.1365	0.3506	0.3696	0.074	0.9023	0.1492	-0.1296	0.5329	-0.2947	0.6388	156.5612	-68.2075	180.8395
149	0.8185	0.6988	0.3967	1.7686	0.5427	1.3157	0.0086	0.217	0.0421	-0.1141	-0.0852	0.0035	0.1468	-0.243	0.0955	0.5126	0.0394	-0.0344	0.5763	-0.0313	0.2797	136.3711	-2.05	177.3726
150	1.9874	0.9416	-0.2833	4.1533	-0.1367	1.7702	-0.102	0.4692	0.2677	-0.7304	0.0225	-0.1546	-0.1452	0.181	0.1027	0.9665	-0.0122	0.0545	1.0889	0.3141	0.4676	167.2418	53.2009	139.0415
151	3.0991	-0.1948	0.2365	0.9301	-0.106	1.1103	0.081	-0.4696	0.013	-0.1133	-0.0776	0.2111	-0.1334	0.3226	0.0081	0.5692	-0.0202	-0.0441	0.6367	0.0894	0.3035	128.7994	19.3923	178.7609
152	2.1167	0.0595	0.525	3.3256	1.741	4.1628	-0.1868	-0.1709	-0.1684	0.2303	-0.0119	-0.087	0.0803	0.1051	0.205	0.4743	0.0461	-0.0956	0.212	0.0301	0.3525	153.936	29.037	296.7862
153	2.577	-3.2841	-2.2058	6.2974	1.981	2.4069	0.001	0.1664	0.1083	-0.1921	-0.243	-0.0788	-0.2035	-0.2242	0.2173	0.4204	-0.004	-0.0402	0.3867	-0.0236	0.6625	214.4887	10.1422	229.9119
154	0.3708	-0.7638	0.269	2.697	-2.283	3.3771	-0.0701	0.0794	-0.0203	-0.1033	-0.0304	-0.3025	0.382	0.2724	0.0585	0.5038	0.0611	-0.0522	0.3475	-0.1229	0.5466	160.0435	-58.7102	232.9331
155	1.9409	-0.9242	-1.4878	1.068	1.0599	3.1049	0.1596	0.295	0.1949	-0.3572	0.1932	-0.3757	-0.2922	0.2591	-0.3103	0.3821	-0.0227	0.096	0.5281	0.0083	0.4043	206.4777	12.4855	186.5892
156	3.6731	0.5516	-0.9928	0.7585	-1.2519	2.3854	-0.088	-0.6505	0.2304	0.3773	-0.1432	-0.0436	-0.0349	-0.1318	0.2085	1.2347	-0.1594	-0.0115	0.7851	-0.0451	0.6915	134.3272	15.853	350.8585
157	6.0774	0.2517	2.1511	3.5711	-0.4652	0.8473	-0.1097	0.5987	0.0416	-0.3714	0.0437	-0.495	0.1044	0.5517	0.0542	1.9185	-0.1489	0.351	2.1753	-0.0839	1.9261	117.4553	16.0618	369.6804
158	1.4629	1.4057	0.1194	3.2796	-2.9606	4.9942	0.2541	0.1748	0.116	-0.1206	-0.0617	0.1657	-0.0453	-0.3503	-0.1803	2.3614	0.1297	0.3563	2.489	-0.215	2.162	102.5565	13.2184	378.2414
159	0.2209	-0.0015	-0.0581	0.1282	-0.022	0.1658	0.0413	0.0029	0.0382	0.0411	-0.031	-0.0008	-0.0255	-0.0142	-0.0152	0.3153	-0.0545	-0.0101	0.3493	-0.0012	0.3333	39.4014	2.3344	76.037
160	6.3444	1.6299	-0.3701	0.4211	-0.0937	0.0213	-0.2049	-0.0253	-0.7561	0.0302	0.4116	1.0743	0.3501	-1.022	-0.1634	0.8963	-0.4223	0.0389	1.6583	-0.0055	1.5516	-17.1886	-48.5687	15.2628
161	0.8707	0.5118	0.9179	1.3067	0.0757	1.2145	-0.2017	-0.0089	-0.0176	-0.404	0.0251	1.3478	-0.0724	-0.7531	0.1644	1.4179	0.1426	-0.2733	1.8126	-0.0621	1.5769	-2.5028	0.0791	-24.5301
162	2.7517	-0.7493	-0.7328	2.5272	0.2006	2.6299	-0.1757	-1.9047	1.0337	1.4098	-0.5227	-0.1319	-0.8555	-0.9054	0.6652	1.6269	-0.0575	0.075	1.5934	-0.3397	1.105	28.1587	1.0272	156.2518
163	1.2759	0.6678	-0.316	1.5502	-0.4524	1.9476	0.225	0.128	-0.0765	-0.0496	0.0238	0.2013	0.3742	0.1123	-0.1987	0.708	-0.0675	0.1007	0.8785	-0.2323	0.7596	-29.8286	-15.4972	61.9723
164	0.03	0.0509	0.0293	0.676	0.3296	0.1615	-0.0203	-0.1449	-0.8825	-0.1083	0.1995	1.1399	1.2255	-1.1207	-0.1731	1.6904	-0.3814	0.1622	2.2477	-0.4162	2.0789	-21.529	-27.3796	164.0475
165	5.4065	-3.143	-4.0285	8.6912	-3.1356	7.5616	0.3872	-1.7615	1.0195	1.9543	-0.1683	-1.5781	-0.8566	1.0453	-0.1774	1.4051	-0.2442	-0.1161	1.4709	-0.149	0.9239	11.9203	-2.2837	182.728
166	0.1255	-0.5693	-0.4703	2.5895	2.0953	1.8399	0.0214	-1.2804	1.5164	0.7942	0.424	0.039	-1.4354	-0.3799	-0.4112	1.4	0.2076	0.1937	1.1752	-0.49	1.5116	-4.8589	89.2945	101.3703
167	0.4929	0.5017	0.1431	0.9301	0.0642	0.1641	-0.0423	0.3517	-0.2633	-0.2506	0.0872	0.003	0.1933	-0.0831	-0.0273	0.6286	-0.1344	-0.0233	0.7989	-0.2814	0.5958	23.8011	-66.6758	16.7873
168	0.2051	0.0139	-0.1455	0.2008	-0.1987	0.653	0.0516	-0.2217	0.0774	0.2235	-0.0225	-0.049	-0.1141	0.1036	0.0048	0.4991	-0.1129	-0.033	0.6056	-0.0725	0.3741	63.4422	7.9065	126.7736
169	0.3242	0.0382	-0.0748	0.4915	-0.0572	0.3107	0.042	0.1203	0.1464	-0.0794	-0.0717	0.2183	-0.1536	-0.2572	0.036	0.5129	0.1888	0.0191	0.7539	-0.0212	0.6663	-54.518	63.7326	63.1867
170	2.8019	1.9793	-1.002	5.7004	0.9147	4.9856	-0.2356	1.0332	1.1859	-1.1459	0.0564	1.5138	-1.0408	-1.0653	0.1419	1.0006	0.4017	-0.1782	1.2345	0.2728	0.9877	-49.8093	102.5892	34.755
171	4.9086	-1.3152	-0.8247	2.5414	2.9724	3.599	0.1755	-0.5827	0.9432	0.3054	0.0705	0.4466	-1.1969	-0.7252	-0.2239	1.6806	0.3044	-0.0961	1.4044	-0.2337	1.715	-43.0405	128.2503	104.7049
172	4.1661	0.9001	-0.535	0.8572	-1.6319	3.6581	-0.1087	-0.1959	1.234	0.686	0.0321	0.5274	-1.3459	-0.4742	0.0791	1.7135	-0.0603	0.3443	1.3734	-0.4764	1.995	-59.4561	113.77	118.7016
173	0.1264	0.3896	0.0834	1.2003	0.2584	0.0574	-0.2504	-0.1431	-0.2142	0.2514	-0.2132	0.427	0.292	-0.0736	0.3673	2.1466	-0.0484	-0.3432	2.3082	-0.1578	2.0387	-112.497	14.847	28.0575
174	0.6543	0.168	-0.0086	1.5235	-0.554	0.2466	-0.0429	0.2597	0.0026	-0.6221	0.1157	0.5348	-0.0683	-0.5215	-0.046	0.9054	0.1713	-0.2193	1.5487	-0.0165	0.9073	-84.0201	48.9651	24.9123
175	0.5366	-0.0129	-0.0552	0.6481	-0.0182	0.3873	0.0686	-0.1209	-0.1534	0.3175	-0.1513	0.2348	0.1019	-0.2213	0.0527	0.6297	-0.1783	0.1643	0.7012	-0.1177	0.654	-60.7884	10.653	106.7212
176	0.4792	0.7233	0.0197	1.2897	0.9955	5.0257	-0.1636	-0.413	0.5246	-0.1971	0.3462	0.9958	-1.196	-2.0613	-0.1621	1.1317	0.2305	0.1416	1.7689	-0.1899	2.1088	-109.4381	58.2417	97.2224
177	1.1454	0.0315	0.0325	0.3181	-0.1258	0.3232	-0.3843	-0.2602	0.2394	-0.1715	0.0676	0.832	0.1158	-0.8443	0.3426	1.7173	0.1453	-0.0192	2.0665	-0.1981	1.9035	-100.0622	79.6335	109.4362
178	0.0233	-0.0257	-0.2378	0.4467	-0.1435	2.6661	0.1454	0.1255	0.1156	0.0054	-0.0566	0.2497	-0.3823	0.0173	-0.0901	0.6139	0.1383	0.1615	1.0126	-0.155	1.1021	-80.4808	56.8094	79.1913
179	0.2596	1.2815	-0.2978	6.3287	-1.4931	0.3531	0.5305	-0.0901	0.3501	0.5641	-0.2659	0.5799	-0.616	-0.1235	-0.2272	1.2902	-0.0116	0.4202	1.264	-0.4279	1.2964	-64.1934	79.14	127.5823
180	0.1096	0.1554	-0.0726	0.2656	0.1346	0.1239	0.0369	0.1174	-0.1093	0.1675	-0.1367	0.07	0.1578	-0.2415	0.0778	0.6087	-0.2537	0.0411	0.9443	-0.2982	0.9252	-74.7459	-47.7752	56.6288
181	0.5094	0.4512	-0.1055	1.3794	-0.1298	0.3116	0.0749	0.0602	-0.045	0.0338	-0.1206	0.0181	0.0147	-0.1478	0.0493	0.4163	0.0486	0.0513	0.5933	-0.0811	0.5481	-35.8573	24.9042	74.9209
182	0.1721	0.0076	0.0018	0.1329	-0.0127	0.1409	0.0203	0.1194	-0.0116	-0.0546	0.0202	0.0147	0.0275	-0.0294	-0.0442	0.4201	0.0046	-0.0526	0.3482	0.018	0.3261	139.7724	3.2787	221.4346
183	4.8293	-0.3931	-0.6771	0.1523	-0.034	1.4218	0.1104	-0.6984	-1.4806	0.8408	0.2994	-2.355	0.7993	2.4426	-0.3439	1.2271	0.3222	-0.3358	1.9256	0.0126	2.1498	183.0076	-36.2662	299.5275
184	1.4688	0.5541	1.1431	1.1899	0.4621	1.1507	0.239	0.1901	0.12	0.1186	-0.4085	-0.4693	-0.1224	0.2736	0.1643	1.194	-0.2168	0.0328	0.7683	0.192	0.8315	154.504	22.382	330.6674
185	2.9625	0.5576	-1.1586	2.173	0.0134	0.8445	-0.1627	1.6918	0.86	-1.3297	0.195	-0.1043	-0.8097	1.3845	0.0518	1.5512	-0.2172	0.1346	1.8429	0.1923	1.1839	170.2341	-7.3765	146.5131
186	1.304	-1.2421	-1.6398	3.1818	0.7138	2.8031	0.3126	-0.3878	-0.2091	0.4367	-0.122	-0.148	0.3544	-0.1489	-0.1699	0.6839	-0.1217	0.0293	0.7252	0.0943	0.7293	205.5539	-10.4732	249.8865
187	2.5252	1.6526	-0.3102	1.2505	0.4411	4.2707	0.1318	0.1176	-2.0053	-0.1702	0.0297	-1.1917	2.0799	1.4615	-0.1211	2.0984	0.4554	-0.1327	1.9045	-0.2088	1.8681	220.9962	-35.1609	152.4196
188	7.3011	-1.1371	-2.0873	7.1949	1.6964	0.8646	0.343	1.8014	0.1769	-1.8526	-0.1546	0.695	0.0769	0.1751	-0.1702	1.7185	-0.1097	-0.0303	1.6391	-0.2787	0.7842	192.2724	-13.4065	125.1265
189	0.0012	-0.0287	0.0273	0.4871	-0.4564	0.4285	0.0741	0.9294	1.3006	-0.7086	0.2826	0.0404	-1.234	0.4559	-0.3676	1.4031	-0.1665	0.1945	1.1196	0.5148	1.2282	187.2095	88.887	196.6284
190	0.4836	-0.6624	0.3265	1.2926	-0.4772	0.145	-0.1201	-0.1521	-0.1383	0.5237	0.2078	0.1059	-0.0309	-0.1186	-0.0987	0.6226	0.037	-0.0544	0.3533	0.0633	0.3795	142.8242	-56.6065	291.6093
191	0.2965	-0.1118	-0.1421	0.2139	0.2043	0.5597	0.0407	0.3129	0.0063	-0.2257	0.0303	0.0334	-0.0384	-0.0953	-0.0202	0.6117	-0.0565	-0.0882	0.7198	0.031	0.3529	128.4253	1.1513	166.1671
192	0.3546	-0.1178	0.0182	0.6069	0.0406	0.2121	-0.0235	-0.0226	0.1834	0.0991	-0.0515	-0.2414	-0.1573	0.0608	0.0864	0.5274	-0.0813	-0.0689	0.3927	0.0759	0.5945	226.9867	69.6171	249.0438
193	3.2211	-1.6619	-2.5599	3.5698	0.1245	4.3024	0.1798	-1.1725	1.2372	0.9684	-0.2988	-0.4357	-0.6684	0.9852	0.065	1.1849	-0.1542	-0.3166	0.6501	-0.2246	0.8882	214.5267	110.1485	273.4754
194	1.4553	1.3627	0.0477	6.051	-3.0775	2.0429	0.2703	0.7598	1.2824	-0.4588	0.2173	-0.5147	-1.328	0.4539	-0.4674	2.207	-0.2159	-0.141	1.1653	0.4086	1.7624	221.9054	132.3088	202.2956
195	0.1969	0.3223	0.1956	0.5324	0.3303	0.2114	-0.0548	-0.0345	0.6651	-0.4693	-0.0462	-0.2102	-0.6527	0.1139	0.0838	2.2478	0.1774	0.1523	2.2317	0.3367	2.2599	241.9848	118.4677	192.3696
196	0.2174	-0.608	0.1037	3.3896	-1.056	0.3958	-0.2349	0.4674	-0.092	-0.4192	-0.4967	-0.5729	0.4484	0.3911	0.6327	1.9843	0.1972	-0.6462	1.8856	-0.1106	1.4616	278.0877	26.153	298.3889
197	1.0662	0.1366	0.1395	1.0873	0.7155	0.7419	-0.0658	-0.3103	0.2237	0.4706	-0.0329	-0.1573	-0.1472	0.2484	0.1189	0.9584	-0.0979	-0.3245	0.8276	-0.0094	0.7582	247.9263	58.5654	293.328
198	0.3701	0.0717	0.1019	0.6222	0.1375	0.2356	0.0379	0.1814	-0.0584	-0.1144	-0.0799	-0.2665	-0.0111	0.1145	0.0353	0.4318	0.0375	0.1115	0.5367	0.1003	0.6568	244.2794	15.3067	210.8236
199	1.6612	-0.4142	2.1259	1.167	-0.6952	5.6749	-0.2386	-0.5768	0.0696	0.707	0.06	-0.6031	-0.7449	1.5795	0.2627	1.2635	-0.3023	-0.1281	2.1339	0.2863	1.8373	291.1587	60.0775	237.041
200	3.2808	2.044	-1.7002	3.9227	-3.0378	2.3659	-0.0333	0.5488	0.0855	-0.3504	0.3105	-0.1051	-0.2899	0.081	-0.218	1.9603	-0.3482	-0.0506	1.5237	0.1751	1.5354	272.6588	90.1674	187.8294
201	0.8056	-0.2899	-1.3165	0.6805	0.6836	2.2401	0.1897	0.0473	0.2472	-0.0299	-0.1095	-0.3674	-0.7657	0.0231	-0.0641	0.6674	-0.1181	0.0112	0.5375	0.1667	1.0394	255.8788	63.61	239.4719
202	1.5076	-0.9156	-0.4821	0.6437	0.5612	0.9475	0.0896	0.0495	0.3766	0.148	0.0111	-0.1302	-0.5243	-0.0782	-0.0494	1.292	-0.096	0.0663	1.2387	0.4815	1.0492	249.7484	84.0327	188.2108
203	-0.1079	-0.0137	0.104	0.5732	-0.2548	0.3339	-0.0156	-0.0571	0.0434	0.1067	0.0376	-0.0887	0.1527	-0.0285	-0.0141	0.5965	0.0694	0.1215	0.5415	0.1714	0.779	249.3448	-40.0852	265.5288
204	0.4731	-0.1028	-0.0344	0.737	0.0787	0.3084	0.0148	0.0002	0.0983	-0.0371	-0.0492	0.0514	-0.178	0.0076	0.0484	0.5041	-0.067	-0.033	0.4386	0.0764	0.4659	208.796	48.5706	235.8693

精密化 TLSグループ

ID	Refine-ID	Refine TLS-ID	Selection details	Auth seq-ID	Auth asym-ID
1	X-RAY DIFFRACTION	1	segid S0A	0
2	X-RAY DIFFRACTION	2	segid S1A	0
3	X-RAY DIFFRACTION	3	segid S2A	0
4	X-RAY DIFFRACTION	4	segid S3A	0
5	X-RAY DIFFRACTION	5	segid S4A	0
6	X-RAY DIFFRACTION	6	segid S5A	0
7	X-RAY DIFFRACTION	7	segid S6A	0
8	X-RAY DIFFRACTION	8	segid S7A	0
9	X-RAY DIFFRACTION	9	segid S8A	0
10	X-RAY DIFFRACTION	10	segid S9A	0
11	X-RAY DIFFRACTION	11	segid S10A	1 - 96	0
12	X-RAY DIFFRACTION	12	segid S11A	2 - 156	1
13	X-RAY DIFFRACTION	13	segid S12A	20 - 143	2
14	X-RAY DIFFRACTION	14	segid S13A	2 - 151	3
15	X-RAY DIFFRACTION	15	segid S14A	11 - 137	4
16	X-RAY DIFFRACTION	16	segid S15A	8 - 131	5
17	X-RAY DIFFRACTION	17	segid S16A	3 - 143	6
18	X-RAY DIFFRACTION	18	segid S17A	2 - 126	7
19	X-RAY DIFFRACTION	19	segid S18A	2 - 146	8
20	X-RAY DIFFRACTION	20	segid S19A	2 - 144	9
21	X-RAY DIFFRACTION	21	segid S20A	15 - 121	0
22	X-RAY DIFFRACTION	22	segid S21A	1 - 87	1
23	X-RAY DIFFRACTION	23	segid S22A	2 - 130	2
24	X-RAY DIFFRACTION	24	segid S23A	2 - 145	3
25	X-RAY DIFFRACTION	25	segid S24A	2 - 135	4
26	X-RAY DIFFRACTION	26	segid S25A	36 - 105	5
27	X-RAY DIFFRACTION	27	segid S26A	2 - 500	6
28	X-RAY DIFFRACTION	28	segid S27A	2 - 101	7
29	X-RAY DIFFRACTION	29	segid S28A	5 - 67	8
30	X-RAY DIFFRACTION	30	segid S29A	4 - 99	9
31	X-RAY DIFFRACTION	31	segid S30A	2 - 61	0
32	X-RAY DIFFRACTION	32	segid S31A	82 - 501	1
33	X-RAY DIFFRACTION	33	segid SRKA	2 - 319	R
34	X-RAY DIFFRACTION	34	segid STMA	9 - 176	M
35	X-RAY DIFFRACTION	35	segid L2A	0
36	X-RAY DIFFRACTION	36	segid L3A	0
37	X-RAY DIFFRACTION	37	segid L4A	0
38	X-RAY DIFFRACTION	38	segid L5A	0
39	X-RAY DIFFRACTION	39	segid L6A	0
40	X-RAY DIFFRACTION	40	segid L7A	0
41	X-RAY DIFFRACTION	41	segid L8A	0
42	X-RAY DIFFRACTION	42	segid L9A	0
43	X-RAY DIFFRACTION	43	segid L10A	2 - 221	0
44	X-RAY DIFFRACTION	44	segid L11A	6 - 174	1
45	X-RAY DIFFRACTION	45	segid L13A	2 - 194	3
46	X-RAY DIFFRACTION	46	segid L14A	3 - 138	4
47	X-RAY DIFFRACTION	47	segid L15A	2 - 204	5
48	X-RAY DIFFRACTION	48	segid L16A	3 - 199	6
49	X-RAY DIFFRACTION	49	segid L17A	2 - 184	7
50	X-RAY DIFFRACTION	50	segid L18A	2 - 186	8
51	X-RAY DIFFRACTION	51	segid L19A and resid 2:73	2 - 73	9
52	X-RAY DIFFRACTION	52	segid L19A and resid 74:126	74 - 126	9
53	X-RAY DIFFRACTION	53	segid L19A and resid 127:183	127 - 183	9
54	X-RAY DIFFRACTION	54	segid L20A	1 - 172	0
55	X-RAY DIFFRACTION	55	segid L21A	2 - 160	1
56	X-RAY DIFFRACTION	56	segid L22A	9 - 108	2
57	X-RAY DIFFRACTION	57	segid L23A	2 - 137	3
58	X-RAY DIFFRACTION	58	segid L24A	1 - 98	4
59	X-RAY DIFFRACTION	59	segid L25A	22 - 142	5
60	X-RAY DIFFRACTION	60	segid L26A	2 - 127	6
61	X-RAY DIFFRACTION	61	segid L27A	2 - 136	7
62	X-RAY DIFFRACTION	62	segid L28A	2 - 149	8
63	X-RAY DIFFRACTION	63	segid L29A	2 - 59	9
64	X-RAY DIFFRACTION	64	segid L30A	9 - 105	0
65	X-RAY DIFFRACTION	65	segid L31A	4 - 112	1
66	X-RAY DIFFRACTION	66	segid L32A	2 - 128	2
67	X-RAY DIFFRACTION	67	segid L33A	2 - 107	3
68	X-RAY DIFFRACTION	68	segid L34A	2 - 113	4
69	X-RAY DIFFRACTION	69	segid L35A	2 - 120	5
70	X-RAY DIFFRACTION	70	segid L36A	2 - 100	6
71	X-RAY DIFFRACTION	71	segid L37A	2 - 100	7
72	X-RAY DIFFRACTION	72	segid L38A	2 - 78	8
73	X-RAY DIFFRACTION	73	segid L39A	2 - 51	9
74	X-RAY DIFFRACTION	74	segid L40A	77 - 500	0
75	X-RAY DIFFRACTION	75	segid L41A	1 - 25	1
76	X-RAY DIFFRACTION	76	segid L42A	2 - 501	2
77	X-RAY DIFFRACTION	77	segid L43A	2 - 501	3
78	X-RAY DIFFRACTION	78	segid S0B	0
79	X-RAY DIFFRACTION	79	segid S1B	0
80	X-RAY DIFFRACTION	80	segid S2B	0
81	X-RAY DIFFRACTION	81	segid S3B	0
82	X-RAY DIFFRACTION	82	segid S4B	0
83	X-RAY DIFFRACTION	83	segid S5B	0
84	X-RAY DIFFRACTION	84	segid S6B	0
85	X-RAY DIFFRACTION	85	segid S7B	0
86	X-RAY DIFFRACTION	86	segid S8B	0
87	X-RAY DIFFRACTION	87	segid S9B	0
88	X-RAY DIFFRACTION	88	segid S10B	1 - 98	0
89	X-RAY DIFFRACTION	89	segid S11B	2 - 147	1
90	X-RAY DIFFRACTION	90	segid S12B	20 - 143	2
91	X-RAY DIFFRACTION	91	segid S13B	2 - 151	3
92	X-RAY DIFFRACTION	92	segid S14B	10 - 137	4
93	X-RAY DIFFRACTION	93	segid S15B	4 - 138	5
94	X-RAY DIFFRACTION	94	segid S16B	2 - 143	6
95	X-RAY DIFFRACTION	95	segid S17B	2 - 122	7
96	X-RAY DIFFRACTION	96	segid S18B	2 - 146	8
97	X-RAY DIFFRACTION	97	segid S19B	2 - 144	9
98	X-RAY DIFFRACTION	98	segid S20B	12 - 121	0
99	X-RAY DIFFRACTION	99	segid S21B	1 - 87	1
100	X-RAY DIFFRACTION	100	segid S22B	2 - 130	2
101	X-RAY DIFFRACTION	101	segid S23B	2 - 145	3
102	X-RAY DIFFRACTION	102	segid S24B	2 - 135	4
103	X-RAY DIFFRACTION	103	segid S25B	37 - 105	5
104	X-RAY DIFFRACTION	104	segid S26B	2 - 500	6
105	X-RAY DIFFRACTION	105	segid S27B	2 - 1	7
106	X-RAY DIFFRACTION	106	segid S28B	5 - 67	8
107	X-RAY DIFFRACTION	107	segid S29B	4 - 99	9
108	X-RAY DIFFRACTION	108	segid S30B	2 - 63	0
109	X-RAY DIFFRACTION	109	segid S31B	77 - 501	1
110	X-RAY DIFFRACTION	110	segid SRKB	2 - 319	R
111	X-RAY DIFFRACTION	111	segid STMB	23 - 174	M
112	X-RAY DIFFRACTION	112	segid L2B	0
113	X-RAY DIFFRACTION	113	segid L3B	0
114	X-RAY DIFFRACTION	114	segid L4B	0
115	X-RAY DIFFRACTION	115	segid L5B	0
116	X-RAY DIFFRACTION	116	segid L6B	0
117	X-RAY DIFFRACTION	117	segid L7B	0
118	X-RAY DIFFRACTION	118	segid L8B	0
119	X-RAY DIFFRACTION	119	segid L9B	0
120	X-RAY DIFFRACTION	120	segid L10B	2 - 221	0
121	X-RAY DIFFRACTION	121	segid L11B	6 - 174	1
122	X-RAY DIFFRACTION	122	segid L12B	9 - 163	2
123	X-RAY DIFFRACTION	123	segid L13B	2 - 195	3
124	X-RAY DIFFRACTION	124	segid L14B	2 - 138	4
125	X-RAY DIFFRACTION	125	segid L15B	2 - 204	5
126	X-RAY DIFFRACTION	126	segid L16B	3 - 199	6
127	X-RAY DIFFRACTION	127	segid L17B	2 - 156	7
128	X-RAY DIFFRACTION	128	segid L18B	2 - 186	8
129	X-RAY DIFFRACTION	129	segid L19B and resid 2:73	2 - 73	9
130	X-RAY DIFFRACTION	130	segid L19B and resid 74:126	74 - 126	9
131	X-RAY DIFFRACTION	131	segid L19B and resid 127:183	127 - 183	9
132	X-RAY DIFFRACTION	132	segid L20B	1 - 172	0
133	X-RAY DIFFRACTION	133	segid L21B	2 - 160	1
134	X-RAY DIFFRACTION	134	segid L22B	11 - 108	2
135	X-RAY DIFFRACTION	135	segid L23B	2 - 137	3
136	X-RAY DIFFRACTION	136	segid L24B	1 - 135	4
137	X-RAY DIFFRACTION	137	segid L25B	23 - 142	5
138	X-RAY DIFFRACTION	138	segid L26B	2 - 127	6
139	X-RAY DIFFRACTION	139	segid L27B	2 - 136	7
140	X-RAY DIFFRACTION	140	segid L28B	2 - 149	8
141	X-RAY DIFFRACTION	141	segid L29B	2 - 59	9
142	X-RAY DIFFRACTION	142	segid L30B	6 - 105	0
143	X-RAY DIFFRACTION	143	segid L31B	4 - 112	1
144	X-RAY DIFFRACTION	144	segid L32B	2 - 128	2
145	X-RAY DIFFRACTION	145	segid L33B	2 - 107	3
146	X-RAY DIFFRACTION	146	segid L34B	2 - 113	4
147	X-RAY DIFFRACTION	147	segid L35B	2 - 120	5
148	X-RAY DIFFRACTION	148	segid L36B	2 - 100	6
149	X-RAY DIFFRACTION	149	segid L37B	2 - 501	7
150	X-RAY DIFFRACTION	150	segid L38B	2 - 78	8
151	X-RAY DIFFRACTION	151	segid L39B	2 - 51	9
152	X-RAY DIFFRACTION	152	segid L40B	77 - 500	0
153	X-RAY DIFFRACTION	153	segid L41B	1 - 25	1
154	X-RAY DIFFRACTION	154	segid L42B	2 - 501	2
155	X-RAY DIFFRACTION	155	segid L43B	2 - 501	3
156	X-RAY DIFFRACTION	156	segid LP0B	3 - 221	0
157	X-RAY DIFFRACTION	157	segid LP1B	1 - 47	1
158	X-RAY DIFFRACTION	158	segid LP2B	1 - 46	2
159	X-RAY DIFFRACTION	159	(segid 25SA and (not resid 1011:1039) and (not resid 1219:1288) and (not resid 1552:1583) and (not resid 2250:2266) and (not resid 2455:2502) and (not resid 2532:2547) and (not resid 2563:2578) and (not resid 3341:3364))	0
160	X-RAY DIFFRACTION	160	(segid 25SA and resid 1011:1039)	1011 - 1039	1
161	X-RAY DIFFRACTION	161	(segid 25SA and resid 1219:1288)	1219 - 1288	1
162	X-RAY DIFFRACTION	162	(segid 25SA and resid 1552:1583)	1552 - 1583	1
163	X-RAY DIFFRACTION	163	(segid 25SA and resid 2250:2266)	2250 - 2266	1
164	X-RAY DIFFRACTION	164	(segid 25SA and resid 2532:2547)	2532 - 2547	1
165	X-RAY DIFFRACTION	165	(segid 25SA and resid 2563:2578)	2563 - 2578	1
166	X-RAY DIFFRACTION	166	(segid 25SA and resid 3341:3364)	3341 - 3364	1
167	X-RAY DIFFRACTION	167	segid 5SA	0
168	X-RAY DIFFRACTION	168	segid 58SA	1 - 158	4
169	X-RAY DIFFRACTION	169	((segid 18SA and resid 1:602) and (not resid 64:86) and (not resid 185:200) and (not resid 219:237) and (not resid 480:509) and (not resid 510:545))	0
170	X-RAY DIFFRACTION	170	(segid 18SA and resid 64:86)	64 - 86	2
171	X-RAY DIFFRACTION	171	(segid 18SA and resid 185:200)	185 - 200	2
172	X-RAY DIFFRACTION	172	(segid 18SA and resid 219:237)	219 - 237	2
173	X-RAY DIFFRACTION	173	(segid 18SA and resid 480:509)	480 - 509	2
174	X-RAY DIFFRACTION	174	(segid 18SA and resid 510:545)	510 - 545	2
175	X-RAY DIFFRACTION	175	((segid 18SA and resid 603:1106) and (not resid 640:694) and (not resid 698:742) and (not resid 743:765) and (not resid 810:855))	0
176	X-RAY DIFFRACTION	176	(segid 18SA and resid 640:694)	640 - 694	2
177	X-RAY DIFFRACTION	177	(segid 18SA and resid 698:742)	698 - 742	2
178	X-RAY DIFFRACTION	178	(segid 18SA and resid 743:765)	743 - 765	2
179	X-RAY DIFFRACTION	179	(segid 18SA and resid 810:855)	810 - 855	2
180	X-RAY DIFFRACTION	180	(segid 18SA and resid 1107:1635)	1107 - 1635	2
181	X-RAY DIFFRACTION	181	(segid 18SA and resid 1636:1799)	1636 - 1799	2
182	X-RAY DIFFRACTION	182	(segid 25SB and (not resid 1011:1039) and (not resid 1219:1288) and (not resid 1552:1583) and (not resid 2250:2266) and (not resid 2455:2502) and (not resid 2532:2547) and (not resid 2563:2578) and (not resid 3341:3364))	0
183	X-RAY DIFFRACTION	183	(segid 25SB and resid 1011:1039)	1011 - 1039	5
184	X-RAY DIFFRACTION	184	(segid 25SB and resid 1219:1288)	1219 - 1288	5
185	X-RAY DIFFRACTION	185	(segid 25SB and resid 1552:1583)	1552 - 1583	5
186	X-RAY DIFFRACTION	186	(segid 25SB and resid 2250:2266)	2250 - 2266	5
187	X-RAY DIFFRACTION	187	(segid 25SB and resid 2532:2547)	2532 - 2547	5
188	X-RAY DIFFRACTION	188	(segid 25SB and resid 2563:2578)	2563 - 2578	5
189	X-RAY DIFFRACTION	189	(segid 25SB and resid 3341:3364)	3341 - 3364	5
190	X-RAY DIFFRACTION	190	segid 5SB	0
191	X-RAY DIFFRACTION	191	segid 58SB	1 - 158	8
192	X-RAY DIFFRACTION	192	((segid 18SB and resid 1:602) and (not resid 64:86) and (not resid 185:200) and (not resid 219:237) and (not resid 480:509) and (not resid 510:545))	0
193	X-RAY DIFFRACTION	193	(segid 18SB and resid 64:86)	64 - 86	6
194	X-RAY DIFFRACTION	194	(segid 18SB and resid 185:200)	185 - 200	6
195	X-RAY DIFFRACTION	195	(segid 18SB and resid 219:237)	219 - 237	6
196	X-RAY DIFFRACTION	196	(segid 18SB and resid 480:509)	480 - 509	6
197	X-RAY DIFFRACTION	197	(segid 18SB and resid 510:545)	510 - 545	6
198	X-RAY DIFFRACTION	198	((segid 18SB and resid 603:1106) and (not resid 640:694) and (not resid 698:742) and (not resid 743:765) and (not resid 810:855))	0
199	X-RAY DIFFRACTION	199	(segid 18SB and resid 640:694)	640 - 694	6
200	X-RAY DIFFRACTION	200	(segid 18SB and resid 698:742)	698 - 742	6
201	X-RAY DIFFRACTION	201	(segid 18SB and resid 743:765)	743 - 765	6
202	X-RAY DIFFRACTION	202	(segid 18SB and resid 810:855)	810 - 855	6
203	X-RAY DIFFRACTION	203	(segid 18SB and resid 1107:1635)	1107 - 1635	6
204	X-RAY DIFFRACTION	204	(segid 18SB and resid 1636:1799)	1636 - 1799	6