- PDB-5tgm: Crystal structure of the S.cerevisiae 80S ribosome in complex wit... -
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基本情報
登録情報
データベース: PDB / ID: 5tgm
タイトル
Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro
要素
(18S ribosomal ...) x 2
(25S ribosomal ...) x 2
(40S Ribosomal Protein ...) x 31
(60S Ribosomal Protein ...) x 45
(ES17) x 2
(Guanine nucleotide-binding protein subunit beta-like ...) x 2
5.8S ribosomal RNA
5S ribosomal RNA
Peptidyl-tRNA analog ACCA-Leu-Phe
Ribosome-bound protein Stm1,Suppressor protein STM1,Ribosome-bound protein Stm1
Suppressor protein STM1,Ribosome-bound protein Stm1
Ubiquitin-40S ribosomal protein S31
Ubiquitin-60S ribosomal protein L40
キーワード
RIBOSOME / translation / protein synthesis / proline / aminoacyl-tRNA / peptide bond formation / catalysis / cyclic amino acids
機能・相同性
機能・相同性情報
triplex DNA binding / ribosome hibernation / translation elongation factor binding / Platelet degranulation / regulation of translational initiation in response to stress / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) / Negative regulators of DDX58/IFIH1 signaling / regulation of amino acid metabolic process / negative regulation of glucose mediated signaling pathway / positive regulation of translational fidelity ...triplex DNA binding / ribosome hibernation / translation elongation factor binding / Platelet degranulation / regulation of translational initiation in response to stress / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) / Negative regulators of DDX58/IFIH1 signaling / regulation of amino acid metabolic process / negative regulation of glucose mediated signaling pathway / positive regulation of translational fidelity / RMTs methylate histone arginines / Protein methylation / mTORC1-mediated signalling / ribosome-associated ubiquitin-dependent protein catabolic process / GDP-dissociation inhibitor activity / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / pre-mRNA 5'-splice site binding / Formation of the ternary complex, and subsequently, the 43S complex / Translation initiation complex formation / Ribosomal scanning and start codon recognition / preribosome, small subunit precursor / nonfunctional rRNA decay / response to cycloheximide / cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / telomeric DNA binding / Major pathway of rRNA processing in the nucleolus and cytosol / mRNA destabilization / SRP-dependent cotranslational protein targeting to membrane / GTP hydrolysis and joining of the 60S ribosomal subunit / negative regulation of translational frameshifting / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / TOR signaling / negative regulation of mRNA splicing, via spliceosome / Formation of a pool of free 40S subunits / preribosome, large subunit precursor / L13a-mediated translational silencing of Ceruloplasmin expression / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / translational elongation / ribosomal large subunit export from nucleus / G-protein alpha-subunit binding / 90S preribosome / positive regulation of protein kinase activity / Ub-specific processing proteases / ribosomal subunit export from nucleus / regulation of translational fidelity / protein-RNA complex assembly / endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / translational termination / maturation of LSU-rRNA / ribosomal small subunit export from nucleus / translation regulator activity / translation repressor activity / DNA-(apurinic or apyrimidinic site) endonuclease activity / rescue of stalled ribosome / telomere maintenance / cellular response to amino acid starvation / ribosome assembly / maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / ribosomal large subunit biogenesis / protein kinase C binding / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / maturation of SSU-rRNA / translational initiation / small-subunit processome / macroautophagy / maintenance of translational fidelity / modification-dependent protein catabolic process / protein tag activity / cytoplasmic stress granule / rRNA processing / ribosome biogenesis / ribosome binding / ribosomal small subunit biogenesis / ribosomal small subunit assembly / small ribosomal subunit / 5S rRNA binding / ribosomal large subunit assembly / cytosolic small ribosomal subunit / large ribosomal subunit rRNA binding / small ribosomal subunit rRNA binding / cytosolic large ribosomal subunit / cytoplasmic translation / negative regulation of translation / rRNA binding / protein ubiquitination / ribosome / structural constituent of ribosome / G protein-coupled receptor signaling pathway / translation / ribonucleoprotein complex / negative regulation of gene expression / response to antibiotic / mRNA binding / ubiquitin protein ligase binding / negative regulation of apoptotic process / nucleolus / perinuclear region of cytoplasm / mitochondrion / DNA binding 類似検索 - 分子機能
Stm1-like, N-terminal / Stm1 / Hyaluronan/mRNA-binding protein / Hyaluronan / mRNA binding family / : / : / Ribosomal protein S26e signature. / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S21e, conserved site ...Stm1-like, N-terminal / Stm1 / Hyaluronan/mRNA-binding protein / Hyaluronan / mRNA binding family / : / : / Ribosomal protein S26e signature. / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S21e, conserved site / Ribosomal protein S21e signature. / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S26e / : / Ribosomal protein S12e signature. / Ribosomal protein S12e / Ribosomal protein L29e / Ribosomal L29e protein family / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / Small (40S) ribosomal subunit Asc1/RACK1 / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Ribosomal protein S2, eukaryotic / S27a-like superfamily / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein L10e, conserved site / Ribosomal protein L10e signature. / Ribosomal protein L27e, conserved site / Ribosomal protein L27e signature. / Ribosomal protein L10e / 40S Ribosomal protein S10 / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal L38e protein family / : / Ribosomal protein S7e signature. / Ribosomal protein L44e signature. / Plectin/S10, N-terminal / Plectin/S10 domain / Ribosomal protein L24e, conserved site / Ribosomal protein L24e signature. / : / Ribosomal protein S10, eukaryotic/archaeal / Ribosomal protein L19, eukaryotic / Ribosomal protein L19/L19e conserved site / Ribosomal protein L19e signature. / Ribosomal protein L6e signature. / Ribosomal protein L13e / Ribosomal protein S8e subdomain, eukaryotes / Ribosomal protein L13e / 60S ribosomal protein L18a/ L20, eukaryotes / Ribosomal protein S25 / S25 ribosomal protein / Ribosomal protein S27a / Ribosomal protein S17e, conserved site / : / Ribosomal protein S27a / Ribosomal protein S17e signature. / Ribosomal protein S27a / Ribosomal protein S3Ae, conserved site / Ribosomal protein S3Ae signature. / Ribosomal protein L44e / Ribosomal protein S30 / Ribosomal protein L44 / Ribosomal protein S30 / Ribosomal protein S2, eukaryotic/archaeal / : / Ribosomal protein L34e, conserved site / Ribosomal protein L34e signature. / Ribosomal protein L5 eukaryotic, C-terminal / Ribosomal L18 C-terminal region / Ribosomal protein L30e signature 1. / 50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal L40e family / Ribosomal protein S27e signature. / Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A / 40S ribosomal protein S4, C-terminal domain / Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A / 40S ribosomal protein S4 C-terminus / Ribosomal protein S4e, N-terminal, conserved site / Ribosomal protein S4e signature. / Ribosomal protein L23/L25, N-terminal / Ribosomal protein L23, N-terminal domain / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal_L40e / Ribosomal protein L40e / Ribosomal protein L40e superfamily / Eukaryotic Ribosomal Protein L27, KOW domain / Ribosomal protein 60S L18 and 50S L18e / Ribosomal Protein L6, KOW domain / Ribosomal protein L18/L18-A/B/e, conserved site 類似検索 - ドメイン・相同性
Chem-8AN / LEUCINE / osmium (III) hexammine / PHENYLALANINE / SPARSOMYCIN / : / : / : / : / : ...Chem-8AN / LEUCINE / osmium (III) hexammine / PHENYLALANINE / SPARSOMYCIN / : / : / : / : / : / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / 40S ribosomal protein S8 / ES17 / Small ribosomal subunit protein uS2A / Small ribosomal subunit protein eS1A / Small ribosomal subunit protein uS4A / Large ribosomal subunit protein uL15 / Large ribosomal subunit protein eL24A / Large ribosomal subunit protein uL23 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein uL30A / Large ribosomal subunit protein uL6A / Large ribosomal subunit protein uL22A / Large ribosomal subunit protein uL24A / Large ribosomal subunit protein eL33A / Large ribosomal subunit protein eL36A / Large ribosomal subunit protein eL29 / Large ribosomal subunit protein eL15A / Large ribosomal subunit protein eL22A / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein uS15 / Ubiquitin-ribosomal protein eS31 fusion protein / Small ribosomal subunit protein uS11A / Small ribosomal subunit protein eS19A / Small ribosomal subunit protein eS21A / Small ribosomal subunit protein uS8A / Large ribosomal subunit protein eL27A / Large ribosomal subunit protein eL31A / Ubiquitin-ribosomal protein eL40A fusion protein / Large ribosomal subunit protein eL20A / Large ribosomal subunit protein eL43A / Large ribosomal subunit protein eL42A / Small ribosomal subunit protein eS24A / Small ribosomal subunit protein eS30A / Small ribosomal subunit protein eS4A / Small ribosomal subunit protein eS6A / Large ribosomal subunit protein uL14A / Large ribosomal subunit protein uL2A / Small ribosomal subunit protein uS17A / Large ribosomal subunit protein eL18A / Small ribosomal subunit protein uS9A / Small ribosomal subunit protein uS13A / Large ribosomal subunit protein eL19A / Large ribosomal subunit protein uL29A / Small ribosomal subunit protein eS32A / Small ribosomal subunit protein uS12A / Large ribosomal subunit protein uL4A / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein eL8A / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein uL18 / Small ribosomal subunit protein uS7 / Large ribosomal subunit protein uL13A / Small ribosomal subunit protein eS7A / Small ribosomal subunit protein uS2A / Small ribosomal subunit protein eS1A / Small ribosomal subunit protein eS27A / Large ribosomal subunit protein eL14A / Small ribosomal subunit protein RACK1 / Large ribosomal subunit protein eL32 / Small ribosomal subunit protein uS10 / Suppressor protein STM1 / Small ribosomal subunit protein eS26B / Small ribosomal subunit protein uS14A / Large ribosomal subunit protein uL16 / Small ribosomal subunit protein eS12 / Large ribosomal subunit protein eL37A / Large ribosomal subunit protein eL38 / Large ribosomal subunit protein eL34A / Small ribosomal subunit protein uS19 / Large ribosomal subunit protein eL6A / Large ribosomal subunit protein eL21A / Small ribosomal subunit protein eS10A / Large ribosomal subunit protein eL13A / Large ribosomal subunit protein uL5B / Small ribosomal subunit protein eS25A / Small ribosomal subunit protein eS28A 類似検索 - 構成要素
2: 18S ribosomal RNA S0: 40S ribosomal protein S0-A S1: 40S ribosomal protein S1-A S2: 40S ribosomal protein S2 S3: 40S ribosomal protein S3 S4: 40S ribosomal protein S4-A S5: 40S ribosomal protein S5 S6: 40S ribosomal protein S6-A S7: 40S ribosomal protein S7-A S8: 40S ribosomal protein S8 S9: 40S ribosomal protein S9-A C0: 40S ribosomal protein S10-A,40S Ribosomal Protein S10 C1: 40S ribosomal protein S11-A,40S Ribosomal Protein S11 C2: 40S Ribosomal Protein S12,40S ribosomal protein S12 C3: 40S ribosomal protein S13 C4: 40S ribosomal protein S14-A C5: 40S Ribosomal Protein S15,40S ribosomal protein S15,40S Ribosomal Protein S15 C6: 40S ribosomal protein S16-A C7: ES17 C8: 40S ribosomal protein S18-A C9: 40S ribosomal protein S19-A D0: 40S ribosomal protein S20 D1: 40S ribosomal protein S21-A D2: 40S ribosomal protein S22-A D3: 40S ribosomal protein S23-A D4: 40S ribosomal protein S24-A D5: 40S ribosomal protein S25-A D6: 40S ribosomal protein S26-B D7: 40S ribosomal protein S27-A D8: 40S ribosomal protein S28-A D9: 40S ribosomal protein S29-A E0: 40S ribosomal protein S30-A E1: Ubiquitin-40S ribosomal protein S31 SR: Guanine nucleotide-binding protein subunit beta-like protein SM: Ribosome-bound protein Stm1,Suppressor protein STM1,Ribosome-bound protein Stm1 1: 25S ribosomal RNA 3: 5S ribosomal RNA 4: 5.8S ribosomal RNA L2: 60S ribosomal protein L2-A L3: 60S ribosomal protein L3 L4: 60S ribosomal protein L4-A L5: 60S ribosomal protein L5 L6: 60S ribosomal protein L6-A L7: 60S ribosomal protein L7-A L8: 60S ribosomal protein L8-A L9: 60S ribosomal protein L9-A M0: 60S ribosomal protein L10 M1: 60S ribosomal protein L11-B M3: 60S ribosomal protein L13-A M4: 60S ribosomal protein L14-A M5: 60S ribosomal protein L15-A M6: 60S ribosomal protein L16-A M7: 60S ribosomal protein L17-A M8: 60S ribosomal protein L18-A M9: 60S ribosomal protein L19-A N0: 60S ribosomal protein L20-A N1: 60S ribosomal protein L21-A N2: 60S ribosomal protein L22-A N3: 60S ribosomal protein L23-A N4: 60S ribosomal protein L24-A N5: 60S ribosomal protein L25 N6: 60S ribosomal protein L26-A N7: 60S ribosomal protein L27-A N8: 60S ribosomal protein L28 N9: 60S ribosomal protein L29 O0: 60S ribosomal protein L30 O1: 60S ribosomal protein L31-A O2: 60S ribosomal protein L32 O3: 60S ribosomal protein L33-A O4: 60S ribosomal protein L34-A O5: 60S ribosomal protein L35-A O6: 60S ribosomal protein L36-A O7: 60S ribosomal protein L37-A O8: 60S ribosomal protein L38 O9: 60S ribosomal protein L39 Q0: Ubiquitin-60S ribosomal protein L40 Q1: 60S ribosomal protein L41-A Q2: 60S ribosomal protein L42-A Q3: 60S ribosomal protein L43-A 6: 18S ribosomal RNA s0: 40S ribosomal protein S0-A s1: 40S ribosomal protein S1-A s2: 40S ribosomal protein S2 s3: 40S ribosomal protein S3 s4: 40S ribosomal protein S4-A s5: 40S ribosomal protein S5 s6: 40S ribosomal protein S6-A s7: 40S ribosomal protein S7-A s8: 40S ribosomal protein S8 s9: 40S ribosomal protein S9-A c0: 40S ribosomal protein S10-A,40S Ribosomal Protein S10 c1: 40S ribosomal protein S11-A,40S Ribosomal Protein S11 c2: 40S Ribosomal Protein S12,40S ribosomal protein S12 c3: 40S ribosomal protein S13 c4: 40S ribosomal protein S14-A c5: 40S Ribosomal Protein S15,40S ribosomal protein S15,40S Ribosomal Protein S15 c6: 40S ribosomal protein S16-A c7: ES17 c8: 40S ribosomal protein S18-A c9: 40S ribosomal protein S19-A d0: 40S ribosomal protein S20 d1: 40S ribosomal protein S21-A d2: 40S ribosomal protein S22-A d3: 40S ribosomal protein S23-A d4: 40S ribosomal protein S24-A d5: 40S ribosomal protein S25-A d6: 40S ribosomal protein S26-B d7: 40S ribosomal protein S27-A d8: 40S ribosomal protein S28-A d9: 40S ribosomal protein S29-A e0: 40S ribosomal protein S30-A e1: Ubiquitin-40S ribosomal protein S31 sR: Guanine nucleotide-binding protein subunit beta-like protein sM: Suppressor protein STM1,Ribosome-bound protein Stm1 5: 25S ribosomal RNA 7: 5S ribosomal RNA 8: 5.8S ribosomal RNA l2: 60S ribosomal protein L2-A l3: 60S ribosomal protein L3 l4: 60S ribosomal protein L4-A l5: 60S ribosomal protein L5 l6: 60S ribosomal protein L6-A l7: 60S ribosomal protein L7-A l8: 60S ribosomal protein L8-A,60S Ribosomal Protein L8 l9: 60S ribosomal protein L9-A m0: 60S ribosomal protein L10 m1: 60S ribosomal protein L11-B m2: 60S Ribosomal Protein L12 m3: 60S ribosomal protein L13-A m4: 60S ribosomal protein L14-A m5: 60S ribosomal protein L15-A m6: 60S ribosomal protein L16-A m7: 60S ribosomal protein L17-A m8: 60S ribosomal protein L18-A m9: 60S ribosomal protein L19-A n0: 60S ribosomal protein L20-A n1: 60S ribosomal protein L21-A n2: 60S ribosomal protein L22-A n3: 60S ribosomal protein L23-A n4: 60S ribosomal protein L24-A n5: 60S ribosomal protein L25 n6: 60S ribosomal protein L26-A n7: 60S ribosomal protein L27-A n8: 60S ribosomal protein L28 n9: 60S ribosomal protein L29 o0: 60S ribosomal protein L30 o1: 60S ribosomal protein L31-A o2: 60S ribosomal protein L32 o3: 60S ribosomal protein L33-A o4: 60S ribosomal protein L34-A o5: 60S ribosomal protein L35-A o6: 60S ribosomal protein L36-A o7: 60S ribosomal protein L37-A o8: 60S ribosomal protein L38 o9: 60S ribosomal protein L39 q0: Ubiquitin-60S ribosomal protein L40 q1: 60S ribosomal protein L41-A q2: 60S ribosomal protein L42-A q3: 60S ribosomal protein L43-A p0: 60S Ribosomal Protein P0 p1: 60S Ribosomal Protein P1/2 p2: 60S Ribosomal Protein P1/2 P: Peptidyl-tRNA analog ACCA-Leu-Phe p: Peptidyl-tRNA analog ACCA-Leu-Phe ヘテロ分子
Ribosome-boundproteinStm1,SuppressorproteinSTM1,Ribosome-boundproteinStm1 / 3BP1 / GU4 nucleic-binding protein 2 / G4p2 protein / POP2 multicopy suppressor protein 4 / ...3BP1 / GU4 nucleic-binding protein 2 / G4p2 protein / POP2 multicopy suppressor protein 4 / Ribosomal subunits association factor / AF / TOM1 suppressor protein 1 / Triplex-binding protein 1
SuppressorproteinSTM1,Ribosome-boundproteinStm1 / 3BP1 / GU4 nucleic-binding protein 2 / G4p2 protein / POP2 multicopy suppressor protein 4 / ...3BP1 / GU4 nucleic-binding protein 2 / G4p2 protein / POP2 multicopy suppressor protein 4 / Ribosomal subunits association factor / AF / TOM1 suppressor protein 1 / Triplex-binding protein 1