登録情報 | データベース: PDB / ID: 4qum |
---|
タイトル | Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide |
---|
要素 | - Mitogen-activated protein kinase 12
- Tyrosine-protein phosphatase non-receptor type 3
|
---|
キーワード | HYDROLASE / Alpha Beta |
---|
機能・相同性 | 機能・相同性情報
positive regulation of peptidase activity / regulation of membrane depolarization during action potential / negative regulation of membrane protein ectodomain proteolysis / regulation of sodium ion transmembrane transporter activity / myoblast differentiation / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / muscle organ development / positive regulation of muscle cell differentiation / Myogenesis / negative regulation of epidermal growth factor receptor signaling pathway ...positive regulation of peptidase activity / regulation of membrane depolarization during action potential / negative regulation of membrane protein ectodomain proteolysis / regulation of sodium ion transmembrane transporter activity / myoblast differentiation / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / muscle organ development / positive regulation of muscle cell differentiation / Myogenesis / negative regulation of epidermal growth factor receptor signaling pathway / negative regulation of cell cycle / negative regulation of mitotic cell cycle / MAP kinase activity / signal transduction in response to DNA damage / sodium channel regulator activity / mitogen-activated protein kinase / p38MAPK events / cytoskeletal protein binding / phosphotyrosine residue binding / protein dephosphorylation / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / liver regeneration / EGFR downregulation / NOD1/2 Signaling Pathway / VEGFA-VEGFR2 Pathway / cytoplasmic side of plasma membrane / Negative regulation of MAPK pathway / MAPK cascade / ATPase binding / peptidyl-serine phosphorylation / cytoskeleton / regulation of cell cycle / intracellular signal transduction / protein serine kinase activity / protein serine/threonine kinase activity / magnesium ion binding / signal transduction / mitochondrion / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Mitogen-activated protein kinase 12 / Protein-tyrosine phosphatase, non-receptor type-3, -4 / PTPN3/4, FERM domain C-lobe / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain / FERM domain signature 1. / FERM conserved site ...Mitogen-activated protein kinase 12 / Protein-tyrosine phosphatase, non-receptor type-3, -4 / PTPN3/4, FERM domain C-lobe / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain / FERM domain signature 1. / FERM conserved site / FERM domain signature 2. / Mitogen-activated protein (MAP) kinase p38-like / FERM central domain / FERM/acyl-CoA-binding protein superfamily / Protein tyrosine phosphatase superfamily / FERM central domain / FERM superfamily, second domain / Protein-Tyrosine Phosphatase; Chain A / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / : / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / PH-like domain superfamily / Ubiquitin-like domain superfamily / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 Tyrosine-protein phosphatase non-receptor type 3 / Mitogen-activated protein kinase 12類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.516 Å |
---|
データ登録者 | Chen, K.E. / Meng, T.C. / Wang, A.H.J. |
---|
引用 | ジャーナル: Sci.Signal. / 年: 2014 タイトル: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. 著者: Chen, K.E. / Lin, S.Y. / Wu, M.J. / Ho, M.R. / Santhanam, A. / Chou, C.C. / Meng, T.C. / Wang, A.H.J. |
---|
履歴 | 登録 | 2014年7月10日 | 登録サイト: RCSB / 処理サイト: PDBJ |
---|
改定 1.0 | 2014年12月10日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2018年7月18日 | Group: Advisory / Data collection / カテゴリ: diffrn_source / pdbx_unobs_or_zero_occ_atoms Item: _diffrn_source.pdbx_synchrotron_beamline / _diffrn_source.type |
---|
改定 1.2 | 2023年11月8日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / struct_conn / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
---|
改定 1.3 | 2023年12月6日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
---|
|
---|