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- PDB-4dv0: Crystal structure of the Thermus thermophilus 30S ribosomal subun... -

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Basic information

Entry
Database: PDB / ID: 4dv0
TitleCrystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U20G
Components
  • (ribosomal protein ...) x 20
  • 16S rRNA
KeywordsRIBOSOME / decoding / Streptomycin / RNA structure / antibiotic resistance
Function / homology
Function and homology information


small ribosomal subunit / tRNA binding / rRNA binding / ribosome / structural constituent of ribosome / translation / ribonucleoprotein complex / mRNA binding / zinc ion binding / metal ion binding / cytoplasm
Similarity search - Function
Ribosomal protein S4/S9, N-terminal domain / Ribosomal Protein S4 Delta 41; Chain A, domain 1 / S16 Ribosomal Protein; Chain: A; / Ribosomal protein S16 / Ribosomal protein S18 / 30s Ribosomal Protein S18 / 30s ribosomal protein s13; domain 2 / Ribosomal protein S13/S18, C-terminal domain / Ribosomal protein S20 / 30s Ribosomal Protein S19; Chain A ...Ribosomal protein S4/S9, N-terminal domain / Ribosomal Protein S4 Delta 41; Chain A, domain 1 / S16 Ribosomal Protein; Chain: A; / Ribosomal protein S16 / Ribosomal protein S18 / 30s Ribosomal Protein S18 / 30s ribosomal protein s13; domain 2 / Ribosomal protein S13/S18, C-terminal domain / Ribosomal protein S20 / 30s Ribosomal Protein S19; Chain A / Ribosomal protein S19/S15 / Ribosomal protein S3, C-terminal domain / Ribosomal Protein S14/S29 / 30s Ribosomal Protein S14; Chain N / Ribosomal Protein S8; Chain: A, domain 1 - #30 / RNA-binding S4 domain / Ribosomal Protein S7 / Ribosomal protein S7/S5 / Ribosomal protein S6/Translation elongation factor EF1B / Ribosomal protein S3 C-terminal domain / Helix hairpin bin / Dna Ligase; domain 1 - #10 / Ribosomal protein S11/S14 / Ribosomal protein S10 / Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A / S15/NS1, RNA-binding / K homology (KH) domain / Double Stranded RNA Binding Domain - #20 / Helicase, Ruva Protein; domain 3 - #50 / Glucose-6-phosphate isomerase like protein; domain 1 / Ribosomal Protein S8; Chain: A, domain 1 / Ribosomal Protein S5; domain 2 - #10 / 30S ribosomal protein Thx / 30S ribosomal protein Thx / 30S ribosomal protein / GMP Synthetase; Chain A, domain 3 / Ribosomal Protein S5; domain 2 / Double Stranded RNA Binding Domain / Ribosomal protein S14, type Z / Helicase, Ruva Protein; domain 3 / Nucleic acid-binding proteins / Dna Ligase; domain 1 / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Ribosomal protein S14/S29 / Ribosomal protein S3, bacterial-type / Ribosomal protein S6, conserved site / Ribosomal protein S6 signature. / Ribosomal protein S19, bacterial-type / Ribosomal protein S7, bacterial/organellar-type / Ribosomal protein S11, bacterial-type / Ribosomal protein S13, bacterial-type / Ribosomal protein S20 / Ribosomal protein S20 superfamily / Ribosomal protein S20 / Ribosomal protein S9, bacterial/plastid / Ribosomal protein S4, bacterial-type / 30S ribosomal protein S17 / Ribosomal protein S5, bacterial-type / Ribosomal protein S6, plastid/chloroplast / Ribosomal protein S2, bacteria/mitochondria/plastid / Ribosomal protein S18, conserved site / Ribosomal protein S18 signature. / Ribosomal protein S16 / Ribosomal protein S16 / Ribosomal protein S16 domain superfamily / Ribosomal protein S15, bacterial-type / Ribosomal protein S6 / Ribosomal protein S6 / Ribosomal protein S6 superfamily / Ribosomal protein S12, bacterial-type / Translation elongation factor EF1B/ribosomal protein S6 / Ribosomal protein S18 / Ribosomal protein S18 / Ribosomal protein S18 superfamily / K Homology domain / K homology RNA-binding domain / Ribosomal protein S3, conserved site / Ribosomal protein S14, conserved site / Ribosomal protein S10, conserved site / : / K Homology domain, type 2 / Ribosomal protein S3, C-terminal / Ribosomal protein S3, C-terminal domain superfamily / Ribosomal protein S15/S19, conserved site / KH domain / Ribosomal protein S19/S15 / Ribosomal protein S19/S15, superfamily / Ribosomal protein S10 / Ribosomal protein S3, C-terminal domain / Few Secondary Structures / Irregular / Ribosomal protein S3 signature. / Ribosomal protein S10 signature. / Ribosomal protein S14 signature. / Ribosomal protein S7, conserved site / K homology domain superfamily, prokaryotic type / Ribosomal protein S17, conserved site / Ribosomal protein S19 / Ribosomal protein S2 signature 1. / Ribosomal protein S13, conserved site
Similarity search - Domain/homology
: / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS7 ...: / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS11 / Small ribosomal subunit protein uS13 / Small ribosomal subunit protein bS20 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS10 / Small ribosomal subunit protein uS19 / 30S ribosomal protein S17 / 30S ribosomal protein S14 type Z / 30S ribosomal protein S8 / Small ribosomal subunit protein uS5 / Small ribosomal subunit protein bTHX / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein bS16 / Small ribosomal subunit protein bS6 / Small ribosomal subunit protein bS18
Similarity search - Component
Biological speciesThermus thermophilus (bacteria)
MethodX-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution: 3.853 Å
AuthorsDemirci, H. / Murphy IV, F. / Murphy, E. / Gregory, S.T. / Dahlberg, A.E. / Jogl, G.
CitationJournal: To be Published
Title: A structural basis for streptomycin resistance
Authors: Demirci, H. / Murphy IV, F. / Murphy, E. / Gregory, S.T. / Dahlberg, A.E. / Jogl, G.
History
DepositionFeb 22, 2012Deposition site: RCSB / Processing site: RCSB
Revision 1.0Feb 27, 2013Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: 16S rRNA
B: ribosomal protein S2
C: ribosomal protein S3
D: ribosomal protein S4
E: ribosomal protein S5
F: ribosomal protein S6
G: ribosomal protein S7
H: ribosomal protein S8
I: ribosomal protein S9
J: ribosomal protein S10
K: ribosomal protein S11
L: ribosomal protein S12
M: ribosomal protein S13
N: ribosomal protein S14
O: ribosomal protein S15
P: ribosomal protein S16
Q: ribosomal protein S17
R: ribosomal protein S18
S: ribosomal protein S19
T: ribosomal protein S20
U: ribosomal protein THX
hetero molecules


Theoretical massNumber of molelcules
Total (without water)790,838300
Polymers783,97521
Non-polymers6,863279
Water7,909439
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)402.108, 402.108, 173.997
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number92
Space group name H-MP41212

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Components

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RNA chain , 1 types, 1 molecules A

#1: RNA chain 16S rRNA /


Mass: 494209.812 Da / Num. of mol.: 1 / Mutation: U20G / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: GenBank: M26923.1

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Ribosomal protein ... , 20 types, 20 molecules BCDEFGHIJKLMNOPQRSTU

#2: Protein ribosomal protein S2 /


Mass: 29317.703 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P80371
#3: Protein ribosomal protein S3 /


Mass: 26751.076 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P80372
#4: Protein ribosomal protein S4 /


Mass: 24373.447 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P80373
#5: Protein ribosomal protein S5 /


Mass: 17583.416 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SHQ5
#6: Protein ribosomal protein S6 /


Mass: 11988.753 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SLP8
#7: Protein ribosomal protein S7 /


Mass: 18050.973 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P17291
#8: Protein ribosomal protein S8 /


Mass: 15868.570 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SHQ2, UniProt: P0DOY9*PLUS
#9: Protein ribosomal protein S9 /


Mass: 14410.614 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P80374
#10: Protein ribosomal protein S10 /


Mass: 11954.968 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SHN7
#11: Protein ribosomal protein S11 /


Mass: 13737.868 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P80376
#12: Protein ribosomal protein S12 /


Mass: 14966.846 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: F6DEQ7, UniProt: Q5SHN3*PLUS
#13: Protein ribosomal protein S13 /


Mass: 14338.861 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P80377
#14: Protein ribosomal protein S14 /


Mass: 7158.725 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SHQ1, UniProt: P0DOY6*PLUS
#15: Protein ribosomal protein S15 /


Mass: 10578.407 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SJ76
#16: Protein ribosomal protein S16 /


Mass: 10409.983 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SJH3
#17: Protein ribosomal protein S17 /


Mass: 12324.670 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SHP7, UniProt: P0DOY7*PLUS
#18: Protein ribosomal protein S18 /


Mass: 10258.299 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SLQ0
#19: Protein ribosomal protein S19 / 40S ribosomal protein S19


Mass: 10605.464 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SHP2
#20: Protein ribosomal protein S20 /


Mass: 11736.143 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: P80380
#21: Protein/peptide ribosomal protein THX / Ribosome


Mass: 3350.030 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Thermus thermophilus (bacteria) / Strain: HB8 / References: UniProt: Q5SIH3

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Non-polymers , 3 types, 718 molecules

#22: Chemical...
ChemComp-MG / MAGNESIUM ION


Mass: 24.305 Da / Num. of mol.: 277 / Source method: obtained synthetically / Formula: Mg
#23: Chemical ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Zn
#24: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 439 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 4.49 Å3/Da / Density % sol: 72.58 %
Crystal growTemperature: 277 K / Method: hanging drop / pH: 6.5 / Details: MPD, pH 6.5, HANGING DROP, temperature 277K

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 24-ID-C / Wavelength: 0.98 Å
DetectorType: ADSC QUANTUM 315 / Detector: CCD / Date: Nov 7, 2010
RadiationMonochromator: Kohzu HLD8-24r / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.98 Å / Relative weight: 1
ReflectionResolution: 3.85→35 Å / Num. all: 130659 / Num. obs: 130659 / % possible obs: 97.6 % / Observed criterion σ(F): -3 / Observed criterion σ(I): -3 / Redundancy: 3.2 % / Rmerge(I) obs: 0.071 / Χ2: 1.084 / Net I/σ(I): 12.2
Reflection shell
Resolution (Å)Redundancy (%)Rmerge(I) obsNum. unique allΧ2Diffraction-ID% possible all
3.85-3.993.20.817131231.241199.5
3.99-4.153.20.601131841.109199.5
4.15-4.343.20.396131691.082199.3
4.34-4.563.20.257131461.102199.1
4.56-4.853.20.168131171.061198.9
4.85-5.223.20.115131101.028198.5
5.22-5.753.20.083130991.01198
5.75-6.573.20.071130241.079197.2
6.57-8.263.20.048129941.151195.9
8.26-353.20.028126930.97190.9

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Processing

Software
NameVersionClassificationNB
DENZOdata reduction
SCALEPACKdata scaling
PHENIXdev_978refinement
PDB_EXTRACT3.1data extraction
HKL-2000data collection
PHENIXdev_978phasing
RefinementMethod to determine structure: FOURIER SYNTHESIS / Resolution: 3.853→34.823 Å / Occupancy max: 1 / Occupancy min: 0.26 / FOM work R set: 0.8741 / SU ML: 0.31 / σ(F): 1.34 / Phase error: 19.47 / Stereochemistry target values: ML
RfactorNum. reflection% reflectionSelection details
Rfree0.2059 6509 4.98 %FROM PDB ENTRY 2VQE
Rwork0.1475 ---
obs0.1504 130643 97.65 %-
all-130643 --
Solvent computationShrinkage radii: 0.86 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL / Bsol: 130.769 Å2 / ksol: 0.244 e/Å3
Displacement parametersBiso max: 517.63 Å2 / Biso mean: 196.6305 Å2 / Biso min: 54.8 Å2
Baniso -1Baniso -2Baniso -3
1--10.2483 Å2-0 Å20 Å2
2---10.2483 Å20 Å2
3---10.0849 Å2
Refinement stepCycle: LAST / Resolution: 3.853→34.823 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms19088 32510 279 439 52316
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.01156381
X-RAY DIFFRACTIONf_angle_d1.42883654
X-RAY DIFFRACTIONf_chiral_restr0.08210413
X-RAY DIFFRACTIONf_plane_restr0.0084888
X-RAY DIFFRACTIONf_dihedral_angle_d19.52426123
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Total num. of bins used: 30

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
3.853-3.89690.2992290.27294098432798
3.8969-3.94260.3292090.25394191440099
3.9426-3.99060.30112120.25044137434999
3.9906-4.04110.31932370.244141774414100
4.0411-4.09420.30732470.237641474394100
4.0942-4.15020.28572080.2154164437299
4.1502-4.20940.29712250.201341694394100
4.2094-4.27210.2571910.1974164435599
4.2721-4.33870.2562490.18734179442899
4.3387-4.40970.23052190.17964150436999
4.4097-4.48560.21162480.15914126437499
4.4856-4.5670.19222180.15224209442799
4.567-4.65460.18842030.14144149435299
4.6546-4.74940.21631980.1374181437999
4.7494-4.85240.19092080.13324174438299
4.8524-4.9650.17032330.11844150438399
4.965-5.08880.17592150.11534173438899
5.0888-5.2260.1791990.10844139433898
5.226-5.37920.17642140.10914160437498
5.3792-5.55220.16782230.10784167439098
5.5522-5.74970.18692210.11054113433498
5.7497-5.97890.17121960.11444165436198
5.9789-6.24950.19022020.11864129433197
6.2495-6.57690.16692120.11444131434397
6.5769-6.98590.18772050.10764138434396
6.9859-7.52020.17772350.114091432696
7.5202-8.26780.1811930.1174140433395
8.2678-9.44330.1832410.12464051429294
9.4433-11.81980.18862130.13324139435294
11.8198-34.8240.23652060.21013833403985
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.6020.0917-0.20.9154-0.1140.7809-0.068-0.1504-0.18640.23470.130.28910.30710.0969-0.04521.09580.25290.18871.01930.03861.3637143.067682.8889-12.7673
23.097-0.37760.7770.80180.31640.37850.0446-1.59040.48270.530.2101-0.511-0.1306-0.0422-0.24891.6189-0.27010.07352.6531-0.79382.002221.8347129.19639.5612
33.23351.3957-0.84280.6602-0.33770.51380.0486-0.6404-0.99360.0602-0.0314-0.79090.3260.3297-0.02331.56470.2817-0.01461.64570.05621.8316166.178671.3333-26.4894
42.41620.27490.87953.3314-2.21712.8647-2.26310.5379-0.78950.35460.6126-0.5148-0.52330.43581.49222.1311-0.20360.40371.66370.67332.8248155.2358157.351-34.421
55.5144-0.6512.30812.1655-3.36246.1486-0.7830.3219-0.234-0.6875-0.5122-0.50080.1934-0.11411.0612.59420.17630.54821.56120.03092.4101151.5779150.1123-37.4538
63.9471.11322.77263.47152.032.43470.2914-1.8185-0.2386-0.2844-0.62220.36810.4629-1.2330.24362.0251-0.65610.85161.9680.13772.9675147.0592159.4074-20.042
76.13691.69356.15176.1672-0.79427.43880.8741-0.90671.2122-0.55-1.2740.0149-0.47771.92030.38412.2449-0.04920.53521.91880.07052.0252164.8804162.3355-17.9581
89.33720.10420.7797.711-3.22321.4717-0.1173-0.80530.6585-0.96621.0414-1.3936-1.34711.4348-1.03361.8344-0.27690.63392.0734-0.90011.8931173.2016155.7797-6.6717
90.78860.27160.23392.1425-1.55941.38490.3546-0.3491.26420.35620.1755-0.7853-1.35740.9747-0.41623.2099-1.24051.27962.9751-0.81692.364191.8552167.05351.7807
104.04692.6801-0.78532.9267-0.24773.7239-0.5077-0.45490.23970.41311.3595-1.4751-0.2712.418-0.95821.6323-0.08140.52481.9243-0.92262.6146173.0125155.0377-10.948
112.8374-2.00992.37914.30032.28538.4043-0.43240.28880.0507-3.03370.5895-1.09430.26040.6651-0.19212.7496-0.36161.27141.1332-0.23892.8866156.0875151.1095-23.2762
122.73170.16963.35272.8351-0.66444.4619-0.76320.09271.06980.97820.4172-0.7953-2.2222-0.90770.27472.6291-0.02010.97991.2591-0.31853.3246156.6285167.3197-21.415
131.1759-0.0742-0.33220.00510.03170.3125-0.42340.43030.8231-0.4507-0.06430.1061-0.40390.11790.20366.5406-0.66891.14791.75390.03743.7428161.988174.0077-23.3464
140.60440.41920.69381.42430.21370.84460.6373-0.32480.6722-0.1388-0.68061.2112-0.8934-0.73890.2522.128-0.06260.37824.1617-1.48622.0849208.7002138.891227.5193
153.0631-1.80562.7433.41-1.60993.0704-1.1653-0.93362.1674-0.1778-0.3186-0.50580.0729-0.55681.26371.7967-0.4094-0.12073.612-0.36442.5592205.3746144.496835.1661
164.9873-1.99710.27924.1498-0.01280.3013-0.5159-1.8130.51181.53090.6684-0.6931-0.40720.5825-0.09123.4573-0.78510.24673.6358-0.56782.6732191.2586141.652344.7211
170.15040.1060.06240.3691-0.03350.04740.1135-0.34620.08440.78350.0219-0.1644-0.30960.10560.04162.9525-0.1942-0.45913.1185-1.47970.8289205.6642139.416546.5379
182.0813-1.99152.19021.9411-2.11322.4298-0.2851-0.94670.98271.5419-0.6121-1.1788-0.2225-0.40680.77712.33910.5456-0.46444.3373-1.18582.6957191.1749146.065430.694
193.8809-1.1567-0.42388.9084-1.52844.15070.7317-1.2049-0.14431.3053-0.15531.795-0.1226-1.438-0.45681.3945-0.37060.23483.6418-0.39091.4785185.8274129.904818.9906
204.19375.13661.26988.1905-2.03888.1034-0.0963-0.53860.78980.2639-0.1335-0.9958-0.55980.57340.28361.2148-0.44580.13283.4279-1.28632.8663195.2952144.19229.668
215.31225.053-5.14194.876-5.41378.1711-0.6046-2.19540.13430.0274-0.00930.19611.4256-0.46370.57331.4020.2979-0.01624.5447-0.49751.1267193.9468126.037123.5963
226.38171.1278-3.05260.2278-0.78273.24390.47760.52470.4297-0.3840.442-0.4041-0.4867-0.0431-0.71981.1726-0.26780.37524.0635-1.53262.351193.5837137.717716.7269
232.7407-2.4699-1.62622.65110.70122.5449-0.04080.0639-0.52390.36160.50290.1934-0.2285-0.3327-0.19443.12940.1988-0.60512.2228-0.09382.0251153.0145110.522937.545
245.0549-1.6738-2.69435.8851-2.33723.40180.7331-2.14521.66420.4996-0.8656-1.1307-1.38142.4785-0.10812.29610.4185-0.00782.7084-0.60761.1713158.8268112.092125.518
252.0337-2.60372.11616.888-3.65779.9678-0.37520.7127-0.9879-1.0911-0.4763-0.35510.7389-0.9640.84641.59260.37370.10921.4555-0.48641.5132138.2298104.873719.8976
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1118.59832.04752.06441.99342.04122.0744-0.16470.31440.6331-0.62120.3050.1111-0.59870.505-0.27111.0232-0.40680.06761.15780.46222.1048125.933787.4598-33.9366
1122.62290.15343.47214.847-2.87098.1034-0.6143-0.3912-0.94230.5547-1.3664-1.1090.70741.54951.53721.0010.10820.05351.40530.5611.5885137.138997.9213-21.7167
1134.45322.25280.893.53294.80758.3659-0.9763-0.5317-0.0534-0.55450.91880.53381.05630.16450.02750.87970.094-0.01110.99510.35461.8011127.067285.2047-33.482
1147.82084.1203-5.61883.8581-4.33335.17770.32591.557-0.1401-1.34570.9732.3741.5751-2.525-1.18021.7162-0.2963-0.9041.88670.61422.7142115.209579.5719-46.6254
1152.2642.04032.17031.94252.02552.12910.1733-0.6686-0.33620.99430.15240.9223-2.3576-0.5643-0.27171.1754-0.05290.14240.83490.49322.7303115.585284.1479-35.1965
1167.9381-5.64134.21546.2184-1.34827.2482-0.0389-0.13120.0041.1853-0.8649-0.3846-0.49930.45490.86881.1715-0.23740.16431.39740.45241.4079117.11479.4413-36.7223
1175.7094-5.8162.61025.9699-3.04775.10210.20510.1553-0.14130.7415-0.1820.5315-0.3897-0.6233-0.09631.339-0.00940.04241.1675-0.17281.3781137.173985.2614-45.1086
1181.2392-2.8791-0.61577.28240.66511.2842-0.168-0.86831.69250.08250.7151-1.3937-1.38180.2112-0.38972.44820.36860.92851.1968-0.68713.1174179.0997140.756-63.9248
1197.4165.74234.10184.60893.15482.35160.13880.19351.1647-1.0174-0.89931.136-1.0612-0.32820.79582.01340.30250.19831.89940.23412.3026172.2481132.5744-75.7531
1208.86713.21247.06162.76714.43939.23560.24051.12031.6776-1.61120.0808-1.3515-1.99111.9937-0.43551.33810.08840.7481.3910.66272.4099180.5828133.4374-74.5969
1216.0859-5.4363-4.71387.16342.53654.86690.3124-0.44550.6808-0.72310.643-4.0158-0.61843.2422-0.87511.09980.27560.28872.3029-0.32372.1104186.0057128.666-66.1053
1224.0477-0.25470.743.3349-0.26622.90330.0507-0.24260.08350.00680.1014-0.43150.18870.64180.09651.73130.23231.29232.588-0.06661.2021177.2366133.7989-60.8355
1234.3014-1.5374-3.99247.56810.18784.14591.3386-0.22451.11120.32710.51910.9689-0.3188-0.9743-1.70431.4408-0.11870.33111.35020.21661.0875174.0591124.5486-69.3044
1244.4339-0.34821.1634.38471.83857.7516-0.27340.76860.727-0.2080.5489-1.14150.27370.5325-0.16071.27190.33040.39662.23190.70821.9807191.3361125.8399-71.7728
1252.50180.81394.32032.94430.43267.823-0.36431.1407-0.3604-1.6490.25321.83811.2337-1.38640.0812.79710.3095-1.13133.5442-1.32883.0397251.5629112.877428.1332
1261.46961.4192-0.17981.93871.277.19770.1914-1.1212-0.07530.7521-0.2871-0.25230.62810.2204-0.05513.98311.2977-1.42444.4756-0.97862.1157251.280399.92242.0355
1271.4037-1.5943-3.3555.93433.59888.0288-0.6985-0.26192.40140.57940.4855-2.0245-1.92032.14090.19342.8543-0.0999-0.7252.7677-0.19584.2726251.90188.708339.0712
1281.434-1.37652.38561.5809-2.21475.0098-0.791-0.6582-0.27020.3744-0.68040.5139-0.8025-0.73621.13441.9508-0.158-0.54344.15450.44473.0363243.927101.20132.169
1292.3485-0.53142.34880.1369-0.49152.7895-0.7879-0.27370.5812-0.455-0.86860.59380.11340.14941.46962.4544-0.4505-0.32933.59590.64523.0184251.11396.868832.6078
1300.1769-0.41740.65530.9863-1.60322.708-0.1759-1.2783-0.65110.6687-0.0721-1.2416-0.78110.7627-0.01542.0323-0.0347-0.54043.94330.45513.0177247.570193.797926.6898
1311.0141-0.9421.31741.8423-1.16531.71430.83372.63690.4995-1.5109-1.4601-0.95650.09091.76770.69592.09910.7134-0.42074.15521.57043.0775252.6408103.221325.585
1324.2223-4.8044-2.08247.06520.20313.9661-0.90950.1034-0.3844-0.3315-0.7683-0.7109-0.50370.71351.4482.90280.8569-0.12822.809-0.07932.5175240.815995.95616.7831
1337.97650.47267.0630.96970.83726.3622-0.1912-0.423-0.25910.27020.79090.40220.44160.0897-0.43411.175-0.41610.41251.18750.24721.6764112.964540.8357-15.2215
1347.25091.27051.0864.36632.44833.79390.2626-1.3690.2785-0.1592-0.05971.51571.307-0.7911-0.08031.7616-0.11860.30490.74380.76892.272199.856944.3452-26.1795
1354.2755-1.05792.38854.22042.42453.6205-0.94870.16190.4545-0.345-0.50910.13830.2149-0.11761.10381.2408-0.62250.15222.01740.63452.369298.837849.6651-35.3293
1368.5981-3.22313.02951.7405-0.77751.4122-0.0397-0.0204-0.18060.5699-0.20080.76830.0110.00330.2191.7378-0.1903-0.16482.1451-1.093.9957250.5289124.88712.5211
1376.1502-1.0783-3.37169.8024-1.86742.76261.1179-1.06670.78160.5588-0.78160.237-1.44110.4717-0.1492.8101-0.4509-0.54882.258-1.11212.4494250.7299131.69117.8652
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resseq 5:920)A5 - 920
2X-RAY DIFFRACTION2chain 'A' and (resseq 921:1400)A921 - 1400
3X-RAY DIFFRACTION3chain 'A' and (resseq 1401:1544)A0
4X-RAY DIFFRACTION4chain 'B' and (resseq 7:25)B7 - 25
5X-RAY DIFFRACTION5chain 'B' and (resseq 26:43)B26 - 43
6X-RAY DIFFRACTION6chain 'B' and (resseq 44:63)B44 - 63
7X-RAY DIFFRACTION7chain 'B' and (resseq 64:87)B64 - 87
8X-RAY DIFFRACTION8chain 'B' and (resseq 88:121)B88 - 121
9X-RAY DIFFRACTION9chain 'B' and (resseq 122:131)B122 - 131
10X-RAY DIFFRACTION10chain 'B' and (resseq 132:180)B132 - 180
11X-RAY DIFFRACTION11chain 'B' and (resseq 181:207)B181 - 207
12X-RAY DIFFRACTION12chain 'B' and (resseq 208:226)B208 - 226
13X-RAY DIFFRACTION13chain 'B' and (resseq 227:240)B227 - 240
14X-RAY DIFFRACTION14chain 'C' and (resseq 2:50)C2 - 50
15X-RAY DIFFRACTION15chain 'C' and (resseq 51:70)C51 - 70
16X-RAY DIFFRACTION16chain 'C' and (resseq 71:82)C71 - 82
17X-RAY DIFFRACTION17chain 'C' and (resseq 83:101)C83 - 101
18X-RAY DIFFRACTION18chain 'C' and (resseq 102:112)C102 - 112
19X-RAY DIFFRACTION19chain 'C' and (resseq 113:169)C113 - 169
20X-RAY DIFFRACTION20chain 'C' and (resseq 170:182)C170 - 182
21X-RAY DIFFRACTION21chain 'C' and (resseq 183:193)C183 - 193
22X-RAY DIFFRACTION22chain 'C' and (resseq 194:207)C194 - 207
23X-RAY DIFFRACTION23chain 'D' and (resseq 2:34)D2 - 34
24X-RAY DIFFRACTION24chain 'D' and (resseq 35:68)D35 - 68
25X-RAY DIFFRACTION25chain 'D' and (resseq 69:99)D69 - 99
26X-RAY DIFFRACTION26chain 'D' and (resseq 100:194)D100 - 194
27X-RAY DIFFRACTION27chain 'D' and (resseq 195:209)D195 - 209
28X-RAY DIFFRACTION28chain 'E' and (resseq 5:16)E5 - 16
29X-RAY DIFFRACTION29chain 'E' and (resseq 17:27)E17 - 27
30X-RAY DIFFRACTION30chain 'E' and (resseq 28:50)E28 - 50
31X-RAY DIFFRACTION31chain 'E' and (resseq 51:63)E51 - 63
32X-RAY DIFFRACTION32chain 'E' and (resseq 64:79)E64 - 79
33X-RAY DIFFRACTION33chain 'E' and (resseq 80:103)E80 - 103
34X-RAY DIFFRACTION34chain 'E' and (resseq 104:127)E104 - 127
35X-RAY DIFFRACTION35chain 'E' and (resseq 128:141)E128 - 141
36X-RAY DIFFRACTION36chain 'E' and (resseq 142:154)E142 - 154
37X-RAY DIFFRACTION37chain 'F' and (resseq 1:10)F1 - 10
38X-RAY DIFFRACTION38chain 'F' and (resseq 11:15)F11 - 15
39X-RAY DIFFRACTION39chain 'F' and (resseq 16:32)F16 - 32
40X-RAY DIFFRACTION40chain 'F' and (resseq 33:42)F33 - 42
41X-RAY DIFFRACTION41chain 'F' and (resseq 43:47)F43 - 47
42X-RAY DIFFRACTION42chain 'F' and (resseq 48:56)F48 - 56
43X-RAY DIFFRACTION43chain 'F' and (resseq 57:68)F57 - 68
44X-RAY DIFFRACTION44chain 'F' and (resseq 69:81)F69 - 81
45X-RAY DIFFRACTION45chain 'F' and (resseq 82:92)F82 - 92
46X-RAY DIFFRACTION46chain 'F' and (resseq 93:101)F93 - 101
47X-RAY DIFFRACTION47chain 'G' and (resseq 2:11)G2 - 11
48X-RAY DIFFRACTION48chain 'G' and (resseq 12:35)G12 - 35
49X-RAY DIFFRACTION49chain 'G' and (resseq 36:69)G36 - 69
50X-RAY DIFFRACTION50chain 'G' and (resseq 70:78)G70 - 78
51X-RAY DIFFRACTION51chain 'G' and (resseq 79:92)G79 - 92
52X-RAY DIFFRACTION52chain 'G' and (resseq 93:110)G93 - 110
53X-RAY DIFFRACTION53chain 'G' and (resseq 111:129)G111 - 129
54X-RAY DIFFRACTION54chain 'G' and (resseq 130:144)G130 - 144
55X-RAY DIFFRACTION55chain 'G' and (resseq 145:156)G145 - 156
56X-RAY DIFFRACTION56chain 'H' and (resseq 1:19)H1 - 19
57X-RAY DIFFRACTION57chain 'H' and (resseq 20:42)H20 - 42
58X-RAY DIFFRACTION58chain 'H' and (resseq 43:62)H43 - 62
59X-RAY DIFFRACTION59chain 'H' and (resseq 63:95)H63 - 95
60X-RAY DIFFRACTION60chain 'H' and (resseq 96:116)H96 - 116
61X-RAY DIFFRACTION61chain 'H' and (resseq 117:138)H117 - 138
62X-RAY DIFFRACTION62chain 'I' and (resseq 2:32)I2 - 32
63X-RAY DIFFRACTION63chain 'I' and (resseq 33:40)I33 - 40
64X-RAY DIFFRACTION64chain 'I' and (resseq 41:69)I41 - 69
65X-RAY DIFFRACTION65chain 'I' and (resseq 70:88)I70 - 88
66X-RAY DIFFRACTION66chain 'I' and (resseq 89:106)I89 - 106
67X-RAY DIFFRACTION67chain 'I' and (resseq 107:128)I107 - 128
68X-RAY DIFFRACTION68chain 'J' and (resseq 3:12)J3 - 12
69X-RAY DIFFRACTION69chain 'J' and (resseq 13:29)J13 - 29
70X-RAY DIFFRACTION70chain 'J' and (resseq 30:42)J30 - 42
71X-RAY DIFFRACTION71chain 'J' and (resseq 43:49)J43 - 49
72X-RAY DIFFRACTION72chain 'J' and (resseq 50:71)J50 - 71
73X-RAY DIFFRACTION73chain 'J' and (resseq 72:84)J72 - 84
74X-RAY DIFFRACTION74chain 'J' and (resseq 85:94)J85 - 94
75X-RAY DIFFRACTION75chain 'J' and (resseq 95:100)J95 - 100
76X-RAY DIFFRACTION76chain 'K' and (resseq 11:34)K11 - 34
77X-RAY DIFFRACTION77chain 'K' and (resseq 35:52)K35 - 52
78X-RAY DIFFRACTION78chain 'K' and (resseq 53:75)K53 - 75
79X-RAY DIFFRACTION79chain 'K' and (resseq 76:86)K76 - 86
80X-RAY DIFFRACTION80chain 'K' and (resseq 87:99)K87 - 99
81X-RAY DIFFRACTION81chain 'K' and (resseq 100:110)K100 - 110
82X-RAY DIFFRACTION82chain 'K' and (resseq 111:126)K111 - 126
83X-RAY DIFFRACTION83chain 'L' and (resseq 5:12)L5 - 12
84X-RAY DIFFRACTION84chain 'L' and (resseq 13:22)L13 - 22
85X-RAY DIFFRACTION85chain 'L' and (resseq 23:32)L23 - 32
86X-RAY DIFFRACTION86chain 'L' and (resseq 33:69)L33 - 69
87X-RAY DIFFRACTION87chain 'L' and (resseq 70:101)L70 - 101
88X-RAY DIFFRACTION88chain 'L' and (resseq 102:128)L102 - 128
89X-RAY DIFFRACTION89chain 'M' and (resseq 2:14)M2 - 14
90X-RAY DIFFRACTION90chain 'M' and (resseq 15:66)M15 - 66
91X-RAY DIFFRACTION91chain 'M' and (resseq 67:94)M67 - 94
92X-RAY DIFFRACTION92chain 'M' and (resseq 95:119)M95 - 119
93X-RAY DIFFRACTION93chain 'N' and (resseq 2:11)N2 - 11
94X-RAY DIFFRACTION94chain 'N' and (resseq 12:21)N12 - 21
95X-RAY DIFFRACTION95chain 'N' and (resseq 22:31)N22 - 31
96X-RAY DIFFRACTION96chain 'N' and (resseq 32:40)N32 - 40
97X-RAY DIFFRACTION97chain 'N' and (resseq 41:61)N41 - 61
98X-RAY DIFFRACTION98chain 'O' and (resseq 2:49)O2 - 49
99X-RAY DIFFRACTION99chain 'O' and (resseq 50:73)O50 - 73
100X-RAY DIFFRACTION100chain 'O' and (resseq 74:88)O74 - 88
101X-RAY DIFFRACTION101chain 'P' and (resseq 1:8)P1 - 8
102X-RAY DIFFRACTION102chain 'P' and (resseq 9:23)P9 - 23
103X-RAY DIFFRACTION103chain 'P' and (resseq 24:33)P24 - 33
104X-RAY DIFFRACTION104chain 'P' and (resseq 34:52)P34 - 52
105X-RAY DIFFRACTION105chain 'P' and (resseq 53:61)P53 - 61
106X-RAY DIFFRACTION106chain 'P' and (resseq 62:67)P62 - 67
107X-RAY DIFFRACTION107chain 'P' and (resseq 68:76)P68 - 76
108X-RAY DIFFRACTION108chain 'P' and (resseq 77:83)P77 - 83
109X-RAY DIFFRACTION109chain 'Q' and (resseq 2:12)Q2 - 12
110X-RAY DIFFRACTION110chain 'Q' and (resseq 13:17)Q13 - 17
111X-RAY DIFFRACTION111chain 'Q' and (resseq 18:28)Q18 - 28
112X-RAY DIFFRACTION112chain 'Q' and (resseq 29:34)Q29 - 34
113X-RAY DIFFRACTION113chain 'Q' and (resseq 35:45)Q35 - 45
114X-RAY DIFFRACTION114chain 'Q' and (resseq 46:55)Q46 - 55
115X-RAY DIFFRACTION115chain 'Q' and (resseq 56:61)Q56 - 61
116X-RAY DIFFRACTION116chain 'Q' and (resseq 62:81)Q62 - 81
117X-RAY DIFFRACTION117chain 'Q' and (resseq 82:100)Q82 - 100
118X-RAY DIFFRACTION118chain 'R' and (resseq 19:24)R19 - 24
119X-RAY DIFFRACTION119chain 'R' and (resseq 25:36)R25 - 36
120X-RAY DIFFRACTION120chain 'R' and (resseq 37:43)R37 - 43
121X-RAY DIFFRACTION121chain 'R' and (resseq 44:52)R44 - 52
122X-RAY DIFFRACTION122chain 'R' and (resseq 53:59)R53 - 59
123X-RAY DIFFRACTION123chain 'R' and (resseq 60:75)R60 - 75
124X-RAY DIFFRACTION124chain 'R' and (resseq 76:88)R76 - 88
125X-RAY DIFFRACTION125chain 'S' and (resseq 2:12)S2 - 12
126X-RAY DIFFRACTION126chain 'S' and (resseq 13:25)S13 - 25
127X-RAY DIFFRACTION127chain 'S' and (resseq 26:30)S26 - 30
128X-RAY DIFFRACTION128chain 'S' and (resseq 31:40)S31 - 40
129X-RAY DIFFRACTION129chain 'S' and (resseq 41:52)S41 - 52
130X-RAY DIFFRACTION130chain 'S' and (resseq 53:66)S53 - 66
131X-RAY DIFFRACTION131chain 'S' and (resseq 67:71)S67 - 71
132X-RAY DIFFRACTION132chain 'S' and (resseq 72:81)S72 - 81
133X-RAY DIFFRACTION133chain 'T' and (resseq 8:45)T8 - 45
134X-RAY DIFFRACTION134chain 'T' and (resseq 46:75)T46 - 75
135X-RAY DIFFRACTION135chain 'T' and (resseq 76:106)T76 - 106
136X-RAY DIFFRACTION136chain 'U' and (resseq 2:8)U2 - 8
137X-RAY DIFFRACTION137chain 'U' and (resseq 9:25)U9 - 25

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