Entry Database : PDB / ID : 4cl7 Structure visualization Downloads & linksTitle Crystal structure of VEGFR-1 domain 2 in presence of Cobalt ComponentsVASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 Details Keywords RECEPTOR / METAL-BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / negative regulation of vascular endothelial cell proliferation / blood vessel morphogenesis / growth factor binding ... vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / negative regulation of vascular endothelial cell proliferation / blood vessel morphogenesis / growth factor binding / monocyte chemotaxis / cellular response to vascular endothelial growth factor stimulus / vascular endothelial growth factor receptor signaling pathway / : / cell surface receptor protein tyrosine kinase signaling pathway / transmembrane receptor protein tyrosine kinase activity / positive regulation of MAP kinase activity / receptor protein-tyrosine kinase / peptidyl-tyrosine phosphorylation / positive regulation of angiogenesis / actin cytoskeleton / cell migration / angiogenesis / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell differentiation / receptor complex / endosome / positive regulation of cell migration / focal adhesion / positive regulation of cell population proliferation / extracellular space / ATP binding / plasma membrane Similarity search - Function Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin I-set ... Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Immunoglobulin V-set domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. ...Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / Vidal, M. / Broutin, I. CitationJournal : Plos One / Year : 2016Title : Biophysical Studies of the Induced Dimerization of Human Vegf R Receptor 1 Binding Domain by Divalent Metals Competing with Vegf-AAuthors: Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / ... Authors : Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / Vidal, M. / Broutin, I. History Deposition Jan 13, 2014 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 28, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Feb 1, 2017 Group : Database referencesRevision 1.2 May 8, 2019 Group : Data collection / Experimental preparation / OtherCategory : database_PDB_rev / database_PDB_rev_record ... database_PDB_rev / database_PDB_rev_record / exptl_crystal_grow / pdbx_database_proc / pdbx_database_status Item : _exptl_crystal_grow.method / _pdbx_database_status.recvd_author_approvalRevision 1.3 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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