Entry | Database: PDB / ID: 5abd |
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Title | CRYSTAL STRUCTURE OF VEGFR-1 DOMAIN 2 IN PRESENCE OF CU |
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Components | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 |
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Keywords | SIGNALING PROTEIN / VEGF / RECEPTOR |
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Function / homology | Function and homology information
vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / negative regulation of vascular endothelial cell proliferation / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / blood vessel morphogenesis / monocyte chemotaxis ...vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / negative regulation of vascular endothelial cell proliferation / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / blood vessel morphogenesis / monocyte chemotaxis / growth factor binding / cellular response to vascular endothelial growth factor stimulus / transmembrane receptor protein tyrosine kinase activity / vascular endothelial growth factor receptor signaling pathway / : / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of MAP kinase activity / receptor protein-tyrosine kinase / peptidyl-tyrosine phosphorylation / positive regulation of angiogenesis / actin cytoskeleton / cell migration / angiogenesis / protein autophosphorylation / receptor complex / positive regulation of MAPK cascade / endosome / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell differentiation / positive regulation of cell migration / focal adhesion / positive regulation of cell population proliferation / extracellular space / ATP binding / plasma membraneSimilarity search - Function Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin I-set ...Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / : / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Immunoglobulin V-set domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Immunoglobulin subtype / Immunoglobulin / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.995 Å |
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Authors | Gaucher, J.-F. / Lascombe, M.-B. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. ...Gaucher, J.-F. / Lascombe, M.-B. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / Vidal, M. / Broutin, I. |
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Citation | Journal: Plos One / Year: 2016 Title: Biophysical Studies of the Induced Dimerization of Human Vegf R Receptor 1 Binding Domain by Divalent Metals Competing with Vegf-A Authors: Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / ...Authors: Gaucher, J.-F. / Reille-Seroussi, M. / Gagey-Eilstein, N. / Broussy, S. / Coric, P. / Seijo, B. / Lascombe, M.-B. / Gautier, B. / Liu, W.-Q. / Huguenot, F. / Inguimbert, N. / Bouaziz, S. / Vidal, M. / Broutin, I. |
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History | Deposition | Aug 5, 2015 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 28, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 1, 2017 | Group: Database references |
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Revision 2.0 | Mar 6, 2019 | Group: Atomic model / Data collection ...Atomic model / Data collection / Experimental preparation / Other Category: atom_site / database_PDB_rev ...atom_site / database_PDB_rev / database_PDB_rev_record / exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.pdbx_auth_atom_name / _exptl_crystal_grow.method / _exptl_crystal_grow.pdbx_details / _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval |
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Revision 2.1 | Jan 10, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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