登録情報 データベース : PDB / ID : 4apf 構造の表示 ダウンロードとリンクタイトル Crystal structure of the human KLHL11-Cul3 complex at 3.1A resolution 要素CULLIN 3 KELCH-LIKE PROTEIN 11 詳細キーワード CELL CYCLE / UBIQUITINATION / E3 LIGASE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
liver morphogenesis / positive regulation of mitotic cell cycle phase transition / trophectodermal cellular morphogenesis / POZ domain binding / nuclear protein quality control by the ubiquitin-proteasome system / regulation protein catabolic process at postsynapse / polar microtubule / anaphase-promoting complex-dependent catabolic process / COPII vesicle coating / stem cell division ... liver morphogenesis / positive regulation of mitotic cell cycle phase transition / trophectodermal cellular morphogenesis / POZ domain binding / nuclear protein quality control by the ubiquitin-proteasome system / regulation protein catabolic process at postsynapse / polar microtubule / anaphase-promoting complex-dependent catabolic process / COPII vesicle coating / stem cell division / RHOBTB3 ATPase cycle / embryonic cleavage / cell projection organization / positive regulation of mitotic metaphase/anaphase transition / Notch binding / RHOBTB1 GTPase cycle / fibroblast apoptotic process / negative regulation of Rho protein signal transduction / ubiquitin ligase complex scaffold activity / negative regulation of type I interferon production / mitotic metaphase chromosome alignment / Cul3-RING ubiquitin ligase complex / stress fiber assembly / protein monoubiquitination / positive regulation of cytokinesis / cyclin binding / sperm flagellum / protein K48-linked ubiquitination / RHOBTB2 GTPase cycle / protein autoubiquitination / endoplasmic reticulum to Golgi vesicle-mediated transport / regulation of cellular response to insulin stimulus / gastrulation / positive regulation of TORC1 signaling / intrinsic apoptotic signaling pathway / cellular response to amino acid stimulus / positive regulation of protein ubiquitination / integrin-mediated signaling pathway / Degradation of DVL / Hedgehog 'on' state / protein destabilization / G1/S transition of mitotic cell cycle / mitotic spindle / Wnt signaling pathway / spindle pole / Regulation of RAS by GAPs / protein polyubiquitination / ubiquitin protein ligase activity / KEAP1-NFE2L2 pathway / Antigen processing: Ubiquitination & Proteasome degradation / cell migration / Neddylation / gene expression / ubiquitin-dependent protein catabolic process / Potential therapeutics for SARS / proteasome-mediated ubiquitin-dependent protein catabolic process / postsynapse / protein ubiquitination / inflammatory response / centrosome / positive regulation of cell population proliferation / ubiquitin protein ligase binding / glutamatergic synapse / negative regulation of transcription by RNA polymerase II / Golgi apparatus / extracellular exosome / nucleoplasm / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #420 / Cullin Repeats / 5 helical Cullin repeat like / BTB/Kelch-associated / BTB And C-terminal Kelch / Cullin protein neddylation domain / BTB And C-terminal Kelch / Cullin, conserved site / Cullin family signature. / Cullin ... Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #420 / Cullin Repeats / 5 helical Cullin repeat like / BTB/Kelch-associated / BTB And C-terminal Kelch / Cullin protein neddylation domain / BTB And C-terminal Kelch / Cullin, conserved site / Cullin family signature. / Cullin / Cullin repeat-like-containing domain superfamily / Cullin protein, neddylation domain / Cullin protein neddylation domain / Kelch / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / Kelch repeat type 1 / Kelch motif / Cullin / Cullin, N-terminal / Cullin homology domain / Cullin homology domain superfamily / Cullin family / Cullin family profile. / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / SKP1/BTB/POZ domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Up-down Bundle / 2-Layer Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 単一同系置換・異常分散 / 解像度 : 3.1 Å 詳細データ登録者 Canning, P. / Cooper, C.D.O. / Krojer, T. / Vollmar, M. / Ugochukwu, E. / Muniz, J.R.C. / Ayinampudi, V. / Savitsky, P. / Arrowsmith, C.H. / Edwards, A.M. ...Canning, P. / Cooper, C.D.O. / Krojer, T. / Vollmar, M. / Ugochukwu, E. / Muniz, J.R.C. / Ayinampudi, V. / Savitsky, P. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / von Delft, F. / Bullock, A.N. / Structural Genomics Consortium (SGC) 引用ジャーナル : J.Biol.Chem. / 年 : 2013タイトル : Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.著者 : Canning, P. / Cooper, C.D.O. / Krojer, T. / Murray, J.W. / Pike, A.C.W. / Chaikuad, A. / Keates, T. / Thangaratnarajah, C. / Hojzan, V. / Marsden, B.D. / Gileadi, O. / Knapp, S. / von Delft, F. / Bullock, A.N. 履歴 登録 2012年4月2日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2012年5月9日 Provider : repository / タイプ : Initial release改定 1.1 2013年2月6日 Group : Database references / Refinement description / Structure summary改定 1.2 2013年3月27日 Group : Database references改定 1.3 2018年1月24日 Group : Database references / Structure summary / カテゴリ : audit_author / citation_author / Item : _audit_author.name / _citation_author.name改定 1.4 2024年5月8日 Group : Data collection / Database references / Otherカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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