4APF

Crystal structure of the human KLHL11-Cul3 complex at 3.1A resolution

Summary for 4APF

• Entry DOI: 10.2210/pdb4apf/pdb
• Related: 4AP2
• Descriptor: KELCH-LIKE PROTEIN 11, CULLIN 3 (3 entities in total)
• Functional Keywords: ubiquitination, e3 ligase, cell cycle
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus: Q13618
• Total number of polymer chains: 2
• Total formula weight: 80250.17

Authors

Canning, P.,Cooper, C.D.O.,Krojer, T.,Vollmar, M.,Ugochukwu, E.,Muniz, J.R.C.,Ayinampudi, V.,Savitsky, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F.,Bullock, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2012-04-02, release date: 2012-05-09, Last modification date: 2018-01-24)

• Primary citation: Canning, P.,Cooper, C.D.O.,Krojer, T.,Murray, J.W.,Pike, A.C.W.,Chaikuad, A.,Keates, T.,Thangaratnarajah, C.,Hojzan, V.,Marsden, B.D.,Gileadi, O.,Knapp, S.,von Delft, F.,Bullock, A.N.; Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.; J.Biol.Chem., 288:7803-, 2013; PubMed: 23349464; DOI: 10.1074/JBC.M112.437996

Experimental method

X-RAY DIFFRACTION (3.1 Å)