登録情報 | データベース: PDB / ID: 3hu6 |
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タイトル | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx/BTB/3-box-PucSBC1 |
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要素 | - Puckered
- Speckle-type POZ protein
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キーワード | Protein Binding / Ligase / ubiquitin / E3 / SPOP / Puckered / Nucleus / Ubl conjugation pathway / Hydrolase |
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機能・相同性 | 機能・相同性情報
imaginal disc eversion / imaginal disc fusion / RAF-independent MAPK1/3 activation / chorion micropyle formation / embryonic anterior midgut (ectodermal) morphogenesis / imaginal disc fusion, thorax closure / chitin-based embryonic cuticle biosynthetic process / JUN kinase phosphatase activity / imaginal disc-derived male genitalia morphogenesis / determination of digestive tract left/right asymmetry ...imaginal disc eversion / imaginal disc fusion / RAF-independent MAPK1/3 activation / chorion micropyle formation / embryonic anterior midgut (ectodermal) morphogenesis / imaginal disc fusion, thorax closure / chitin-based embryonic cuticle biosynthetic process / JUN kinase phosphatase activity / imaginal disc-derived male genitalia morphogenesis / determination of digestive tract left/right asymmetry / negative regulation of stress-activated protein kinase signaling cascade / Negative regulation of MAPK pathway / negative regulation of peptidoglycan recognition protein signaling pathway / dorsal closure / follicle cell of egg chamber development / MAP kinase tyrosine phosphatase activity / protein tyrosine/threonine phosphatase activity / dorsal appendage formation / compound eye development / positive regulation of border follicle cell migration / MAP kinase tyrosine/serine/threonine phosphatase activity / regulation of proteolysis / negative regulation of programmed cell death / negative regulation of MAPK cascade / myosin phosphatase activity / Cul3-RING ubiquitin ligase complex / molecular function inhibitor activity / protein-serine/threonine phosphatase / phosphoprotein phosphatase activity / protein secretion / negative regulation of tumor necrosis factor-mediated signaling pathway / localization / epidermis development / JNK cascade / regulation of G2/M transition of mitotic cell cycle / protein dephosphorylation / protein-tyrosine-phosphatase / determination of adult lifespan / Hedgehog 'on' state / wound healing / protein polyubiquitination / positive regulation of immune response / cellular response to oxidative stress / actin cytoskeleton organization / proteasome-mediated ubiquitin-dependent protein catabolic process / response to oxidative stress / nuclear speck / ubiquitin protein ligase binding / positive regulation of gene expression / negative regulation of apoptotic process / Golgi apparatus / endoplasmic reticulum / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 SPOP, C-terminal BACK domain / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / MATH domain / Dual specificity phosphatase, catalytic domain / Dual specificity phosphatase, catalytic domain / Dual specificity phosphatase, catalytic domain / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology ...SPOP, C-terminal BACK domain / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / MATH domain / Dual specificity phosphatase, catalytic domain / Dual specificity phosphatase, catalytic domain / Dual specificity phosphatase, catalytic domain / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / Dual specificity protein phosphatase domain / Dual specificity protein phosphatase domain profile. / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / SKP1/BTB/POZ domain superfamily / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 Speckle-type POZ protein / Puckered, isoform A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Zhuang, M. / Schulman, B.A. |
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引用 | ジャーナル: Mol.Cell / 年: 2009 タイトル: Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. 著者: Zhuang, M. / Calabrese, M.F. / Liu, J. / Waddell, M.B. / Nourse, A. / Hammel, M. / Miller, D.J. / Walden, H. / Duda, D.M. / Seyedin, S.N. / Hoggard, T. / Harper, J.W. / White, K.P. / Schulman, B.A. |
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履歴 | 登録 | 2009年6月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年10月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2021年10月13日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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改定 1.3 | 2023年9月6日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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