[English] 日本語
![](img/lk-miru.gif)
- PDB-2aab: Structural basis of antigen mimicry in a clinically relevant mela... -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 2aab | ||||||
---|---|---|---|---|---|---|---|
Title | Structural basis of antigen mimicry in a clinically relevant melanoma antigen system | ||||||
![]() |
| ||||||
![]() | IMMUNE SYSTEM / Anti-idiotypic antibody / molecular mimicry / melanoma / immunotherapy | ||||||
Function / homology | Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta![]() | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Chang, C.-C. / Hernandez-Guzman, F.G. / Luo, W. / Wang, X. / Ferrone, S. / Ghosh, D. | ||||||
![]() | ![]() Title: Structural basis of antigen mimicry in a clinically relevant melanoma antigen system. Authors: Chang, C.-C. / Hernandez-Guzman, F.G. / Luo, W. / Wang, X. / Ferrone, S. / Ghosh, D. | ||||||
History |
| ||||||
Remark 999 | SEQUENCE an appropriate sequence database reference was not available at the time of processing. |
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 98 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 73.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 373.9 KB | Display | ![]() |
---|---|---|---|---|
Full document | ![]() | 388.3 KB | Display | |
Data in XML | ![]() | 11.4 KB | Display | |
Data in CIF | ![]() | 17.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2rscS S: Starting model for refinement |
---|---|
Similar structure data |
-
Links
-
Assembly
Deposited unit | ![]()
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||
Unit cell |
| ||||||||
Details | Monoclonal antibody fragment Fab' consisting of a light chain L and a heavy chain H |
-
Components
#1: Antibody | Mass: 23993.562 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) ![]() ![]() |
---|---|
#2: Antibody | Mass: 26233.570 Da / Num. of mol.: 1 / Fragment: Fab fragment / Source method: isolated from a natural source / Source: (natural) ![]() ![]() |
#3: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: ![]() |
---|
-
Sample preparation
Crystal | Density Matthews: 2.3 Å3/Da / Density % sol: 50 % |
---|---|
Crystal grow | Temperature: 295 K / Method: vapor diffusion, hanging drop / pH: 7.5 Details: PEG 6000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K |
-Data collection
Diffraction | Mean temperature: 100 K |
---|---|
Diffraction source | Source: ![]() |
Detector | Type: RIGAKU RAXIS IV / Detector: IMAGE PLATE / Date: Jan 1, 2002 / Details: mirrors |
Radiation | Monochromator: graphite / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Resolution: 2.5→33 Å / Num. all: 17003 / Num. obs: 16656 / % possible obs: 98 % / Observed criterion σ(F): 2 / Observed criterion σ(I): 1 / Redundancy: 5.5 % / Biso Wilson estimate: 45.8 Å2 / Rmerge(I) obs: 0.067 |
Reflection shell | Resolution: 2.5→2.59 Å / Mean I/σ(I) obs: 4.2 / % possible all: 95 |
-
Processing
Software |
| |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Method to determine structure: ![]() Starting model: 2RSC Resolution: 2.5→33 Å / σ(F): 2 / Stereochemistry target values: Engh & Huber
| |||||||||||||||||||||||||
Refine analyze | Luzzati coordinate error obs: 0.34 Å / Luzzati sigma a obs: 0.31 Å | |||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.5→33 Å
| |||||||||||||||||||||||||
Refine LS restraints |
|