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- PDB-5xti: Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 -

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登録情報
データベース: PDB / ID: 5xti
タイトルCryo-EM architecture of human respiratory chain megacomplex-I2III2IV2
要素
  • (Cytochrome b-c1 complex subunit ...) x 9
  • (Cytochrome c oxidase subunit ...) x 13
  • (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit ...) x 12
  • (NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit ...) x 11
  • (NADH dehydrogenase [ubiquinone] 1 subunit ...) x 2
  • (NADH dehydrogenase [ubiquinone] flavoprotein ...) x 3
  • (NADH dehydrogenase [ubiquinone] iron-sulfur protein ...) x 7
  • (NADH-ubiquinone oxidoreductase chain ...) x 7
  • Acyl carrier protein, mitochondrial
  • Cytochrome b
  • Cytochrome c1, heme protein, mitochondrial
  • NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
キーワードOXIDOREDUCTASE/ELECTRON TRANSPORT / Homo sapiens / Oxidoreductase / Respiratory / OXIDOREDUCTASE-ELECTRON TRANSPORT complex
機能・相同性
機能・相同性情報


Complex III assembly / Complex III assembly / Complex III assembly / Complex III assembly / Complex III assembly / response to D-galactosamine / Complex III assembly / Complex III assembly / Complex III assembly / Complex III assembly ...Complex III assembly / Complex III assembly / Complex III assembly / Complex III assembly / Complex III assembly / response to D-galactosamine / Complex III assembly / Complex III assembly / Complex III assembly / Complex III assembly / Complex IV assembly / mitochondrial large ribosomal subunit assembly / Complex I biogenesis / TP53 Regulates Metabolic Genes / Mitochondrial Fatty Acid Beta-Oxidation / protein lipoylation / Protein lipoylation / response to mercury ion / respiratory chain complex IV assembly / Cytoprotection by HMOX1 / Respiratory electron transport / subthalamus development / pons development / protein insertion into mitochondrial inner membrane / mitochondrial respirasome assembly / response to cobalamin / cerebellar Purkinje cell layer development / ubiquinone biosynthetic process / Mitochondrial ribosome-associated quality control / mitochondrial respiratory chain complex III assembly / blastocyst hatching / Respiratory electron transport / Mitochondrial translation termination / pyramidal neuron development / response to alkaloid / cellular respiration / thalamus development / respiratory chain complex IV / cellular response to oxygen levels / Mitochondrial protein import / iron-sulfur cluster assembly complex / mesenchymal stem cell proliferation / reproductive system development / mitochondrial large ribosomal subunit binding / respiratory chain complex / gliogenesis / mitochondrial [2Fe-2S] assembly complex / cytochrome-c oxidase / mesenchymal stem cell differentiation / circulatory system development / respiratory chain complex III / negative regulation of non-canonical NF-kappaB signal transduction / oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor / oxidative phosphorylation / response to glucagon / quinol-cytochrome-c reductase / mitochondrial electron transport, cytochrome c to oxygen / positive regulation of mitochondrial membrane potential / cardiac muscle tissue development / neural precursor cell proliferation / [2Fe-2S] cluster assembly / oxygen sensor activity / quinol-cytochrome-c reductase activity / oxidoreductase activity, acting on NAD(P)H / cytochrome-c oxidase activity / azurophil granule membrane / response to copper ion / stem cell division / mitochondrial electron transport, ubiquinol to cytochrome c / iron-sulfur cluster assembly / Mitochondrial protein degradation / sodium ion transport / hypothalamus development / midbrain development / ubiquinone binding / acyl binding / electron transport coupled proton transport / regulation of protein phosphorylation / NADH:ubiquinone reductase (H+-translocating) / acyl carrier activity / mitochondrial ATP synthesis coupled electron transport / positive regulation of ATP biosynthetic process / NADH dehydrogenase activity / mitochondrial respiratory chain complex I assembly / proton motive force-driven mitochondrial ATP synthesis / mitochondrial electron transport, NADH to ubiquinone / RHOG GTPase cycle / animal organ regeneration / response to hyperoxia / respiratory chain complex I / positive regulation of execution phase of apoptosis / response to cAMP / response to cadmium ion / NADH dehydrogenase (ubiquinone) activity / endopeptidase activator activity / quinone binding / enzyme regulator activity / ATP synthesis coupled electron transport / cellular response to interferon-beta / negative regulation of reactive oxygen species biosynthetic process
類似検索 - 分子機能
Cytochrome b-c1 complex subunit 10 / Single alpha-helix domain superfamily / Ubiquinol-cytochrome C reductase complex, 6.4kD protein / Cytochrome c oxidase, subunit 8 / Mitochondrial cytochrome c oxidase subunit VIc/VIIs / Cytochrome c oxidase, subunit 8 superfamily / Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily / : / Cytochrome oxidase c subunit VIII / Cytochrome c oxidase subunit VIc ...Cytochrome b-c1 complex subunit 10 / Single alpha-helix domain superfamily / Ubiquinol-cytochrome C reductase complex, 6.4kD protein / Cytochrome c oxidase, subunit 8 / Mitochondrial cytochrome c oxidase subunit VIc/VIIs / Cytochrome c oxidase, subunit 8 superfamily / Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily / : / Cytochrome oxidase c subunit VIII / Cytochrome c oxidase subunit VIc / Cytochrome c oxidase subunit VIIa, metazoa / Cytochrome C oxidase, subunit VIIB / Cytochrome c oxidase subunit IV / Cytochrome C oxidase, subunit VIIB domain superfamily / Cytochrome c oxidase, subunit VIIa superfamily / Cytochrome C oxidase chain VIIB / Cytochrome c oxidase, subunit VIa, conserved site / Cytochrome c oxidase subunit VIa signature. / Cytochrome c oxidase, subunit VIa / Cytochrome c oxidase, subunit VIa superfamily / Cytochrome c oxidase subunit VIa / Ubiquinol-cytochrome c reductase 8kDa, N-terminal / Ubiquinol-cytochrome c reductase 8 kDa, N-terminal / Cytochrome c oxidase, subunit VIb / : / Cytochrome c oxidase subunit Vb, zinc binding region signature. / Cytochrome c oxidase subunit VIIc / Cytochrome c oxidase subunit IV family / Cytochrome c oxidase, subunit VIb superfamily / Cytochrome c oxidase subunit VIIc superfamily / Cytochrome c oxidase subunit IV superfamily / Cytochrome c oxidase subunit VIIc / Cytochrome c oxidase subunit IV / Cytochrome c oxidase subunit 2, C-terminal / Cytochrome oxidase c subunit VIb / Cytochrome c oxidase, subunit Va/VI / Cytochrome c oxidase, subunit Va/VI superfamily / Cytochrome c oxidase subunit Va / Cytochrome c oxidase subunit VII / Cytochrome c oxidase subunit VII / Globular protein, non-globular alpha/beta subunit / Complex1_LYR-like / Cytochrome c oxidase, subunit Vb / Cytochrome c oxidase subunit Vb / Cytochrome c oxidase subunit Vb, zinc binding domain profile. / Cytochrome c oxidase, subunit Vb superfamily / Cytochrome c oxidase subunit III domain / Cytochrome c oxidase, subunit II / Cytochrome b-c1 complex, subunit 6 / Cytochrome c oxidase subunit I domain / Cytochrome C oxidase subunit II, transmembrane domain / Cytochrome b-c1 complex subunit 8 / UcrQ family / Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily / Cytochrome C oxidase subunit II, transmembrane domain / Cytochrome oxidase subunit II transmembrane region profile. / Cytochrome b-c1 complex subunit 7 / Cytochrome b-c1 complex subunit 7 superfamily / Ubiquinol-cytochrome C reductase complex 14kD subunit / Cytochrome c oxidase subunit III / Cytochrome c oxidase subunit III-like / Cytochrome c oxidase, subunit III, 4-helical bundle / Cytochrome c oxidase subunit III / Heme-copper oxidase subunit III family profile. / Cytochrome b-c1 complex subunit 8 superfamily / Cytochrome c oxidase subunit III-like superfamily / Cytochrome b-c1 complex subunit Rieske, transmembrane domain / Ubiquinol cytochrome reductase transmembrane region / Cytochrome b-c1 complex subunit 9 / Cytochrome b-c1 complex subunit 9 superfamily / Cytochrome b-c1 complex subunit 9 / Ubiquinol-cytochrome C reductase hinge domain / Ubiquinol-cytochrome C reductase hinge domain superfamily / Ubiquinol-cytochrome C reductase hinge protein / Cytochrome c1, transmembrane anchor, C-terminal / Cytochrome c/quinol oxidase subunit II / : / Cytochrome b / Cytochrome C oxidase subunit II, transmembrane domain superfamily / Copper centre Cu(A) / CO II and nitrous oxide reductase dinuclear copper centers signature. / Ubiquinol-cytochrome c reductase, iron-sulphur subunit / NADH-ubiquinone oxidoreductase 1 subunit C1 / NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial / : / NADH:ubiquinone oxidoreductase, ESSS subunit / ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) / Cytochrome c1 / Cytochrome C1 family / Cytochrome c oxidase, subunit I, copper-binding site / Heme-copper oxidase catalytic subunit, copper B binding region signature. / Peptidase M16, zinc-binding site / Insulinase family, zinc-binding region signature. / Cytochrome c oxidase-like, subunit I domain / Cytochrome oxidase subunit I profile. / : / Cytochrome b/b6, C-terminal / Cytochrome b(C-terminal)/b6/petD / Cytochrome b/b6 C-terminal region profile. / Cytochrome c oxidase subunit I
類似検索 - ドメイン・相同性
Chem-8Q1 / CARDIOLIPIN / COPPER (II) ION / FE2/S2 (INORGANIC) CLUSTER / FLAVIN MONONUCLEOTIDE / HEME-A / HEME C / PROTOPORPHYRIN IX CONTAINING FE / Chem-NDP / 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine ...Chem-8Q1 / CARDIOLIPIN / COPPER (II) ION / FE2/S2 (INORGANIC) CLUSTER / FLAVIN MONONUCLEOTIDE / HEME-A / HEME C / PROTOPORPHYRIN IX CONTAINING FE / Chem-NDP / 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / Chem-PLX / IRON/SULFUR CLUSTER / NADH-ubiquinone oxidoreductase chain 4 / NADH-ubiquinone oxidoreductase chain 3 / NADH-ubiquinone oxidoreductase chain 1 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial / Acyl carrier protein, mitochondrial / Cytochrome b-c1 complex subunit 8 / Cytochrome b-c1 complex subunit 10 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 / NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial / NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial / NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 / NADH dehydrogenase [ubiquinone] 1 subunit C2 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 / Cytochrome b / Cytochrome c oxidase subunit 1 / Cytochrome c oxidase subunit 3 / Cytochrome c oxidase subunit 4 isoform 1, mitochondrial / Cytochrome c oxidase subunit 5A, mitochondrial / Cytochrome c oxidase subunit 5B, mitochondrial / Cytochrome c oxidase subunit 6B1 / Cytochrome c oxidase subunit 7C, mitochondrial / NADH-ubiquinone oxidoreductase chain 2 / NADH-ubiquinone oxidoreductase chain 4 / NADH-ubiquinone oxidoreductase chain 5 / Cytochrome c oxidase subunit 6C / Cytochrome c oxidase subunit 7A1, mitochondrial / Cytochrome c oxidase subunit 6A2, mitochondrial / Cytochrome b-c1 complex subunit 6, mitochondrial / Cytochrome c1, heme protein, mitochondrial / Cytochrome c oxidase subunit 8B, mitochondrial / Cytochrome c oxidase subunit 7B, mitochondrial / Cytochrome b-c1 complex subunit 7 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 / NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial / Cytochrome b-c1 complex subunit 2, mitochondrial / NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial / Cytochrome b-c1 complex subunit 1, mitochondrial / Cytochrome b-c1 complex subunit Rieske, mitochondrial / NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 / NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 / Cytochrome c oxidase subunit 2 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial / NADH-ubiquinone oxidoreductase chain 2 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 / NADH-ubiquinone oxidoreductase chain 6 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 / Cytochrome b-c1 complex subunit 9 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 / NADH-ubiquinone oxidoreductase chain 4L / NADH-ubiquinone oxidoreductase chain 5
類似検索 - 構成要素
生物種Homo sapiens (ヒト)
Bos taurus (ウシ)
手法電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 17.4 Å
データ登録者Gu, J. / Wu, M. / Yang, M.
資金援助 中国, 5件
組織認可番号国
Ministry of Science and Technology2016YFA0501100 中国
Ministry of Science and Technology2017YFA0504600 中国
National Science Fund for Distinguished Young Scholars31625008 中国
National Natural Science Foundation of China21532004 中国
National Natural Science Foundation of China31570733 中国
引用ジャーナル: Cell / 年: 2017
タイトル: Architecture of Human Mitochondrial Respiratory Megacomplex IIIIIV.
著者: Runyu Guo / Shuai Zong / Meng Wu / Jinke Gu / Maojun Yang /
要旨: The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions. To understand its architecture, ...The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions. To understand its architecture, we examined the human respiratory chain megacomplex-IIIIIV (MCIIIIIV) with 140 subunits and a subset of associated cofactors using cryo-electron microscopy. The MCIIIIIV forms a circular structure with the dimeric CIII located in the center, where it is surrounded by two copies each of CI and CIV. Two cytochrome c (Cyt.c) molecules are positioned to accept electrons on the surface of the c state CIII dimer. Analyses indicate that CII could insert into the gaps between CI and CIV to form a closed ring, which we termed the electron transport chain supercomplex. The structure not only reveals the precise assignment of individual subunits of human CI and CIII, but also enables future in-depth analysis of the electron transport chain as a whole.
履歴
登録2017年6月19日登録サイト: PDBJ / 処理サイト: PDBJ
改定 1.02017年9月13日Provider: repository / タイプ: Initial release
改定 1.12017年12月6日Group: Data processing / Database references / カテゴリ: citation / em_software
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _em_software.name
改定 1.22018年11月28日Group: Data collection / Other / カテゴリ: pdbx_database_status / Item: _pdbx_database_status.process_site
改定 1.32019年11月6日Group: Advisory / Data collection ...Advisory / Data collection / Derived calculations / Other
カテゴリ: cell / pdbx_struct_conn_angle ...cell / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / pdbx_validate_close_contact / struct_conn / struct_site / struct_site_gen
Item: _cell.Z_PDB
改定 1.42019年11月20日Group: Advisory / Derived calculations
カテゴリ: pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / struct_conn
改定 2.02025年4月9日Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Structure summary
カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / pdbx_entry_details / pdbx_modification_feature / pdbx_unobs_or_zero_occ_atoms / pdbx_validate_chiral / struct_conn / struct_conn_type
Item: _atom_site.Cartn_x / _atom_site.Cartn_y ..._atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_atom_id / _atom_site.label_atom_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.mon_nstd_flag / _chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.formula_weight / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_unobs_or_zero_occ_atoms.auth_atom_id / _pdbx_unobs_or_zero_occ_atoms.label_atom_id / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id
改定 2.12025年9月17日Group: Advisory / Derived calculations / Structure summary
カテゴリ: pdbx_modification_feature / pdbx_validate_close_contact ...pdbx_modification_feature / pdbx_validate_close_contact / struct_conn / struct_conn_type

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構造の表示

ムービー
  • 登録構造単位
  • Jmolによる作画
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  • EMマップとの重ね合わせ
  • マップデータ: EMDB-6776
  • UCSF Chimeraによる作画
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ムービービューア
構造ビューア分子:
MolmilJmol/JSmol

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集合体

登録構造単位
A: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
B: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
C: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
E: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
F: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
G: Acyl carrier protein, mitochondrial
H: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
I: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
J: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
K: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
L: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
M: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
N: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
O: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
P: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Q: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
S: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
T: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
U: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
V: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
W: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
X: Acyl carrier protein, mitochondrial
Y: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Z: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
a: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
b: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
c: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
d: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
e: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
f: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
g: NADH dehydrogenase [ubiquinone] 1 subunit C2
h: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
i: NADH-ubiquinone oxidoreductase chain 2
j: NADH-ubiquinone oxidoreductase chain 3
k: NADH-ubiquinone oxidoreductase chain 4L
l: NADH-ubiquinone oxidoreductase chain 5
m: NADH-ubiquinone oxidoreductase chain 6
n: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
o: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
p: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
r: NADH-ubiquinone oxidoreductase chain 4
s: NADH-ubiquinone oxidoreductase chain 1
u: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
v: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
w: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
x: Cytochrome c oxidase subunit 1
y: Cytochrome c oxidase subunit 2
z: Cytochrome c oxidase subunit 3
0: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
1: Cytochrome c oxidase subunit 5A, mitochondrial
2: Cytochrome c oxidase subunit 5B, mitochondrial
3: Cytochrome c oxidase subunit 6A2, mitochondrial
4: Cytochrome c oxidase subunit 6B1
5: Cytochrome c oxidase subunit 6C
6: Cytochrome c oxidase subunit 7A1, mitochondrial
7: Cytochrome c oxidase subunit 7B, mitochondrial
8: Cytochrome c oxidase subunit 7C, mitochondrial
9: Cytochrome c oxidase subunit 8B, mitochondrial
AA: Cytochrome b-c1 complex subunit 8
AB: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AC: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AD: Cytochrome b-c1 complex subunit 9
AE: Cytochrome b-c1 complex subunit 6, mitochondrial
AF: Cytochrome b-c1 complex subunit 7
AG: Cytochrome b-c1 complex subunit 10
AH: Cytochrome c1, heme protein, mitochondrial
AJ: Cytochrome b
AK: Cytochrome b-c1 complex subunit 2, mitochondrial
AL: Cytochrome b-c1 complex subunit 1, mitochondrial
AN: Cytochrome b-c1 complex subunit 8
AO: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AP: Cytochrome b-c1 complex subunit Rieske, mitochondrial
AQ: Cytochrome b-c1 complex subunit 9
AR: Cytochrome b-c1 complex subunit 6, mitochondrial
AS: Cytochrome b-c1 complex subunit 7
AT: Cytochrome b-c1 complex subunit 10
AU: Cytochrome c1, heme protein, mitochondrial
AV: Cytochrome b
AW: Cytochrome b-c1 complex subunit 2, mitochondrial
AY: Cytochrome b-c1 complex subunit 1, mitochondrial
BA: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
BB: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
BC: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
BE: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
BF: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
BG: Acyl carrier protein, mitochondrial
BH: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
BI: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
BJ: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
BK: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
BL: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
BM: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
BN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
BO: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
BP: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
BQ: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
BS: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
BT: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
BU: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
BV: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
BW: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
BX: Acyl carrier protein, mitochondrial
BY: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
BZ: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Ba: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Bb: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Bc: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Bd: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Be: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Bf: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Bg: NADH dehydrogenase [ubiquinone] 1 subunit C2
Bh: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Bi: NADH-ubiquinone oxidoreductase chain 2
Bj: NADH-ubiquinone oxidoreductase chain 3
Bk: NADH-ubiquinone oxidoreductase chain 4L
Bl: NADH-ubiquinone oxidoreductase chain 5
Bm: NADH-ubiquinone oxidoreductase chain 6
Bn: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Bo: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Bp: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Br: NADH-ubiquinone oxidoreductase chain 4
Bs: NADH-ubiquinone oxidoreductase chain 1
Bu: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Bv: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Bw: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Bx: Cytochrome c oxidase subunit 1
By: Cytochrome c oxidase subunit 2
Bz: Cytochrome c oxidase subunit 3
B0: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
B1: Cytochrome c oxidase subunit 5A, mitochondrial
B2: Cytochrome c oxidase subunit 5B, mitochondrial
B3: Cytochrome c oxidase subunit 6A2, mitochondrial
B4: Cytochrome c oxidase subunit 6B1
B5: Cytochrome c oxidase subunit 6C
B6: Cytochrome c oxidase subunit 7A1, mitochondrial
B7: Cytochrome c oxidase subunit 7B, mitochondrial
B8: Cytochrome c oxidase subunit 7C, mitochondrial
B9: Cytochrome c oxidase subunit 8B, mitochondrial
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)2,828,732238
ポリマ－2,756,873138
非ポリマー71,859100
水00
1


  • 登録構造と同一
  • 登録者が定義した集合体
  • 根拠: gel filtration
タイプ名称対称操作数
identity operation1_5551

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要素

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NADH dehydrogenase [ubiquinone] flavoprotein ... , 3種, 6分子 ABAKBKOBO

#1: タンパク質 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial / Complex I-51kD / CI-51kD / NADH dehydrogenase flavoprotein 1 / NADH-ubiquinone oxidoreductase 51 kDa subunit


分子量: 47323.938 Da / 分子数: 2 / 断片: UNP RESIDUES 27-457 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: P49821, NADH:ubiquinone reductase (H+-translocating), NADH dehydrogenase
#10: タンパク質・ペプチド NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial / Complex I-9kD / CI-9kD / NADH-ubiquinone oxidoreductase 9 kDa subunit / Renal carcinoma antigen NY-REN-4


分子量: 3900.312 Da / 分子数: 2 / 断片: UNP RESIDUES 74-106 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P56181
#14: タンパク質 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial / NADH-ubiquinone oxidoreductase 24 kDa subunit


分子量: 23430.881 Da / 分子数: 2 / 断片: UNP RESIDUES 36-247 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: P19404, NADH:ubiquinone reductase (H+-translocating), NADH dehydrogenase

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NADH dehydrogenase [ubiquinone] iron-sulfur protein ... , 7種, 14分子 BBBCBCLBLPBPQBQTBThBh

#2: タンパク質 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial / Complex I-23kD / CI-23kD / NADH-ubiquinone oxidoreductase 23 kDa subunit / TYKY subunit


分子量: 20314.037 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: O00217, NADH:ubiquinone reductase (H+-translocating), NADH dehydrogenase
#3: タンパク質 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial / Complex I-20kD / CI-20kD / NADH-ubiquinone oxidoreductase 20 kDa subunit / PSST subunit


分子量: 17887.928 Da / 分子数: 2 / 断片: UNP RESIDUES 58-213 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: O75251, NADH:ubiquinone reductase (H+-translocating), NADH dehydrogenase
#11: タンパク質 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial / Complex I-18 kDa / CI-18 kDa / Complex I-AQDQ / CI-AQDQ / NADH-ubiquinone oxidoreductase 18 kDa subunit


分子量: 13721.598 Da / 分子数: 2 / 断片: UNP RESIDUES 58-175 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O43181
#15: タンパク質 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial / Complex I-30kD / CI-30kD / NADH-ubiquinone oxidoreductase 30 kDa subunit


分子量: 24432.656 Da / 分子数: 2 / 断片: UNP RESIDUES 43-250 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: O75489, NADH:ubiquinone reductase (H+-translocating), NADH dehydrogenase
#16: タンパク質 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial / Complex I-49kD / CI-49kD / NADH-ubiquinone oxidoreductase 49 kDa subunit


分子量: 49236.480 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: O75306, NADH:ubiquinone reductase (H+-translocating), NADH dehydrogenase
#18: タンパク質 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / Complex I-13kD-A / CI-13kD-A / NADH-ubiquinone oxidoreductase 13 kDa-A subunit


分子量: 10578.848 Da / 分子数: 2 / 断片: UNP RESIDUES 29-123 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O75380
#31: タンパク質 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 / Complex I-15 kDa / CI-15 kDa / NADH-ubiquinone oxidoreductase 15 kDa subunit


分子量: 12314.254 Da / 分子数: 2 / 断片: UNP RESIDUES 2-105 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O43920

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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit ... , 12種, 24分子 EBEFBFHBHIBIJBJNBNSBSUBUVBVWBWuBuwBw

#4: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 / Complex I-B14 / CI-B14 / LYR motif-containing protein 6 / NADH-ubiquinone oxidoreductase B14 subunit


分子量: 13758.070 Da / 分子数: 2 / 断片: UNP RESIDUES 42-154 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P56556
#5: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 / Complex I-B8 / CI-B8 / NADH-ubiquinone oxidoreductase B8 subunit


分子量: 9535.905 Da / 分子数: 2 / 断片: UNP RESIDUES 14-96 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O43678
#7: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 / Complex I subunit B13 / Complex I-13kD-B / CI-13kD-B / NADH-ubiquinone oxidoreductase 13 kDa-B subunit


分子量: 13119.208 Da / 分子数: 2 / 断片: UNP RESIDUES 5-116 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q16718
#8: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 / Complex I-B14.5a / CI-B14.5a / NADH-ubiquinone oxidoreductase subunit B14.5a


分子量: 12282.051 Da / 分子数: 2 / 断片: UNP RESIDUES 4-113 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95182
#9: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial / Complex I-39kD / CI-39kD / NADH-ubiquinone oxidoreductase 39 kDa subunit


分子量: 38387.594 Da / 分子数: 2 / 断片: UNP RESIDUES 40-376 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q16795
#13: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 / 13 kDa differentiation-associated protein / Complex I-B17.2 / CIB17.2 / NADH-ubiquinone ...13 kDa differentiation-associated protein / Complex I-B17.2 / CIB17.2 / NADH-ubiquinone oxidoreductase subunit B17.2


分子量: 16880.068 Da / 分子数: 2 / 断片: UNP RESIDUES 2-144 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q9UI09
#17: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 / Complex I-MWFE / CI-MWFE / NADH-ubiquinone oxidoreductase MWFE subunit


分子量: 8084.391 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O15239
#19: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 / Complex I-B9 / CI-B9 / NADH-ubiquinone oxidoreductase B9 subunit


分子量: 9156.602 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95167
#20: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 / Complex I-B14.7 / CI-B14.7 / NADH-ubiquinone oxidoreductase subunit B14.7


分子量: 14736.853 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q86Y39
#21: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 / Cell death regulatory protein GRIM-19 / Complex I-B16.6 / CI-B16.6 / Gene associated with retinoic ...Cell death regulatory protein GRIM-19 / Complex I-B16.6 / CI-B16.6 / Gene associated with retinoic and interferon-induced mortality 19 protein / Gene associated with retinoic and IFN-induced mortality 19 protein / NADH-ubiquinone oxidoreductase B16.6 subunit


分子量: 16132.570 Da / 分子数: 2 / 断片: UNP RESIDUES 7-144 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q9P0J0
#42: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 / Complex I-19kD / CI-19kD / Complex I-PGIV / CI-PGIV / NADH-ubiquinone oxidoreductase 19 kDa subunit


分子量: 19853.736 Da / 分子数: 2 / 断片: UNP RESIDUES 4-172 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P51970
#44: タンパク質 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial / Complex I-42kD / CI-42kD / NADH-ubiquinone oxidoreductase 42 kDa subunit


分子量: 37200.270 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95299

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タンパク質 , 4種, 10分子 GXBGBXMBMAHAUAJAV

#6: タンパク質
Acyl carrier protein, mitochondrial / ACP / CI-SDAP / NADH-ubiquinone oxidoreductase 9.6 kDa subunit


分子量: 9845.247 Da / 分子数: 4 / 断片: UNP RESIDUES 72-196 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O14561
#12: タンパク質 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial / Complex I-75kD / CI-75kD


分子量: 75471.484 Da / 分子数: 2 / 断片: UNP RESIDUES 30-716 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: P28331, NADH:ubiquinone reductase (H+-translocating), NADH dehydrogenase
#65: タンパク質 Cytochrome c1, heme protein, mitochondrial / Complex III subunit 4 / Complex III subunit IV / Cytochrome b-c1 complex subunit 4 / Ubiquinol- ...Complex III subunit 4 / Complex III subunit IV / Cytochrome b-c1 complex subunit 4 / Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit / Cytochrome c-1


分子量: 27388.395 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P08574
#66: タンパク質 Cytochrome b / Complex III subunit 3 / Complex III subunit III / Cytochrome b-c1 complex subunit 3 / Ubiquinol- ...Complex III subunit 3 / Complex III subunit III / Cytochrome b-c1 complex subunit 3 / Ubiquinol-cytochrome-c reductase complex cytochrome b subunit


分子量: 42543.016 Da / 分子数: 2 / 断片: UNP RESIDUES 2-479 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P00156

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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit ... , 11種, 22分子 YBYZBZaBabBbcBcdBdeBenBnoBopBpvBv

#22: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial / Complex I-AGGG / CI-AGGG / NADH-ubiquinone oxidoreductase AGGG subunit


分子量: 7468.270 Da / 分子数: 2 / 断片: UNP RESIDUES 39-97 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95178
#23: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 / Complex I-B12 / CI-B12 / NADH-ubiquinone oxidoreductase B12 subunit


分子量: 9261.605 Da / 分子数: 2 / 断片: UNP RESIDUES 10-89 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O43676
#24: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial / Complex I-SGDH / CI-SGDH / NADH-ubiquinone oxidoreductase SGDH subunit


分子量: 16573.160 Da / 分子数: 2 / 断片: UNP RESIDUES 52-189 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O43674
#25: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 / Complex I-B17 / CI-B17 / NADH-ubiquinone oxidoreductase B17 subunit


分子量: 15008.635 Da / 分子数: 2 / 断片: UNP RESIDUES 3-126 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95139
#26: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial / Complex I-ASHI / CI-ASHI / NADH-ubiquinone oxidoreductase ASHI subunit


分子量: 18267.562 Da / 分子数: 2 / 断片: UNP RESIDUES 34-186 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95169
#27: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 / Complex I-PDSW / CI-PDSW / NADH-ubiquinone oxidoreductase PDSW subunit


分子量: 20721.650 Da / 分子数: 2 / 断片: UNP RESIDUES 1-171 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O96000
#28: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial / Complex I-ESSS / CI-ESSS / NADH-ubiquinone oxidoreductase ESSS subunit / Neuronal protein 17.3 / p17.3


分子量: 11494.942 Da / 分子数: 2 / 断片: UNP RESIDUES 54-150 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q9NX14
#37: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 / Complex I-MNLL / CI-MNLL / NADH-ubiquinone oxidoreductase MNLL subunit


分子量: 6741.883 Da / 分子数: 2 / 断片: UNP RESIDUES 3-58 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O75438
#38: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 / Complex I-B15 / CI-B15 / NADH-ubiquinone oxidoreductase B15 subunit


分子量: 15100.399 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95168
#39: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 / Complex I-B22 / CI-B22 / LYR motif-containing protein 3 / NADH-ubiquinone oxidoreductase B22 subunit


分子量: 21189.141 Da / 分子数: 2 / 断片: UNP RESIDUES 8-179 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q9Y6M9
#43: タンパク質 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 / Cell adhesion protein SQM1 / Complex I-B18 / CI-B18 / NADH-ubiquinone oxidoreductase B18 subunit


分子量: 14997.401 Da / 分子数: 2 / 断片: UNP RESIDUES 3-124 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P17568

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NADH dehydrogenase [ubiquinone] 1 subunit ... , 2種, 4分子 fBfgBg

#29: タンパク質・ペプチド NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial / Complex I-KFYI / CI-KFYI / NADH-ubiquinone oxidoreductase KFYI subunit


分子量: 5704.602 Da / 分子数: 2 / 断片: UNP RESIDUES 28-74 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O43677
#30: タンパク質 NADH dehydrogenase [ubiquinone] 1 subunit C2 / Complex I-B14.5b / CI-B14.5b / Human lung cancer oncogene 1 protein / HLC-1 / NADH-ubiquinone ...Complex I-B14.5b / CI-B14.5b / Human lung cancer oncogene 1 protein / HLC-1 / NADH-ubiquinone oxidoreductase subunit B14.5b


分子量: 14209.521 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O95298

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NADH-ubiquinone oxidoreductase chain ... , 7種, 14分子 iBijBjkBklBlmBmrBrsBs

#32: タンパク質 NADH-ubiquinone oxidoreductase chain 2


分子量: 39007.656 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: Q4GRX1, UniProt: P03891*PLUS, NADH:ubiquinone reductase (H+-translocating)
#33: タンパク質 NADH-ubiquinone oxidoreductase chain 3


分子量: 13147.871 Da / 分子数: 2 / 断片: UNP RESIDUES 1-115 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: B9EE38, NADH:ubiquinone reductase (H+-translocating)
#34: タンパク質 NADH-ubiquinone oxidoreductase chain 4L


分子量: 10702.086 Da / 分子数: 2 / 断片: UNP RESIDUES 1-97 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: V9JN72, NADH:ubiquinone reductase (H+-translocating)
#35: タンパク質 NADH-ubiquinone oxidoreductase chain 5


分子量: 67096.023 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: X5BVZ3, UniProt: P03915*PLUS, NADH:ubiquinone reductase (H+-translocating)
#36: タンパク質 NADH-ubiquinone oxidoreductase chain 6


分子量: 18660.979 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: Q8HAX7, NADH:ubiquinone reductase (H+-translocating)
#40: タンパク質 NADH-ubiquinone oxidoreductase chain 4


分子量: 51689.688 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: B2XJG5, UniProt: P03905*PLUS, NADH:ubiquinone reductase (H+-translocating)
#41: タンパク質 NADH-ubiquinone oxidoreductase chain 1


分子量: 35621.215 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト)
参照: UniProt: H9PGF0, NADH:ubiquinone reductase (H+-translocating)

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Cytochrome c oxidase subunit ... , 13種, 26分子 xBxyByzBz0B01B12B23B34B45B56B67B78B89B9

#45: タンパク質 Cytochrome c oxidase subunit 1 / Cytochrome c oxidase polypeptide I


分子量: 57065.844 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P00396, cytochrome-c oxidase
#46: タンパク質 Cytochrome c oxidase subunit 2 / Cytochrome c oxidase polypeptide II


分子量: 26040.393 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P68530
#47: タンパク質 Cytochrome c oxidase subunit 3 / Cytochrome c oxidase polypeptide III


分子量: 29957.627 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P00415
#48: タンパク質 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial / Cytochrome c oxidase polypeptide IV / Cytochrome c oxidase subunit IV isoform 1 / COX IV-1


分子量: 16913.367 Da / 分子数: 2 / 断片: UNP RESIDUES 26-169 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P00423
#49: タンパク質 Cytochrome c oxidase subunit 5A, mitochondrial / Cytochrome c oxidase polypeptide Va


分子量: 12453.081 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P00426
#50: タンパク質 Cytochrome c oxidase subunit 5B, mitochondrial / Cytochrome c oxidase polypeptide VIa / Cytochrome c oxidase polypeptide Vb


分子量: 10684.038 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P00428
#51: タンパク質 Cytochrome c oxidase subunit 6A2, mitochondrial / Cytochrome c oxidase polypeptide VIa-heart / COXVIAH / Cytochrome c oxidase polypeptide VIb


分子量: 9452.687 Da / 分子数: 2 / 断片: UNP RESIDUES 13-96 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P07471
#52: タンパク質 Cytochrome c oxidase subunit 6B1 / Cytochrome c oxidase polypeptide VII / Cytochrome c oxidase subunit AED / Cytochrome c oxidase ...Cytochrome c oxidase polypeptide VII / Cytochrome c oxidase subunit AED / Cytochrome c oxidase subunit VIb isoform 1 / COX VIb-1


分子量: 8925.979 Da / 分子数: 2 / 断片: UNP RESIDUES 12-86 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P00429
#53: タンパク質 Cytochrome c oxidase subunit 6C / Cytochrome c oxidase polypeptide VIc / Cytochrome c oxidase subunit STA


分子量: 8494.982 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P04038
#54: タンパク質 Cytochrome c oxidase subunit 7A1, mitochondrial / Cytochrome c oxidase subunit VIIIc / VIIIC / Cytochrome c oxidase subunit VIIa-heart / Cytochrome c ...Cytochrome c oxidase subunit VIIIc / VIIIC / Cytochrome c oxidase subunit VIIa-heart / Cytochrome c oxidase subunit VIIa-H / Cytochrome c oxidase subunit VIIa-muscle / Cytochrome c oxidase subunit VIIa-M


分子量: 6286.220 Da / 分子数: 2 / 断片: UNP RESIDUES 22-77 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P07470
#55: タンパク質・ペプチド Cytochrome c oxidase subunit 7B, mitochondrial / Cytochrome c oxidase polypeptide VIIb / IHQ


分子量: 5442.168 Da / 分子数: 2 / 断片: UNP RESIDUES 30-78 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P13183
#56: タンパク質・ペプチド Cytochrome c oxidase subunit 7C, mitochondrial / Cytochrome c oxidase polypeptide VIIIA / Cytochrome c oxidase polypeptide VIIc


分子量: 5449.396 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P00430
#57: タンパク質・ペプチド Cytochrome c oxidase subunit 8B, mitochondrial / Cytochrome c oxidase polypeptide VIII-heart / Cytochrome c oxidase subunit 8-1 / Cytochrome c ...Cytochrome c oxidase polypeptide VIII-heart / Cytochrome c oxidase subunit 8-1 / Cytochrome c oxidase subunit 8H / IX / VIIIb


分子量: 4738.523 Da / 分子数: 2 / 断片: UNP RESIDUES 25-67 / 由来タイプ: 天然 / 由来: (天然) Bos taurus (ウシ) / 参照: UniProt: P10175

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Cytochrome b-c1 complex subunit ... , 9種, 18分子 AAANABAOACAPADAQAEARAFASAGATAKAWALAY

#58: タンパク質 Cytochrome b-c1 complex subunit 8 / Complex III subunit 8 / Complex III subunit VIII / Ubiquinol-cytochrome c reductase complex 9.5 kDa ...Complex III subunit 8 / Complex III subunit VIII / Ubiquinol-cytochrome c reductase complex 9.5 kDa protein / Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C


分子量: 9791.181 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O14949
#59: タンパク質 Cytochrome b-c1 complex subunit Rieske, mitochondrial / Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / ...Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / Ubiquinol-cytochrome c reductase iron-sulfur subunit


分子量: 5893.814 Da / 分子数: 2 / 断片: UNP RESIDUES 1-57 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P47985, quinol-cytochrome-c reductase
#60: タンパク質 Cytochrome b-c1 complex subunit Rieske, mitochondrial / Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / ...Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / Ubiquinol-cytochrome c reductase iron-sulfur subunit


分子量: 21645.578 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P47985, quinol-cytochrome-c reductase
#61: タンパク質 Cytochrome b-c1 complex subunit 9 / Complex III subunit 9 / Complex III subunit X / Cytochrome c1 non-heme 7 kDa protein / Ubiquinol- ...Complex III subunit 9 / Complex III subunit X / Cytochrome c1 non-heme 7 kDa protein / Ubiquinol-cytochrome c reductase complex 7.2 kDa protein


分子量: 7189.299 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: Q9UDW1
#62: タンパク質 Cytochrome b-c1 complex subunit 6, mitochondrial / Complex III subunit 6 / Complex III subunit VIII / Cytochrome c1 non-heme 11 kDa protein / ...Complex III subunit 6 / Complex III subunit VIII / Cytochrome c1 non-heme 11 kDa protein / Mitochondrial hinge protein / Ubiquinol-cytochrome c reductase complex 11 kDa protein


分子量: 8861.742 Da / 分子数: 2 / 断片: UNP RESIDUES 18-91 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P07919
#63: タンパク質 Cytochrome b-c1 complex subunit 7 / Complex III subunit 7 / Complex III subunit VII / QP-C / Ubiquinol-cytochrome c reductase complex ...Complex III subunit 7 / Complex III subunit VII / QP-C / Ubiquinol-cytochrome c reductase complex 14 kDa protein


分子量: 13037.842 Da / 分子数: 2 / 断片: UNP RESIDUES 6-111 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P14927
#64: タンパク質 Cytochrome b-c1 complex subunit 10 / Complex III subunit 10 / Complex III subunit XI / Ubiquinol-cytochrome c reductase complex 6.4 kDa protein


分子量: 5958.912 Da / 分子数: 2 / 断片: UNP RESIDUES 2-52 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: O14957
#67: タンパク質 Cytochrome b-c1 complex subunit 2, mitochondrial / Complex III subunit 2 / Core protein II / Ubiquinol-cytochrome-c reductase complex core protein 2


分子量: 44946.582 Da / 分子数: 2 / 断片: UNP RESIDUES 35-453 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P22695
#68: タンパク質 Cytochrome b-c1 complex subunit 1, mitochondrial / Complex III subunit 1 / Core protein I / Ubiquinol-cytochrome-c reductase complex core protein 1


分子量: 49181.430 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P31930

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非ポリマー , 14種, 100分子

#69: 化合物
ChemComp-SF4 / IRON/SULFUR CLUSTER


分子量: 351.640 Da / 分子数: 12 / 由来タイプ: 合成 / 式: Fe4S4
#70: 化合物 ChemComp-FMN / FLAVIN MONONUCLEOTIDE / RIBOFLAVIN MONOPHOSPHATE / FMN


分子量: 456.344 Da / 分子数: 2 / 由来タイプ: 合成 / 式: C17H21N4O9P
#71: 化合物...
ChemComp-PLX / (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL


分子量: 767.132 Da / 分子数: 21 / 由来タイプ: 合成 / 式: C42H89NO8P / コメント: リン脂質*YM
#72: 化合物
ChemComp-8Q1 / S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate / S-dodecanoyl-4'-phosphopantetheine


分子量: 540.651 Da / 分子数: 4 / 由来タイプ: 合成 / 式: C23H45N2O8PS
#73: 化合物 ChemComp-NDP / NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / NADPH


分子量: 745.421 Da / 分子数: 2 / 由来タイプ: 合成 / 式: C21H30N7O17P3
#74: 化合物
ChemComp-FES / FE2/S2 (INORGANIC) CLUSTER


分子量: 175.820 Da / 分子数: 6 / 由来タイプ: 合成 / 式: Fe2S2
#75: 化合物
ChemComp-CDL / CARDIOLIPIN / DIPHOSPHATIDYL GLYCEROL / BIS-(1,2-DIACYL-SN-GLYCERO-3-PHOSPHO)-1',3'-SN-GLYCEROL


分子量: 1464.043 Da / 分子数: 19 / 由来タイプ: 合成 / 式: C81H156O17P2 / コメント: リン脂質*YM
#76: 化合物
ChemComp-PEE / 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE


分子量: 744.034 Da / 分子数: 14 / 由来タイプ: 合成 / 式: C41H78NO8P / コメント: DOPE, リン脂質*YM
#77: 化合物
ChemComp-CU / COPPER (II) ION


分子量: 63.546 Da / 分子数: 6 / 由来タイプ: 合成 / 式: Cu
#78: 化合物 ChemComp-MG / MAGNESIUM ION / マグネシウムジカチオン


分子量: 24.305 Da / 分子数: 2 / 由来タイプ: 合成 / 式: Mg
#79: 化合物
ChemComp-HEA / HEME-A


分子量: 852.837 Da / 分子数: 4 / 由来タイプ: 合成 / 式: C49H56FeN4O6
#80: 化合物 ChemComp-ZN / ZINC ION


分子量: 65.409 Da / 分子数: 2 / 由来タイプ: 合成 / 式: Zn
#81: 化合物 ChemComp-HEC / HEME C


分子量: 618.503 Da / 分子数: 2 / 由来タイプ: 合成 / 式: C34H34FeN4O4
#82: 化合物
ChemComp-HEM / PROTOPORPHYRIN IX CONTAINING FE / HEME


分子量: 616.487 Da / 分子数: 4 / 由来タイプ: 合成 / 式: C34H32FeN4O4

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詳細

Has protein modificationY

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実験情報

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実験

実験手法: 電子顕微鏡法
EM実験試料の集合状態: PARTICLE / ３次元再構成法: 単粒子再構成法

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試料調製

構成要素名称: Human respiratory chain megacomplex-I2III2IV2 / タイプ: COMPLEX / Entity ID: #1-#68 / 由来: NATURAL
由来(天然)生物種: Homo sapiens (ヒト)
緩衝液pH: 7.4
試料包埋: NO / シャドウイング: NO / 染色: NO / 凍結: YES
急速凍結凍結剤: ETHANE

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電子顕微鏡撮影

実験機器
モデル: Titan Krios / 画像提供: FEI Company
顕微鏡モデル: FEI TITAN KRIOS
電子銃電子線源: FIELD EMISSION GUN / 加速電圧: 300 kV / 照射モード: OTHER
電子レンズモード: BRIGHT FIELD
撮影電子線照射量: 1.25 e/Å2
フィルム・検出器のモデル: FEI FALCON II (4k x 4k)

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解析

EMソフトウェア
ID名称バージョンカテゴリ
1EMAN2.1粒子像選択
2AutoEMation2画像取得
4CTFFIND3CTF補正
7Coot0.8.2モデルフィッティング
9RELION1.4初期オイラー角割当
10RELION1.4最終オイラー角割当
12RELION1.4３次元再構成
13PHENIX1.11.1モデル精密化
CTF補正タイプ: NONE
対称性点対称性: C1 (非対称)
3次元再構成解像度: 17.4 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 粒子像の数: 8600 / 対称性のタイプ: POINT

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る