登録情報 データベース : PDB / ID : 2vip 構造の表示 ダウンロードとリンクタイトル Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator 要素UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B 詳細 キーワード HYDROLASE / PLASMINOGEN ACTIVATION / EGF-LIKE DOMAIN / BLOOD COAGULATION / INHIBITOR / POLYMORPHISM / GLYCOPROTEIN / FIBRINOLYSIS / KRINGLE / ZYMOGEN / SECRETED / PROTEASE / UROKINASE-TYPE PLASMINOGEN ACTIVATOR / PHARMACEUTICAL / SERINE PROTEASE / PHOSPHORYLATION機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
u-plasminogen activator / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / regulation of wound healing / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / regulation of smooth muscle cell migration / regulation of signaling receptor activity ... u-plasminogen activator / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / regulation of wound healing / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / regulation of smooth muscle cell migration / regulation of signaling receptor activity / serine-type endopeptidase complex / Dissolution of Fibrin Clot / smooth muscle cell migration / serine protease inhibitor complex / plasminogen activation / regulation of cell adhesion mediated by integrin / tertiary granule membrane / negative regulation of fibrinolysis / regulation of cell adhesion / specific granule membrane / fibrinolysis / chemotaxis / blood coagulation / regulation of cell population proliferation / response to hypoxia / positive regulation of cell migration / external side of plasma membrane / serine-type endopeptidase activity / focal adhesion / Neutrophil degranulation / cell surface / signal transduction / proteolysis / extracellular space / extracellular exosome / extracellular region / plasma membrane 類似検索 - 分子機能 : / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. ... : / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. / EGF-like domain / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性 ACETATE ION / Chem-L1R / Urokinase-type plasminogen activator 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / OTHER / 解像度 : 1.72 Å 詳細データ登録者 Frederickson, M. / Callaghan, O. / Chessari, G. / Congreve, M. / Cowan, S.R. / Matthews, J.E. / McMenamin, R. / Smith, D. / Vinkovic, M. / Wallis, N.G. 引用ジャーナル : J.Med.Chem. / 年 : 2008タイトル : Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator著者 : Frederickson, M. / Callaghan, O. / Chessari, G. / Congreve, M. / Cowan, S.R. / Matthews, J.E. / Mcmenamin, R. / Smith, D. / Vinkovic, M. / Wallis, N.G. 履歴 登録 2007年12月5日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2008年1月22日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2017年7月5日 Group : Data collection / カテゴリ : diffrn_source / Item : _diffrn_source.type
すべて表示 表示を減らす Remark 700 SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AA" IN EACH CHAIN ON SHEET RECORDS BELOW ... SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AA" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL. THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 7-STRANDED BARREL THIS IS REPRESENTED BY A 8-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL.