Author results

1OP0
  • Download 1op0
  • View 1op0
Molmil generated image of 1op0
CRYSTAL STRUCTURE OF AAV-SP-I, A GLYCOSYLATED SNAKE VENOM SERINE PROTEINASE FROM AGKISTRODON ACUTUS
Descriptor:Venom serine proteinase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Zhu, Z., Teng, M., Niu, L.
Deposit date:2003-03-04
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures and Amidolytic Activities of Two Glycosylated Snake Venom Serine Proteinases
J.BIOL.CHEM., 280, 2005
1OP2
  • Download 1op2
  • View 1op2
Molmil generated image of 1op2
CRYSTAL STRUCTURE OF AAV-SP-II, A GLYCOSYLATED SNAKE VENOM SERINE PROTEINASE FROM AGKISTRODON ACUTUS
Descriptor:Venom serine proteinase, N-ACETYL-D-GLUCOSAMINE, SULFATE ION
Authors:Zhu, Z., Teng, M., Niu, L.
Deposit date:2003-03-04
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures and Amidolytic Activities of Two Glycosylated Snake Venom Serine Proteinases
J.BIOL.CHEM., 280, 2005
1WT9
  • Download 1wt9
  • View 1wt9
Molmil generated image of 1wt9
CRYSTAL STRUCTURE OF AA-X-BP-I, A SNAKE VENOM PROTEIN WITH THE ACTIVITY OF BINDING TO COAGULATION FACTOR X FROM AGKISTRODON ACUTUS
Descriptor:agkisacutacin A chain, anticoagulant protein-B, CALCIUM ION
Authors:Zhu, Z., Liu, S., Mo, X., Yu, X., Liang, Z., Zang, J., Zhao, W., Teng, M., Niu, L.
Deposit date:2004-11-18
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Characterizations and Crystal structures of two snake venom proteins with the activity of binding coagulation factor X from Agkistrodon acutus
To be Published
1Y17
  • Download 1y17
  • View 1y17
Molmil generated image of 1y17
CRYSTAL STRUCTURE OF AA-X-BP-II, A SNAKE VENOM PROTEIN WITH THE ACTIVITY OF BINDING TO COAGULATION FACTOR X FROM AGKISTRODON ACUTUS
Descriptor:anticoagulant protein A, anticoagulant protein-B, CALCIUM ION
Authors:Zhu, Z., Liu, S., Mo, X., Yu, X., Liang, Z., Zang, J., Zhao, W., Teng, M., Niu, L.
Deposit date:2004-11-17
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterizations and Crystal structures of two snake venom proteins with the activity of binding coagulation factor X from Agkistrodon acutus
To be Published
1HXR
  • Download 1hxr
  • View 1hxr
Molmil generated image of 1hxr
CRYSTAL STRUCTURE OF MSS4 AT 1.65 ANGSTROMS
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4, ZINC ION
Authors:Zhu, Z., Dumas, J.J., Lietzke, S.E., Lambright, D.G.
Deposit date:2001-01-16
Release date:2001-02-14
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release.
Biochemistry, 40, 2001
2GJJ
  • Download 2gjj
  • View 2gjj
Molmil generated image of 2gjj
CRYSTAL STRUCTURE OF A SINGLE CHAIN ANTIBODY SCA21 AGAINST HER2/ERBB2
Descriptor:A21 single-chain antibody fragment against erbB2, GLYCEROL
Authors:Zhu, Z.
Deposit date:2006-03-31
Release date:2006-10-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Epitope mapping and structural analysis of an anti-ErbB2 antibody A21: Molecular basis for tumor inhibitory mechanism
Proteins, 70, 2007
3L58
  • Download 3l58
  • View 3l58
Molmil generated image of 3l58
STRUCTURE OF BACE BOUND TO SCH589432
Descriptor:Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L59
  • Download 3l59
  • View 3l59
Molmil generated image of 3l59
STRUCTURE OF BACE BOUND TO SCH710413
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5B
  • Download 3l5b
  • View 3l5b
Molmil generated image of 3l5b
STRUCTURE OF BACE BOUND TO SCH713601
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z,5R)-3-(3-chlorobenzyl)-2-imino-5-methyl-5-(2-methylpropyl)imidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5C
  • Download 3l5c
  • View 3l5c
Molmil generated image of 3l5c
STRUCTURE OF BACE BOUND TO SCH723871
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, 1-(4-cyanophenyl)-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5D
  • Download 3l5d
  • View 3l5d
Molmil generated image of 3l5d
STRUCTURE OF BACE BOUND TO SCH723873
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, 1-butyl-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5E
  • Download 3l5e
  • View 3l5e
Molmil generated image of 3l5e
STRUCTURE OF BACE BOUND TO SCH736062
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (4S)-1-(4-{[(2Z,4R)-4-(2-cyclohexylethyl)-4-(cyclohexylmethyl)-2-imino-5-oxoimidazolidin-1-yl]methyl}benzyl)-4-propylimidazolidin-2-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5F
  • Download 3l5f
  • View 3l5f
Molmil generated image of 3l5f
STRUCTURE OF BACE BOUND TO SCH736201
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)-2-imino-3-methylimidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3EDZ
  • Download 3edz
  • View 3edz
Molmil generated image of 3edz
CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF TACE WITH HYDROXAMATE INHIBITOR
Descriptor:ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ...
Authors:Mazzola, R.D., Zhu, Z., Sinning, L., McKittrick, B., Lavey, B., Spitler, J., Kozlowski, J., Neng-Yang, S., Zhou, G., Guo, Z., Orth, P., Madison, V., Sun, J., Lundell, D., Niu, X.
Deposit date:2008-09-03
Release date:2008-09-23
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
Bioorg.Med.Chem.Lett., 18, 2008
4R97
  • Download 4r97
  • View 4r97
Molmil generated image of 4r97
CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF KKO
Descriptor:platelet factor 4 antibody KKO light chain, platelet factor 4 antibody KKO heavy chain, ZINC ION, ...
Authors:Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
Deposit date:2014-09-03
Release date:2015-12-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4R9W
  • Download 4r9w
  • View 4r9w
Molmil generated image of 4r9w
CRYSTAL STRUCTURE OF PLATELET FACTOR 4 COMPLEXED WITH FONDAPARINUX
Descriptor:Platelet factor 4, TRISULFOAMINO HEPARIN PENTASACCHARIDE
Authors:Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
Deposit date:2014-09-08
Release date:2015-12-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4R9Y
  • Download 4r9y
  • View 4r9y
Molmil generated image of 4r9y
CRYSTAL STRUCTURE OF KKOFAB IN COMPLEX WITH PLATELET FACTOR 4
Descriptor:Platelet factor 4, Platelet factor 4 antibody KKO light chain, Platelet factor 4 antibody KKO heavy chain
Authors:Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
Deposit date:2014-09-08
Release date:2015-12-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (4.11 Å)
Cite:Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4RAU
  • Download 4rau
  • View 4rau
Molmil generated image of 4rau
CRYSTAL STRUCTURE OF RTOFAB IN COMPLEX WITH HUMAN PF4
Descriptor:RTOFab light chain, RTOFab heavy chain, Platelet factor 4
Authors:Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
Deposit date:2014-09-11
Release date:2016-03-16
Method:X-RAY DIFFRACTION (3.74 Å)
Cite:crystal structure of RTOFab in complex with platelet factor 4
To be Published
6J71
  • Download 6j71
  • View 6j71
Molmil generated image of 6j71
HUA21-SCFV IN COMPLEX WITH THE EXTRACELLULAR DOMAIN(ECD) OF HER2
Descriptor:Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, BETA-D-MANNOSE, ...
Authors:Wang, Z., Guo, G., Cheng, B., Zhu, Z., Niu, L., Zhang, H.
Deposit date:2019-01-16
Release date:2019-02-27
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.918 Å)
Cite:Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells.
Acta Crystallogr D Struct Biol, 75, 2019
2A4G
  • Download 2a4g
  • View 2a4g
Molmil generated image of 2a4g
HEPATITIS C PROTEASE NS3-4A SERINE PROTEASE WITH KETOAMIDE INHIBITOR SCH225724 BOUND
Descriptor:NS3 protease/helicase, NS4a peptide, ZINC ION, ...
Authors:Arasappan, A., Njoroge, F.G., Chan, T.Y., Bennett, F., Bogen, S.L., Chen, K., Gu, H., Hong, L., Jao, E., Liu, Y.T., Lovey, R.G., Parekh, T., Pike, R.E., Pinto, P., Santhanam, B., Venkatraman, S., Vaccaro, H., Wang, H., Yang, X., Zhu, Z., Mckittrick, B., Saksena, A.K., Girijavallabhan, V., Pichardo, J., Butkiewicz, N., Ingram, R., Malcolm, B., Prongay, A.J., Yao, N., Marten, B., Madison, V., Kemp, S., Levy, O., Lim-Wilby, M., Tamura, S., Ganguly, A.K.
Deposit date:2005-06-28
Release date:2006-07-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
2B5A
  • Download 2b5a
  • View 2b5a
Molmil generated image of 2b5a
C.BCLI, CONTROL ELEMENT OF THE BCLI RESTRICTION-MODIFICATION SYSTEM
Descriptor:C.BclI, ACETIC ACID
Authors:Sawaya, M.R., Zhu, Z., Mersha, F., Chan, S.H., Dabur, R., Xu, S.Y., Balendiran, G.K.
Deposit date:2005-09-28
Release date:2006-01-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.543 Å)
Cite:Crystal Structure of the Restriction-Modification System Control Element C.BclI and Mapping of Its Binding Site.
Structure, 13, 2005
3EHQ
  • Download 3ehq
  • View 3ehq
Molmil generated image of 3ehq
CRYSTAL STRUCTURE OF HUMAN OSTEOCLAST STIMULATING FACTOR
Descriptor:Osteoclast-stimulating factor 1, 1,2-ETHANEDIOL
Authors:Tong, S., Zhou, H., Gao, Y., Zhu, Z., Zhang, X., Teng, M., Niu, L.
Deposit date:2008-09-14
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
3EHR
  • Download 3ehr
  • View 3ehr
Molmil generated image of 3ehr
CRYSTAL STRUCTURE OF HUMAN OSTEOCLAST STIMULATING FACTOR
Descriptor:Osteoclast-stimulating factor 1
Authors:Tong, S., Zhou, H., Gao, Y., Zhu, Z., Zhang, X., Teng, M., Niu, L.
Deposit date:2008-09-14
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
3MD3
  • Download 3md3
  • View 3md3
Molmil generated image of 3md3
CRYSTAL STRUCTURE OF THE FIRST TWO RRM DOMAINS OF YEAST POLY(U) BINDING PROTEIN (PUB1)
Descriptor:Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1, SULFATE ION, GLYCEROL
Authors:Li, H., Shi, H., Zhu, Z., Wang, H., Niu, L., Teng, M.
Deposit date:2010-03-29
Release date:2010-05-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the First Two RRM Domains of Yeast Poly(U) Binding Protein (Pub1)
To be published
3OF7
  • Download 3of7
  • View 3of7
Molmil generated image of 3of7
THE CRYSTAL STRUCTURE OF PRP20P FROM SACCHAROMYCES CEREVISIAE AND ITS BINDING PROPERTIES TO GSP1P AND HISTONES
Descriptor:Regulator of chromosome condensation
Authors:Wu, F., Liu, Y., Zhu, Z., Huang, H., Ding, B., Wu, J., Shi, Y.
Deposit date:2010-08-14
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 1.9A crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones.
J.Struct.Biol., 174, 2011