Author results

1OP0
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CRYSTAL STRUCTURE OF AAV-SP-I, A GLYCOSYLATED SNAKE VENOM SERINE PROTEINASE FROM AGKISTRODON ACUTUS
分子名称:Venom serine proteinase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Zhu, Z., Teng, M., Niu, L.
登録日2003-03-04
公開日2004-05-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structures and Amidolytic Activities of Two Glycosylated Snake Venom Serine Proteinases
J.BIOL.CHEM., 280, 2005
1OP2
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CRYSTAL STRUCTURE OF AAV-SP-II, A GLYCOSYLATED SNAKE VENOM SERINE PROTEINASE FROM AGKISTRODON ACUTUS
分子名称:Venom serine proteinase, N-ACETYL-D-GLUCOSAMINE, SULFATE ION
著者Zhu, Z., Teng, M., Niu, L.
登録日2003-03-04
公開日2004-05-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures and Amidolytic Activities of Two Glycosylated Snake Venom Serine Proteinases
J.BIOL.CHEM., 280, 2005
1WT9
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CRYSTAL STRUCTURE OF AA-X-BP-I, A SNAKE VENOM PROTEIN WITH THE ACTIVITY OF BINDING TO COAGULATION FACTOR X FROM AGKISTRODON ACUTUS
分子名称:agkisacutacin A chain, anticoagulant protein-B, CALCIUM ION
著者Zhu, Z., Liu, S., Mo, X., Yu, X., Liang, Z., Zang, J., Zhao, W., Teng, M., Niu, L.
登録日2004-11-18
公開日2006-03-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Characterizations and Crystal structures of two snake venom proteins with the activity of binding coagulation factor X from Agkistrodon acutus
To be Published
1Y17
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CRYSTAL STRUCTURE OF AA-X-BP-II, A SNAKE VENOM PROTEIN WITH THE ACTIVITY OF BINDING TO COAGULATION FACTOR X FROM AGKISTRODON ACUTUS
分子名称:anticoagulant protein A, anticoagulant protein-B, CALCIUM ION
著者Zhu, Z., Liu, S., Mo, X., Yu, X., Liang, Z., Zang, J., Zhao, W., Teng, M., Niu, L.
登録日2004-11-17
公開日2006-03-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Characterizations and Crystal structures of two snake venom proteins with the activity of binding coagulation factor X from Agkistrodon acutus
To be Published
1HXR
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CRYSTAL STRUCTURE OF MSS4 AT 1.65 ANGSTROMS
分子名称:GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4, ZINC ION
著者Zhu, Z., Dumas, J.J., Lietzke, S.E., Lambright, D.G.
登録日2001-01-16
公開日2001-02-14
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release.
Biochemistry, 40, 2001
2GJJ
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CRYSTAL STRUCTURE OF A SINGLE CHAIN ANTIBODY SCA21 AGAINST HER2/ERBB2
分子名称:A21 single-chain antibody fragment against erbB2, GLYCEROL
著者Zhu, Z.
登録日2006-03-31
公開日2006-10-01
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Epitope mapping and structural analysis of an anti-ErbB2 antibody A21: Molecular basis for tumor inhibitory mechanism
Proteins, 70, 2007
3L58
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STRUCTURE OF BACE BOUND TO SCH589432
分子名称:Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE
著者Strickland, C., Zhu, Z.
登録日2009-12-21
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L59
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STRUCTURE OF BACE BOUND TO SCH710413
分子名称:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one
著者Strickland, C., Zhu, Z.
登録日2009-12-21
公開日2010-02-16
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5B
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STRUCTURE OF BACE BOUND TO SCH713601
分子名称:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z,5R)-3-(3-chlorobenzyl)-2-imino-5-methyl-5-(2-methylpropyl)imidazolidin-4-one
著者Strickland, C., Zhu, Z.
登録日2009-12-21
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5C
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STRUCTURE OF BACE BOUND TO SCH723871
分子名称:Beta-secretase 1, D(-)-TARTARIC ACID, 1-(4-cyanophenyl)-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
著者Strickland, C., Zhu, Z.
登録日2009-12-21
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5D
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STRUCTURE OF BACE BOUND TO SCH723873
分子名称:Beta-secretase 1, D(-)-TARTARIC ACID, 1-butyl-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
著者Strickland, C., Zhu, Z.
登録日2009-12-21
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5E
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STRUCTURE OF BACE BOUND TO SCH736062
分子名称:Beta-secretase 1, D(-)-TARTARIC ACID, (4S)-1-(4-{[(2Z,4R)-4-(2-cyclohexylethyl)-4-(cyclohexylmethyl)-2-imino-5-oxoimidazolidin-1-yl]methyl}benzyl)-4-propylimidazolidin-2-one
著者Strickland, C., Zhu, Z.
登録日2009-12-21
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5F
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STRUCTURE OF BACE BOUND TO SCH736201
分子名称:Beta-secretase 1, D(-)-TARTARIC ACID, (2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)-2-imino-3-methylimidazolidin-4-one
著者Strickland, C., Zhu, Z.
登録日2009-12-21
公開日2010-02-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3EDZ
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF TACE WITH HYDROXAMATE INHIBITOR
分子名称:ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ...
著者Mazzola, R.D., Zhu, Z., Sinning, L., McKittrick, B., Lavey, B., Spitler, J., Kozlowski, J., Neng-Yang, S., Zhou, G., Guo, Z., Orth, P., Madison, V., Sun, J., Lundell, D., Niu, X.
登録日2008-09-03
公開日2008-09-23
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
Bioorg.Med.Chem.Lett., 18, 2008
4R97
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF KKO
分子名称:platelet factor 4 antibody KKO light chain, platelet factor 4 antibody KKO heavy chain, ZINC ION, ...
著者Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
登録日2014-09-03
公開日2015-12-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4R9W
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CRYSTAL STRUCTURE OF PLATELET FACTOR 4 COMPLEXED WITH FONDAPARINUX
分子名称:Platelet factor 4, TRISULFOAMINO HEPARIN PENTASACCHARIDE
著者Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
登録日2014-09-08
公開日2015-12-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4R9Y
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CRYSTAL STRUCTURE OF KKOFAB IN COMPLEX WITH PLATELET FACTOR 4
分子名称:Platelet factor 4, Platelet factor 4 antibody KKO light chain, Platelet factor 4 antibody KKO heavy chain
著者Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
登録日2014-09-08
公開日2015-12-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (4.11 Å)
主引用文献Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4RAU
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CRYSTAL STRUCTURE OF RTOFAB IN COMPLEX WITH HUMAN PF4
分子名称:RTOFab light chain, RTOFab heavy chain, Platelet factor 4
著者Cai, Z., Zhu, Z., Liu, Q., Greene, M.I.
登録日2014-09-11
公開日2016-03-16
実験手法X-RAY DIFFRACTION (3.74 Å)
主引用文献crystal structure of RTOFab in complex with platelet factor 4
To be Published
6J71
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HUA21-SCFV IN COMPLEX WITH THE EXTRACELLULAR DOMAIN(ECD) OF HER2
分子名称:Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, BETA-D-MANNOSE, ...
著者Wang, Z., Guo, G., Cheng, B., Zhu, Z., Niu, L., Zhang, H.
登録日2019-01-16
公開日2019-02-27
最終更新日2019-06-26
実験手法X-RAY DIFFRACTION (2.918 Å)
主引用文献Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells.
Acta Crystallogr D Struct Biol, 75, 2019
2A4G
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HEPATITIS C PROTEASE NS3-4A SERINE PROTEASE WITH KETOAMIDE INHIBITOR SCH225724 BOUND
分子名称:NS3 protease/helicase, NS4a peptide, ZINC ION, ...
著者Arasappan, A., Njoroge, F.G., Chan, T.Y., Bennett, F., Bogen, S.L., Chen, K., Gu, H., Hong, L., Jao, E., Liu, Y.T., Lovey, R.G., Parekh, T., Pike, R.E., Pinto, P., Santhanam, B., Venkatraman, S., Vaccaro, H., Wang, H., Yang, X., Zhu, Z., Mckittrick, B., Saksena, A.K., Girijavallabhan, V., Pichardo, J., Butkiewicz, N., Ingram, R., Malcolm, B., Prongay, A.J., Yao, N., Marten, B., Madison, V., Kemp, S., Levy, O., Lim-Wilby, M., Tamura, S., Ganguly, A.K.
登録日2005-06-28
公開日2006-07-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
2B5A
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C.BCLI, CONTROL ELEMENT OF THE BCLI RESTRICTION-MODIFICATION SYSTEM
分子名称:C.BclI, ACETIC ACID
著者Sawaya, M.R., Zhu, Z., Mersha, F., Chan, S.H., Dabur, R., Xu, S.Y., Balendiran, G.K.
登録日2005-09-28
公開日2006-01-03
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.543 Å)
主引用文献Crystal Structure of the Restriction-Modification System Control Element C.BclI and Mapping of Its Binding Site.
Structure, 13, 2005
3EHQ
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CRYSTAL STRUCTURE OF HUMAN OSTEOCLAST STIMULATING FACTOR
分子名称:Osteoclast-stimulating factor 1, 1,2-ETHANEDIOL
著者Tong, S., Zhou, H., Gao, Y., Zhu, Z., Zhang, X., Teng, M., Niu, L.
登録日2008-09-14
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
3EHR
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CRYSTAL STRUCTURE OF HUMAN OSTEOCLAST STIMULATING FACTOR
分子名称:Osteoclast-stimulating factor 1
著者Tong, S., Zhou, H., Gao, Y., Zhu, Z., Zhang, X., Teng, M., Niu, L.
登録日2008-09-14
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
3MD3
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CRYSTAL STRUCTURE OF THE FIRST TWO RRM DOMAINS OF YEAST POLY(U) BINDING PROTEIN (PUB1)
分子名称:Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1, SULFATE ION, GLYCEROL
著者Li, H., Shi, H., Zhu, Z., Wang, H., Niu, L., Teng, M.
登録日2010-03-29
公開日2010-05-05
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of the First Two RRM Domains of Yeast Poly(U) Binding Protein (Pub1)
To be published
3OF7
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THE CRYSTAL STRUCTURE OF PRP20P FROM SACCHAROMYCES CEREVISIAE AND ITS BINDING PROPERTIES TO GSP1P AND HISTONES
分子名称:Regulator of chromosome condensation
著者Wu, F., Liu, Y., Zhu, Z., Huang, H., Ding, B., Wu, J., Shi, Y.
登録日2010-08-14
公開日2011-03-23
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The 1.9A crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones.
J.Struct.Biol., 174, 2011