Author results

7BYR
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BD23-FAB IN COMPLEX WITH THE S ECTODOMAIN TRIMER
Descriptor:SARS-CoV-2 Spike glycoprotein, Ab23-Fab-Heavy Chain, Ab23-Fab-Light Chain, ...
Authors:Zhu, Q., Wang, G., Xiao, J.
Deposit date:2020-04-24
Release date:2020-06-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.
Cell, 182, 2020
6Y07
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DESIGNING A GRANULOPOIETIC PROTEIN BY TOPOLOGICAL RESCAFFOLDING 1: SOHAIR
Descriptor:sohair
Authors:ElGamacy, M., Coles, M.
Deposit date:2020-02-06
Release date:2020-03-18
Method:SOLUTION NMR
Cite:Designing of novel granulopoietic proteins by topological rescaffolding
To Be Published
6Y06
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SOHAIR: A DESIGNED GRANULOPOIETIC PROTEIN BY TOPOLOGICAL RESCAFFOLDING
Descriptor:Moevan
Authors:ElGamacy, M., Coles, M.
Deposit date:2020-02-06
Release date:2020-03-18
Last modified:2020-03-25
Method:SOLUTION NMR
Cite:Designing of novel granulopoietic proteins by topological rescaffolding
To Be Published
6UOE
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3-25 FAB GERMLINE-REVERSION VARIANT BOUND TO AN HCMV GB-DERIVED PEPTIDE
Descriptor:3-25 Fab heavy chain, 3-25 Fab light chain, Envelope glycoprotein B, ...
Authors:Wrapp, D., McLellan, J.S.
Deposit date:2019-10-14
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Characterization of a broadly neutralizing antibody that recognizes antigenic domain-2 of HCMV gB
To Be Published
6QH2
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SOLUTION NMR ENSEMBLE FOR A CHIMERIC KH-S1 DOMAIN CONSTRUCT OF EXOSOMAL POLYNUCLEOTIDE PHOSPHRYLASE AT 298K COMPILED USING THE COMAND METHOD
Descriptor:Polyribonucleotide nucleotidyltransferase
Authors:ElGamacy, M., Truffault, V., Zhu, H., Coles, M.
Deposit date:2019-01-14
Release date:2019-04-10
Last modified:2019-05-15
Method:SOLUTION NMR
Cite:Mapping Local Conformational Landscapes of Proteins in Solution.
Structure, 27, 2019
6QFP
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SOLUTION NMR ENSEMBLE FOR MLBQ AT 298K COMPILED USING THE COMAND METHOD
Descriptor:Putative lipoprotein
Authors:ElGamacy, M., Truffault, V., Zhu, H., Coles, M.
Deposit date:2019-01-10
Release date:2019-04-10
Last modified:2019-05-15
Method:SOLUTION NMR
Cite:Mapping Local Conformational Landscapes of Proteins in Solution.
Structure, 27, 2019
6QF8
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SOLUTION NMR ENSEMBLE FOR HUMAN UBIQUITIN AT 298K COMPILED USING THE COMAND METHOD
Descriptor:Polyubiquitin-B
Authors:ElGamacy, M., Truffault, V., Zhu, H., Coles, M.
Deposit date:2019-01-09
Release date:2019-04-10
Last modified:2019-05-15
Method:SOLUTION NMR
Cite:Mapping Local Conformational Landscapes of Proteins in Solution.
Structure, 27, 2019
6NJE
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CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 22
Descriptor:Kinesin-like protein KIF22, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Walker, B.C., Zhu, H., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Park, H., Cochran, J.C., Structural Genomics Consortium (SGC)
Deposit date:2019-01-03
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the motor domain of human kinesin family member 22
To Be Published
6N5V
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CRYSTAL STRUCTURE OF STRICTOSIDINE IN COMPLEX WITH 1H-INDOLE-4-ETHANAMINE
Descriptor:Strictosidine synthase, 2-(1H-indol-4-yl)ethan-1-amine
Authors:Cai, Y., Shao, N., Xie, H., Futamura, Y., Panjikar, S., Liu, H., Zhu, H., Osada, H., Zou, H.
Deposit date:2018-11-22
Release date:2019-11-27
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine
to be published
6MV2
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2.05A RESOLUTION STRUCTURE OF THE CS-B5R DOMAINS OF HUMAN NCB5OR (NADP+ FORM)
Descriptor:Cytochrome b5 reductase 4, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Lovell, S., Mehzabeen, N., Battaile, K.P., Benson, D.R., Cooper, A., Gao, P., Zhu, H.
Deposit date:2018-10-24
Release date:2019-07-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of the naturally fused CS and cytochrome b5reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+nicotinamide ring.
Acta Crystallogr D Struct Biol, 75, 2019
6MV1
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2.15A RESOLUTION STRUCTURE OF THE CS-B5R DOMAINS OF HUMAN NCB5OR (NAD+ FORM)
Descriptor:Cytochrome b5 reductase 4, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lovell, S., Mehzabeen, N., Battaile, K.P., Benson, D.R., Cooper, A., Gao, P., Zhu, H.
Deposit date:2018-10-24
Release date:2019-07-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structures of the naturally fused CS and cytochrome b5reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+nicotinamide ring.
Acta Crystallogr D Struct Biol, 75, 2019
6MOO
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CO-CRYSTAL STRUCTURE OF P. AERUGINOSA LPXC-ACHN975 COMPLEX
Descriptor:UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diynyl]benzamide
Authors:Stein, A.J., Assar, Z., Holt, M.C., Cohen, F., Andrews, L., Cirz, R.
Deposit date:2018-10-04
Release date:2019-07-17
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
6MOD
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CO-CRYSTAL STRUCTURE OF P. AERUGINOSA LPXC-50432 COMPLEX
Descriptor:UDP-3-O-acyl-N-acetylglucosamine deacetylase, MAGNESIUM ION, N-[(1S)-2-(hydroxyamino)-1-(3-methoxy-1,1-dioxo-1lambda~6~-thietan-3-yl)-2-oxoethyl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide, ...
Authors:Stein, A.J., Holt, M.C., Assar, Z., Cohen, F., Andrews, L., Cirz, R.
Deposit date:2018-10-04
Release date:2019-07-17
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
6MO5
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CO-CRYSTAL STRUCTURE OF P. AERUGINOSA LPXC-50228 COMPLEX
Descriptor:UDP-3-O-acyl-N-acetylglucosamine deacetylase, N-[(2S)-1-(hydroxyamino)-3-methyl-3-{[(oxetan-3-yl)methyl]sulfonyl}-1-oxobutan-2-yl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide, MAGNESIUM ION
Authors:Stein, A.J., Holt, M.C., Assar, Z., Cohen, F., Andrews, L., Cirz, R.
Deposit date:2018-10-04
Release date:2019-07-17
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
6MO4
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CO-CRYSTAL STRUCTURE OF P. AERUGINOSA LPXC-50067 COMPLEX
Descriptor:UDP-3-O-acyl-N-acetylglucosamine deacetylase, MAGNESIUM ION, N-[(2R)-1-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-1-oxobutan-2-yl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide
Authors:Stein, A.J., Assar, Z., Holt, M.C., Cohen, F., Andrews, L., Cirz, R.
Deposit date:2018-10-04
Release date:2019-07-17
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.844 Å)
Cite:Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
6LM3
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NEUTRALIZATION MECHANISM OF A MONOCLONAL ANTIBODY TARGETING A PORCINE CIRCOVIRUS TYPE 2 CAP PROTEIN CONFORMATIONAL EPITOPE
Descriptor:Capsid protein
Authors:Sun, Z., Huang, L., Xia, D., Wei, Y., Sun, E., Zhu, H., Bian, H., Wu, H., Feng, L., Wang, J., Liu, C.
Deposit date:2019-12-24
Release date:2020-02-12
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
6L62
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NEUTRALIZATION MECHANISM OF A MONOCLONAL ANTIBODY TARGETING A PORCINE CIRCOVIRUS TYPE 2 CAP PROTEIN CONFORMATIONAL EPITOPE
Descriptor:Light chain of Fab fragment, Heavy chain of Fab fragment, Capsid protein
Authors:Sun, Z., Huang, L., Xia, D., Wei, Y., Sun, E., Zhu, H., Bian, H., Wu, H., Feng, L., Wang, J., Liu, C.
Deposit date:2019-10-25
Release date:2020-02-12
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
6KSQ
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MIDDLE DOMAIN OF HUMAN HSP90 ALPHA
Descriptor:Heat shock protein HSP 90-alpha
Authors:Su, H.X., Zhou, C., Zhang, N.X., Xu, Y.C.
Deposit date:2019-08-25
Release date:2020-02-26
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone.
Iscience, 23, 2020
6KE3
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CRYSTAL STRUCTURE OF THE ALPHA BATA HETERODIMER OF HUMAN IDH3 IN COMPLEX WITH NADH
Descriptor:Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit beta, ...
Authors:Sun, P., Ding, J.
Deposit date:2019-07-03
Release date:2019-09-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.307 Å)
Cite:Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase.
J.Biol.Chem., 294, 2019
6KDY
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CRYSTAL STRUCTURE OF THE ALPHA BATA HETERODIMER OF HUMAN IDH3 IN COMPLEX WITH NAD.
Descriptor:Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit beta, ...
Authors:Sun, P., Ding, J.
Deposit date:2019-07-03
Release date:2019-09-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase.
J.Biol.Chem., 294, 2019
6KDF
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CRYSTAL STRUCTURE OF THE ALPHA BETA HETERODIMER OF HUMAN IDH3 IN APO FORM.
Descriptor:Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit beta
Authors:Sun, P., Ding, J.
Deposit date:2019-07-02
Release date:2019-09-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase.
J.Biol.Chem., 294, 2019
6KDE
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CRYSTAL STRUCTURE OF THE ALPHA BETA HETERODIMER OF HUMAN IDH3 IN COMPLEX WITH CA(2+)
Descriptor:Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit beta, ...
Authors:Sun, P., Ding, J.
Deposit date:2019-07-02
Release date:2019-09-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.999 Å)
Cite:Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase.
J.Biol.Chem., 294, 2019
6JLQ
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CRYSTAL STRUCTURE OF HUMAN USP46-WDR48-WDR20 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, WD repeat-containing protein 20,highly similar to WD repeat protein 20,WD repeat-containing protein 20, ...
Authors:Zhu, H., Zhang, T., Ding, J.
Deposit date:2019-03-06
Release date:2019-07-10
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Structural insights into the activation of USP46 by WDR48 and WDR20.
Cell Discov, 5, 2019
6IKM
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CRYSTAL STRUCTURE OF SPUE-SPERMIDINE IN COMPLEX WITH SCFV5
Descriptor:Polyamine transport protein, ScFv5, SULFATE ION, ...
Authors:Wu, D., Sun, X.
Deposit date:2018-10-16
Release date:2019-12-25
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.398 Å)
Cite:A Potent Anti-SpuE Antibody Allosterically Inhibits Type III Secretion System and Attenuates Virulence of Pseudomonas Aeruginosa.
J.Mol.Biol., 431, 2019
6HQV
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PENTAFUNCTIONAL AROM COMPLEX FROM CHAETOMIUM THERMOPHILUM
Descriptor:Pentafunctional AROM polypeptide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION, ...
Authors:Arora Verasto, H., Hartmann, M.D.
Deposit date:2018-09-25
Release date:2020-05-06
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Architecture and functional dynamics of the pentafunctional AROM complex.
Nat.Chem.Biol., 2020
167327
数据于2020-08-05公开中