6M3C
| hAPC-h1573 Fab complex | Descriptor: | Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, h1573 Fab H chain, ... | Authors: | Wang, X, Wang, D, Zhao, X, Egner, U. | Deposit date: | 2020-03-03 | Release date: | 2020-07-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. Nat Commun, 11, 2020
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6M3B
| hAPC-c25k23 Fab complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, ... | Authors: | Wang, X, Li, L, Zhao, X, Egner, U. | Deposit date: | 2020-03-03 | Release date: | 2020-07-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. Nat Commun, 11, 2020
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3RJX
| Crystal Structure of Hyperthermophilic Endo-Beta-1,4-glucanase | Descriptor: | Endoglucanase FnCel5A | Authors: | Zheng, B.S, Yang, W, Zhao, X.Y, Wang, Y.G, Lou, Z.Y, Rao, Z.H, Feng, Y. | Deposit date: | 2011-04-15 | Release date: | 2011-12-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of hyperthermophilic endo-beta-1,4-glucanase: implications for catalytic mechanism and thermostability. J.Biol.Chem., 287, 2012
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8HQN
| Activation mechanism of GPR132 by 9(S)-HODE | Descriptor: | (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HQE
| Cryo-EM structure of the apo-GPR132-Gi | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HQM
| Activation mechanism of GPR132 by NPGLY | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HVI
| Activation mechanism of GPR132 by compound NOX-6-7 | Descriptor: | 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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