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2KKF
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BU of 2kkf by Molmil
Solution structure of MLL CXXC domain in complex with palindromic CPG DNA
Descriptor: 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', Histone-lysine N-methyltransferase HRX, ZINC ION
Authors:Cierpicki, T, Riesbeck, J.E, Grembecka, J.E, Lukasik, S.M, Popovic, R, Omonkowska, M, Shultis, D.S, Zeleznik-Le, N.J, Bushweller, J.H.
Deposit date:2009-06-18
Release date:2009-12-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.
Nat.Struct.Mol.Biol., 17, 2010
6B7G
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BU of 6b7g by Molmil
Solution NMR structure of BCoR in complex with AF9 (BCoR-AF9)
Descriptor: BCL-6 corepressor, Protein AF-9
Authors:Schmidt, C.R, Kuntimaddi, A, Leach, B.I, Bushweller, J.H.
Deposit date:2017-10-04
Release date:2018-10-10
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity.
Blood Cancer Discov, 1, 2020
2MV7
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BU of 2mv7 by Molmil
Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9)
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, Protein AF-9
Authors:Kuntimaddi, A, Bushweller, J.H.
Deposit date:2014-09-24
Release date:2015-04-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential.
Cell Rep, 11, 2015
1JSP
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BU of 1jsp by Molmil
NMR Structure of CBP Bromodomain in complex with p53 peptide
Descriptor: CREB-BINDING PROTEIN, tumor protein p53
Authors:He, Y, Mujtaba, S, Zeng, L, Yan, S, Zhou, M.-M.
Deposit date:2001-08-17
Release date:2002-08-17
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
2JYI
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BU of 2jyi by Molmil
Solution structure of MLL CXXC domain
Descriptor: ZINC ION, Zinc finger protein HRX
Authors:Cierpicki, T, Bushweller, J.H.
Deposit date:2007-12-13
Release date:2008-12-09
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity
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