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3QX3
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND ETOPOSIDE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Farh, L., Lin, L.Y., Lin, T.S., Yu, Y.J., Yen, T.J., Chiang, C.W., Chan, N.L.
Deposit date:2011-03-01
Release date:2011-07-06
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333, 2011
4KBY
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MSTING/C-DI-GMP
Descriptor:Stimulator of interferon genes protein, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Chin, K.H., Su, Y.C., Tu, J.L., Chou, S.H.
Deposit date:2013-04-24
Release date:2013-05-29
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
Acta Crystallogr.,Sect.D, 69, 2013
4KC0
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MSTING
Descriptor:Stimulator of interferon genes protein
Authors:Chin, K.H., Su, Y.C., Tu, J.L., Chou, S.H.
Deposit date:2013-04-24
Release date:2013-05-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
Acta Crystallogr.,Sect.D, 69, 2013
4MD6
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CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH INHIBITOR 5R
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, ...
Authors:Cui, W., Huang, M., Shao, Y., Luo, H.
Deposit date:2013-08-22
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure.
Biochem Pharmacol, 89, 2014
4ZGY
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STRUCTURE OF HUMAN ORNITHINE DECARBOXYLASE IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
Descriptor:Ornithine decarboxylase, Ornithine decarboxylase antizyme 1, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Wu, H.Y., Chan, N.L.
Deposit date:2015-04-24
Release date:2015-09-02
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZGZ
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STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
Descriptor:Antizyme inhibitor 1, Ornithine decarboxylase antizyme 1
Authors:Chen, S.F., Wu, H.Y., Chan, N.L.
Deposit date:2015-04-24
Release date:2015-09-02
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (5.81 Å)
Cite:Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
5ZEN
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH DNA: A NEW QUATERNARY CONFORMATION SHOWING OPENING OF THE PROTEIN-LINKED DNA-GATE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Chen, S.F., Wang, Y.R., Chan, N.L.
Deposit date:2018-02-27
Release date:2018-08-08
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5ZQF
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5-IODOURIDINE-CONTAINING-DNA IN SPACE GROUP P3221
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-D(P*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ...
Authors:Chen, S.F., Wang, Y.R., Chan, N.L.
Deposit date:2018-04-18
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.873 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5ZRF
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5-IODOURIDINE-CONTAINING-DNA AND ETOPOSIDE IN SPACE GROUP P21
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ...
Authors:Chen, S.F., Wang, Y.R., Wu, C.C., Chan, N.L.
Deposit date:2018-04-24
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018