4GJP | | CRYSTAL STRUCTURE OF THE TAL EFFECTOR DHAX3 BOUND TO DSDNA CONTAINING REPETITIVE METHYL-CPG | | 分子名称: | Hax3, DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*(5CM)P*GP*(5CM)P*GP*TP*CP*TP*CP*T)-3'), DNA (5'-D(*AP*GP*AP*GP*AP*CP*GP*CP*GP*AP*AP*GP*GP*GP*AP*CP*A)-3'), ... | | 著者 | Yan, N., Deng, D., Yan, C.Y., Yin, P., Pan, X.J., Shi, Y.G. | | 登録日 | 2012-08-10 | | 公開日 | 2012-10-03 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Crystal structure of a protein complex
To be Published
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4GJR | | CRYSTAL STRUCTURE OF THE TAL EFFECTOR DHAX3 BOUND TO METHYLATED DSDNA | | 分子名称: | Hax3, DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*(5CM)P*TP*AP*(5CM)P*CP*TP*CP*(5CM)P*CP*T)-3'), DNA (5'-D(*AP*GP*GP*GP*AP*GP*GP*TP*AP*GP*AP*GP*GP*GP*AP*CP*A)-3') | | 著者 | Yan, N., Deng, D., Yan, C.Y., Yin, P., Pan, X.J., Shi, Y.G. | | 登録日 | 2012-08-10 | | 公開日 | 2012-10-03 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of a protein complex
To be Published
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1SDZ | | CRYSTAL STRUCTURE OF DIAP1 BIR1 BOUND TO A REAPER PEPTIDE | | 分子名称: | Apoptosis 1 inhibitor, Reaper, ZINC ION | | 著者 | Yan, N., Wu, J.W., Shi, Y. | | 登録日 | 2004-02-15 | | 公開日 | 2004-04-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
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1SE0 | | CRYSTAL STRUCTURE OF DIAP1 BIR1 BOUND TO A GRIM PEPTIDE | | 分子名称: | Apoptosis 1 inhibitor, Cell death protein Grim, ZINC ION | | 著者 | Yan, N., Wu, J.W., Shi, Y. | | 登録日 | 2004-02-15 | | 公開日 | 2004-04-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
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1TY4 | | CRYSTAL STRUCTURE OF A CED-9/EGL-1 COMPLEX | | 分子名称: | Apoptosis regulator ced-9, EGg Laying defective EGL-1, programmed cell death activator | | 著者 | Yan, N., Gu, L., Kokel, D., Xue, D., Shi, Y. | | 登録日 | 2004-07-07 | | 公開日 | 2004-09-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4
Mol.Cell, 15, 2004
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2A5Y | | STRUCTURE OF A CED-4/CED-9 COMPLEX | | 分子名称: | Apoptosis regulator ced-9, ced-4, MAGNESIUM ION, ... | | 著者 | Yan, N., Liu, Q., Hao, Q., Gu, L., Shi, Y. | | 登録日 | 2005-07-01 | | 公開日 | 2005-10-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.
Nature, 437, 2005
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2FP3 | |
4GC0 | | THE STRUCTURE OF THE MFS (MAJOR FACILITATOR SUPERFAMILY) PROTON:XYLOSE SYMPORTER XYLE BOUND TO 6-BROMO-6-DEOXY-D-GLUCOSE | | 分子名称: | D-xylose-proton symporter, 6-bromo-6-deoxy-beta-D-glucopyranose, nonyl beta-D-glucopyranoside | | 著者 | Yan, N., Sun, L.F., Zeng, X., Yan, C.Y. | | 登録日 | 2012-07-28 | | 公開日 | 2012-10-17 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
Nature, 490, 2012
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3NEF | | HIGH-RESOLUTION PYRABACTIN-BOUND PYL1 STRUCTURE | | 分子名称: | Abscisic acid receptor PYL1, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide | | 著者 | Yan, N. | | 登録日 | 2010-06-08 | | 公開日 | 2010-06-16 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Functional mechanism of the ABA agonist pyrabactin
J.Biol.Chem., 285, 2010
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3NEG | |
3NR4 | | PYRABACTIN-BOUND PYL2 | | 分子名称: | Abscisic acid receptor PYL2, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide | | 著者 | Yan, N. | | 登録日 | 2010-06-30 | | 公開日 | 2010-07-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | | 主引用文献 | Single amino acid alteration between Valine and Isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2
J.Biol.Chem., 285, 2010
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6P2J | | DIMERIC STRUCTURE OF ACAT1 | | 分子名称: | Sterol O-acyltransferase 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | | 著者 | Yan, N., Qian, H.W. | | 登録日 | 2019-05-21 | | 公開日 | 2020-05-20 | | 最終更新日 | 2020-06-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for catalysis and substrate specificity of human ACAT1.
Nature, 581, 2020
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6P2P | | TETRAMERIC STRUCTURE OF ACAT1 | | 分子名称: | Sterol O-acyltransferase 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | | 著者 | Yan, N., Qian, H.W. | | 登録日 | 2019-05-21 | | 公開日 | 2020-05-20 | | 最終更新日 | 2020-06-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for catalysis and substrate specificity of human ACAT1.
Nature, 581, 2020
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6DMB | | CRYO-EM STRUCTURE OF HUMAN PTCH1 | | 分子名称: | Protein patched homolog 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N., Gong, X., Qian, H.W. | | 登録日 | 2018-06-04 | | 公開日 | 2018-07-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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6DMO | |
6DMY | | CRYO-EM STRUCTURE OF HUMAN PTCH1 AND SHHN COMPLEX | | 分子名称: | Protein patched homolog 1, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N., Gong, X., Qian, H.W. | | 登録日 | 2018-06-05 | | 公開日 | 2018-07-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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6KZO | | MEMBRANE PROTEIN | | 分子名称: | Voltage-dependent T-type calcium channel subunit alpha-1G, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N. | | 登録日 | 2019-09-25 | | 公開日 | 2019-12-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576, 2019
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6KZP | | CALCIUM CHANNEL-LIGAND | | 分子名称: | Voltage-dependent T-type calcium channel subunit alpha-1G,Voltage-dependent T-type calcium channel subunit alpha-1G, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N. | | 登録日 | 2019-09-25 | | 公開日 | 2019-12-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576, 2019
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6N7G | | CRYO-EM STRUCTURE OF TETRAMERIC PTCH1 IN COMPLEX WITH SHHNP (FORM I) | | 分子名称: | Protein patched homolog 1, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N., Gong, X., Qian, H.W. | | 登録日 | 2018-11-27 | | 公開日 | 2019-05-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | | 主引用文献 | Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Nat Commun, 10, 2019
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6N7H | | CRYO-EM STRUCTURE OF THE 2:1 HPTCH1-SHHP COMPLEX | | 分子名称: | Protein patched homolog 1, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N., Gong, X., Qian, H.W. | | 登録日 | 2018-11-27 | | 公開日 | 2019-05-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Nat Commun, 10, 2019
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6N7K | | CRYO-EM STRUCTURE OF TETRAMERIC PTCH1 IN COMPLEX WITH SHHNP (FORM II) | | 分子名称: | Protein patched homolog 1, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N., Gong, X., Qian, H.W. | | 登録日 | 2018-11-27 | | 公開日 | 2019-05-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Nat Commun, 10, 2019
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6VWX | | NACHBAC IN LIPID NANODISC | | 分子名称: | BH1501 protein, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION | | 著者 | Yan, N., Gao, S. | | 登録日 | 2020-02-20 | | 公開日 | 2020-06-24 | | 最終更新日 | 2020-07-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VX3 | | NACHBAC IN GDN | | 分子名称: | BH1501 protein, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | | 著者 | Yan, N., Gao, S. | | 登録日 | 2020-02-21 | | 公開日 | 2020-06-24 | | 最終更新日 | 2020-07-08 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VXO | | NACHBAC-NAV1.7VSDII CHIMERA IN NANODISC | | 分子名称: | NaChBac-Nav1.7VSDII chimera, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | | 著者 | Yan, N., Gao, S. | | 登録日 | 2020-02-22 | | 公開日 | 2020-06-24 | | 最終更新日 | 2020-07-08 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6W5R | | NPC1 STRUCTURE IN NANODISC | | 分子名称: | NPC intracellular cholesterol transporter 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N., Qian, H.W., Wu, X.L. | | 登録日 | 2020-03-13 | | 公開日 | 2020-06-17 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2.
Cell, 182, 2020
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