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6GYP
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CRYO-EM STRUCTURE OF THE CBF3-CORE-NDC10-DBD COMPLEX OF THE BUDDING YEAST KINETOCHORE
Descriptor:Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1, ...
Authors:Yan, K., Zhang, Z., Yang, J., McLaughlin, S.H., Barford, D.
Deposit date:2018-07-01
Release date:2018-12-05
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Architecture of the CBF3-centromere complex of the budding yeast kinetochore.
Nat. Struct. Mol. Biol., 25, 2018
6GYS
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CRYO-EM STRUCTURE OF THE CBF3-CEN3 COMPLEX OF THE BUDDING YEAST KINETOCHORE
Descriptor:Centromere DNA-binding protein complex CBF3 subunit C, Centromere DNA-binding protein complex CBF3 subunit B, Suppressor of kinetochore protein 1, ...
Authors:Yan, K., Zhang, Z., Yang, J., McLaughlin, S.H., Barford, D.
Deposit date:2018-07-01
Release date:2018-12-05
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Architecture of the CBF3-centromere complex of the budding yeast kinetochore.
Nat. Struct. Mol. Biol., 25, 2018
6GYU
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CRYO-EM STRUCTURE OF THE CBF3-MSK COMPLEX OF THE BUDDING YEAST KINETOCHORE
Descriptor:Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1, ...
Authors:Yan, K., Zhang, Z., Yang, J., McLaughlin, S.H., Barford, D.
Deposit date:2018-07-02
Release date:2018-12-05
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Architecture of the CBF3-centromere complex of the budding yeast kinetochore.
Nat. Struct. Mol. Biol., 25, 2018
6QLD
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STRUCTURE OF INNER KINETOCHORE CCAN-CENP-A COMPLEX
Descriptor:Inner kinetochore subunit MIF2, DNA (125-MER), Inner kinetochore subunit MCM16, ...
Authors:Yan, K., Yang, J., Zhang, Z., McLaughlin, S.H., Chang, L., Fasci, D., Heck, A.J.R., Barford, D.
Deposit date:2019-01-31
Release date:2019-10-02
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (4.15 Å)
Cite:Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.
Nature, 574, 2019
6QLE
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STRUCTURE OF INNER KINETOCHORE CCAN COMPLEX
Descriptor:Central kinetochore subunit MCM16,Central kinetochore subunit MCM16,Inner kinetochore subunit MCM16,Mcm16p, Central kinetochore subunit CTF3,Inner kinetochore subunit CTF3,Central kinetochore subunit CTF3,Inner kinetochore subunit CTF3, Inner kinetochore subunit MCM22,Inner kinetochore subunit MCM22,Inner kinetochore subunit MCM22,Inner kinetochore subunit MCM22, ...
Authors:Yan, K., Yang, J., Zhang, Z., McLaughlin, S.H., Chang, L., Fasci, D., Heck, A.J.R., Barford, D.
Deposit date:2019-01-31
Release date:2019-10-02
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.
Nature, 574, 2019
6QLF
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STRUCTURE OF INNER KINETOCHORE CCAN COMPLEX WITH MASK1
Descriptor:Inner kinetochore subunit IML3, Inner kinetochore subunit CHL4, Inner kinetochore subunit MCM21, ...
Authors:Yan, K., Yang, J., Zhang, Z., McLaughlin, S.H., Chang, L., Fasci, D., Heck, A.J.R., Barford, D.
Deposit date:2019-01-31
Release date:2019-10-02
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.
Nature, 574, 2019
2L5C
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SOLUTION STRUCTURES OF HUMAN PIWI-LIKE 1 PAZ DOMAIN
Descriptor:Piwi-like protein 1
Authors:Zeng, L., Zhang, Q., Yan, K., Zhou, M.
Deposit date:2010-10-29
Release date:2011-04-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
2L5D
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SOLUTION STRUCTURES OF HUMAN PIWI-LIKE 1 PAZ DOMAIN WITH SSRNA (5'-PUGACA)
Descriptor:Piwi-like protein 1, 5'-R(*UP*GP*AP*CP*A)-3'
Authors:Zeng, L., Zhang, Q., Yan, K., Zhou, M.
Deposit date:2010-10-29
Release date:2011-04-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
3J8G
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ELECTRON CRYO-MICROSCOPY STRUCTURE OF ENGA BOUND WITH THE 50S RIBOSOMAL SUBUNIT
Descriptor:5S rRNA, 23S rRNA, 50S ribosomal protein L28, ...
Authors:Zhang, X., Yan, K., Zhang, Y., Li, N., Ma, C., Li, Z., Zhang, Y., Feng, B., Liu, J., Sun, Y., Xu, Y., Lei, J., Gao, N.
Deposit date:2014-10-24
Release date:2014-11-26
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly
Nucleic Acids Res., 2014
3JCD
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STRUCTURE OF ESCHERICHIA COLI EF4 IN POSTTRANSLOCATIONAL RIBOSOMES (POST EF4)
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3JCE
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STRUCTURE OF ESCHERICHIA COLI EF4 IN PRETRANSLOCATIONAL RIBOSOMES (PRE EF4)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
5H4P
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STRUCTURAL SNAPSHOT OF CYTOPLASMIC PRE-60S RIBOSOMAL PARTICLES BOUND WITH NMD3, LSG1, TIF6 AND REH1
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Ma, C., Wu, S., Li, N., Chen, Y., Yan, K., Li, Z., Zheng, L., Lei, J., Woolford, J.L., Gao, N.
Deposit date:2016-11-01
Release date:2017-01-25
Last modified:2017-06-14
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1
Nat. Struct. Mol. Biol., 24, 2017
3JBU
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MECHANISMS OF RIBOSOME STALLING BY SECM AT MULTIPLE ELONGATION STEPS
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, J., Pan, X.J., Yan, K.G., Sun, S., Gao, N., Sui, S.F.
Deposit date:2015-10-16
Release date:2016-01-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Mechanisms of ribosome stalling by SecM at multiple elongation steps
Elife, 4, 2015
3JBV
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MECHANISMS OF RIBOSOME STALLING BY SECM AT MULTIPLE ELONGATION STEPS
Descriptor:RNA (1530-MER), 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Zhang, J., Pan, X.J., Yan, K.G., Sun, S., Gao, N., Sui, S.F.
Deposit date:2015-10-16
Release date:2016-01-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Mechanisms of ribosome stalling by SecM at multiple elongation steps
Elife, 4, 2015
3JCT
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CRYO-EM STRUCTURE OF EUKARYOTIC PRE-60S RIBOSOMAL SUBUNITS
Descriptor:60S ribosomal protein L2-A, 60S ribosomal protein L3, 60S ribosomal protein L4-A, ...
Authors:Wu, S., Kumcuoglu, B., Yan, K.G., Brown, H., Zhang, Y.X., Tan, D., Gamalinda, M., Yuan, Y., Li, Z.F., Jakovljevic, J., Ma, C.Y., Lei, J.L., Dong, M.Q., Woolford Jr., J.L., Gao, N.
Deposit date:2016-03-09
Release date:2016-06-01
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes
Nature, 534, 2016
5ERC
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X-RAY CRYSTAL STRUCTURE OF BRPF1 PZP DOMAIN
Descriptor:Peregrin, ZINC ION, CALCIUM ION
Authors:Klein, B.J., Andrews, F.H., Kutateladze, T.G.
Deposit date:2015-11-13
Release date:2015-12-30
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.
Nucleic Acids Res., 44, 2016
5UK8
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THE CO-STRUCTURE OF (R)-4-(6-(1-(CYCLOPROPYLSULFONYL)CYCLOPROPYL)-2-(1H-INDOL-4-YL)PYRIMIDIN-4-YL)-3-METHYLMORPHOLINE AND A RATIONALLY DESIGNED PI3K-ALPHA MUTANT THAT MIMICS ATR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine
Authors:Knapp, M.S., Mamo, M., Elling, R.A.
Deposit date:2017-01-20
Release date:2017-06-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors.
J. Mol. Biol., 429, 2017
5UKJ
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THE CO-STRUCTURE OF N,N-DIMETHYL-4-[(6R)-6-METHYL-5-(1H-PYRROLO[2,3- B]PYRIDIN-4-YL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5- A]PYRAZIN-3-YL]BENZENESULFONAMIDE AND A RATIONALLY DESIGNED PI3K-ALPHA MUTANT THAT MIMICS ATR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide
Authors:Knapp, M.S., Elling, R.A., Mamo, M.
Deposit date:2017-01-23
Release date:2017-05-10
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors.
J. Mol. Biol., 429, 2017
5UL1
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THE CO-STRUCTURE OF 3-AMINO-6-(4-((1-(DIMETHYLAMINO)PROPAN-2-YL)SULFONYL)PHENYL)-N-PHENYLPYRAZINE-2-CARBOXAMIDE AND A RATIONALLY DESIGNED PI3K-ALPHA MUTANT THAT MIMICS ATR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-amino-6-(4-{[(2S)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-N-phenylpyrazine-2-carboxamide
Authors:Knapp, M.S., Elling, R.A., Mamo, M.
Deposit date:2017-01-23
Release date:2017-05-10
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors.
J. Mol. Biol., 429, 2017
5GPN
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ARCHITECTURE OF MAMMALIAN RESPIRASOME
Descriptor:Cytochrome b-c1 complex subunit 1, mitochondrial, Cytochrome b-c1 complex subunit 2, ...
Authors:Gu, J., Wu, M., Guo, R., Yang, M.
Deposit date:2016-08-03
Release date:2017-04-05
Last modified:2017-04-12
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:The architecture of the mammalian respirasome.
Nature, 537, 2016