Author results

6OPK
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PHOSPHORYLATED ERK2 WITH VERTEX-11E
Descriptor:Mitogen-activated protein kinase 1, 4-{2-[(2-chloro-4-fluorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
Authors:Vigers, G.P., Rudolph, J.
Deposit date:2019-04-25
Release date:2019-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OPI
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PHOSPHORYLATED ERK2 WITH SCH-CPD336
Descriptor:Mitogen-activated protein kinase 1, (3R)-N-[3-(2-cyclopropylpyridin-4-yl)-1H-indazol-5-yl]-3-(methoxymethyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}ethyl)pyrrolidine-3-carboxamide
Authors:Vigers, G.P., Smith, D.
Deposit date:2019-04-25
Release date:2019-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OPH
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PHOSPHORYLATED ERK2 WITH GDC-0994
Descriptor:Mitogen-activated protein kinase 1, 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one
Authors:Vigers, G.P., Smith, D.
Deposit date:2019-04-25
Release date:2019-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OPG
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PHOSPHORYLATED ERK2 WITH AMP-PNP
Descriptor:Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Vigers, G.P., Smith, D.
Deposit date:2019-04-25
Release date:2019-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
6N4O
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HUMAN ARGONAUTE2-MIR-122 BOUND TO A SEED AND SUPPLEMENTARY PAIRED TARGET
Descriptor:Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3'), RNA (5'-R(*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3')
Authors:Sheu-Gruttadauria, J., MacRae, I.J.
Deposit date:2018-11-19
Release date:2019-05-08
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2.
Embo J., 38, 2019
6N13
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UBCH7-UB COMPLEX WITH R0RBR PARKIN AND PHOSPHOUBIQUITIN
Descriptor:E3 ubiquitin-protein ligase parkin, ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Condos, T.E.C., Dunkerley, K.M., Freeman, E.A., Barber, K.R., Aguirre, J.D., Chaugule, V.K., Xiao, Y., Konermann, L., Walden, H., Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2018-12-12
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018
6J7M
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COMPLEX STRUCTURE OF THE PSEUDOMONAS AERUGINOSA RHAMNOSYLTRANSFERASE EARP WITH THE ACCEPTOR ELONGATION FACTOR EF-P
Descriptor:Earp, Elongation factor P, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:He, C., Li, F.
Deposit date:2019-01-18
Release date:2019-05-15
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.
J.Bacteriol., 201, 2019
6J7L
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA EARP IN COMPLEX WITH TDP
Descriptor:Pseudomonas aeruginosa Earp, THYMIDINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Li, F.
Deposit date:2019-01-18
Release date:2019-05-15
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.
J.Bacteriol., 201, 2019
6J7K
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA EARP IN COMPLEX WITH TDP-RHA
Descriptor:Pseudomonas aeruginosa Earp, 2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Li, F.
Deposit date:2019-01-18
Release date:2019-05-15
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.
J.Bacteriol., 201, 2019
6J7J
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA EARP
Descriptor:Pseudomonas aeruginosa Earp, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:He, C., Li, F.
Deposit date:2019-01-18
Release date:2019-05-15
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.
J.Bacteriol., 201, 2019
6J2P
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE SPP1 IN COMPLEX WITH H3K4ME3
Descriptor:COMPASS component SPP1, Histone H3, ZINC ION
Authors:He, C., Li, F.
Deposit date:2019-01-02
Release date:2019-09-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis for histone H3K4me3 recognition by the N-terminal domain of the PHD finger protein Spp1.
Biochem.J., 476, 2019
6C66
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CRISPR RNA-GUIDED SURVEILLANCE COMPLEX, PRE-NICKING
Descriptor:CRISPR-associated helicase, Cas3 family, CRISPR-associated protein, ...
Authors:Xiao, Y., Luo, M., Liao, M., Ke, A.
Deposit date:2018-01-17
Release date:2018-06-27
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structure basis for RNA-guided DNA degradation by Cascade and Cas3.
Science, 361, 2018
6B4U
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH A BIM COMPETITIVE INHIBITOR
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, 7-(2-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid
Authors:Judge, R.A., Souers, A.J.
Deposit date:2017-09-27
Release date:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J. Med. Chem., 58, 2015
6B4L
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH A BIM COMPETITIVE INHIBITOR
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, 3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid
Authors:Judge, R.A., Souers, A.J.
Deposit date:2017-09-26
Release date:2017-10-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J. Med. Chem., 58, 2015
6A5E
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CRYSTAL STRUCTURE OF PLANT PEPTIDE RALF23 IN COMPLEX WITH FER AND LLG2
Descriptor:Receptor-like protein kinase FERONIA, GPI-anchored protein LLG2, RALF23, ...
Authors:Xiao, Y., Chai, J.
Deposit date:2018-06-23
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2.766 Å)
Cite:Crystal structure of plant peptide RALF23 in complex with FER and LLG2
To Be Published
6A5D
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CRYSTAL STRUCTURE OF PLANT GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEIN LLG1
Descriptor:GPI-anchored protein LLG1, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE
Authors:Xiao, Y., Chai, J.
Deposit date:2018-06-23
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Crystal structure of plant Glycosylphosphatidylinositol-anchored Protein LLG1
To Be Published
6A5C
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CRYSTAL STRUCTURE OF PLANT RECEPTOR-LIKE KINASE ANX2
Descriptor:Receptor-like protein kinase ANXUR2
Authors:Xiao, Y., Chai, J.
Deposit date:2018-06-23
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal structure of plant Receptor-like Kinase ANX2
To Be Published
6A5B
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CRYSTAL STRUCTURE OF PLANT RECEPTOR-LIKE KINASE FER
Descriptor:Receptor-like protein kinase FERONIA
Authors:Xiao, Y., Chai, J.
Deposit date:2018-06-23
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Crystal structure of plant Receptor-like Kinase FER
To Be Published
6A5A
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CRYSTAL STRUCTURE OF PLANT RECEPTOR-LIKE KINASE ANX1
Descriptor:Receptor-like protein kinase ANXUR1
Authors:Xiao, Y., Chai, J.
Deposit date:2018-06-22
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2.942 Å)
Cite:Crystal structure of plant Receptor-like Kinase ANX1
To Be Published
5ZMD
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CRYSTAL STRUCTURE OF FTO IN COMPLEX WITH M6DA MODIFIED SSDNA
Descriptor:Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ...
Authors:Zhang, X., Wei, L.H., Luo, J., Xiao, Y., Liu, J., Zhang, W., Zhang, L., Jia, G.F.
Deposit date:2018-04-02
Release date:2019-04-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5YSW
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CRYSTAL STRUCTURE ANALYSIS OF RIF16 IN COMPLEX WITH R-L
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (2S,12E,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(acetyloxy)-5,6,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-9-yl hydroxyacetate
Authors:Li, F.W., Qi, F.F., Xiao, Y.L., Zhao, G.P., Li, S.Y.
Deposit date:2017-11-15
Release date:2018-07-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Deciphering the late steps of rifamycin biosynthesis.
Nat Commun, 9, 2018
5YSM
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CRYSTAL STRUCTURE ANALYSIS OF RIF16
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Li, F.W., Qi, F.F., Xiao, Y.L., Zhao, G.P., Li, S.Y.
Deposit date:2017-11-14
Release date:2018-07-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Deciphering the late steps of rifamycin biosynthesis.
Nat Commun, 9, 2018
5YJ7
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STRUCTURAL INSIGHT INTO THE BETA-GH1 GLUCOSIDASE BGLN1 FROM OLEAGINOUS MICROALGAE NANNOCHLOROPSIS
Descriptor:Glycoside hydrolase, CALCIUM ION, GLYCEROL
Authors:Dong, S., Liu, Y.J., Zhou, H.X., Xiao, Y., Xu, J., Cui, Q., Wang, X.Q., Feng, Y.G.
Deposit date:2017-10-09
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural insight into the beta-GH1 glucosidase BGLN1 from oleaginous microalgae Nannochloropsis
To Be Published
5XVP
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E. FAE CAS1-CAS2/PRESPACER/TARGET TERNARY COMPLEX REVEALING THE FULLY INTEGRATED STATES
Descriptor:CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (73-MER), ...
Authors:Xiao, Y., Ng, S., Nam, K.H., Ke, A.
Deposit date:2017-06-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017
5XVO
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E. FAE CAS1-CAS2/PRESPACER/TARGET TERNARY COMPLEX REVEALING DNA SAMPLING AND HALF-INTEGRATION STATES
Descriptor:CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Xiao, Y., Ng, S., Nam, K.H., Ke, A.
Deposit date:2017-06-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017