3UB0

Crystal structure of the nonstructural protein 7 and 8 complex of Feline Coronavirus

Summary for 3UB0

• Entry DOI: 10.2210/pdb3ub0/pdb
• Descriptor: Non-structural protein 6, nsp6,, Non-structural protein 7, nsp7 (3 entities in total)
• Functional Keywords: feline coronavirus, nonstructural protein, primer-independent rna polymerase, replication
• Biological source: Feline infectious peritonitis virus (FCoV); More
• Cellular location: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : Q98VG9 Q98VG9
• Total number of polymer chains: 6
• Total formula weight: 83050.12

Authors

Xiao, Y.,Hilgenfeld, R.,Ma, Q. (deposition date: 2011-10-22, release date: 2012-02-22, Last modification date: 2017-11-08)

• Primary citation: Xiao, Y.,Ma, Q.,Restle, T.,Shang, W.,Svergun, D.I.,Ponnusamy, R.,Sczakiel, G.,Hilgenfeld, R.; Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity.; J.Virol., 86:4444-4454, 2012; PubMed: 22318142; DOI: 10.1128/JVI.06635-11

Experimental method

X-RAY DIFFRACTION (2.6 Å)