Author results

6LQI
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CRYO-EM STRUCTURE OF THE MOUSE PIEZO1 ISOFORM PIEZO1.1
Descriptor:Piezo-type mechanosensitive ion channel component 1
Authors:Geng, J., Liu, W., Zhou, H., Zhang, T., Wang, L., Zhang, M., Shen, B., Li, X., Xiao, B.
Deposit date:2020-01-13
Release date:2020-03-04
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.
Neuron, 106, 2020
6KG7
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CRYO-EM STRUCTURE OF THE MAMMALIAN TACTILE CHANNEL PIEZO2
Descriptor:Piezo-type mechanosensitive ion channel component 2, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Wang, L., Zhou, H., Zhang, M., Liu, W., Deng, T., Zhao, Q., Li, Y., Lei, J., Li, X., Xiao, B.
Deposit date:2019-07-11
Release date:2019-09-04
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure and mechanogating of the mammalian tactile channel PIEZO2.
Nature, 573, 2019
6AGF
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STRUCTURE OF THE HUMAN VOLTAGE-GATED SODIUM CHANNEL NAV1.4 IN COMPLEX WITH BETA1
Descriptor:Sodium channel protein type 4 subunit alpha, Sodium channel subunit beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pan, X.J., li, Z.Q., Zhou, Q., Shen, H.Z., Wu, K., Huang, X.S., Chen, J.F., Zhang, J.R., Zhu, X.C., Lei, J.L., Xiong, W., Gong, H.P., Xiao, B.L., Yan, N.
Deposit date:2018-08-11
Release date:2018-10-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta 1.
Science, 362, 2018
6AP9
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CRYSTAL STRUCTURE OF HGSTP1-1 WITH S-NITROSATION OF CYS101
Descriptor:Glutathione S-transferase P, GLUTATHIONE, OXIDIZED GLUTATHIONE DISULFIDE, ...
Authors:Kumari, V., Ji, X.
Deposit date:2017-08-17
Release date:2018-08-22
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Cysteine S-nitrosylation of hGSTP1-1 by nitric oxide (NO)-releasing prodrugs
to be published
5Z10
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STRUCTURE OF THE MECHANOSENSITIVE PIEZO1 CHANNEL
Descriptor:Piezo-type mechanosensitive ion channel component 1
Authors:Zhao, Q., Zhou, H., Chi, S., Wang, Y., Wang, J., Geng, J., Wu, K., Liu, W., Zhang, T., Dong, M.-Q., Wang, J., Li, X., Xiao, B.
Deposit date:2017-12-22
Release date:2018-01-31
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structure and mechanogating mechanism of the Piezo1 channel.
Nature, 554, 2018
5ISO
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STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Xiao, B., Hubbard, J.A., Gamblin, S.J.
Deposit date:2016-03-15
Release date:2017-03-29
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
To Be Published
5JCW
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CRYSTAL STRUCTURE OF HGSTP1-1 WITH GLUTATHIONE ADDUCT OF PHENETHYL ISOTHIOCYANATE
Descriptor:Glutathione S-transferase P, L-gamma-glutamyl-S-[(2-phenylethyl)carbamothioyl]-L-cysteinylglycine, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Kumari, V., Ji, X.
Deposit date:2016-04-15
Release date:2016-10-12
Method:X-RAY DIFFRACTION (1.945 Å)
Cite:Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical.
Plos One, 11, 2016
5IQP
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14-3-3 PROTEIN TAU ISOFORM
Descriptor:14-3-3 protein theta, SULFATE ION
Authors:Xiao, B., Smerdon, S.J., Gamblin, S.J.
Deposit date:2016-03-11
Release date:2016-03-23
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
3JAC
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CRYO-EM STUDY OF A CHANNEL
Descriptor:Piezo-type mechanosensitive ion channel component 1
Authors:Ge, J., Li, W., Zhao, Q., Li, N., Xiao, B., Gao, N., Yang, M.
Deposit date:2015-06-05
Release date:2015-09-23
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Architecture of the mammalian mechanosensitive Piezo1 channel
Nature, 527, 2015
4RAX
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A REGULATORY DOMAIN OF AN ION CHANNEL
Descriptor:Piezo-type mechanosensitive ion channel component 1
Authors:Ge, J., Yang, M.
Deposit date:2014-09-11
Release date:2015-09-23
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Architecture of the mammalian mechanosensitive Piezo1 channel.
Nature, 527, 2015
4CFE
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STRUCTURE OF FULL LENGTH HUMAN AMPK IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
Descriptor:5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B., Sanders, M.J., Carmena, D., Bright, N.J., Haire, L.F., Underwood, E., Patel, B.R., Heath, R.B., Walker, P.A., Hallen, S., Giordanetto, F., Martin, S.R., Carling, D., Gamblin, S.J.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.023 Å)
Cite:Structural Basis of Ampk Regulation by Small Molecule Activators.
Nat.Commun., 4, 2013
4CFF
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STRUCTURE OF FULL LENGTH HUMAN AMPK IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A THIENOPYRIDONE DERIVATIVE (A-769662)
Descriptor:5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B., Sanders, M.J., Carmena, D., Bright, N.J., Haire, L.F., Underwood, E., Patel, B.R., Heath, R.B., Walker, P.A., Hallen, S., Giordanetto, F., Martin, S.R., Carling, D., Gamblin, S.J.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.924 Å)
Cite:Structural Basis of Ampk Regulation by Small Molecule Activators.
Nat.Commun., 4, 2013
4CFH
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STRUCTURE OF AN ACTIVE FORM OF MAMMALIAN AMPK
Descriptor:5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., Saiu, P., Howell, S.A., Aasland, R., Martin, S.R., Carling, D., Gamblin, S.J.
Deposit date:2013-11-18
Release date:2013-12-25
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
3T4N
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STRUCTURE OF THE REGULATORY FRAGMENT OF SACCHAROMYCES CEREVISIAE AMPK IN COMPLEX WITH ADP
Descriptor:Carbon catabolite-derepressing protein kinase, SNF1 protein kinase subunit beta-2, Nuclear protein SNF4, ...
Authors:Mayer, F.V., Heath, R., Underwood, E., Sanders, M.J., Carmena, D., McCartney, R., Leiper, F.C., Xiao, B., Jing, C., Walker, P.A., Haire, L.F., Ogrodowicz, R., Martin, S.R., Schmdit, M.C., Gamblin, S.J., Carling, D.
Deposit date:2011-07-26
Release date:2011-11-09
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
3TDH
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STRUCTURE OF THE REGULATORY FRAGMENT OF SCCHAROMYCES CEREVISIAE AMPK IN COMPLEX WITH AMP
Descriptor:Carbon catabolite-derepressing protein kinase, SNF1 protein kinase subunit beta-2, Nuclear protein SNF4, ...
Authors:Mayer, F.V., Heath, R., Underwood, E., Sanders, M.J., Carmena, D., McCartney, R., Leiper, F.C., Xiao, B., Jing, C., Walker, P.A., Haire, L.F., Ogrodowicz, R., Martin, S.R., Schmidt, M.C., Gamblin, S.J., Carling, D.
Deposit date:2011-08-11
Release date:2011-11-09
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
3TE5
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STRUCTURE OF THE REGULATORY FRAGMENT OF SACCHROMYCES CEREVISIAE AMPK IN COMPLEX WITH NADH
Descriptor:Carbon catabolite-derepressing protein kinase, SNF1 protein kinase subunit beta-2, Nuclear protein SNF4, ...
Authors:Mayer, F.V., Heath, R., Underwood, E., Sanders, M.J., Carmena, D., McCartney, R., Leiper, F.C., Xiao, B., Jing, C., Walker, P.A., Haire, L.F., Ogrodowicz, R., Martin, S.R., Schmidt, M.C., Gamblin, S.J., Carling, D.
Deposit date:2011-08-12
Release date:2011-11-09
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
2Y8L
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STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH TWO ADP
Descriptor:5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., Saiu, P., Howell, S.A., Aasland, R., Martin, S.R., Carling, D., Gamblin, S.J.
Deposit date:2011-02-07
Release date:2011-03-16
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2Y8Q
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STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH ONE ADP
Descriptor:5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., Saiu, P., Howell, S.A., Aasland, R., Martin, S.R., Carling, D., Gamblin, S.J.
Deposit date:2011-02-09
Release date:2011-03-16
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2YA3
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STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP
Descriptor:5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., Saiu, P., Howell, S.A., Aasland, R., Martin, S.R., Carling, D., Gamblin, S.J.
Deposit date:2011-02-17
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
3KUE
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CRYSTAL STRUCTURE OF E. COLI HPPK(E77A)
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION, ACETATE ION
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-11-27
Release date:2010-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.538 Å)
Cite:Roles of residues E77 and H115 in E. coli HPPK
To be Published
3KUG
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CRYSTAL STRUCTURE OF E. COLI HPPK(H115A)
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-11-27
Release date:2010-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Roles of residues E77 and H115 in E. coli HPPK
To be Published
3ILI
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CRYSTAL STRUCTURE OF E. COLI HPPK(D95A)
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-08-07
Release date:2010-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional roles of residues D95 and D97 in E. coli HPPK
To be Published
3ILL
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CRYSTAL STRUCTURE OF E. COLI HPPK(D97A)
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-08-07
Release date:2010-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural and functional roles of residues D95 and D97 in E. coli HPPK
To be Published
3HSD
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CRYSTAL STRUCTURE OF E. COLI HPPK(Y53A)
Descriptor:HPPK, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.652 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK.
To be Published
3HSJ
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CRYSTAL STRUCTURE OF E. COLI HPPK(N55A)
Descriptor:HPPK, ACETATE ION, GLYCEROL
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published
167327
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