Author results

5XAJ
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STRUCTURAL MIMICRY OF THE DENGUE VIRUS ENVELOPE GLYCOPROTEIN REVEALED BY THE CRYSTALLOGRAPHIC STUDY OF AN IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX.
Descriptor:FabHM14c10 heavy chain, FabHM14c10 light chain, Fab E1 light chain, ...
Authors:Wong, Y.H., Goh, B.C., Lescar, J.
Deposit date:2017-03-13
Release date:2017-06-14
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex
J. Virol., 2017
5ZBI
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CRYSTAL STRUCTURE OF ASPARAGINYL ENDOPEPTIDASES FROM VIOLA CANADENSIS
Descriptor:Peptide asparaginyl ligase, SODIUM ION
Authors:Wong, Y.H., Lescar, J.
Deposit date:2018-02-12
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of Peptide asparaginyl ligase from Viola canadensis
To Be Published
5AAM
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STRUCTURE OF A REDESIGNED CROSS-REACTIVE ANTIBODY TO DENGUE VIRUS WITH INCREASED IN VIVO POTENCY
Descriptor:SCFV513, ENVELOPE PROTEIN
Authors:Wong, Y.H., Robinson, L.N., Lescar, J., Sasisekharan, R.
Deposit date:2015-07-27
Release date:2015-08-05
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope.
Cell(Cambridge,Mass.), 162, 2015
5GM8
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ, SINEFUNGIN
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMB
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMC
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5WYQ
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W., McBee, M.E., Maenpuen, S., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M., Chaiyen, P.
Deposit date:2017-01-15
Release date:2017-12-20
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 2019
5WYR
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, SINEFUNGIN
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W.H., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2017-01-15
Release date:2017-12-20
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 2019
6JKI
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, SINEFUNGIN, GLYCEROL, ...
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W.H., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2019-03-01
Release date:2019-07-03
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 2019
5FSW
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RNA DEPENDENT RNA POLYMERASE QDE-1 FROM THIELAVIA TERRESTRIS
Descriptor:RNA DEPENDENT RNA POLYMERASE QDE-1
Authors:Qian, X., Hamid, F.M., El Sahili, A., Darwis, D.A., Wong, Y.H., Bhushan, S., Makeyev, E.V., Lescar, J.
Deposit date:2016-01-08
Release date:2016-03-02
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Functional Evolution in Orthologous Cell-Encoded RNA-Dependent RNA Polymerases
J.Biol.Chem., 291, 2016
5H0I
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NAME TO BE RELEASED WHEN PUBLISHED
Descriptor:Asparaginyl endopeptidase
Authors:Yang, R., Wong, Y.H., Lescar, J., Wu, B.
Deposit date:2016-10-04
Release date:2017-03-29
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Engineering a Catalytically Efficient Recombinant Protein Ligase
J. Am. Chem. Soc., 139, 2017
6ID4
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DEFINING THE STRUCTURAL BASIS FOR HUMAN ALLOANTIBODY BINDING TO HUMAN LEUKOCYTE ANTIGEN ALLELE HLA-A*11:01
Descriptor:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ...
Authors:Lescar, J., Wong, Y.H., Liew, C.W., Gu, Y., MacAry, P.A.
Deposit date:2018-09-08
Release date:2019-02-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.
Nat Commun, 10, 2019
5ZHI
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APO CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:tRNA (guanine-N(1)-)-methyltransferase
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHJ
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH S-ADENOSYL HOMOCYSTEINE (SAH)
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHK
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-[(4-{[cyclohexyl(ethyl)amino]methyl}phenyl)methyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHL
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHM
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(diethylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide, S-ADENOSYLMETHIONINE
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHN
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-27
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
6JOE
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, ~{N}-[[4-[(4-azanylpiperidin-1-yl)methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2,3-d]pyrimidine-5-carboxamide, PHOSPHATE ION, ...
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2019-03-20
Release date:2019-09-04
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
6JOF
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, ~{N}-[[4-[(4-azanylpiperidin-1-yl)methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2019-03-20
Release date:2019-09-04
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
3OUO
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STRUCTURE OF THE NUCLEOPROTEIN FROM RIFT VALLEY FEVER VIRUS
Descriptor:Nucleoprotein, NITRITE ION
Authors:Ferron, F., Danek, E.I., Li, Z., Luo, D., Wong, Y.H., Coutard, B., Lantez, V., Charrel, R., Canard, B., Walz, T., Lescar, J.
Deposit date:2010-09-15
Release date:2011-05-25
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
3OV9
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STRUCTURE OF THE NUCLEOPROTEIN FROM RIFT VALLEY FEVER VIRUS
Descriptor:Nucleoprotein, NITRITE ION, SODIUM ION
Authors:Ferron, F., Danek, E.I., Li, Z., Luo, D., Wong, Y.H., Coutard, B., Lantez, V., Charrel, R., Canard, B., Walz, T., Lescar, J.
Deposit date:2010-09-16
Release date:2011-05-25
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
5AAW
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STRUCTURE OF A REDESIGNED CROSS-REACTIVE ANTIBODY TO DENGUE VIRUS WITH INCREASED IN VIVO POTENCY
Descriptor:SCFV513, DENGUE SEROTYPE 4 ENVELOPE PROTEIN DOMAIN 3
Authors:Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R.
Deposit date:2015-07-30
Release date:2015-09-30
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope.
Cell(Cambridge,Mass.), 162, 2015
5XGB
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CRYSTAL STRUCTURE OF THE PAS-GGDEF-EAL DOMAIN OF PA0861 FROM PSEUDOMONAS AERUGINOSA
Descriptor:Uncharacterized protein
Authors:Liu, C., Liew, C.W., Sreekanth, R., Lescar, J.
Deposit date:2017-04-13
Release date:2017-12-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.
J. Bacteriol., 200, 2018
5XGD
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CRYSTAL STRUCTURE OF THE PAS-GGDEF-EAL DOMAIN OF PA0861 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH GTP
Descriptor:Uncharacterized protein PA0861, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Liu, C., Liew, C.W., Sreekanth, R., Lescar, J.
Deposit date:2017-04-13
Release date:2017-12-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.
J. Bacteriol., 200, 2018
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