Author results

1C5L
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:thrombin, Hirudin, SODIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5M
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (COAGULATION FACTOR X)
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5N
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:Thrombin light chain, Thrombin heavy chain, Hirudin, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5O
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:Thrombin light chain, Thrombin heavy chain, Hirudin, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5P
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, MAGNESIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5Q
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, CHLORIDE ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5R
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CITRATE ANION, CALCIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5S
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, SULFATE ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5T
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5U
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, MAGNESIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5V
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, MAGNESIUM ION
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5W
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5X
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5Y
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5Z
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, BENZAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
2MQ6
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SOLUTION STRUCTURE OF Y125F MUTANT OF ERF1 N-DOMAIN
Descriptor:Eukaryotic peptide chain release factor subunit 1
Authors:Pillay, S., Li, Y., Wong, L., Pervushin, K.
Deposit date:2014-06-12
Release date:2015-06-17
Method:SOLUTION NMR
Cite:Structural insights of eRF1 mutants and their correlation with stop codon recognition
To be Published
2MQ9
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SOLUTION STRUCTURE OF E55Q MUTANT OF ERF1 N-DOMAIN
Descriptor:Eukaryotic peptide chain release factor subunit 1
Authors:Pillay, S., Li, Y., Wong, L., Pervushin, K.
Deposit date:2014-06-13
Release date:2015-07-01
Method:SOLUTION NMR
Cite:Structural insights of eRF1 mutants and their correlation with stop codon recognition
To be Published
2OGU
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CRYSTAL STRUCTURE OF THE ISOLATED MTHK RCK DOMAIN
Descriptor:Calcium-gated potassium channel mthK
Authors:Kuo, M.M.C., Baker, K.A., Wong, L., Choe, S.
Deposit date:2007-01-08
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Dynamic oligomeric conversions of the cytoplasmic RCK domains mediate MthK potassium channel activity.
Proc.Natl.Acad.Sci.Usa, 104, 2007
5ABS
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CRYSTAL STRUCTURE OF THE C-TERMINAL COILED-COIL DOMAIN OF CIN85 IN SPACE GROUP P321
Descriptor:SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1, ZINC ION
Authors:Wong, L., Habeck, M., Griesinger, C., Becker, S.
Deposit date:2015-08-07
Release date:2016-07-13
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:The Adaptor Protein Cin85 Assembles Intracellular Signaling Clusters for B Cell Activation.
Sci.Signal., 9, 2016
1TRB
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CONVERGENT EVOLUTION OF SIMILAR FUNCTION IN TWO STRUCTURALLY DIVERGENT ENZYMES
Descriptor:THIOREDOXIN REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kuriyan, J., Krishna, T.S.R.
Deposit date:1991-09-07
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Convergent evolution of similar function in two structurally divergent enzymes.
Nature, 352, 1991
1WOF
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CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR N1
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Rao, Z.
Deposit date:2004-08-18
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMD
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N9
Descriptor:3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-09
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMP
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CRYSTAL STRUCTURE OF PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS MPRO IN COMPLEX WITH AN INHIBITOR N1
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMQ
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N3
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2D2D
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CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR I2
Descriptor:3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE
Authors:Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Ding, Y., Rao, Z.
Deposit date:2005-09-08
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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