Author results

1YVF
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH INHIBITOR PHA-00729145
Descriptor:HCV NS5B POLYMERASE, PHOSPHATE ION, CHLORIDE ION, ...
Authors:Pfefferkorn, J.A., Greene, M.L., Nugent, R.A., Gross, R.J., Mitchell, M.A., Finzel, B.C., Harris, M.S., Wells, P.A., Shelly, J.A., Anstadt, R.A., Kilkuskie, R.E., Kopta, L.A., Schwende, F.J.
Deposit date:2005-02-15
Release date:2005-04-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid.
Bioorg.Med.Chem.Lett., 15, 2005
1Z4U
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH INHIBITOR PHA-00799585
Descriptor:HCV NS5B POLYMERASE, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Pfefferkorn, J.A., Greene, M., Nugent, R., Gross, R.J., Mitchell, M.A., Finzel, B.C., Harris, M.S., Wells, P.A., Shelly, J.A., Anstadt, R.
Deposit date:2005-03-16
Release date:2005-06-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid
Bioorg.Med.Chem.Lett., 15, 2005
2GV9
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CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 DNA POLYMERASE
Descriptor:DNA polymerase, SULFATE ION, MERCURY (II) ION, ...
Authors:Liu, S.
Deposit date:2006-05-02
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structure of the herpes simplex virus 1 DNA polymerase.
J.Biol.Chem., 281, 2006
3FQM
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CRYSTAL STRUCTURE OF A NOVEL DIMERIC FORM OF HCV NS5A DOMAIN I PROTEIN
Descriptor:Non-structural protein 5A, ZINC ION, GLYCEROL
Authors:Love, R.A.
Deposit date:2009-01-07
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus
J.Virol., 83, 2009
3FQQ
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CRYSTAL STRUCTURE OF A NOVEL DIMERIC FORM OF HCV NS5A DOMAIN I PROTEIN
Descriptor:Non-structural protein 5A, ZINC ION, GLYCEROL, ...
Authors:Love, R.A.
Deposit date:2009-01-07
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus
J.Virol., 83, 2009
3G0E
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KIT KINASE DOMAIN IN COMPLEX WITH SUNITINIB
Descriptor:Mast/stem cell growth factor receptor, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Authors:Gajiwala, K.S., Wu, J.C., Lunney, E.A., Gemetri, G.D.
Deposit date:2009-01-27
Release date:2009-02-24
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Proc.Natl.Acad.Sci.USA, 106, 2009
3G0F
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KIT KINASE DOMAIN MUTANT D816H IN COMPLEX WITH SUNITINIB
Descriptor:Mast/stem cell growth factor receptor, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, SULFATE ION
Authors:Gajiwala, K.S., Wu, J.C., Lunney, E.A., Demetri, G.D.
Deposit date:2009-01-27
Release date:2009-02-24
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Proc.Natl.Acad.Sci.USA, 106, 2009
3ML8
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DISCOVERY OF THE HIGHLY POTENT PI3K/MTOR DUAL INHIBITOR PF-04691502 THROUGH STRUCTURE BASED DRUG DESIGN
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 8-cyclopentyl-6-[3-(hydroxymethyl)phenyl]-4-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Authors:Knighton, D.R.
Deposit date:2010-04-16
Release date:2010-06-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.
ACS Med Chem Lett, 4, 2013
3ML9
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DISCOVERY OF THE HIGHLY POTENT PI3K/MTOR DUAL INHIBITOR PF-04691502 THROUGH STRUCTURE BASED DRUG DESIGN
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Authors:Knighton, D.R.
Deposit date:2010-04-16
Release date:2010-06-02
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.
ACS Med Chem Lett, 4, 2013
4HVB
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CATALYTIC UNIT OF PI3KG IN COMPLEX WITH PI3K/MTOR DUAL INHIBITOR PF-04979064
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-3-methyl-8-(6-methylpyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
Authors:Knighton, D.R., Cheng, H.
Deposit date:2012-11-05
Release date:2013-11-20
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.
ACS Med Chem Lett, 4, 2013
5UGH
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CRYSTAL STRUCTURE OF MAT2A BOUND TO THE ALLOSTERIC INHIBITOR PF-02929366
Descriptor:S-adenosylmethionine synthase isoform type-2, 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
Authors:Kaiser, S.E., Feng, J., Stewart, A.E.
Deposit date:2017-01-08
Release date:2017-05-17
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.062 Å)
Cite:Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
Nat. Chem. Biol., 13, 2017