Author results

2JBH
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HUMAN PHOSPHORIBOSYL TRANSFERASE DOMAIN CONTAINING 1
Descriptor:PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1, PHOSPHATE ION, CALCIUM ION, ...
Authors:Welin, M., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Eklund, H., Ericsson, U.B., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Nordlund, P.
Deposit date:2006-12-07
Release date:2006-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Functional Studies of the Human Phosphoribosyltransferase Domain Containing Protein 1.
FEBS J., 277, 2010
2UW2
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CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE SUBUNIT R2
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M2 SUBUNIT, FE (III) ION
Authors:Welin, M., Ogg, D., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Kotenyova, T., Magnusdottir, A., Moche, M., Nilsson-Ehle, P., Nyman, T., Persson, C., Sagemark, J., Sundstrom, M., Stenmark, P., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Wallden, K., Weigelt, J., Nordlund, P.
Deposit date:2007-03-16
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Ribonucleotide Reductase Subunit R2
To be Published
2V40
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HUMAN ADENYLOSUCCINATE SYNTHETASE ISOZYME 2 IN COMPLEX WITH GDP
Descriptor:ADENYLOSUCCINATE SYNTHETASE ISOZYME 2, GUANOSINE-5'-DIPHOSPHATE
Authors:Welin, M., Moche, M., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Tresaugues, L., van den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2007-06-27
Release date:2007-07-10
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human Adenylosuccinate Synthetase Isozyme 2 in Complex with Gdp
To be Published
2V4U
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HUMAN CTP SYNTHETASE 2 - GLUTAMINASE DOMAIN IN COMPLEX WITH 5-OXO-L- NORLEUCINE
Descriptor:CTP SYNTHASE 2
Authors:Welin, M., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wisniewska, M., Weigelt, J., Wikstrom, M., Nordlund, P.
Deposit date:2008-09-29
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Human Ctp Synthetase 2 - Glutaminase Domain in Complex with 5-Oxo-L-Norleucine
To be Published
2V9Y
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HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE
Descriptor:PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE, SULFATE ION
Authors:Welin, M., Lehtio, L., Arrowsmith, C.H., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Herman, M.D., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Tresaugues, L., van den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2007-08-28
Release date:2007-09-11
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Studies of Tri-Functional Human Gart.
Nucleic Acids Res., 38, 2010
2VKT
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HUMAN CTP SYNTHETASE 2 - GLUTAMINASE DOMAIN
Descriptor:CTP SYNTHASE 2
Authors:Welin, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Svensson, L., Thorsell, A.G., van den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2007-12-28
Release date:2008-01-15
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human Ctp Synthetase 2 - Glutaminase Domain
To be Published
2VPI
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HUMAN GMP SYNTHETASE - GLUTAMINASE DOMAIN
Descriptor:GMP SYNTHASE
Authors:Welin, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Svensson, L., Thorsell, A.G., Van Der Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-02-29
Release date:2008-03-11
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human Gmp Synthetase - Glutaminase Domain
To be Published
2VR2
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HUMAN DIHYDROPYRIMIDINASE
Descriptor:DIHYDROPYRIMIDINASE, ZINC ION, CHLORIDE ION
Authors:Welin, M., Karlberg, T., Andersson, J., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, I., Kallas, A., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Wikstrom, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-03-25
Release date:2008-04-01
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of Human Dihydropyrimidinase
To be Published
2VUX
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HUMAN RIBONUCLEOTIDE REDUCTASE, SUBUNIT M2 B
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B, FE (III) ION
Authors:Welin, M., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Svensson, L., Thorsell, A.G., Tresaugues, L., van Den Berg, S., Weigelt, J., Wikstrom, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-05-31
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Ribonucleotide Reductase, Subunit M2 B
To be Published
2VXO
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HUMAN GMP SYNTHETASE IN COMPLEX WITH XMP
Descriptor:GMP SYNTHASE [GLUTAMINE-HYDROLYZING], XANTHOSINE-5'-MONOPHOSPHATE, SULFATE ION
Authors:Welin, M., Lehtio, L., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wisniewska, M., Wikstrom, M., Nordlund, P.
Deposit date:2008-07-08
Release date:2008-08-12
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Substrate Specificity and Oligomerization of Human Gmp Synthetase
J.Mol.Biol., 425, 2013
2W7T
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TRYPANOSOMA BRUCEI CTPS - GLUTAMINASE DOMAIN WITH BOUND ACIVICIN
Descriptor:PUTATIVE CYTIDINE TRIPHOSPHATE SYNTHASE, CHLORIDE ION
Authors:Welin, M., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Wikstrom, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-12-30
Release date:2009-01-13
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin
To be Published
2XRF
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CRYSTAL STRUCTURE OF HUMAN URIDINE PHOSPHORYLASE 2
Descriptor:URIDINE PHOSPHORYLASE 2, MAGNESIUM ION, URACIL, ...
Authors:Welin, M., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Der Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P.
Deposit date:2010-09-14
Release date:2010-09-29
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Uridine Phosphorylase 2
To be Published
2XRI
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CRYSTAL STRUCTURE OF HUMAN ERI1 EXORIBONUCLEASE 3
Descriptor:ERI1 EXORIBONUCLEASE 3, MAGNESIUM ION, GLYCEROL
Authors:Welin, M., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Thorsell, A.G., Tresaugues, L., Van Der Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P.
Deposit date:2010-09-15
Release date:2010-09-29
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Human Eri1 Exoribonuclease 3
To be Published
3DH1
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CRYSTAL STRUCTURE OF HUMAN TRNA-SPECIFIC ADENOSINE-34 DEAMINASE SUBUNIT ADAT2
Descriptor:tRNA-specific adenosine deaminase 2, ZINC ION
Authors:Welin, M., Tresaugues, L., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Thorsell, A.G., van der Berg, S., Wisniewska, M., Wikstrom, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-06-16
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human tRNA-specific adenosine-34 deaminase subunit ADAT2.
To be Published
3Q90
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CRYSTAL STRUCTURE OF THE NTF2 DOMAIN OF RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1
Descriptor:Ras GTPase-activating protein-binding protein 1
Authors:Welin, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2011-01-07
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1
To be Published
4A1N
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HUMAN MITOCHONDRIAL ENDO-EXONUCLEASE
Descriptor:NUCLEASE EXOG, MITOCHONDRIAL, MAGNESIUM ION, ...
Authors:Welin, M., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Nyman, T., Persson, C., Schuler, H., Thorsell, A.G., Tresaugues, L., Weigelt, J., Nordlund, P.
Deposit date:2011-09-16
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Mitochondrial Endo-Exonuclease
To be Published
2JAQ
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STRUCTURE OF DEOXYADENOSINE KINASE FROM M. MYCOIDES WITH BOUND DCTP
Descriptor:DEOXYGUANOSINE KINASE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE
Authors:Welin, M., Wang, L., Eriksson, S., Eklund, H.
Deposit date:2006-11-30
Release date:2007-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Function Analysis of a Bacterial Deoxyadenosine Kinase Reveals the Basis for Substrate Specificity.
J.Mol.Biol., 366, 2007
2JAS
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STRUCTURE OF DEOXYADENOSINE KINASE FROM M.MYCOIDES WITH BOUND DATP
Descriptor:DEOXYGUANOSINE KINASE, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Welin, M., Wang, L., Eriksson, S., Eklund, H.
Deposit date:2006-11-30
Release date:2007-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-Function Analysis of a Bacterial Deoxyadenosine Kinase Reveals the Basis for Substrate Specificity.
J.Mol.Biol., 366, 2007
2JAT
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STRUCTURE OF DEOXYADENOSINE KINASE FROM M.MYCOIDES WITH PRODUCTS DCMP AND A FLEXIBLE DCDP BOUND
Descriptor:DEOXYGUANOSINE KINASE, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Welin, M., Wang, L., Eriksson, S., Eklund, H.
Deposit date:2006-11-30
Release date:2007-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Function Analysis of a Bacterial Deoxyadenosine Kinase Reveals the Basis for Substrate Specificity.
J.Mol.Biol., 366, 2007
1XBT
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CRYSTAL STRUCTURE OF HUMAN THYMIDINE KINASE 1
Descriptor:Thymidine kinase, cytosolic, ZINC ION, ...
Authors:Welin, M., Kosinska, U., Mikkelsen, N.E., Carnrot, C., Zhu, C., Wang, L., Eriksson, S., Munch-Petersen, B., Eklund, H.
Deposit date:2004-08-31
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of thymidine kinase 1 of human and mycoplasmic origin
Proc.Natl.Acad.Sci.Usa, 101, 2004
1ZM7
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CRYSTAL STRUCTURE OF D. MELANOGASTER DEOXYRIBONUCLEOSIDE KINASE MUTANT N64D IN COMPLEX WITH DTTP
Descriptor:Deoxynucleoside kinase, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Welin, M., Skovgaard, T., Knecht, W., Berenstein, D., Munch-Petersen, B., Piskur, J., Eklund, H.
Deposit date:2005-05-10
Release date:2005-05-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D.
Febs J., 272, 2005
1ZMX
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CRYSTAL STRUCTURE OF D. MELANOGASTER DEOXYRIBONUCLEOSIDE KINASE N64D MUTANT IN COMPLEX WITH THYMIDINE
Descriptor:Deoxynucleoside kinase, SULFATE ION, THYMIDINE
Authors:Welin, M., Skovgaard, T., Knecht, W., Berenstein, D., Munch-Petersen, B., Piskur, J., Eklund, H.
Deposit date:2005-05-11
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D.
Febs J., 272, 2005
2UZ3
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CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM
Descriptor:THYMIDINE KINASE, ZINC ION, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Welin, M., Kosinska, U., Mikkelsen, N.E., Carnrot, C., Zhu, C., Wang, L., Eriksson, S., Munch-Petersen, B., Eklund, H.
Deposit date:2007-04-24
Release date:2007-05-29
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of Thymidine Kinase 1 of Human and Mycoplasmic Origin
Proc.Natl.Acad.Sci.USA, 101, 2004
2QK4
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HUMAN GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, CHLORIDE ION, SULFATE ION, ...
Authors:Lehtio, L., Welin, M., Arrowsmith, C.H., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Herman, M.D., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Tresaugues, L., van den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2007-07-10
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural studies of tri-functional human GART.
Nucleic Acids Res., 38, 2010
4AQL
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HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR
Descriptor:GUANINE DEAMINASE, ZINC ION, 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate
Authors:Welin, M., Egeblad, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Schuler, H., Thorsell, A.G., Tresaugues, L., Weigelt, J., Nordlund, P.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Pan-Pathway Based Interaction Profiling of Fda-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism.
Plos One, 7, 2012