5Z3W | |
5ZM8 | | CRYSTAL STRUCTURE OF ORP2-ORD IN COMPLEX WITH PI(4,5)P2 | | Descriptor: | Oxysterol-binding protein-related protein 2, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate | | Authors: | Wang, H., Dong, J.Q., Wang, J., Wu, J.W. | | Deposit date: | 2018-04-01 | | Release date: | 2019-01-02 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).
Mol. Cell, 73, 2019
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1WWI | | CRYSTAL STRUCTURE OF TTK003001566 FROM THERMUS THERMOPHILUS HB8 | | Descriptor: | hypothetical protein TTHA1479 | | Authors: | Wang, H., Murayama, K., Terada, T., Chen, L., Liu, Z.J., Wang, B.C., Shirouzu, M., Kuramitsu, S., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-01-05 | | Release date: | 2005-07-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Crystal structure of ttk003001566 from Thermus Thermophilus HB8
TO BE PUBLISHED
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2CSL | | CRYSTAL STRUCTURE OF TTHA0137 FROM THERMUS THERMOPHILUS HB8 | | Descriptor: | protein translation initiation inhibitor | | Authors: | Wang, H., Murayama, K., Terada, T., Chen, L., Jin, Z., Chrzas, J., Liu, Z.J., Wang, B.C., Shirouzu, M., Kuramitsu, S., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-22 | | Release date: | 2005-11-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of TTHA0137 from Thermus Thermophilus HB8
To be Published
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2DY1 | | CRYSTAL STRUCTURE OF EF-G-2 FROM THERMUS THERMOPHILUS | | Descriptor: | Elongation factor G, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE | | Authors: | Wang, H., Takemoto, C., Murayama, K., Terada, T., Chen, L., Liu, Z.J., Wang, B.C., Shirouzu, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-09-04 | | Release date: | 2007-09-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of EF-G-2 from Thermus thermophilus
To be Published
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2NZ0 | | CRYSTAL STRUCTURE OF POTASSIUM CHANNEL KV4.3 IN COMPLEX WITH ITS REGULATORY SUBUNIT KCHIP1 (CASP TARGET) | | Descriptor: | Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 3, CALCIUM ION, ... | | Authors: | Wang, H., Yan, Y., Shen, Y., Chen, L., Wang, K. | | Deposit date: | 2006-11-22 | | Release date: | 2006-12-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis for modulation of Kv4 K(+) channels by auxiliary KChIP subunits.
Nat.Neurosci., 10, 2007
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3NGN | | CRYSTAL STRUCTURE OF THE HUMAN CNOT6L NUCLEASE DOMAIN IN COMPLEX WITH AMP | | Descriptor: | CCR4-NOT transcription complex subunit 6-like, ADENOSINE MONOPHOSPHATE | | Authors: | Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z. | | Deposit date: | 2010-06-12 | | Release date: | 2010-07-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Embo J., 2010
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3NGO | | CRYSTAL STRUCTURE OF THE HUMAN CNOT6L NUCLEASE DOMAIN IN COMPLEX WITH POLY(A) DNA | | Descriptor: | CCR4-NOT transcription complex subunit 6-like, 5'-D(*AP*AP*AP*A)-3', MAGNESIUM ION | | Authors: | Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z. | | Deposit date: | 2010-06-12 | | Release date: | 2010-07-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Embo J., 2010
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3NGQ | | CRYSTAL STRUCTURE OF THE HUMAN CNOT6L NUCLEASE DOMAIN | | Descriptor: | CCR4-NOT transcription complex subunit 6-like, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, MAGNESIUM ION | | Authors: | Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z. | | Deposit date: | 2010-06-13 | | Release date: | 2010-07-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Embo J., 2010
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4RGW | | CRYSTAL STRUCTURE OF A TAF1-TAF7 COMPLEX IN HUMAN TRANSCRIPTION FACTOR IID | | Descriptor: | Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 7, GLYCEROL | | Authors: | Wang, H., Curran, E.C., Hinds, T.R., Wang, E.H., Zheng, N. | | Deposit date: | 2014-09-30 | | Release date: | 2014-12-03 | | Last modified: | 2014-12-17 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.
Cell Res., 24, 2014
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5C3I | | CRYSTAL STRUCTURE OF THE QUATERNARY COMPLEX OF HISTONE H3-H4 HETERODIMER WITH CHAPERONE ASF1 AND THE REPLICATIVE HELICASE SUBUNIT MCM2 | | Descriptor: | Histone chaperone ASF1A, Histone H3.1, Histone H4, ... | | Authors: | Wang, H., Wang, M., Yang, N., Xu, R.M. | | Deposit date: | 2015-06-17 | | Release date: | 2015-07-29 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
Protein Cell, 6, 2015
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1ZKL | | MULTIPLE DETERMINANTS FOR INHIBITOR SELECTIVITY OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES | | Descriptor: | High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ... | | Authors: | Wang, H., Liu, Y., Chen, Y., Robinson, H., Ke, H. | | Deposit date: | 2005-05-03 | | Release date: | 2005-07-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7
J.Biol.Chem., 280, 2005
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2H40 | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF UNLIGANDED PDE5 | | Descriptor: | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION | | Authors: | Wang, H., Liu, Y., Huai, Q., Cai, J., Zoraghi, R., Francis, S.H., Corbin, J.D., Robinson, H., Xin, Z., Lin, G., Ke, H. | | Deposit date: | 2006-05-23 | | Release date: | 2006-06-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
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2PW3 | | STRUCTURE OF THE PDE4D-CAMP COMPLEX | | Descriptor: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | Authors: | Wang, H., Robinson, H., Ke, H. | | Deposit date: | 2007-05-10 | | Release date: | 2007-10-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.
J.Mol.Biol., 371, 2007
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3ECM | | CRYSTAL STRUCTURE OF THE UNLIGANDED PDE8A CATALYTIC DOMAIN | | Descriptor: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION | | Authors: | Wang, H., Yan, Z., Yang, S., Cai, J., Robinson, H., Ke, H. | | Deposit date: | 2008-09-01 | | Release date: | 2008-11-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry, 47, 2008
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3ECN | | CRYSTAL STRUCTURE OF PDE8A CATALYTIC DOMAIN IN COMPLEX WITH IBMX | | Descriptor: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, 3-ISOBUTYL-1-METHYLXANTHINE, ZINC ION, ... | | Authors: | Wang, H., Yan, Z., Yang, S., Cai, J., Robinson, H., Ke, H. | | Deposit date: | 2008-09-01 | | Release date: | 2008-11-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry, 47, 2008
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3K3E | | CRYSTAL STRUCTURE OF THE PDE9A CATALYTIC DOMAIN IN COMPLEX WITH (R)-BAY73-6691 | | Descriptor: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... | | Authors: | Wang, H., Luo, X., Ye, M., Hou, J., Robinson, H., Ke, H. | | Deposit date: | 2009-10-02 | | Release date: | 2010-02-16 | | Last modified: | 2013-11-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
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3K3H | | CRYSTAL STRUCTURE OF THE PDE9A CATALYTIC DOMAIN IN COMPLEX WITH (S)-BAY73-6691 | | Descriptor: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... | | Authors: | Wang, H., Luo, X., Ye, M., Hou, J., Robinson, H., Ke, H. | | Deposit date: | 2009-10-02 | | Release date: | 2010-02-16 | | Last modified: | 2013-11-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
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3LFV | | CRYSTAL STRUCTURE OF UNLIGANDED PDE5A GAF DOMAIN | | Descriptor: | cGMP-specific 3',5'-cyclic phosphodiesterase | | Authors: | Wang, H., Robinson, H., Ke, H. | | Deposit date: | 2010-01-18 | | Release date: | 2010-09-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
J.Biol.Chem., 285, 2010
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3MF0 | | CRYSTAL STRUCTURE OF PDE5A GAF DOMAIN (89-518) | | Descriptor: | cGMP-specific 3',5'-cyclic phosphodiesterase | | Authors: | Wang, H., Robinson, H., Ke, H. | | Deposit date: | 2010-04-01 | | Release date: | 2010-09-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
J.Biol.Chem., 285, 2010
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3V93 | | UNLIGANDED STRUCTURE OF TCRPDEC1 CATALYTIC DOMAIN | | Descriptor: | Cyclic nucleotide specific phosphodiesterase, ZINC ION, MAGNESIUM ION | | Authors: | Wang, H., Kunz, S., Chen, G., Seebeck, T., Wan, Y., Robinson, H., Martinelli, S., Ke, H. | | Deposit date: | 2011-12-23 | | Release date: | 2012-02-22 | | Last modified: | 2013-01-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
J.Biol.Chem., 287, 2012
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3V94 | | TCRPDEC1 CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR WYQ16 | | Descriptor: | Cyclic nucleotide specific phosphodiesterase, propan-2-yl {[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonyl}carbamate, ZINC ION, ... | | Authors: | Wang, H., Kunz, S., Chen, G., Seebeck, T., Wan, Y., Robinson, H., Martinelli, S., Ke, H. | | Deposit date: | 2011-12-23 | | Release date: | 2012-02-22 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | TcrPDEC1 catalytic domain in complex with inhibitor wyq16
To be Published
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2H42 | | CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH SILDENAFIL | | Descriptor: | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... | | Authors: | Wang, H., Ke, H. | | Deposit date: | 2006-05-23 | | Release date: | 2006-06-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
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2H44 | | CRYSTAL STRUCTURE OF PDE5A1 IN COMPLEX WITH ICARISID II | | Descriptor: | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... | | Authors: | Wang, H., Ke, H. | | Deposit date: | 2006-05-23 | | Release date: | 2006-06-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
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2QYK | | CRYSTAL STRUCTURE OF PDE4A10 IN COMPLEX WITH INHIBITOR NPV | | Descriptor: | Cyclic AMP-specific phosphodiesterase HSPDE4A10, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, ZINC ION, ... | | Authors: | Wang, H., Peng, M., Chen, Y., Geng, J., Robinson, H., Houslay, M. | | Deposit date: | 2007-08-15 | | Release date: | 2008-04-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
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