5X8Y | | A MUTATION IDENTIFIED IN NEONATAL MICROCEPHALY DESTABILIZES ZIKA VIRUS NS1 ASSEMBLY IN VITRO | | Descriptor: | ZIKV NS1 | | Authors: | Wang, D., Chen, C., Liu, S., Zhou, H., Yang, K., Zhao, Q., Ji, X., Chen, C., Xie, W., Wang, Z., Mi, L.Z., Yang, H. | | Deposit date: | 2017-03-03 | | Release date: | 2017-05-17 | | Method: | X-RAY DIFFRACTION (2.817 Å) | | Cite: | A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro
Sci Rep, 7, 2017
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6A8G | | THE CRYSTAL STRUCTURE OF MUPAIN-1-IG IN COMPLEX WITH MUPA-SPD AT PH8.5 | | Descriptor: | muPAin-1-IG, Urokinase-type plasminogen activator chain B, PHOSPHATE ION | | Authors: | Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z. | | Deposit date: | 2018-07-08 | | Release date: | 2019-02-20 | | Last modified: | 2019-09-04 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
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6A8N | | THE CRYSTAL STRUCTURE OF MUPAIN-1-IG-2 IN COMPLEX WITH MUPA-SPD AT PH8.5 | | Descriptor: | Urokinase-type plasminogen activator B, CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS | | Authors: | Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z. | | Deposit date: | 2018-07-09 | | Release date: | 2019-02-20 | | Last modified: | 2019-09-04 | | Method: | X-RAY DIFFRACTION (2.489 Å) | | Cite: | Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
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1S9K | |
1W24 | | CRYSTAL STRUCTURE OF HUMAN VPS29 | | Descriptor: | VACUOLAR PROTEIN SORTING PROTEIN 29 | | Authors: | Wang, D., Guo, M., Teng, M., Niu, L. | | Deposit date: | 2004-06-26 | | Release date: | 2005-03-23 | | Last modified: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites.
J.Biol.Chem., 280, 2005
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2CGA | |
2E2H | | RNA POLYMERASE II ELONGATION COMPLEX AT 5 MM MG2+ WITH GTP | | Descriptor: | 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-14 | | Release date: | 2006-12-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.95 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2E2I | | RNA POLYMERASE II ELONGATION COMPLEX IN 5 MM MG+2 WITH 2'-DGTP | | Descriptor: | 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-14 | | Release date: | 2006-12-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2E2J | | RNA POLYMERASE II ELONGATION COMPLEX IN 5 MM MG+2 WITH GMPCPP | | Descriptor: | 5'-R(P*AP*UP*CP*GP*AP*GP*AP*GP*G)-3', 27-MER DNA template strand, 5'-D(P*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*A)-3', ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-14 | | Release date: | 2006-12-12 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2NVQ | | RNA POLYMERASE II ELONGATION COMPLEX IN 150 MM MG+2 WITH 2'DUTP | | Descriptor: | 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-13 | | Release date: | 2006-12-12 | | Last modified: | 2015-05-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2NVT | | RNA POLYMERASE II ELONGATION COMPLEX IN 150 MM MG+2 WITH GMPCPP | | Descriptor: | 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', 5'-D(P*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*T)-3', 5'-D(*GP*TP*AP*CP*TP*TP*G)-3', ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-13 | | Release date: | 2006-12-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.36 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2NVX | | RNA POLYMERASE II ELONGATION COMPLEX IN 5 MM MG+2 WITH 2'-DUTP | | Descriptor: | 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 28-MER DNA template strand, ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-13 | | Release date: | 2006-12-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2NVY | | RNA POLYMERASE II FORM II IN 150 MM MN+2 | | Descriptor: | DNA-directed RNA polymerase II largest subunit, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 45 kDa polypeptide, ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-13 | | Release date: | 2006-12-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2NVZ | | RNA POLYMERASE II ELONGATION COMPLEX WITH UTP, UPDATED 11/2006 | | Descriptor: | 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2006-11-14 | | Release date: | 2006-12-19 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (4.3 Å) | | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2YU9 | | RNA POLYMERASE II ELONGATION COMPLEX IN 150 MM MG+2 WITH UTP | | Descriptor: | 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ... | | Authors: | Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. | | Deposit date: | 2007-04-06 | | Release date: | 2007-04-24 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
Cell(Cambridge,Mass.), 127, 2006
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3GTG | | BACKTRACKED RNA POLYMERASE II COMPLEX WITH 12MER RNA | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.78 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3GTJ | | BACKTRACKED RNA POLYMERASE II COMPLEX WITH 13MER RNA | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3GTK | | BACKTRACKED RNA POLYMERASE II COMPLEX WITH 18MER RNA | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3GTL | | BACKTRACKED RNA POLYMERASE II COMPLEX WITH 13MER WITH G<>U MISMATCH | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.38 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3GTM | | CO-COMPLEX OF BACKTRACKED RNA POLYMERASE II WITH TFIIS | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2019-07-31 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3GTO | | BACKTRACKED RNA POLYMERASE II COMPLEX WITH 15MER RNA | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3GTP | | BACKTRACKED RNA POLYMERASE II COMPLEX WITH 24MER RNA | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3GTQ | | BACKTRACKED RNA POLYMERASE II COMPLEX INDUCED BY DAMAGE | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Bushnell, D.A., Huang, X., Westover, K.D., Levitt, M., Kornberg, R.D. | | Deposit date: | 2009-03-27 | | Release date: | 2009-06-09 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
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3M3Y | | RNA POLYMERASE II ELONGATION COMPLEX C | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Zhu, G., Huang, X., Lippard, S.J. | | Deposit date: | 2010-03-10 | | Release date: | 2010-05-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3M4O | | RNA POLYMERASE II ELONGATION COMPLEX B | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Wang, D., Zhu, G., Huang, X., Lippard, S.J. | | Deposit date: | 2010-03-11 | | Release date: | 2010-05-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.57 Å) | | Cite: | X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
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