Author results

1RWE
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ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
Descriptor:insulin, Insulin, ZINC ION, ...
Authors:Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
1J73
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CRYSTAL STRUCTURE OF AN UNSTABLE INSULIN ANALOG WITH NATIVE ACTIVITY.
Descriptor:insulin a, insulin b, ZINC ION
Authors:Wan, Z., Zhao, M., Nakagawa, S., Jia, W., Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1JCA
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NON-STANDARD DESIGN OF UNSTABLE INSULIN ANALOGUES WITH ENHANCED ACTIVITY
Descriptor:insulin a, insulin b, ZINC ION
Authors:Weiss, M.A., Wan, Z., Zhao, M., Chu, Y.-C., Nakagawa, S.H., Burke, G.T., Jia, W., Hellmich, R., Katsoyannis, P.G.
Deposit date:2001-06-08
Release date:2001-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, PHENOL, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
1WAV
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CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN
Descriptor:INSULIN, PHENOL, ZINC ION
Authors:Liang, D.-C., Ding, J.-H., Chang, W.-R., Wan, Z.-L.
Deposit date:1996-02-28
Release date:1997-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular replacement study on form-B monoclinic crystal of insulin.
Sci.China, Ser.C: Life Sci., 39, 1996
4P65
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CRYSTAL STRUCTURE OF AN CYCLOHEXYLALANINE SUBSTITUTED INSULIN ANALOG.
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Pandyarajan, V., Wan, Z., Weiss, M.A.
Deposit date:2014-03-21
Release date:2014-10-22
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
1Q4V
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CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR
Descriptor:Insulin, ZINC ION, PHENOL
Authors:Wan, Z.L., Xu, B., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-08-04
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Biochemistry, 42, 2003
1ZV1
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CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OF DOUBLESEX PROTEIN FROM D. MELANOGASTER
Descriptor:Doublesex protein
Authors:Weiss, M.A., Bayrer, J.R., Wan, Z., Li, B., Phillips, N.B.
Deposit date:2005-06-01
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation
J.Biol.Chem., 280, 2005
2LWZ
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NMR STRUCTURES OF SINGLE-CHAIN INSULIN
Descriptor:SINGLE-CHAIN INSULIN
Authors:Weiss, M.A., Yang, Y.
Deposit date:2012-08-09
Release date:2013-08-28
Method:SOLUTION NMR
Cite:Dynamic repair of an amyloidogenic protein: Insulin fibrillation is blocked by tethering a nascent alpha-helix
To be Published
5EMS
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CRYSTAL STRUCTURE OF AN IODINATED INSULIN ANALOG
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Lawrence, M.C., Pandyarajan, V., Wan, Z., Weiss, M.A.
Deposit date:2015-11-06
Release date:2016-11-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
J. Biol. Chem., 291, 2016
5LYY
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FRAGMENT-BASED INHIBITORS OF LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2
Descriptor:Platelet-activating factor acetylhydrolase, 3-[2-(4-fluoranylphenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione
Authors:Woolford, A., Day, P.
Deposit date:2016-09-29
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
5LZ2
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FRAGMENT-BASED INHIBITORS OF LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2
Descriptor:Platelet-activating factor acetylhydrolase, SODIUM ION, CHLORIDE ION, ...
Authors:Woolford, A., Day, p.
Deposit date:2016-09-29
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
5LZ4
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FRAGMENT-BASED INHIBITORS OF LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2
Descriptor:Platelet-activating factor acetylhydrolase, CHLORIDE ION, 5-[2-(4,4-dimethyl-2-oxidanylidene-pyrrolidin-1-yl)ethoxy]-2-fluoranyl-benzenecarbonitrile
Authors:Woolford, A., Day, P.
Deposit date:2016-09-29
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
5LZ5
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FRAGMENT-BASED INHIBITORS OF LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2
Descriptor:Platelet-activating factor acetylhydrolase, CHLORIDE ION, 2-fluoranyl-5-[2-[(4~{S})-4-methyl-2-oxidanylidene-4-phenyl-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile
Authors:Woolford, A.J.A., Day, P.J.
Deposit date:2016-09-29
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
5LZ7
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FRAGMENT-BASED INHIBITORS OF LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2
Descriptor:Platelet-activating factor acetylhydrolase, CHLORIDE ION, 2-fluoranyl-5-[2-[(4~{R})-4-methyl-2-oxidanylidene-4-phenyl-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile
Authors:Woolford, A., Day, P.
Deposit date:2016-09-29
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
5LZ8
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FRAGMENT-BASED INHIBITORS OF LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2
Descriptor:Platelet-activating factor acetylhydrolase, CHLORIDE ION, 5-[2-[(4~{S})-4-~{tert}-butyl-2-oxidanylidene-pyrrolidin-1-yl]ethoxy]-2-fluoranyl-benzenecarbonitrile
Authors:Woolford, A., Day, P.
Deposit date:2016-09-29
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
5LZ9
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FRAGMENT-BASED INHIBITORS OF LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2
Descriptor:Platelet-activating factor acetylhydrolase, CHLORIDE ION, SODIUM ION, ...
Authors:Woolford, A., Day, P.
Deposit date:2016-09-29
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
1HTV
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CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN
Descriptor:INSULIN, ZINC ION
Authors:Ye, J., Chang, W., Liang, D.
Deposit date:2001-01-01
Release date:2001-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of destripeptide (B28-B30) insulin: implications for insulin dissociation.
Biochim.Biophys.Acta, 1547, 2001