Author results

3ZGZ
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND TOXIC MOIETY FROM AGROCIN 84 (TM84) IN AMINOACYLATION-LIKE CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE, TRNA-LEU UAA ISOACCEPTOR, ZINC ION, ...
Authors:Chopra, S., Palencia, A., Virus, C., Tripathy, A., Temple, B.R., Velazquez-Campoy, A., Cusack, S., Reader, J.S.
Deposit date:2012-12-19
Release date:2013-01-30
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plant Tumour Biocontrol Agent Employs a tRNA-Dependent Mechanism to Inhibit Leucyl-tRNA Synthetase
Nat.Commun., 4, 2013
1YUC
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HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BOUND TO PHOSPHOLIPID AND A FRAGMENT OF HUMAN SHP
Descriptor:Orphan nuclear receptor NR5A2, Nuclear receptor 0B2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Ortlund, E.A., Yoonkwang, L., Solomon, I.H., Hager, J.M., Safi, R., Choi, Y., Guan, Z., Tripathy, A., Raetz, C.R.H., McDonnell, D.P., Moore, D.D., Redinbo, M.R.
Deposit date:2005-02-13
Release date:2005-03-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
Nat.Struct.Mol.Biol., 12, 2005
3ZY7
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CRYSTAL STRUCTURE OF COMPUTATIONALLY REDESIGNED GAMMA-ADAPTIN APPENDAGE DOMAIN FORMING A SYMMETRIC HOMODIMER
Descriptor:AP-1 COMPLEX SUBUNIT GAMMA-1, ISOPROPYL ALCOHOL, DI(HYDROXYETHYL)ETHER
Authors:Stranges, P.B., Machius, M., Miley, M.J., Tripathy, A., Kuhlman, B.
Deposit date:2011-08-17
Release date:2011-12-28
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Computational Design of a Symmetric Homodimer Using Beta-Strand Assembly.
Proc.Natl.Acad.Sci.USA, 108, 2011
6ECA
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LACTOBACILLUS RHAMNOSUS BETA-GLUCURONIDASE
Descriptor:Beta-glucuronidase, GLYCEROL, CHLORIDE ION
Authors:Biernat, K.A., Pellock, S.J., Bhatt, A.P., Bivins, M.M., Walton, W.G., Tran, B.N.T., Wei, L., Snider, M.C., Cesmat, A.P., Tripathy, A., Erie, D.A., Redinbo, M.R.R.
Deposit date:2018-08-07
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.853 Å)
Cite:Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases.
Sci Rep, 9, 2019
3RJW
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CRYSTAL STRUCTURE OF HISTONE LYSINE METHYLTRANSFERASE G9A WITH AN INHIBITOR
Descriptor:Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, A., Wasney, G.A., Tempel, W., Liu, F., Barsyte, D., Allali-Hassani, A., Chen, X., Chau, I., Hajian, T., Senisterra, G., Chavda, N., Arora, K., Siarheyeva, A., Kireev, D.B., Herold, J.M., Bochkarev, A., Bountra, C., Weigelt, J., Edwards, A.M., Frye, S.V., Arrowsmith, C.H., Brown, P.J., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)
Deposit date:2011-04-15
Release date:2011-05-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Nat.Chem.Biol., 7, 2011
2V66
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CRYSTAL STRUCTURE OF THE COILED-COIL DOMAIN OF NDEL1 (A.A. 58 TO 169) C
Descriptor:NUCLEAR DISTRIBUTION PROTEIN NUDE-LIKE 1, MERCURY (II) ION
Authors:Tarricone, C., Perrina, F., Musacchio, A.
Deposit date:2007-07-13
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structure of the Coiled-Coil Domain of Ndel1 and the Basis of its Interaction with Lis1, the Causal Protein of Miller-Dieker Lissencephaly.
Structure, 15, 2007
2V71
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COILED-COIL REGION OF NUDEL
Descriptor:NUCLEAR DISTRIBUTION PROTEIN NUDE-LIKE 1
Authors:Derewenda, U., Cooper, D.R., Kim, M.H., Derewenda, Z.S.
Deposit date:2007-07-25
Release date:2007-11-27
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:The Structure of the Coiled-Coil Domain of Ndel1 and the Basis of its Interaction with Lis1, the Causal Protein of Miller-Dieker Lissencephaly.
Structure, 15, 2007
4HT6
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THE STRUCTURE OF A YEAST DYNEIN DYN2-PAC11 COMPLEX AND EFFECT ON SINGLE MOLECULE DYNEIN MOTOR ACTIVITY
Descriptor:Dynein light chain 1, cytoplasmic, WD repeat-containing protein PAC11
Authors:Slep, K.C., Romes, E.R.
Deposit date:2012-10-31
Release date:2013-09-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization.
Mol Biol Cell, 24, 2013
2HTF
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THE SOLUTION STRUCTURE OF THE BRCT DOMAIN FROM HUMAN POLYMERASE REVEALS HOMOLOGY WITH THE TDT BRCT DOMAIN
Descriptor:DNA polymerase mu
Authors:DeRose, E.F., Clarkson, M.W., Gilmore, S.A., Ramsden, D.A., Mueller, G.A., London, R.E., Lee, A.L.
Deposit date:2006-07-25
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining.
Biochemistry, 46, 2007
2M0O
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THE SOLUTION STRUCTURE OF HUMAN PHF1 IN COMPLEX WITH H3K36ME3
Descriptor:PHD finger protein 1, H3K36me3 peptide
Authors:Song, J., Patel, D.J.
Deposit date:2012-10-30
Release date:2013-01-16
Last modified:2013-02-27
Method:SOLUTION NMR
Cite:An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting.
Mol.Cell, 49, 2013
3P8H
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CRYSTAL STRUCTURE OF L3MBTL1 (MBT REPEAT) IN COMPLEX WITH A NICOTINAMIDE ANTAGONIST
Descriptor:Lethal(3)malignant brain tumor-like protein, 3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]pyridine, SULFATE ION, ...
Authors:Lam, R., Herold, J.M., Ouyang, H., Tempel, W., Gao, C., Ravichandran, M., Senisterra, G., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Kireev, D., Frye, S.V., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2010-10-13
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Small-molecule ligands of methyl-lysine binding proteins.
J.Med.Chem., 54, 2011
4DS1
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THE STRUCTURE OF A YEAST DYN2-NUP159 COMPLEX AND THE MOLECULAR BASIS FOR THE DYNEIN LIGHT CHAIN - NUCLEAR PORE INTERACTION
Descriptor:Dynein light chain 1, cytoplasmic, Nucleoporin NUP159
Authors:Slep, K.C., Romes, E.M.
Deposit date:2012-02-17
Release date:2012-03-21
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction.
J.Biol.Chem., 287, 2012
4KGH
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CRYSTAL STRUCTURE OF HUMAN SPLUNC1 LACKING THE SECRETION SIGNAL SEQUENCE
Descriptor:BPI fold-containing family A member 1, NITRATE ION, AMMONIUM ION, ...
Authors:Betts, L., Walton, W.G.
Deposit date:2013-04-29
Release date:2013-09-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.806 Å)
Cite:Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KGO
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CRYSTAL STRUCTURE OF DOUBLE LEUCINE TO METHIONINE MUTANT HUMAN SPLUNC1 LACKING THE SECRETION SIGNAL SEQUENCE
Descriptor:BPI fold-containing family A member 1
Authors:Betts, L., Walton, W.G.
Deposit date:2013-04-29
Release date:2013-09-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.194 Å)
Cite:Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.
Proc.Natl.Acad.Sci.USA, 110, 2013
6ANO
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CRYSTAL STRUCTURE OF HUMAN FLASH N-TERMINAL DOMAIN
Descriptor:CASP8-associated protein 2
Authors:Aik, W.S., Tong, L.
Deposit date:2017-08-14
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.
PLoS ONE, 12, 2017
6AOZ
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CRYSTAL STRUCTURE OF HUMAN FLASH N-TERMINAL DOMAIN C54S/C83A (CRYSTAL FORM 1)
Descriptor:CASP8-associated protein 2, 1,2-ETHANEDIOL
Authors:Aik, W.S., Tong, L.
Deposit date:2017-08-16
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.
PLoS ONE, 12, 2017
6AP0
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CRYSTAL STRUCTURE OF HUMAN FLASH N-TERMINAL DOMAIN C54S/C83A (CRYSTAL FORM 2)
Descriptor:CASP8-associated protein 2
Authors:Aik, W.S., Tong, L.
Deposit date:2017-08-16
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.581 Å)
Cite:The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.
PLoS ONE, 12, 2017
6AYH
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SALMONELLA ENTERICA GUSR
Descriptor:TetR family transcriptional regulator, GLYCEROL, 4-nitrophenyl beta-D-glucopyranosiduronic acid
Authors:Little, M.S., Pellock, S.J.
Deposit date:2017-09-08
Release date:2017-12-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AYI
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ESCHERICHIA COLI GUSR
Descriptor:HTH-type transcriptional regulator UidR, 4-nitrophenyl beta-D-glucopyranosiduronic acid
Authors:Little, M.S., Pellock, S.J.
Deposit date:2017-09-08
Release date:2017-12-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AZ6
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STREPTOCOCCUS AGALACTIAE GNTR
Descriptor:GntR family transcriptional regulator
Authors:Pellock, S.J., Redinbo, M.R.
Deposit date:2017-09-10
Release date:2017-12-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AZH
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CLOSTRIDIUM PERFRINGENS PUTATIVE FATTY ACID METABOLISM REGULATOR
Descriptor:TetR family transcriptional regulator
Authors:William, W.G., Redinbo, M.R.
Deposit date:2017-09-11
Release date:2017-12-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6D1N
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APO STRUCTURE OF BACTEROIDES UNIFORMIS BETA-GLUCURONIDASE 1
Descriptor:Beta-galactosidase/beta-glucuronidase, GLYCEROL, CHLORIDE ION
Authors:Walton, W.G., Pellock, S.J., Redinbo, M.R.
Deposit date:2018-04-12
Release date:2018-10-17
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis.
J. Biol. Chem., 293, 2018
6D1P
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APO STRUCTURE OF BACTEROIDES UNIFORMIS BETA-GLUCURONIDASE 3
Descriptor:Glycosyl hydrolases family 2, sugar binding domain protein, SODIUM ION, ...
Authors:Walton, W.G., Pellock, S.J., Redinbo, M.R.
Deposit date:2018-04-12
Release date:2018-10-17
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis.
J. Biol. Chem., 293, 2018
6D41
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BACTERIODES UNIFORMIS BETA-GLUCURONIDASE 1 BOUND TO D-GLUCARO-1,5-LACTONE
Descriptor:Beta-galactosidase/beta-glucuronidase, GLYCEROL, CHLORIDE ION, ...
Authors:Walton, W.G., Pellock, S.J., Redinbo, M.R.
Deposit date:2018-04-17
Release date:2018-10-17
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis.
J. Biol. Chem., 293, 2018
6D50
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BACTEROIDES UNIFORMS BETA-GLUCURONIDASE 2 BOUND TO D-GLUCARO-1,5-LACTONE
Descriptor:Glycosyl hydrolases family 2, sugar binding domain protein, CALCIUM ION, ...
Authors:Walton, W.G., Pellock, S.J., Redinbo, M.R.
Deposit date:2018-04-19
Release date:2018-10-17
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis.
J. Biol. Chem., 293, 2018
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