Author results

6SDA
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BD2924 C10 ACYL-COENZYMEA BOUND FORM
Descriptor:Probable acyl-CoA dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, decanoyl-CoA
Authors:Lovering, A.L., Harding, C.J.
Deposit date:2019-07-26
Release date:2019-09-11
Last modified:2020-03-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Target highlights in CASP13: Experimental target structures through the eyes of their authors.
Proteins, 87, 2019
6SD8
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BD2924 APO-FORM
Descriptor:Probable acyl-CoA dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Lovering, A.L., Harding, C.J.
Deposit date:2019-07-26
Release date:2019-09-11
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Target highlights in CASP13: Experimental target structures through the eyes of their authors.
Proteins, 87, 2019
6MIW
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WWE DOMAIN OF HUMAN HUWE1
Descriptor:E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Halabelian, L., Loppnau, P., Tempel, W., Wong, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-09-20
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:WWE domain of human HUWE1
To Be Published
6L00
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CRYSTAL STRUCTURE OF THE CELL-WALL BINDING DOMAIN (CBD) OF ENDOLYSIN LYSIME-EF1
Descriptor:Lysin
Authors:Ouyang, S.Y., Zhen, X.K.
Deposit date:2019-09-25
Release date:2020-02-19
Last modified:2020-04-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage.
Plos Pathog., 16, 2020
6IST
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CRYSTAL STRUCTURE OF A WILD TYPE ENDOLYSIN LYSIME-EF1
Descriptor:Lysin, CALCIUM ION
Authors:Ouyang, S.Y.
Deposit date:2018-11-19
Release date:2019-11-20
Last modified:2020-04-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage.
Plos Pathog., 16, 2020
6E46
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERROUS HEME AND TRYPTOPHAN
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E45
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) FREE ENZYME IN THE FERROUS STATE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E44
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) FREE ENZYME IN THE FERRIC STATE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, PHOSPHATE ION
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E43
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH A BMS-978587 ANALOG
Descriptor:Indoleamine 2,3-dioxygenase 1, (1R,2S)-2-(4-[cyclohexyl(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, BENZOIC ACID
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E42
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERRIC HEME AND 4-CHLOROPHENYL IMIDAZOLE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-(3-chlorophenyl)-1H-imidazole, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E41
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERRIC HEME AND AN EPACADOSTAT ANALOG
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]sulfanyl}-1,2,5-oxadiazole-3-carboximidamide
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E40
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CRYSTAL STRUCTURE OF THE INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEXED WITH FERRIC HEME AND EPACADOSTAT
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E24
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TERNARY STRUCTURE OF C-MYC-TBP-TAF1
Descriptor:Transcription initiation factor TFIID subunit 1,Myc proto-oncogene protein,TATA-box-binding protein
Authors:Wei, Y., Dong, A., Sunnerhagen, M., Penn, L., Tong, Y., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2018-07-10
Release date:2019-10-02
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:Multiple direct interactions of TBP with the MYC oncoprotein.
Nat.Struct.Mol.Biol., 26, 2019
6E16
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TERNARY STRUCTURE OF C-MYC-TBP-TAF1
Descriptor:Transcription initiation factor TFIID subunit 1,Myc proto-oncogene protein,TATA-box-binding protein
Authors:Wei, Y., Dong, A., Sunnerhagen, M., Penn, L., Tong, Y., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2018-07-09
Release date:2019-10-02
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Multiple direct interactions of TBP with the MYC oncoprotein.
Nat.Struct.Mol.Biol., 26, 2019
6D0S
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RABGAP DOMAIN OF HUMAN TBC1D22B
Descriptor:TBC1 domain family member 22B, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2018-04-10
Release date:2018-06-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RabGAP domain of human TBC1D22B
To be Published
6CVZ
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CRYSTAL STRUCTURE OF THE WD40-REPEAT OF RFWD3
Descriptor:E3 ubiquitin-protein ligase RFWD3, MAGNESIUM ION
Authors:DONG, A., LOPPNAU, P., SEITOVA, A., HUTCHINSON, A., TEMPEL, W., WEI, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-03-29
Release date:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the WD40-repeat of RFWD3
to be published
6CP9
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CONTACT-DEPENDENT GROWTH INHIBITION TOXIN - IMMUNITY PROTEIN COMPLEX FROM KLEBSIELLA PNEUMONIAE 342
Descriptor:CdiA, CdiI
Authors:Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
Deposit date:2018-03-13
Release date:2019-03-13
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.
Structure, 27, 2019
6CP8
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CONTACT-DEPENDENT GROWTH INHIBITION TOXIN-IMMUNITY PROTEIN COMPLEX FROM FROM E. COLI 3006
Descriptor:CdiA, CdiI, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
Deposit date:2018-03-13
Release date:2019-03-13
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.
Structure, 27, 2019
6BY9
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CRYSTAL STRUCTURE OF EHMT1
Descriptor:Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
Authors:Dong, A., Wei, Y., Li, A., Tempel, W., Han, S., Sunnerhagen, M., Penn, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-12-20
Release date:2018-01-31
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of EHMT1
to be published
5YYL
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STRUCTURE OF MAJOR ROYAL JELLY PROTEIN 1 OLIGOMER
Descriptor:Major royal jelly protein 1, Apisimin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Tian, W., Chen, Z.
Deposit date:2017-12-10
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun, 9, 2018
5YMR
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THE CRYSTAL STRUCTURE OF ISEG
Descriptor:Formate acetyltransferase, 2-hydroxyethylsulfonic acid, GLYCEROL
Authors:Lin, L., Zhang, J., Xing, M., Hua, G., Guo, C., Hu, Y., Wei, Y., Ang, E., Zhao, H., Zhang, Y., Yuchi, Z.
Deposit date:2017-10-22
Release date:2019-03-20
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
Nat Commun, 10, 2019
5WRW
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STRUCTURE OF HUMAN APO-SRP72
Descriptor:Signal recognition particle subunit SRP72, SULFATE ION
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5WRV
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COMPLEX STRUCTURE OF HUMAN SRP72/SRP68
Descriptor:Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72, ACETATE ION, ...
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5WCH
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN USP9X
Descriptor:Probable ubiquitin carboxyl-terminal hydrolase FAF-X, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5VBT
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CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC AND POTENT USP7 UBIQUITIN VARIANT INHIBITOR
Descriptor:UBH04
Authors:DONG, A., DONG, X., LIU, L., GUO, Y., LI, Y., ZHANG, W., WALKER, J.R., SIDHU, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-03-30
Release date:2017-06-07
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
to be published