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5OSK
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TUBULIN-7J COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Menchon, G., Prota, A.E., Steinmetz, M.O., Potter, B.V.L.
Deposit date:2017-08-17
Release date:2017-12-20
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.
J. Med. Chem., 61, 2018
4TMF
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH HYDROLYSED COMPOUND JMS713
Descriptor:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 5-O-[(R)-{[(S)-[4-(8-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)butoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D-ribofuranose
Authors:Zhang, H., Swarbrick, J., Potter, B., Hao, Q.
Deposit date:2014-06-01
Release date:2015-05-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
J.Med.Chem., 57, 2014
3U4H
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CD38 STRUCTURE-BASED INHIBITOR DESIGN USING THE N1-CYCLIC INOSINE 5'-DIPHOSPHATE RIBOSE TEMPLATE
Descriptor:ADP-ribosyl cyclase 1, 8-Amino-N1-Cyclic Inosine 5'-Diphosphoribose
Authors:Liu, Q., Hao, Q., Lee, H.C., Graeff, R.
Deposit date:2011-10-08
Release date:2012-10-10
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.878 Å)
Cite:CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
3U4I
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CD38 STRUCTURE-BASED INHIBITOR DESIGN USING THE N1-CYCLIC INOSINE 5'-DIPHOSPHATE RIBOSE TEMPLATE
Descriptor:ADP-ribosyl cyclase 1, Cyclic adenosine 5'-diphosphocarbocyclic ribose
Authors:Liu, Q., Hao, Q., Lee, H.C., Graeff, R.
Deposit date:2011-10-08
Release date:2012-10-10
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.118 Å)
Cite:CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
4A9C
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CRYSTAL STRUCTURE OF HUMAN SHIP2 IN COMPLEX WITH BIPHENYL 2,3',4,5',6- PENTAKISPHOSPHATE
Descriptor:PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2, BIPHENYL 2,3',4,5',6-PENTAKISPHOSPHATE
Authors:Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Graslund, S., Karlberg, T., Mills, S.J., Moche, M., Nyman, T., Persson, C., Potter, B.V.L., Schuler, H., Thorsell, A.G., Weigelt, J., Nordlund, P.
Deposit date:2011-11-25
Release date:2012-05-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with Ship2 Provides a Rationale for Drug Discovery.
Acs Chem.Biol., 7, 2012
2XMY
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DISCOVERY AND CHARACTERISATION OF 2-ANILINO-4-(THIAZOL-5-YL) PYRIMIDINE TRANSCRIPTIONAL CDK INHIBITORS AS ANTICANCER AGENTS
Descriptor:CELL DIVISION PROTEIN KINASE 2, 4-[4-(3,4-DIMETHYL-2-OXO-2,3-DIHYDRO-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-N-(2-METHOXY-ETHYL)-BENZENESULFONAMIDE
Authors:Wang, S., Griffiths, G., Midgley, C.A., Barnett, A.L., Cooper, M., Grabarek, J., Ingram, L., Jackson, W., Kontopidis, G., McClue, S.J., McInnes, C., McLachlan, J., Meades, C., Mezna, M., Stuart, I., Thomas, M.P., Zheleva, D.I., Lane, D.P., Jackson, R.C., Glover, D.M., Blake, D.G., Fischer, P.M.
Deposit date:2010-07-29
Release date:2010-11-10
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
Chem.Biol., 17, 2010
2XNB
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DISCOVERY AND CHARACTERISATION OF 2-ANILINO-4-(THIAZOL-5-YL) PYRIMIDINE TRANSCRIPTIONAL CDK INHIBITORS AS ANTICANCER AGENTS
Descriptor:CELL DIVISION PROTEIN KINASE 2, 3,4-DIMETHYL-5-(2-{[(1Z)-4-PIPERAZIN-1-YLCYCLOHEXA-2,4-DIEN-1-YLIDENE]AMINO}PYRIMIDIN-4-YL)-1,3-THIAZOL-2(3H)-ONE
Authors:Wang, S., Griffiths, G., Midgley, C.A., Barnett, A.L., Cooper, M., Grabarek, J., Ingram, L., Jackson, W., Kontopidis, G., McClue, S.J., McInnes, C., McLachlan, J., Meades, C., Mezna, M., Stuart, I., Thomas, M.P., Zheleva, D.I., Lane, D.P., Jackson, R.C., Glover, D.M., Blake, D.G., Fischer, P.M.
Deposit date:2010-08-01
Release date:2010-11-10
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
Chem.Biol., 17, 2010
1B94
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RESTRICTION ENDONUCLEASE ECORV WITH CALCIUM
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3'), RESTRICTION ENDONUCLEASE ECORV, CALCIUM ION
Authors:Thomas, M.P., Halford, S.E., Brady, R.L.
Deposit date:1999-02-19
Release date:1999-02-26
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group.
Nucleic Acids Res., 27, 1999
1B95
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ANALYSIS OF A MUTATIONAL HOT-SPOT IN THE ECORV RESTRICTION ENDONUCLEASE: A CATALYTIC ROLE FOR A MAIN CHAIN CARBONYL GROUP
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3'), RESTRICTION ENDONUCLEASE ECORV
Authors:Thomas, M.P., Halford, S.E., Brady, R.L.
Deposit date:1999-02-19
Release date:1999-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group.
Nucleic Acids Res., 27, 1999
1B96
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ANALYSIS OF A MUTATIONAL HOT-SPOT IN THE ECORV RESTRICTION ENDONUCLEASE: A CATALYTIC ROLE FOR A MAIN CHAIN CARBONYL GROUP
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3'), RESTRICTION ENDONUCLEASE ECORV
Authors:Thomas, M.P., Halford, S.E., Brady, R.L.
Deposit date:1999-02-19
Release date:1999-02-26
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group.
Nucleic Acids Res., 27, 1999
1B97
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ANALYSIS OF A MUTATIONAL HOT-SPOT IN THE ECORV RESTRICTION ENDONUCLEASE: A CATALYTIC ROLE FOR A MAIN CHAIN CARBONYL GROUP
Descriptor:DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3'), RESTRICTION ENDONUCLEASE ECORV
Authors:Thomas, M.P., Halford, S.E., Brady, R.L.
Deposit date:1999-02-19
Release date:1999-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group.
Nucleic Acids Res., 27, 1999