5OSK

Tubulin-7j complex

Summary for 5OSK

Entry DOI	10.2210/pdb5osk/pdb
Descriptor	Tubulin alpha-1B chain, 3-(2,5-Dimethoxybenzyl)-7-sulfamoyloxy-6-methoxy-3,4-dihydroquinazolin-2(1H)-one, CALCIUM ION, ... (14 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule quinazolinones
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043
Total number of polymer chains	6
Total formula weight	265632.40
Authors	Menchon, G.,Prota, A.E.,Steinmetz, M.O.,Potter, B.V.L. (deposition date: 2017-08-17, release date: 2017-12-20, Last modification date: 2024-01-17)
Primary citation	Dohle, W.,Jourdan, F.L.,Menchon, G.,Prota, A.E.,Foster, P.A.,Mannion, P.,Hamel, E.,Thomas, M.P.,Kasprzyk, P.G.,Ferrandis, E.,Steinmetz, M.O.,Leese, M.P.,Potter, B.V.L. Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure. J. Med. Chem., 61:1031-1044, 2018 Cited by PubMed: 29227648 DOI: 10.1021/acs.jmedchem.7b01474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation