Author results

5OCE
  • Download 5oce
  • View 5oce
Molmil generated image of 5oce
THE MOLECULAR MECHANISM OF SUBSTRATE RECOGNITION AND CATALYSIS OF THE MEMBRANE ACYLTRANSFERASE PATA -- COMPLEX OF PATA WITH PALMITATE, MANNOSE, AND PALMITOYL-6-MANNOSE
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID, BETA-D-MANNOSE, ...
Authors:Albesa-Jove, D., Tersa, M., Guerin, M.E.
Deposit date:2017-06-30
Release date:2017-12-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria.
ACS Chem. Biol., 13, 2018
5F2T
  • Download 5f2t
  • View 5f2t
Molmil generated image of 5f2t
CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - C 2 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID, MAGNESIUM ION
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F2Z
  • Download 5f2z
  • View 5f2z
Molmil generated image of 5f2z
CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - P21 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F31
  • Download 5f31
  • View 5f31
Molmil generated image of 5f31
CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - P 42 21 2 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID, ETHANOL, ...
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F34
  • Download 5f34
  • View 5f34
Molmil generated image of 5f34
CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH S-HEXADECYL COENZYME A - P21 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (3.281 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
4ZIL
  • Download 4zil
  • View 4zil
Molmil generated image of 4zil
CRYSTAL STRUCTURE OF RV2466C AND OXIDOREDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN ITS REDUCED STATE
Descriptor:DSBA oxidoreductase, MAGNESIUM ION
Authors:Albesa-Jove, D., Urresti, S., Comino, N., Tersa, M., Guerin, M.E.
Deposit date:2015-04-28
Release date:2015-11-18
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.507 Å)
Cite:The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.
J.Biol.Chem., 290, 2015
4NXI
  • Download 4nxi
  • View 4nxi
Molmil generated image of 4nxi
RV2466C MEDIATES THE ACTIVATION OF TP053 TO KILL REPLICATING AND NON-REPLICATING MYCOBACTERIUM TUBERCULOSIS
Descriptor:Uncharacterized protein, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Albesa-Jove, D., Urresti, S., Comino, N., Guerin, M.E.
Deposit date:2013-12-09
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Acs Chem.Biol., 9, 2014