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1S0V
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BU of 1s0v by Molmil
Structural basis for substrate selection by T7 RNA polymerase
Descriptor: 5'-D(*G*GP*GP*AP*AP*TP*CP*GP*AP*TP*AP*TP*CP*GP*CP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*AP*TP*TP*CP*CP*C)-3', 5'-R(*AP*AP*CP*U*GP*CP*GP*GP*CP*GP*AP*U)-3', ...
Authors:Temiakov, D, Patlan, V, Anikin, M, McAllister, W.T, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-01-05
Release date:2004-02-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for substrate selection by t7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
2A6H
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BU of 2a6h by Molmil
Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
9BDC
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BU of 9bdc by Molmil
Cryo-EM Structure of the TEFM-bound Human Mitochondrial Transcription Substrate Rejection Complex
Descriptor: DNA-directed RNA polymerase, mitochondrial, Non-Template Strand DNA (NT27mt_+1T), ...
Authors:Herbine, K.H, Nayak, A.R, Temiakov, D.
Deposit date:2024-04-11
Release date:2024-09-04
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
9BDD
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BU of 9bdd by Molmil
Cryo-EM Structure of Non-Cognate Substrate Bound in the Entry Site (ES) of Human Mitochondrial Transcription Elongation Complex
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ...
Authors:Herbine, K.H, Nayak, A.R, Temiakov, D.
Deposit date:2024-04-11
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
8T7E
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BU of 8t7e by Molmil
Cryo-EM structure of the Backtracking Initiation Complex (VII) of Human Mitochondrial DNA Polymerase Gamma
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D.
Deposit date:2023-06-20
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural basis for DNA proofreading.
Nat Commun, 14, 2023
8U8V
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BU of 8u8v by Molmil
Cryo-EM structure of Substrate ATP Bound in the Insertion Site (IS) of Human Mitochondrial Transcription Elongation Complex
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ...
Authors:Herbine, K.H, Nayak, A.R, Temiakov, D.
Deposit date:2023-09-18
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
8U8U
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BU of 8u8u by Molmil
Cryo-EM Structure of Cognate Substrate ATP Bound in the Entry Site (ES) of Human Mitochondrial Transcription Elongation Complex
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ...
Authors:Herbine, K.H, Nayak, A.R, Temiakov, D.
Deposit date:2023-09-18
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
3SPA
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BU of 3spa by Molmil
Crystal Structure of Human Mitochondrial RNA Polymerase
Descriptor: CHLORIDE ION, DNA-directed RNA polymerase, mitochondrial, ...
Authors:Ringel, R, Sologub, M, Morozov, Y.I, Litonin, D, Cramer, P, Temiakov, D.
Deposit date:2011-07-01
Release date:2011-09-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of human mitochondrial RNA polymerase
Nature, 478, 2011
6ERO
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BU of 6ero by Molmil
Structure of human TFB2M
Descriptor: CHLORIDE ION, Dimethyladenosine transferase 2, mitochondrial,Dimethyladenosine transferase 2, ...
Authors:Hillen, H.S, Morozov, Y.I, Sarfallah, A, Temiakov, D, Cramer, P.
Deposit date:2017-10-18
Release date:2017-11-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis of Mitochondrial Transcription Initiation.
Cell, 171, 2017
6ERP
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BU of 6erp by Molmil
Structure of the human mitochondrial transcription initiation complex at the LSP promoter
Descriptor: DNA-directed RNA polymerase, mitochondrial, Dimethyladenosine transferase 2, ...
Authors:Hillen, H.S, Morozov, Y.I, Sarfallah, A, Temiakov, D, Cramer, P.
Deposit date:2017-10-18
Release date:2017-11-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (4.502 Å)
Cite:Structural Basis of Mitochondrial Transcription Initiation.
Cell, 171, 2017
6ERQ
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BU of 6erq by Molmil
Structure of the human mitochondrial transcription initiation complex at the HSP promoter
Descriptor: DNA-directed RNA polymerase, mitochondrial, Dimethyladenosine transferase 2, ...
Authors:Hillen, H.S, Morozov, Y.I, Sarfallah, A, Temiakov, D, Cramer, P.
Deposit date:2017-10-18
Release date:2017-11-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Structural Basis of Mitochondrial Transcription Initiation.
Cell, 171, 2017
4BOC
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BU of 4boc by Molmil
Structure of mitochondrial RNA polymerase elongation complex
Descriptor: 5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3', 5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3', ...
Authors:Schwinghammer, K, Cheung, A, Morozov, Y, Agaronyan, K, Temiakov, D, Cramer, P.
Deposit date:2013-05-18
Release date:2013-09-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Human Mitochondrial RNA Polymerase Elongation Complex
Nat.Struct.Mol.Biol., 20, 2013
9C52
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BU of 9c52 by Molmil
Cryo-EM structure of the Strand displacement Complex (I) of Yeast Mitochondrial DNA polymerase Gamma (MIP1) with downstream DNA
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, DNA polymerase gamma, ...
Authors:Nayak, A.R, Sokolova, V.O, Sillamaa, S, Sedmen, J, Temiakov, D.
Deposit date:2024-06-05
Release date:2025-03-19
Last modified:2025-03-26
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase.
Nat Commun, 16, 2025
9C53
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BU of 9c53 by Molmil
Cryo-EM structure of the Strand displacement Complex (II) of Yeast Mitochondrial DNA polymerase Gamma (MIP1) with downstream DNA
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, DNA polymerase gamma, ...
Authors:Nayak, A.R, Sokolova, V.O, Sillamaa, S, Sedmen, J, Temiakov, D.
Deposit date:2024-06-05
Release date:2025-03-19
Last modified:2025-04-23
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase.
Nat Commun, 16, 2025
9C51
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BU of 9c51 by Molmil
Cryo-EM structure of the Strand displacement Complex (IV) of Yeast Mitochondrial DNA polymerase Gamma (MIP1) with downstream DNA
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase gamma, MAGNESIUM ION, ...
Authors:Nayak, A.R, Sokolova, V.O, Sillamaa, S, Sedmen, J, Temiakov, D.
Deposit date:2024-06-05
Release date:2025-03-19
Last modified:2025-03-26
Method:ELECTRON MICROSCOPY (2.42 Å)
Cite:Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase.
Nat Commun, 16, 2025
9D2I
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BU of 9d2i by Molmil
Cryo-EM structure of the Strand displacement Complex (III) of Yeast Mitochondrial DNA polymerase Gamma (MIP1) with downstream DNA
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, DNA polymerase gamma, ...
Authors:Nayak, A.R, Sokolova, V.O, Sillamaa, S, Sedmen, J, Temiakov, D.
Deposit date:2024-08-08
Release date:2025-03-19
Last modified:2025-03-26
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase.
Nat Commun, 16, 2025
9E6H
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BU of 9e6h by Molmil
Cryo-EM structure of Maackia amurensis seed Leukoagglutinin (lectin), MASL
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, MANGANESE (II) ION, ...
Authors:Nayak, A.R, Goldberg, G.S, Temiakov, D.
Deposit date:2024-10-30
Release date:2025-04-09
Last modified:2025-05-07
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Maackia amurensis seed lectin structure and sequence comparison with other M. amurensis lectins.
J.Biol.Chem., 301, 2025
7A9W
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BU of 7a9w by Molmil
Structure of yeast Rmd9p in complex with 20nt target RNA
Descriptor: CHLORIDE ION, Protein RMD9, mitochondrial, ...
Authors:Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M.
Deposit date:2020-09-02
Release date:2021-04-07
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 118, 2021
7A9X
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BU of 7a9x by Molmil
Structure of yeast Rmd9p in complex with 16nt target RNA
Descriptor: CHLORIDE ION, Protein RMD9, mitochondrial, ...
Authors:Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M.
Deposit date:2020-09-02
Release date:2021-04-07
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 118, 2021
8G5K
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BU of 8g5k by Molmil
Cryo-EM structure of the Wedge Alignment Complex (VIII) of Human Mitochondrial DNA Polymerase Gamma
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D.
Deposit date:2023-02-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for DNA proofreading.
Nat Commun, 14, 2023
8G5M
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BU of 8g5m by Molmil
Cryo-EM structure of the Mismatch Locking Complex (III) of Human Mitochondrial DNA Polymerase Gamma
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D.
Deposit date:2023-02-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Structural basis for DNA proofreading.
Nat Commun, 14, 2023
8G5P
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BU of 8g5p by Molmil
Cryo-EM structure of the Guide loop Engagement Complex (V) of Human Mitochondrial DNA Polymerase Gamma
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D.
Deposit date:2023-02-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:Structural basis for DNA proofreading.
Nat Commun, 14, 2023
8G5O
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BU of 8g5o by Molmil
Cryo-EM structure of the Guide loop Engagement Complex (IV) of Human Mitochondrial DNA Polymerase Gamma
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D.
Deposit date:2023-02-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Structural basis for DNA proofreading.
Nat Commun, 14, 2023
8G5I
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BU of 8g5i by Molmil
Cryo-EM structure of the Mismatch Sensing Complex (I) of Human Mitochondrial DNA Polymerase Gamma
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D.
Deposit date:2023-02-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Structural basis for DNA proofreading.
Nat Commun, 14, 2023
8G5J
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BU of 8g5j by Molmil
Cryo-EM structure of the Mismatch Uncoupling Complex (II) of Human Mitochondrial DNA Polymerase Gamma
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
Authors:Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D.
Deposit date:2023-02-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.63 Å)
Cite:Structural basis for DNA proofreading.
Nat Commun, 14, 2023

 

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