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4A5S
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CRYSTAL STRUCTURE OF HUMAN DPP4 IN COMPLEX WITH A NOVAL HETEROCYCLIC DPP4 INHIBITOR
Descriptor:DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM, 6-[(3S)-3-AMINOPIPERIDIN-1-YL]-5-BENZYL-4-OXO-3-(QUINOLIN-4-YLMETHYL)-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBONITRILE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ostermann, N., Kroemer, M., Zink, F., Gerhartz, B., Sutton, J.M., Clark, D.E., Dunsdon, S.J., Fenton, G., Fillmore, A., Harris, N.V., Higgs, C., Hurley, C.A., Krintel, S.L., MacKenzie, R.E., Duttaroy, A., Gangl, E., Maniara, W., Sedrani, R., Namoto, K., Sirockin, F., Trappe, J., Hassiepen, U., Baeschlin, D.K.
Deposit date:2011-10-28
Release date:2012-02-08
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Novel Heterocyclic Dpp-4 Inhibitors for the Treatment of Type 2 Diabetes.
Bioorg.Med.Chem.Lett., 22, 2012
1OJQ
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THE CRYSTAL STRUCTURE OF C3STAU2 FROM S. AUREUS
Descriptor:ADP-RIBOSYLTRANSFERASE
Authors:Evans, H.R., Sutton, J.M., Holloway, D.E., Ayriss, J., Shone, C.C., Acharya, K.R.
Deposit date:2003-07-15
Release date:2003-08-28
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:The Crystal Structure of C3Stau2 from Staphylococcus Aureus and its Complex with Nad
J.Biol.Chem., 278, 2003
1OJZ
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THE CRYSTAL STRUCTURE OF C3STAU2 FROM S. AUREUS WITH NAD
Descriptor:ADP-RIBOSYLTRANSFERASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Evans, H.R., Sutton, J.M., Holloway, D.E., Ayriss, J., Shone, C.C., Acharya, K.R.
Deposit date:2003-07-16
Release date:2003-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The Crystal Structure of C3Stau2 from Staphylococcus Aureus and its Complex with Nad
J.Biol.Chem., 278, 2003
1UZI
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C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM
Descriptor:MONO-ADP-RIBOSYLTRANSFERASE C3, CYCLO-TETRAMETAVANADATE, VANADATE ION, ...
Authors:Evans, H.R., Holloway, D.E., Sutton, J.M., Ayriss, J., Shone, C.C., Acharya, K.R.
Deposit date:2004-03-12
Release date:2004-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:C3 Exoenzyme from Clostridium Botulinum: Structure of a Tetragonal Crystal Form and a Reassessment of Nad-Induced Flexure
Acta Crystallogr.,Sect.D, 60, 2004
2BOV
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MOLECULAR RECOGNITION OF AN ADP-RIBOSYLATING CLOSTRIDIUM BOTULINUM C3 EXOENZYME BY RALA GTPASE
Descriptor:RAS-RELATED PROTEIN RAL-A, MONO-ADP-RIBOSYLTRANSFERASE C3, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Holbourn, K.P., Sutton, J.M., Evans, H.R., Shone, C.C., Acharya, K.R.
Deposit date:2005-04-14
Release date:2005-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Molecular Recognition of an Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme by Rala Gtpase
Proc.Natl.Acad.Sci.USA, 102, 2005
6P90
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CRYSTAL STRUCTURE OF PADHDPS2-H56Q MUTANT
Descriptor:4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, CHLORIDE ION
Authors:Impey, R.E., Panjikar, S., Hall, C.J., Bock, L.J., Sutton, J.M., Perugini, M.A., Soares da Costa, T.P.
Deposit date:2019-06-08
Release date:2019-08-07
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation.
Febs J., 287, 2020
6UE0
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CRYSTAL STRUCTURE OF DIHYDRODIPICOLINATE SYNTHASE FROM KLEBSIELLA PNEUMONIAE BOUND TO PYRUVATE
Descriptor:4-hydroxy-tetrahydrodipicolinate synthase, SULFATE ION, CHLORIDE ION
Authors:Impey, R.E., Lee, M., Hawkins, D.A., Sutton, J.M., Panjikar, S., Perugini, M.A., Soares da Costa, T.P.
Deposit date:2019-09-20
Release date:2020-02-05
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens.
Febs Lett., 2020
4N8D
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DPP4 COMPLEXED WITH SYN-7AA
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Ostermann, N., Zink, F., Kroemer, M.
Deposit date:2013-10-17
Release date:2014-02-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.
Bioorg.Med.Chem.Lett., 24, 2014
4N8E
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DPP4 COMPLEXED WITH COMPOUND 12A
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Ostermann, N., Zink, F., Kroemer, M.
Deposit date:2013-10-17
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.
Bioorg.Med.Chem.Lett., 24, 2014
6GIJ
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NMR STRUCTURE OF TEMPORIN B KKG6A IN SDS MICELLES
Descriptor:temporinB_KKG6A
Authors:Manzo, G., Mason, J.A.
Deposit date:2018-05-12
Release date:2018-06-13
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity.
Sci Rep, 9, 2019
6GIK
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NMR STRUCTURE OF TEMPORIN B L1FK IN SDS MICELLES
Descriptor:temporinB_L1FK
Authors:Manzo, G., Mason, J.A.
Deposit date:2018-05-12
Release date:2018-06-13
Last modified:2019-09-11
Method:SOLUTION NMR
Cite:Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity.
Sci Rep, 9, 2019
6GIL
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NMR STRUCTURE OF TEMPORIN B IN SDS MICELLES
Descriptor:Temporin-B
Authors:Manzo, G., Mason, J.A.
Deposit date:2018-05-12
Release date:2018-06-13
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity.
Sci Rep, 9, 2019
6GS5
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NMR STRUCTURE OF TEMPORIN L IN SDS MICELLES
Descriptor:Temporin-L
Authors:Manzo, G., Mason, J.A.
Deposit date:2018-06-13
Release date:2018-07-18
Last modified:2019-08-14
Method:SOLUTION NMR
Cite:Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities.
Sci Rep, 9, 2019
6GS9
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NMR STRUCTURE OF AUREIN 2.5 IN SDS MICELLES
Descriptor:Aurein 2.5
Authors:Manzo, G., Mason, J.A.
Deposit date:2018-06-13
Release date:2018-07-18
Last modified:2019-08-14
Method:SOLUTION NMR
Cite:Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities.
Sci Rep, 9, 2019
2A78
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CRYSTAL STRUCTURE OF THE C3BOT-RALA COMPLEX REVEALS A NOVEL TYPE OF ACTION OF A BACTERIAL EXOENZYME
Descriptor:Ras-related protein Ral-A, Mono-ADP-ribosyltransferase C3, MAGNESIUM ION, ...
Authors:Pautsch, A., Vogelsgesang, M., Trankle, J., Herrmann, C., Aktories, K.
Deposit date:2005-07-05
Release date:2005-10-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme.
Embo J., 24, 2005
2A9K
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CRYSTAL STRUCTURE OF THE C3BOT-NAD-RALA COMPLEX REVEALS A NOVEL TYPE OF ACTION OF A BACTERIAL EXOENZYME
Descriptor:Ras-related protein Ral-A, Mono-ADP-ribosyltransferase C3, MAGNESIUM ION, ...
Authors:Pautsch, A., Vogelsgesang, M., Trankle, J., Herrmann, C., Aktories, K.
Deposit date:2005-07-12
Release date:2005-10-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme.
Embo J., 24, 2005