Author results

5VX6
  • Download 5vx6
  • View 5vx6
Molmil generated image of 5vx6
STRUCTURE OF BACILLUS SUBTILIS INHIBITOR OF MOTILITY (MOTI/DGRA)
Descriptor:Uncharacterized protein YpfA, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Subramanian, S., Dann III, C.
Deposit date:2017-05-23
Release date:2017-11-22
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA inBacillus subtilis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2XE0
  • Download 2xe0
  • View 2xe0
Molmil generated image of 2xe0
MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:I-CREI V2V3 VARIANT, 24MER DNA, ACETATE ION, ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Redondo, P., Villate, M., Merino, N., Marenchino, M., D'Abramo, M., Gervasio, F.L., Grizot, S., Daboussi, F., Smith, J., Chion-Sotine, I., Paques, F., Duchateau, P., Alibes, A., Stricher, F., Serrano, L., Blanco, F.J., Montoya, G.
Deposit date:2010-05-10
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
Nucleic Acids Res., 39, 2011
3MX9
  • Download 3mx9
  • View 3mx9
Molmil generated image of 3mx9
MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:Protein scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*CP*CP*TP*GP*AP*GP*AP*AP*CP*AP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXA
  • Download 3mxa
  • View 3mxa
Molmil generated image of 3mxa
MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(P*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXB
  • Download 3mxb
  • View 3mxb
Molmil generated image of 3mxb
MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:V3(E8K), V2(K7E-G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
6NF9
  • Download 6nf9
  • View 6nf9
Molmil generated image of 6nf9
STRUCTURE OF M. SPRETUS ENDOGENOUS VIRUS ELEMENT (EVE) VIRUS-LIKE PARTICLE (VLP)
Descriptor:Mus Spretus Endogenous Viral Element
Authors:Callaway, H.M., Subramanian, S.
Deposit date:2018-12-19
Release date:2019-01-23
Last modified:2019-03-13
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Examination and Reconstruction of Three Ancient Endogenous Parvovirus Capsid Protein Gene Remnants Found in Rodent Genomes.
J. Virol., 93, 2019
3C0K
  • Download 3c0k
  • View 3c0k
Molmil generated image of 3c0k
CRYSTAL STRUCTURE OF A RIBOSOMAL RNA METHYLTRANFERASE
Descriptor:UPF0064 protein yccW
Authors:Subramanian, S., Jayaraman, S., Bujnicki, J.
Deposit date:2008-01-21
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes
J.Mol.Biol., 383, 2008
3F9I
  • Download 3f9i
  • View 3f9i
Molmil generated image of 3f9i
CRYSTAL STRUCTURE OF 3-KETOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE RICKETTSIA PROWAZEKII
Descriptor:3-oxoacyl-[acyl-carrier-protein] reductase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-11-13
Release date:2008-11-25
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 A resolution.
Acta Crystallogr.,Sect.F, 67, 2011
4O3V
  • Download 4o3v
  • View 4o3v
Molmil generated image of 4o3v
CRYSTAL STRUCTURE OF A VIRB8-LIKE PROTEIN OF TYPE IV SECRETION SYSTEM FROM RICKETTSIA TYPHI
Descriptor:VirB8-like protein of type IV secretion system, S,R MESO-TARTARIC ACID
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-12-18
Release date:2014-03-05
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
MBio, 6, 2015
5VAL
  • Download 5val
  • View 5val
Molmil generated image of 5val
BRAF IN COMPLEX WITH N-(3-(TERT-BUTYL)PHENYL)-4-METHYL-3-(6-MORPHOLINOPYRIMIDIN-4-YL)BENZAMIDE
Descriptor:Serine/threonine-protein kinase B-raf, N-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide
Authors:Mamo, M., Appleton, B.A.
Deposit date:2017-03-27
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J. Med. Chem., 60, 2017
5VAM
  • Download 5vam
  • View 5vam
Molmil generated image of 5vam
BRAF IN COMPLEX WITH RAF709
Descriptor:Serine/threonine-protein kinase B-raf, N-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide
Authors:Mamo, M., Appleton, B.A.
Deposit date:2017-03-27
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J. Med. Chem., 60, 2017
5D9K
  • Download 5d9k
  • View 5d9k
Molmil generated image of 5d9k
RSK2 N-TERMINAL KINASE IN COMPLEX WITH BI-D1870
Descriptor:Ribosomal protein S6 kinase alpha-3, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, GLYCEROL
Authors:Appleton, B.A.
Deposit date:2015-08-18
Release date:2015-09-02
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
J.Med.Chem., 58, 2015
5D9L
  • Download 5d9l
  • View 5d9l
Molmil generated image of 5d9l
RSK2 N-TERMINAL KINASE IN COMPLEX WITH BIS-PHENOL PYRAZOLE
Descriptor:Ribosomal protein S6 kinase alpha-3, 4,4'-(1H-pyrazole-3,4-diyl)diphenol, GLYCEROL
Authors:Appleton, B.A.
Deposit date:2015-08-18
Release date:2015-09-02
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
J.Med.Chem., 58, 2015
4JF8
  • Download 4jf8
  • View 4jf8
Molmil generated image of 4jf8
CRYSTAL STRUCTURE OF A TRWG COMPONENT OF TYPE IV SECRETION SYSTEM PROTEIN FROM BARTONELLA BIRTLESII
Descriptor:TrwG component of type IV secretion system, 1,2-ETHANEDIOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-02-27
Release date:2014-03-05
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
MBio, 6, 2015
4KZ1
  • Download 4kz1
  • View 4kz1
Molmil generated image of 4kz1
CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF VIRB8 FROM BARTONELLA GRAHAMII
Descriptor:VirB8 protein
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-05-29
Release date:2014-03-12
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
MBio, 6, 2015
4LSO
  • Download 4lso
  • View 4lso
Molmil generated image of 4lso
CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF A TYPE IV SECRETION SYSTEM PROTEIN VIRB8 FROM BARTONELLA QUINTANA TOULOUSE
Descriptor:Type IV secretion system protein virB8
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-07-22
Release date:2014-03-05
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
MBio, 6, 2015
4MEI
  • Download 4mei
  • View 4mei
Molmil generated image of 4mei
CRYSTAL STRUCTURE OF A VIRB8 TYPE IV SECRETION SYSTEM MACHINERY SOLUBLE DOMAIN FROM BARTONELLA TRIBOCORUM
Descriptor:VirB8 protein
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-08-26
Release date:2014-03-05
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
MBio, 6, 2015
4NHF
  • Download 4nhf
  • View 4nhf
Molmil generated image of 4nhf
CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF TRWG TYPE IV SECRETION MACHINERY FROM BARTONELLA GRAHAMII
Descriptor:TrwG protein, CALCIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-11-04
Release date:2014-03-05
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
MBio, 6, 2015
4NW5
  • Download 4nw5
  • View 4nw5
Molmil generated image of 4nw5
RSK2 N-TERMINAL KINASE IN COMPLEX WITH 2-AMINO-7-SUBSTITUTED BENZOXAZOLE COMPOUND 8
Descriptor:Ribosomal protein S6 kinase alpha-3, 7-(2-fluoro-6-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine
Authors:Appleton, B.A.
Deposit date:2013-12-05
Release date:2014-02-19
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4NW6
  • Download 4nw6
  • View 4nw6
Molmil generated image of 4nw6
RSK2 N-TERMINAL KINASE IN COMPLEX WITH 2-AMINO-7-SUBSTITUTED BENZOXAZOLE COMPOUND 27
Descriptor:Ribosomal protein S6 kinase alpha-3, 7-(1H-benzimidazol-7-yl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine
Authors:Appleton, B.A.
Deposit date:2013-12-05
Release date:2014-02-19
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
5CT7
  • Download 5ct7
  • View 5ct7
Molmil generated image of 5ct7
BRAF IN COMPLEX WITH RAF265
Descriptor:Serine/threonine-protein kinase B-raf, 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Authors:Appleton, B.A.
Deposit date:2015-07-23
Release date:2015-09-09
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Acs Med.Chem.Lett., 6, 2015
6B8J
  • Download 6b8j
  • View 6b8j
Molmil generated image of 6b8j
CO-STRUCTURE OF HUMAN GLYCOGEN SYNTHASE KINASE BETA WITH A SELECTIVE (5-IMIDAZOL-2-YL-4-PHENYLPYRIMIDIN-2-YL)[2-(2-PYRIDYLAMINO)ETHYL]AMINE INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, VAL-SEP-ARG-ARG, GLYCEROL, ...
Authors:Bussiere, D.E.
Deposit date:2017-10-08
Release date:2017-11-08
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
J. Med. Chem., 60, 2017
3GTD
  • Download 3gtd
  • View 3gtd
Molmil generated image of 3gtd
2.4 ANGSTROM CRYSTAL STRUCTURE OF FUMARATE HYDRATASE FROM RICKETTSIA PROWAZEKII
Descriptor:Fumarate hydratase class II, MALONATE ION, SODIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-03-27
Release date:2009-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria.
Acta Crystallogr.,Sect.F, 67, 2011
5TS9
  • Download 5ts9
  • View 5ts9
Molmil generated image of 5ts9
CRYSTAL STRUCTURE OF CHORISMATE MUTASE FROM BURKHOLDERIA PHYMATUM
Descriptor:Chorismate mutase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-10-28
Release date:2016-11-23
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of chorismate mutase from Burkholderia phymatum.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6CNZ
  • Download 6cnz
  • View 6cnz
Molmil generated image of 6cnz
CRYSTAL STRUCTURE OF CHORISMATE MUTASE FROM BURKHOLDERIA THAILANDENSIS
Descriptor:Chorismate mutase, NITRATE ION, 1,2-ETHANEDIOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-03-09
Release date:2018-03-21
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of chorismate mutase from Burkholderia thailandensis.
Acta Crystallogr F Struct Biol Commun, 74, 2018
<12>