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6XVI
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BU of 6xvi by Molmil
Crystal structure of Megabody Mb-Nb207-c7HopQ_A12
Descriptor: Outer membrane protein,Outer membrane protein,Mb-Nb207-c7HopQ_A12
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-22
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
6XUX
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BU of 6xux by Molmil
Crystal structure of Megabody Mb-Nb207-cYgjK_NO
Descriptor: CALCIUM ION, Nanobody,Glucosidase YgjK,Glucosidase YgjK,Nanobody
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.90000641 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
6XV8
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BU of 6xv8 by Molmil
Crystal structure of Megabody Mb-Nb207-c7HopQ_G10
Descriptor: Outer membrane protein
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
2X1Q
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BU of 2x1q by Molmil
Gelsolin Nanobody
Descriptor: GELSOLIN NANOBODY
Authors:Van Den Abbeele, A, Declercq, S, De Ganck, A, De Corte, V, Van Loo, B, Srinivasan, V, Steyaert, J, Van De Kerckhove, J, Gettemans, J.
Deposit date:2010-01-03
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:A Llama-Derived Gelsolin Single-Domain Antibody Blocks Gelsolin-G-Actin Interaction.
Cell.Mol.Life Sci., 67, 2010
1HOZ
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BU of 1hoz by Molmil
CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX
Descriptor: CALCIUM ION, GLYCEROL, INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE
Authors:Versees, W, Decanniere, K, Pelle, R, Depoorter, J, Parkin, D.W, Steyaert, J.
Deposit date:2000-12-12
Release date:2001-12-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.
J.Mol.Biol., 307, 2001
2X6M
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BU of 2x6m by Molmil
Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein
Descriptor: ALPHA-SYNUCLEIN PEPTIDE, HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY
Authors:DeGenst, E, Guilliams, T, Wellens, J, O'Day, E.M, Waudby, C.A, Meehan, S, Dumoulin, M, Hsu, S.-T.D, Cremades, N, Verschueren, K.H.G, Pardon, E, Wyns, L, Steyaert, J, Christodoulou, J, Dobson, C.M.
Deposit date:2010-02-18
Release date:2010-06-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure and Properties of a Complex of Alpha-Synuclein and a Single-Domain Camelid Antibody.
J.Mol.Biol., 402, 2010
6I53
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BU of 6i53 by Molmil
Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Laverty, D, Desai, R, Uchanski, T, Masiulis, S, Wojciech, J.S, Malinauskas, T, Zivanov, J, Pardon, E, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-11-12
Release date:2019-01-02
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer.
Nature, 565, 2019
2AAD
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BU of 2aad by Molmil
THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT
Descriptor: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 ISOZYME
Authors:Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W.
Deposit date:1992-09-15
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant.
Biochemistry, 31, 1992
2AAE
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BU of 2aae by Molmil
THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT
Descriptor: CALCIUM ION, PHOSPHATE ION, RIBONUCLEASE T1
Authors:Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W.
Deposit date:1992-09-15
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant.
Biochemistry, 31, 1992
1YOE
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BU of 1yoe by Molmil
Crystal structure of a the E. coli pyrimidine nucleoside hydrolase YbeK with bound ribose
Descriptor: CALCIUM ION, Hypothetical protein ybeK, alpha-D-ribofuranose
Authors:Muzzolini, L, Versees, W, Steyaert, J, Degano, M.
Deposit date:2005-01-27
Release date:2006-01-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure of the E. coli pyrimidine nucleoside hydrolase YbeK with bound ribose
To be Published
8QZ2
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BU of 8qz2 by Molmil
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61)
Descriptor: Nanobody 61, POTASSIUM ION, Potassium channel subfamily K member 10
Authors:Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2023-10-26
Release date:2024-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Nat Commun, 15, 2024
8QZ1
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BU of 8qz1 by Molmil
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58)
Descriptor: Isoform B of Potassium channel subfamily K member 10, Nanobody 58, POTASSIUM ION
Authors:Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2023-10-26
Release date:2024-05-29
Method:X-RAY DIFFRACTION (3.588 Å)
Cite:Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Nat Commun, 15, 2024
8QZ3
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BU of 8qz3 by Molmil
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Nanobody 67, POTASSIUM ION, ...
Authors:Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2023-10-26
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Nat Commun, 15, 2024
8QZ4
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BU of 8qz4 by Molmil
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76)
Descriptor: BARIUM ION, CHOLESTEROL HEMISUCCINATE, Nanobody 76, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2023-10-26
Release date:2024-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Nat Commun, 15, 2024
8V8K
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BU of 8v8k by Molmil
Crystal Structure of Nanobody NbE
Descriptor: Nanobody NbE
Authors:Koehl, A, Manglik, A, Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Steyaert, J, Ballet, S, Boland, A, Stoeber, M.
Deposit date:2023-12-05
Release date:2024-09-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist
To Be Published
4CND
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BU of 4cnd by Molmil
Crystal structure of E.coli TrmJ
Descriptor: DI(HYDROXYETHYL)ETHER, TRNA (CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
4CNE
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BU of 4cne by Molmil
Crystal structure of E.coli TrmJ in complex with S-adenosyl-L- homocysteine
Descriptor: DI(HYDROXYETHYL)ETHER, S-ADENOSYL-L-HOMOCYSTEINE, TRNA (CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
4CNG
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BU of 4cng by Molmil
Crystal structure of Sulfolobus acidocaldarius TrmJ in complex with S-adenosyl-L-Homocysteine
Descriptor: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, SPOU RRNA METHYLASE
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
4CNF
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BU of 4cnf by Molmil
Crystal structure of Sulfolobus acidocaldarius TrmJ
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Van Laer, B, Somme, J, Roovers, M, Steyaert, J, Droogmans, L, Versees, W.
Deposit date:2014-01-22
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates.
RNA, 20, 2014
1BIR
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BU of 1bir by Molmil
RIBONUCLEASE T1, PHE 100 TO ALA MUTANT COMPLEXED WITH 2' GMP
Descriptor: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1
Authors:Doumen, J, Gonciarz, M, Zegers, I, Loris, R, Wyns, L, Steyaert, J.
Deposit date:1996-01-04
Release date:1996-08-17
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A catalytic function for the structurally conserved residue Phe 100 of ribonuclease T1.
Protein Sci., 5, 1996
5JQH
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BU of 5jqh by Molmil
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, CHOLESTEROL, Endolysin,Beta-2 adrenergic receptor, ...
Authors:Staus, D.P, Strachan, R.T, Manglik, A, Pani, B, Kahsai, A.W, Kim, T.H, Wingler, L.M, Ahn, S, Chatterjee, A, Masoudi, A, Kruse, A.C, Pardon, E, Steyaert, J, Weis, W.I, Prosser, R.S, Kobilka, B.K, Costa, T, Lefkowitz, R.J.
Deposit date:2016-05-05
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Nature, 535, 2016
7PHP
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BU of 7php by Molmil
Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM
Descriptor: Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ...
Authors:Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P.
Deposit date:2021-08-18
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
7ZC2
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BU of 7zc2 by Molmil
Dipeptide and tripeptide Permease C (DtpC)
Descriptor: Amino acid/peptide transporter
Authors:Killer, M, Finocchio, G, Pardon, E, Steyaert, J, Loew, C.
Deposit date:2022-03-25
Release date:2022-07-06
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C.
Front Mol Biosci, 9, 2022
2X1O
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BU of 2x1o by Molmil
Gelsolin Nanobody
Descriptor: GELSOLIN NANOBODY
Authors:Van Den Abbeele, A, Declercq, S, De Ganck, A, De Corte, V, Van Loo, B, Srinivasan, V, Steyaert, J, Van De Kerckhove, J, Gettemans, J.
Deposit date:2010-01-03
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:A Llama-Derived Gelsolin Single-Domain Antibody Blocks Gelsolin-G-Actin Interaction.
Cell.Mol.Life Sci., 67, 2010
3BIR
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BU of 3bir by Molmil
DISECTING HISTIDINE INTERACTIONS IN RIBONUCLEASE T1 BY ASN AND GLN SUBSTITUTIONS
Descriptor: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1
Authors:Doumen, J, Steyaert, J.
Deposit date:1997-06-27
Release date:1997-12-31
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissecting histidine interactions of ribonuclease T1 with asparagine and glutamine replacements: analysis of double mutant cycles at one position.
J.Mol.Biol., 275, 1998

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