Author results

1A36
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TOPOISOMERASE I/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3'), TOPOISOMERASE I
Authors:Stewart, L., Redinbo, M.R., Qiu, X., Champoux, J.J., Hol, W.G.J.
Deposit date:1998-01-29
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A model for the mechanism of human topoisomerase I.
Science, 279, 1998
3CEZ
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CRYSTAL STRUCTURE OF METHIONINE-R-SULFOXIDE REDUCTASE FROM BURKHOLDERIA PSEUDOMALLEI
Descriptor:Methionine-R-sulfoxide reductase, ZINC ION, ACETIC ACID
Authors:Staker, B., Napuli, A., Nakazawa, S.H., Castaneda, L., Alkafeef, S., Vanvoorhis, W., Stewart, L., Myler, P., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-02-29
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Methionine-R-sulfoxide reductase from Burkholderia pseudomallei.
To be Published
1A31
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HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I)
Authors:Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.J.
Deposit date:1998-01-27
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1A35
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HUMAN TOPOISOMERASE I/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I)
Authors:Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.
Deposit date:1998-01-29
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1LPQ
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN NON-COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX CONTAINING AN 8-OXOG LESION
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I
Authors:Lesher, D.T., Pommier, Y., Stewart, L., Redinbo, M.R.
Deposit date:2002-05-08
Release date:2002-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:8-Oxoguanine rearranges the active site of human topoisomerase I
Proc.Natl.Acad.Sci.USA, 99, 2002
1NH3
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HUMAN TOPOISOMERASE I ARA-C COMPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3', 5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3', ...
Authors:Chrencik, J.E., Burgin, A.B., Pommier, Y., Stewart, L., Redinbo, M.R.
Deposit date:2002-12-18
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex
J.Biol.Chem., 278, 2003
1RR8
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STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ...
Authors:Chrencik, J.E., Staker, B.L., Burgin, A.B., Stewart, L., Redinbo, M.R.
Deposit date:2003-12-08
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
1RRJ
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STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ...
Authors:Chrencik, J.E., Staker, B.L., Burgin, A.B., Stewart, L., Redinbo, M.R.
Deposit date:2003-12-08
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
1SC7
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDENOISOQUINOLINE MJ-II-38 AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Deposit date:2004-02-11
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1SEU
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDOLOCARBAZOLE SA315F AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Deposit date:2004-02-18
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1T8I
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON CAMPTOTHECIN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Deposit date:2004-05-12
Release date:2005-05-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1TL8
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDENOISOQUINOLINE AI-III-52 AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Ioanoviciu, A., Antony, S., Pommier, Y., Staker, B.L., Stewart, L., Cushman, M.
Deposit date:2004-06-09
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis
J.Med.Chem., 48, 2005
2RHH
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ WITH BOUND SULFATE ION
Descriptor:Cell Division Protein ftsZ, SULFATE ION
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
2RHJ
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ WITH TWO SULFATE IONS AND SODIUM ION IN THE NUCLEOTIDE POCKET
Descriptor:Cell Division Protein ftsZ, ACETATE ION, SULFATE ION, ...
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
2RHL
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ NCS DIMER WITH BOUND GDP
Descriptor:Cell Division Protein ftsZ, GUANOSINE-5'-DIPHOSPHATE
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
2RHO
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SYNTHETIC GENE ENCODED BACILLUS SUBTILIS FTSZ NCS DIMER WITH BOUND GDP AND GTP-GAMMA-S
Descriptor:Cell Division Protein ftsZ, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE
Authors:Lovell, S., Halloran, Z., Hjerrild, K., Sheridan, D., Burgin, A., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-10-09
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
BMC Biotechnol., 9, 2009
3BL7
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG156844
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL9
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG157493
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BLA
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG153249
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3CXK
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1.7 A CRYSTAL STRUCTURE OF METHIONINE-R-SULFOXIDE REDUCTASE FROM BURKHOLDERIA PSEUDOMALLEI: CRYSTALLIZATION IN A MICROFLUIDIC CRYSTAL CARD.
Descriptor:Methionine-R-sulfoxide reductase, ZINC ION, ACETATE ION
Authors:Lovell, S., Gerdts, C., Staker, B., Craigen, D., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-04-24
Release date:2008-05-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).
Acta Crystallogr.,Sect.D, 64, 2008
4DGQ
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CRYSTAL STRUCTURE OF NON-HEME CHLOROPEROXIDASE FROM BURKHOLDERIA CENOCEPACIA
Descriptor:Non-heme chloroperoxidase, 1,2-ETHANEDIOL
Authors:Gardberg, A.S., Edwards, T.E., Abendroth, J.A., Staker, B., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-01-26
Release date:2012-03-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of Non-heme chloroperoxidase from Burkholderia cenocepacia
To be Published
4EFI
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CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER PROTEIN) SYNTHASE FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:3-oxoacyl-(Acyl-carrier protein) synthase, UNKNOWN LIGAND, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Craig, T.K., Abendroth, J., Staker, B., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-03-29
Release date:2012-04-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
4F2G
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THE CRYSTAL STRUCTURE OF ORNITHINE CARBAMOYLTRANSFERASE FROM BURKHOLDERIA THAILANDENSIS E264
Descriptor:Ornithine carbamoyltransferase 1, 1,2-ETHANEDIOL, PHOSPHATE ION
Authors:Craig, T.K., Fox, D., Staker, B., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-05-07
Release date:2012-05-30
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
4H4G
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CRYSTAL STRUCTURE OF (3R)-HYDROXYMYRISTOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE FROM BURKHOLDERIA THAILANDENSIS E264
Descriptor:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Authors:Craig, T.K., Edwards, T.E., Staker, B., Stewart, L., Lorimer, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-09-17
Release date:2012-10-03
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
3L56
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CRYSTAL STRUCTURE OF THE LARGE C-TERMINAL DOMAIN OF POLYMERASE BASIC PROTEIN 2 FROM INFLUENZA VIRUS A/VIET NAM/1203/2004 (H5N1)
Descriptor:Polymerase PB2
Authors:Staker, B.L., Edwards, T., Eric, S., Raymond, A., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-21
Release date:2010-03-09
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010