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1MHN
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BU of 1mhn by Molmil
High resolution crystal structure of the SMN Tudor domain
Descriptor: Survival motor neuron protein
Authors:Sprangers, R, Groves, M.R, Sinning, I, Sattler, M.
Deposit date:2002-08-20
Release date:2003-03-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High Resolution X-ray and NMR Structures of the SMN Tudor Domain: conformational variation in the binding site for symmetrically dimethylated arginine residues
J.Mol.Biol., 327, 2003
8PNK
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BU of 8pnk by Molmil
Crystal structure of the Ded1p RecA1 domain
Descriptor: ATP-dependent RNA helicase DED1
Authors:Huebner, J, Sprangers, R.
Deposit date:2023-06-30
Release date:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Ded1p RecA1 domain
To Be Published
7PVM
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BU of 7pvm by Molmil
NMR structure of the C. thermophilum Xrn2 zinc finger
Descriptor: 5'-3' exoribonuclease, ZINC ION
Authors:Overbeck, J.H, Sprangers, R, Wurm, J.P.
Deposit date:2021-10-05
Release date:2022-07-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Observation of conformational changes that underlie the catalytic cycle of Xrn2.
Nat.Chem.Biol., 18, 2022
1QMC
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BU of 1qmc by Molmil
C-terminal DNA-binding domain of HIV-1 integrase, NMR, 42 structures
Descriptor: HIV-1 INTEGRASE
Authors:Eijkelenboom, A.P.A.M, Sprangers, R, Hard, K, Puras Lutzke, R.A, Plasterk, R.H.A, Boelens, R, Kaptein, R.
Deposit date:1999-09-27
Release date:1999-12-14
Last modified:2015-10-14
Method:SOLUTION NMR
Cite:Refined Solution Structure of the C-Terminal DNA-Binding Domain of Human Immunovirus-1 Integrase.
Proteins: Struct.,Funct., Genet., 36, 1999
1Y7O
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BU of 1y7o by Molmil
The structure of Streptococcus pneumoniae A153P ClpP
Descriptor: ATP-dependent Clp protease proteolytic subunit, CALCIUM ION
Authors:Kimber, M.S, Gribun, A, Ching, R, Sprangers, R, Fiebig, K.M, Houry, W.A.
Deposit date:2004-12-09
Release date:2005-02-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation.
J.Biol.Chem., 280, 2005
7OPK
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BU of 7opk by Molmil
Crystal structure of C. thermophilum Xrn2
Descriptor: 5'-3' exoribonuclease, MAGNESIUM ION
Authors:Overbeck, J.H, Sprangers, R.
Deposit date:2021-06-01
Release date:2022-07-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Observation of conformational changes that underlie the catalytic cycle of Xrn2.
Nat.Chem.Biol., 18, 2022
5JP4
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BU of 5jp4 by Molmil
Crystal structure of S. pombe Dcp1 in complex with the decapping enhancer EDC
Descriptor: Uncharacterized protein C18G6.09c, mRNA-decapping enzyme subunit 1
Authors:Wurm, J.P, Sprangers, R.
Deposit date:2016-05-03
Release date:2016-06-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface.
Rna, 22, 2016
5N2V
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BU of 5n2v by Molmil
Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Edc1, MAGNESIUM ION, ...
Authors:Holdermann, I, Sprangers, R.
Deposit date:2017-02-08
Release date:2017-05-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6GBS
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BU of 6gbs by Molmil
Crystal Structure of the C. themophilum Scavenger Decapping Enzyme DcpS apo form
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Putative mRNA decapping protein
Authors:Fuchs, A.-L, Neu, A, Sprangers, R.
Deposit date:2018-04-16
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.946 Å)
Cite:Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme.
Proc.Natl.Acad.Sci.USA, 117, 2020
6TRQ
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BU of 6trq by Molmil
S.c. Scavenger Decapping Enzyme DcpS in complex with the capped RNA dinucleotide m7G-GU
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, L-GUANOSINE-5'-MONOPHOSPHATE, PHOSPHONATE, ...
Authors:Fuchs, A.-L, Neu, A, Sprangers, R.
Deposit date:2019-12-19
Release date:2020-07-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.944 Å)
Cite:Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme.
Proc.Natl.Acad.Sci.USA, 117, 2020
7BBB
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BU of 7bbb by Molmil
Solution structure of C-terminal RecA and RRM domains of the DEAD box helicase DbpA
Descriptor: ATP-dependent RNA helicase DbpA
Authors:Wurm, J.P, Sprangers, R.
Deposit date:2020-12-17
Release date:2021-07-14
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for the activation of the DEAD-box RNA helicase DbpA by the nascent ribosome.
Proc.Natl.Acad.Sci.USA, 118, 2021
5BV3
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BU of 5bv3 by Molmil
Yeast Scavenger Decapping Enzyme in complex with m7GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, CHLORIDE ION, SULFATE ION, ...
Authors:Neu, A, Neu, U, Sprangers, R.
Deposit date:2015-06-04
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:An excess of catalytically required motions inhibits the scavenger decapping enzyme.
Nat.Chem.Biol., 11, 2015
1G5V
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BU of 1g5v by Molmil
SOLUTION STRUCTURE OF THE TUDOR DOMAIN OF THE HUMAN SMN PROTEIN
Descriptor: SURVIVAL MOTOR NEURON PROTEIN 1
Authors:Selenko, P, Sprangers, R, Stier, G, Buehler, D, Fischer, U, Sattler, M.
Deposit date:2000-11-02
Release date:2001-05-02
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:SMN tudor domain structure and its interaction with the Sm proteins.
Nat.Struct.Biol., 8, 2001
4Q2S
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BU of 4q2s by Molmil
Crystal Structure of S. pombe Pdc1 Ge1 Domain
Descriptor: PDC1 GE1 DOMAIN
Authors:Noeldeke, E.R, Neu, A, Zocher, G, Sprangers, R.
Deposit date:2014-04-09
Release date:2014-10-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:In vitro reconstitution of a cellular phase-transition process that involves the mRNA decapping machinery.
Angew.Chem.Int.Ed.Engl., 53, 2014
3SWN
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BU of 3swn by Molmil
Structure of the LSm657 Complex: An Assembly Intermediate of the LSm1 7 and LSm2 8 Rings
Descriptor: U6 snRNA-associated Sm-like protein LSm5, U6 snRNA-associated Sm-like protein LSm6, U6 snRNA-associated Sm-like protein LSm7, ...
Authors:Mund, M, Neu, A, Ullmann, J.L, Neu, U, Sprangers, R.
Deposit date:2011-07-14
Release date:2011-10-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings.
J.Mol.Biol., 414, 2011
4A53
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BU of 4a53 by Molmil
Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6
Descriptor: EDC3
Authors:Fromm, S.A, Truffault, V, Kamenz, J, Braun, J.E, Hoffmann, N.A, Izaurralde, E, Sprangers, R.
Deposit date:2011-10-24
Release date:2012-02-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Structural Basis of Edc3- and Scd6-Mediated Activation of the Dcp1:Dcp2 Mrna Decapping Complex.
Embo J., 31, 2011
4A54
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BU of 4a54 by Molmil
Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6
Descriptor: EDC3, MRNA DECAPPING COMPLEX SUBUNIT 2
Authors:Fromm, S.A, Truffault, V, Kamenz, J, Braun, J.E, Hoffmann, N.A, Izaurralde, E, Sprangers, R.
Deposit date:2011-10-24
Release date:2012-02-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Structural Basis of Edc3- and Scd6-Mediated Activation of the Dcp1:Dcp2 Mrna Decapping Complex.
Embo J., 31, 2011
2KU2
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BU of 2ku2 by Molmil
Dynamic Regulation of Archaeal Proteasome Gate Opening as Studied by TROSY-NMR
Descriptor: Proteasome subunit alpha
Authors:Religa, T.L, Sprangers, R, Kay, L.E.
Deposit date:2010-02-11
Release date:2010-04-21
Last modified:2021-10-13
Method:SOLUTION NMR
Cite:Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMR.
Science, 328, 2010
2KU1
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BU of 2ku1 by Molmil
Dynamic Regulation of Archaeal Proteasome Gate Opening as Studied by TROSY-NMR
Descriptor: Proteasome subunit alpha
Authors:Religa, T.L, Sprangers, R, Kay, L.E.
Deposit date:2010-02-11
Release date:2010-04-21
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMR.
Science, 328, 2010
1K1G
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BU of 1k1g by Molmil
STRUCTURAL BASIS FOR RECOGNITION OF THE INTRON BRANCH SITE RNA BY SPLICING FACTOR 1
Descriptor: 5'-R(*UP*AP*UP*AP*CP*UP*AP*AP*CP*AP*A)-3', SF1-Bo isoform
Authors:Liu, Z, Luyten, I, Bottomley, M.J, Messias, A.C, Houngninou-Molango, S, Sprangers, R, Zanier, K, Kramer, A, Sattler, M.
Deposit date:2001-09-25
Release date:2001-11-07
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for recognition of the intron branch site RNA by splicing factor 1.
Science, 294, 2001
1O0P
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BU of 1o0p by Molmil
Solution Structure of the third RNA Recognition Motif (RRM) of U2AF65 in complex with an N-terminal SF1 peptide
Descriptor: Splicing Factor SF1, Splicing factor U2AF 65 kDa subunit
Authors:Selenko, P, Gregorovic, G, Sprangers, R, Stier, G, Rhani, Z, Kramer, A, Sattler, M.
Deposit date:2003-02-24
Release date:2003-05-06
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural Basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP
Mol.Cell, 11, 2003
1OPI
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BU of 1opi by Molmil
SOLUTION STRUCTURE OF THE THIRD RNA RECOGNITION MOTIF (RRM) OF U2AF65 IN COMPLEX WITH AN N-TERMINAL SF1 PEPTIDE
Descriptor: SPLICING FACTOR SF1, SPLICING FACTOR U2AF 65 KDA SUBUNIT
Authors:Selenko, P, Gregorovic, G, Sprangers, R, Stier, G, Rhani, Z, Kramer, A, Sattler, M.
Deposit date:2003-03-05
Release date:2004-03-16
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP
Mol.Cell, 11, 2003
7AC8
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BU of 7ac8 by Molmil
Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Descriptor: GLUTAMINE, Imidazole glycerol phosphate synthase subunit HisF, Imidazole glycerol phosphate synthase subunit HisH, ...
Authors:Sung, S, Wilmanns, M.
Deposit date:2020-09-10
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Nat Commun, 12, 2021

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