5MGE | |
5MGF | |
5MGG | |
5MGJ | |
5MGK | |
5MGL | |
5MGM | |
5MPZ | |
5MQE | |
5MQG | |
5MQK | |
2LRI | | NMR STRUCTURE OF THE SECOND PHD FINGER OF AIRE (AIRE-PHD2) | | Descriptor: | Autoimmune regulator, ZINC ION | | Authors: | Gaetani, M., Chignola, F., Mollica, L., Quilici, G., Mannella, V., Spiliotopoulos, D., Musco, G. | | Deposit date: | 2012-04-03 | | Release date: | 2012-10-17 | | Last modified: | 2013-01-16 | | Method: | SOLUTION NMR | | Cite: | AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.
Nucleic Acids Res., 40, 2012
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2NAA | | NSD1-PHD_5-C5HCH TANDEM DOMAIN STRUCTURE | | Descriptor: | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, ZINC ION | | Authors: | Berardi, A., Quilici, G., Spiliotopoulos, D., Musco, G. | | Deposit date: | 2015-12-22 | | Release date: | 2016-03-09 | | Last modified: | 2016-05-04 | | Method: | SOLUTION NMR | | Cite: | Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.
Nucleic Acids Res., 44, 2016
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2NAB | | NIZP1-C2HR ZINC FINGER STRUCTURE | | Descriptor: | Zinc finger protein 496, ZINC ION | | Authors: | Berardi, A., Quilici, G., Spiliotopoulos, D., Corral-Rodriguez, M., Martin, F., Degano, M., Tonon, G., Musco, G. | | Deposit date: | 2015-12-22 | | Release date: | 2016-03-09 | | Last modified: | 2016-05-04 | | Method: | SOLUTION NMR | | Cite: | Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.
Nucleic Acids Res., 44, 2016
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4TS8 | | CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH XZ08 | | Descriptor: | CREB-binding protein, 1,2-ETHANEDIOL, 4-(1-acetyl-1H-indol-3-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one | | Authors: | Dong, J., Gartenmann, L., Spiliotopoulos, D., Caflisch, A. | | Deposit date: | 2014-06-18 | | Release date: | 2015-07-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the bromodomain of human CREBBP in complex with XZ08
To Be Published
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6FG6 | | CRYSTAL STRUCTURE OF BAZ2A BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 1 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-(2-azanylethyl)-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-10 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FGF | | CRYSTAL STRUCTURE OF BAZ2A BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 2 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-[3-[(4-fluorophenyl)carbonylamino]propyl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-10 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FGG | | CRYSTAL STRUCTURE OF BAZ2A BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 5 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-[3-[2-(dimethylamino)ethyl]-2-oxidanylidene-1,3-benzoxazol-5-yl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-10 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FGT | | CRYSTAL STRUCTURE OF BAZ2B BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 3 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2B, ~{N}-[(1-azanylcyclohexyl)methyl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-11 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FGU | | CRYSTAL STRUCTURE OF BAZ2B BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 4 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2B, 1-methyl-6-oxidanylidene-~{N}-(2-pyrrolidin-1-ylethyl)pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-11 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FGV | | CRYSTAL STRUCTURE OF BAZ2A BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 3 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-[(1-azanylcyclohexyl)methyl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-11 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FGW | | CRYSTAL STRUCTURE OF BAZ2A BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 4 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2A, 1-methyl-6-oxidanylidene-~{N}-(2-pyrrolidin-1-ylethyl)pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-11 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.725 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FH6 | | CRYSTAL STRUCTURE OF BAZ2B BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 1 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2B, ~{N}-(2-azanylethyl)-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-12 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.082 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6FH7 | | CRYSTAL STRUCTURE OF BAZ2B BROMODOMAIN IN COMPLEX WITH 1-METHYLPYRIDINONE COMPOUND 2 | | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2B, ~{N}-[3-[(4-fluorophenyl)carbonylamino]propyl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide | | Authors: | Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. | | Deposit date: | 2018-01-12 | | Release date: | 2018-05-30 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
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6EQ2 | | MTH1 IN COMPLEX WITH FRAGMENT 6 | | Descriptor: | 7,8-dihydro-8-oxoguanine triphosphatase, 1~{H}-imidazo[4,5-b]pyridin-2-amine | | Authors: | Wiedmer, L., Sledz, P., Caflisch, A. | | Deposit date: | 2017-10-12 | | Release date: | 2018-10-31 | | Last modified: | 2019-08-14 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
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