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6FGW

Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridinone compound 4

Summary for 6FGW
Entry DOI10.2210/pdb6fgw/pdb
Related6FG6 6FGF 6FGG 6FGH 6FGI 6FGT 6FGU 6FGV
DescriptorBromodomain adjacent to zinc finger domain protein 2A, 1-methyl-6-oxidanylidene-~{N}-(2-pyrrolidin-1-ylethyl)pyridine-3-carboxamide (3 entities in total)
Functional Keywordsfour helical bundle, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight12758.36
Authors
Dalle Vedove, A.,Spiliotopoulos, D.,Lolli, G.,Caflisch, A. (deposition date: 2018-01-11, release date: 2018-05-30, Last modification date: 2024-01-17)
Primary citationDalle Vedove, A.,Spiliotopoulos, D.,D'Agostino, V.G.,Marchand, J.R.,Unzue, A.,Nevado, C.,Lolli, G.,Caflisch, A.
Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13:1479-1487, 2018
Cited by
PubMed: 29770599
DOI: 10.1002/cmdc.201800234
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.725 Å)
Structure validation

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