Author results

2AIO
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METALLO BETA LACTAMASE L1 FROM STENOTROPHOMONAS MALTOPHILIA COMPLEXED WITH HYDROLYZED MOXALACTAM
Descriptor:Metallo-beta-lactamase L1, ZINC ION, SULFATE ION, ...
Authors:Spencer, J., Read, J., Sessions, R.B., Howell, S., Blackburn, G.M., Gamblin, S.J.
Deposit date:2005-07-30
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antibiotic Recognition by Binuclear Metallo-beta-Lactamases Revealed by X-ray Crystallography
J.Am.Chem.Soc., 127, 2005
3IT5
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CRYSTAL STRUCTURE OF THE LASA VIRULENCE FACTOR FROM PSEUDOMONAS AERUGINOSA
Descriptor:Protease lasA, ZINC ION
Authors:Spencer, J., Murphy, L.M., Conners, R., Sessions, R.B., Gamblin, S.J.
Deposit date:2009-08-27
Release date:2009-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases.
J.Mol.Biol., 396, 2010
3IT7
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CRYSTAL STRUCTURE OF THE LASA VIRULENCE FACTOR FROM PSEUDOMONAS AERUGINOSA
Descriptor:Protease lasA, ZINC ION, L(+)-TARTARIC ACID, ...
Authors:Spencer, J., Murphy, L.M., Conners, R., Sessions, R.B., Gamblin, S.J.
Deposit date:2009-08-27
Release date:2009-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases.
J.Mol.Biol., 396, 2010
4UA4
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STRUCTURE OF THE VIM-2 METALLO-BETA-LACTAMASE IN COMPLEX WITH A BISTHIAZOLIDINE INHIBITOR
Descriptor:Beta-lactamase class B VIM-2, ZINC ION, GLYCEROL, ...
Authors:Spencer, J.
Deposit date:2014-08-08
Release date:2014-09-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structure of the VIM-2 Metallo-beta-Lactamase in Complex with a Bisthiazolidine Inhibitor
To Be Published
2QIN
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STENOTROPHOMONAS MALTOPHILIA L1 METALLO-BETA-LACTAMASE ASP-120 CYS MUTANT
Descriptor:Metallo-beta-lactamase L1, ZINC ION, MAGNESIUM ION
Authors:Spencer, J.
Deposit date:2007-07-05
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Basis for the Role of Asp-120 in Metallo-beta-lactamases.
Biochemistry, 46, 2007
5EV6
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CRYSTAL STRUCTURE OF THE NATIVE, DI-ZINC METALLO-BETA-LACTAMASE IMP-1
Descriptor:Beta-lactamase IMP-1, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Spencer, J., Hinchliffe, P.
Deposit date:2015-11-19
Release date:2016-06-01
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Proc.Natl.Acad.Sci.USA, 113, 2016
1GHV
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:THROMBIN, ACETYL HIRUDIN, SODIUM ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GHW
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:THROMBIN, ACETYL HIRUDIN, SODIUM ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site
J.Mol.Biol., 307, 2001
1GHX
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:THROMBIN, ACETYL HIRUDIN, ZINC ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GHY
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:THROMBIN, ACETYL HIRUDIN, ZINC ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GHZ
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, MAGNESIUM ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI0
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, MAGNESIUM ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI1
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI2
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI3
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, 2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI4
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, ZINC ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI5
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI6
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:BETA-TRYPSIN, CALCIUM ION, CHLORIDE ION, ...
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI7
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:UROKINASE-TYPE PLASMINOGEN ACTIVATOR, 2-(2-OXO-1,2-DIHYDRO-PYRIDIN-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, CITRIC ACID
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI8
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:UROKINASE-TYPE PLASMINOGEN ACTIVATOR, CITRIC ACID, 2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1GI9
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A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Descriptor:UROKINASE-TYPE PLASMINOGEN ACTIVATOR, 2-(2-HYDROXY-5-METHOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, CITRIC ACID
Authors:Katz, B.A., Elrod, K., Luong, C., Rice, M., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hatayte, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
Deposit date:2001-01-22
Release date:2002-01-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
J.Mol.Biol., 307, 2001
1KQ7
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E315Q MUTANT FORM OF FUMARASE C FROM E.COLI
Descriptor:FUMARATE HYDRATASE CLASS II, D-MALATE, CITRIC ACID
Authors:Weaver, T.M., Estevez, M., Skarda, J., Spencer, J.
Deposit date:2002-01-04
Release date:2002-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation.
Protein Sci., 11, 2002
2QJS
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STENOTROPHOMONAS MALTOPHILIA L1 METALLO-BETA-LACTAMASE ASP-120 ASN MUTANT
Descriptor:Metallo-beta-lactamase L1, ZINC ION
Authors:Crisp, J., Conners, R., Spencer, J.
Deposit date:2007-07-09
Release date:2007-08-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Basis for the Role of Asp-120 in Metallo-beta-lactamases
Biochemistry, 46, 2007
5ENE
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH 5-AMINO-2-BENZYL-1,3-OXAZOLE-4-CARBONITRILE (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, 5-azanyl-2-(phenylmethyl)-1,3-oxazole-4-carbonitrile
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Amin, J., Szykowska, A., Burgess-Brown, N., Spencer, J., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016
5ENF
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH FRAGMENT-4 N10142 (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, 1,2-ETHANEDIOL, 5-azanyl-2-(2-methylpropyl)-1,3-oxazole-4-carbonitrile
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Amin, J., Szykowska, A., Burgess-Brown, N., Spencer, J., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016