7A61

Crystal structure of KPC-2 with hydrolyzed faropenem (ring-open form)

Summary for 7A61

Entry DOI	10.2210/pdb7a61/pdb
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, (2~{R})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-butyl-2,3-dihydro-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... (5 entities in total)
Functional Keywords	metallo-beta-lactamase, antibiotic, faropenem, catalysis, antimicrobial protein
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	31663.43
Authors	Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2020-08-24, release date: 2021-02-24, Last modification date: 2024-01-31)
Primary citation	Lucic, A.,Hinchliffe, P.,Malla, T.R.,Tooke, C.L.,Brem, J.,Calvopina, K.,Lohans, C.T.,Rabe, P.,McDonough, M.A.,Armistead, T.,Orville, A.M.,Spencer, J.,Schofield, C.J. Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215:113257-113257, 2021 Cited by PubMed: 33618159 DOI: 10.1016/j.ejmech.2021.113257 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation