Author results

2CMW
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STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITH 2-(2- HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
Descriptor:CASEIN KINASE I ISOFORM GAMMA-1, 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE, PHOSPHATE ION, ...
Authors:Bunkoczi, G., Rellos, P., Das, S., Savitsky, P., Niesen, F., Sobott, F., Fedorov, O., Pike, A.C.W., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., Knapp, S.
Deposit date:2006-05-15
Release date:2006-06-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of Human Casein Kinase 1 Gamma-1 in Complex with 2-(2-Hydroxyethylamino)-6-(3-Chloroanilino)-9-Isopropylpurine (Casp Target)
To be Published
2J1L
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CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD
Descriptor:RHO-RELATED GTP-BINDING PROTEIN RHOD, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Pike, A.C.W., Johansson, C., Gileadi, C., Niesen, F.H., Sobott, F., Schoch, G., Elkins, J., Smee, C., Gorrec, F., Watt, S., Bray, J., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2006-08-14
Release date:2006-09-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Human Rho-Related GTP-Binding Protein Rhod
To be Published
2UZP
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CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN PROTEIN KINASE C GAMMA.
Descriptor:PROTEIN KINASE C GAMMA TYPE, PYRIDOXAL-5'-PHOSPHATE, COBALT (II) ION, ...
Authors:Pike, A.C.W., Amos, A., Johansson, C., Sobott, F., Savitsky, P., Berridge, G., Fedorov, O., Umeano, C., Gorrec, F., Bunkoczi, G., Debreczeni, J., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2007-04-30
Release date:2007-05-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of C2 Domain of Protein Kinase C Gamma
To be Published
2BUJ
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CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE
Descriptor:SERINE/THREONINE-PROTEIN KINASE 16, CHLORIDE ION, STAUROSPORINE
Authors:Debreczeni, J.E., Eswaran, J., Bullock, A., Filippakopoulos, P., Kavanagh, K., Amos, A., Fedorov, O., Sobott, F., Ball, L.J., von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Knapp, S.
Deposit date:2005-06-13
Release date:2005-07-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine
To be Published
2C47
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STRUCTURE OF CASEIN KINASE 1 GAMMA 2
Descriptor:CASEIN KINASE 1 GAMMA 2 ISOFORM, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, MAGNESIUM ION
Authors:Bunkoczi, G., Rellos, P., Das, S., Ugochukwu, E., Fedorov, O., Sobott, F., Eswaran, J., Amos, A., Ball, L., von Delft, F., Bullock, A., Debreczeni, J., Turnbull, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2005-10-16
Release date:2005-11-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of Casein Kinase 1 Gamma 2
To be Published
2CLS
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THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE
Descriptor:RHO-RELATED GTP-BINDING PROTEIN RHO6, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Pike, A.C.W., Yang, X., Colebrook, S., Gileadi, O., Sobott, F., Bray, J., Wen Hwa, L., Marsden, B., Zhao, Y., Schoch, G., Elkins, J., Debreczeni, J.E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2006-04-28
Release date:2006-05-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published
2EXE
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED CLK3
Descriptor:Dual specificity protein kinase CLK3
Authors:Papagrigoriou, E., Rellos, P., Das, S., Bullock, A., Ball, L.J., Turnbull, A., Savitsky, P., Fedorov, O., Johansson, C., Ugochukwu, E., Sobott, F., von Delft, F., Edwards, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-11-08
Release date:2005-11-15
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the phosphorylated CLK3
TO BE PUBLISHED
2JAM
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G, POLYPEPTIDE, 1,2-ETHANEDIOL, ...
Authors:Debreczeni, J.E., Bullock, A., Keates, T., Niesen, F.H., Salah, E., Shrestha, L., Smee, C., Sobott, F., Pike, A.C.W., Bunkoczi, G., von Delft, F., Turnbull, A., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
Deposit date:2006-11-29
Release date:2007-03-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G
To be Published
2BQ0
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14-3-3 PROTEIN BETA (HUMAN)
Descriptor:14-3-3 BETA/ALPHA
Authors:Yang, X., Elkins, J.M., Fedorov, O., Longman, E.J., Sobott, L., Ball, L.J., Sundstrom, M., Arrowsmith, C., Edwards, A., Doyle, D.A.
Deposit date:2005-04-26
Release date:2005-05-06
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2IWI
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CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
Descriptor:SERINE/THREONINE-PROTEIN KINASE PIM-2, RUTHENIUM-PYRIDOCARBAZOLE-1
Authors:Russo, S., Debreczeni, J.E., Amos, A., Bullock, A.N., Fedorov, O., Niesen, F., Sobott, F., Turnbull, A., Pike, A.C.W., Ugochukwu, E., Papagrigoriou, E., Bunkoczi, G., Gorrec, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., von Delft, F., Knapp, S.
Deposit date:2006-06-30
Release date:2006-08-02
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
PLoS ONE, 4, 2009
2XDV
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF FLJ14393
Descriptor:MYC-INDUCED NUCLEAR ANTIGEN, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Krojer, T., Muniz, J.R.C., Ng, S.S., Pilka, E., Guo, K., Pike, A.C.W., Filippakopoulos, P., Knapp, S., Kavanagh, K.L., Gileadi, O., Bunkoczi, G., Yue, W.W., Niesen, F., Sobott, F., Fedorov, O., Savitsky, P., Kochan, G., Daniel, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2010-05-07
Release date:2010-05-26
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
2ES0
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS6
Descriptor:regulator of G-protein signalling 6
Authors:Schoch, G.A., Phillips, C., Turnbull, A., Niesen, F., Johansson, C., Elkins, J.M., Longman, E., Gilealdi, C., Sobott, F., Ball, L., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-10-25
Release date:2005-11-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2J7T
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CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND TO SU11274
Descriptor:SERINE/THREONINE-PROTEIN KINASE 10, CALCIUM ION, ACETATE ION, ...
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Das, S., Debreczeni, J., Sobott, F., Watt, S., Savitsky, P., Eswaran, J., Turnbull, A.P., Papagrigoriou, E., Ugochukwa, E., Gorrec, F., Umeano, C.C., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2006-10-17
Release date:2006-11-07
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2OC3
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 18
Descriptor:Tyrosine-protein phosphatase non-receptor type 18
Authors:Ugochukwu, E., Barr, A., Alfano, I., Gorrec, F., Umeano, C., Savitsky, P., Sobott, F., Eswaran, J., Papagrigoriou, E., Debreczeni, J.E., Turnbull, A., Bunkoczi, G., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
1Z57
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CRYSTAL STRUCTURE OF HUMAN CLK1 IN COMPLEX WITH 10Z-HYMENIALDISINE
Descriptor:Dual specificity protein kinase CLK1, DEBROMOHYMENIALDISINE
Authors:Debreczeni, J., Das, S., Knapp, S., Bullock, A., Guo, K., Amos, A., Fedorov, O., Edwards, A., Sundstrom, M., von Delft, F., Niesen, F.H., Ball, L., Sobott, F., Arrowsmith, C., Structural Genomics Consortium (SGC)
Deposit date:2005-03-17
Release date:2005-04-12
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2AHS
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE RECEPTOR PHOSPHATASE BETA
Descriptor:Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, SODIUM ION, ...
Authors:Ugochukwu, E., Eswaran, J., Barr, A., Gileadi, O., Sobott, F., Burgess, N., Ball, L., Bray, J., von Delft, F., Debreczeni, J., Bunkoczi, G., Turnbull, A., Das, S., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-07-28
Release date:2005-08-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2CLQ
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STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5, STAUROSPORINE
Authors:Bunkoczi, G., Salah, E., Fedorov, O., Pike, A., Gileadi, O., von Delft, F., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
Deposit date:2006-04-28
Release date:2006-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Functional Characterization of the Human Protein Kinase Ask1.
Structure, 15, 2007
2EU9
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CRYSTAL STRUCTURE OF CLK3
Descriptor:Dual specificity protein kinase CLK3, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Rellos, P., Das, S., Ugochukwu, E., Turnbull, A., von Delft, F., Bunkoczi, G., Sobott, F., Bullock, A., Fedorov, O., Gileadi, C., Savitsky, P., Edwards, A., Aerrowsmith, C., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2005-10-28
Release date:2005-11-08
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2G3Y
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CRYSTAL STRUCTURE OF THE HUMAN SMALL GTPASE GEM
Descriptor:GTP-binding protein GEM, GUANOSINE-5'-DIPHOSPHATE
Authors:Ugochukwu, E., Soundararajan, M., Elkins, J., Gileadi, C., Schoch, G., Sobott, F., Fedorov, O., Bray, J., Pantic, N., Berridge, G., Burgess, N., Lee, W.H., Turnbull, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-02-21
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human small GTPase GEM
To be Published
2JII
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STRUCTURE OF VACCINIA RELATED KINASE 3
Descriptor:SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3, 1,2-ETHANEDIOL
Authors:Bunkoczi, G., Eswaran, J., Pike, A.C.W., Uppenberg, J., Ugochukwu, E., von Delft, F., Cooper, C., Salah, E., Savitsky, P., Burgess-Brown, N., Keates, T., Fedorov, O., Sobott, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.
Structure, 17, 2009
5NOC
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SOLUTION NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF PARB (SPO0J)
Descriptor:Stage 0 sporulation protein J
Authors:Higman, V.A., Fisher, G.L.M., Dillingham, M.S., Crump, M.P.
Deposit date:2017-04-11
Release date:2017-12-13
Last modified:2017-12-27
Method:SOLUTION NMR
Cite:The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere.
Elife, 6, 2017
2BMJ
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GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
Descriptor:CENTAURIN GAMMA 1
Authors:Yang, X., Elkins, J.M., Soundararajan, M., Arrowsmith, C., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-03-14
Release date:2005-04-12
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Centaurin Gamma-1 Gtpase-Like Domain Functions as an Ntpase.
Biochem.J., 401, 2007
2BR9
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14-3-3 PROTEIN EPSILON (HUMAN) COMPLEXED TO PEPTIDE
Descriptor:14-3-3 PROTEIN EPSILON, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Yang, X., Elkins, J.M., Soundararajan, M., Fedorov, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Doyle, D.A.
Deposit date:2005-05-03
Release date:2005-05-12
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2BTP
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14-3-3 PROTEIN THETA (HUMAN) COMPLEXED TO PEPTIDE
Descriptor:14-3-3 PROTEIN TAU, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Elkins, J.M., Johansson, A.C.E., Smee, C., Yang, X., Sundstrom, M., Edwards, A., Arrowsmith, C., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-06-05
Release date:2005-06-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2C23
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14-3-3 PROTEIN BETA (HUMAN) IN COMPLEX WITH EXOENZYME S PEPTIDE
Descriptor:14-3-3 BETA/ALPHA, EXOENZYME S PEPTIDE
Authors:Elkins, J.M., Schoch, G.A., Yang, X., Sundstrom, M., Arrowsmith, C., Edwards, A., Doyle, D.A.
Deposit date:2005-09-26
Release date:2005-09-29
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
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