Author results

1MF4
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STRUCTURE-BASED DESIGN OF POTENT AND SELECTIVE INHIBITORS OF PHOSPHOLIPASE A2: CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN PHOSHOLIPASE A2 FROM NAJA NAJA SAGITTIFERA AND A DESIGNED PEPTIDE INHIBITOR AT 1.9 A RESOLUTION
Descriptor:Phospholipase A2, VAL-ALA-PHE-ARG-SER, CALCIUM ION
Authors:Singh, R.K., Vikram, P., Paramsivam, M., Jabeen, T., Sharma, S., Makker, J., Dey, S., Kaur, P., Srinivasan, A., Singh, T.P.
Deposit date:2002-08-09
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features
Biochemistry, 42, 2003
1LN8
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CRYSTAL STRUCTURE OF A NEW ISOFORM OF PHOSPHOLIPASE A2 FROM NAJA NAJA SAGITTIFERA AT 1.6 A RESOLUTION
Descriptor:Phospholipase A2, CALCIUM ION, PHOSPHATE ION
Authors:Singh, R.K., Vikram, P., Paramasivam, M., Jabeen, T., Sharma, S., Kaur, P., Srinivasan, A., Singh, T.P.
Deposit date:2002-05-03
Release date:2003-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of a New Form of Phospholipase A2 from Naja naja sagittifera at 1.6 A Resolution
to be published
1SZ8
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CRYSTAL STRUCTURE OF AN ACIDIC PHOSPHOLIPASE A2 FROM NAJA NAJA SAGITTIFERA AT 1.5 A RESOLUTION
Descriptor:Phospholipase A2 isoform 3, CALCIUM ION, PHOSPHATE ION, ...
Authors:Singh, R.K., Sharma, S., Jabeen, T., Kaur, P., Singh, T.P.
Deposit date:2004-04-05
Release date:2004-04-20
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of an Acidic Phospholipase A2 from Naja Naja Sagittifera at 1.5 A Resolution
To be Published
1T37
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DESIGN OF SPECIFIC INHIBITORS OF PHOSPHOLIPASE A2: CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN GROUP I PHOSPHOLIPASE A2 AND A DESIGNED PENTAPEPTIDE LEU-ALA-ILE-TYR-SER AT 2.6A RESOLUTION
Descriptor:Phospholipase A2 isoform 3, Synthetic peptide, ACETATE ION
Authors:Singh, R.K., Singh, N., Jabeen, T., Makker, J., Sharma, S., Dey, S., Singh, T.P.
Deposit date:2004-04-25
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution.
J.Drug Target., 13, 2005
1ZM6
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CRYSTAL STRUCTURE OF THE COMPLEX FORMED BEWEEN A GROUP I PHOSPHOLIPASE A2 AND DESIGNED PENTA PEPTIDE LEU-ALA-ILE-TYR-SER AT 2.6A RESOLUTION
Descriptor:Phospholipase A2 isoform 3, designed penta peptide Leu-Ala-Ile-Tyr-Ser, ACETATE ION
Authors:Singh, R.K., Singh, N., Jabeen, T., Sharma, S., Dey, S., Singh, T.P.
Deposit date:2005-05-10
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution.
J.Drug Target., 13, 2005
1EGQ
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ENHANCEMENT OF ENZYME ACTIVITY THROUGH THREE-PHASE PARTITIONING: CRYSTAL STRUCTURE OF A MODIFIED SERINE PROTEINASE AT 1.5 A RESOLUTION
Descriptor:PROTEINASE K, CALCIUM ION, ACETIC ACID
Authors:Singh, R.K., Gourinath, S., Sharma, S., Ray, I., Gupta, M.N., Singh, T.P.
Deposit date:2000-02-16
Release date:2001-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Enhancement of enzyme activity through three-phase partitioning: crystal structure of a modified serine proteinase at 1.5 A resolution.
Protein Eng., 14, 2001
1OXR
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ASPIRIN INDUCES ITS ANTI-INFLAMMATORY EFFECTS THROUGH ITS SPECIFIC BINDING TO PHOSPHOLIPASE A2: CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN PHOSPHOLIPASE A2 AND ASPIRIN AT 1.9A RESOLUTION
Descriptor:Phospholipase A2 isoform 3, 2-(ACETYLOXY)BENZOIC ACID, CALCIUM ION
Authors:Singh, R.K., Ethayathulla, A.S., Jabeen, T., Sharma, S., Kaur, P., Srinivasan, A., Singh, T.P.
Deposit date:2003-04-03
Release date:2004-04-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A2: crystal structure of the complex formed between phospholipase A2 and aspirin at 1.9 angstroms resolution.
J.Drug Target., 13, 2005
1YXL
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CRYSTAL STRUCTURE OF A NOVEL PHOSPHOLIPASE A2 FROM NAJA NAJA SAGITTIFERA AT 1.5 A RESOLUTION
Descriptor:Phospholipase A2 isoform 3, CALCIUM ION, PHOSPHATE ION, ...
Authors:Singh, R.K., Jabeen, T., Sharma, S., Kaur, P., Singh, T.P.
Deposit date:2005-02-22
Release date:2005-03-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.477 Å)
Cite:Crystal Structure of a novel phospholipase A2 from Naja naja sagittifera at 1.5 A resolution
To be Published
1W0D
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THE HIGH RESOLUTION STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LEUB (RV2995C)
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, SULFATE ION
Authors:Singh, R.K., Kefala, G., Janowski, R., Mueller-Dieckmann, C., Weiss, M.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-06-03
Release date:2004-12-14
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The High Resolution Structure of Leub (Rv2995C) from Mycobacterium Tuberculosis
J.Mol.Biol., 346, 2005
2JCG
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APO FORM OF THE CATABOLITE CONTROL PROTEIN A (CCPA) FROM BACILLUS MEGATERIUM, WITH THE DNA BINDING DOMAIN
Descriptor:GLUCOSE-RESISTANCE AMYLASE REGULATOR, CALCIUM ION
Authors:Singh, R.K., Panjikar, S., Palm, G.J., Hinrichs, W.
Deposit date:2006-12-22
Release date:2007-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Apo Form of the Catabolite Control Protein a (Ccpa) from Bacillus Megaterium with a DNA-Binding Domain.
Acta Crystallogr.,Sect.F, 63, 2007
4NFY
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CRYSTAL STRUCTURE OF 3-PHOSPHOGLYCERATE DEHYDROGENASE FROM ENTAMOEBA HISTOLYTICA
Descriptor:D-3-phosphoglycerate dehydrogenase, putative, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Singh, R.K., Gourinath, S.
Deposit date:2013-11-01
Release date:2014-10-08
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine.
Febs J., 281, 2014
4NJM
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CRYSTAL STRUCTURE OF PHOSPHOGLYCERATE BOUND 3-PHOSPHOGLYCERATE DEHYDROGENASE IN ENTAMOEBA HISTOLYTICA
Descriptor:D-3-phosphoglycerate dehydrogenase, putative, 3-PHOSPHOGLYCERIC ACID
Authors:Singh, R.K., Gourinath, S.
Deposit date:2013-11-11
Release date:2014-10-08
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine.
Febs J., 281, 2014
4NJO
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CRYSTAL STRUCTURE OF COFACTOR(NAD+) BOUND 3-PHOSPHOGLYCERATE DEHYDROGENASE IN ENTAMOEBA HISTOLYTICA
Descriptor:D-3-phosphoglycerate dehydrogenase, putative, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Singh, R.K., Gourinath, S.
Deposit date:2013-11-11
Release date:2014-10-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine.
Febs J., 281, 2014
5F8V
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CRYSTAL STRUCTURE OF PLP BOUND PHOSPHOSERINE AMINOTRANSFERASE (PSAT) FROM TRICHOMONAS VAGINALIS
Descriptor:Aminotransferase, class V family protein
Authors:Singh, R.K., Gourinath, S.
Deposit date:2015-12-09
Release date:2016-10-19
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural investigation and inhibitory response of halide on phosphoserine aminotransferase from Trichomonas vaginalis.
Biochim.Biophys.Acta, 1860, 2016
5YB0
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CRYSTAL STRUCTURE OF WILD TYPE PHOSPHOSERINE AMINOTRANSFERASE (PSAT) FROM E. HISTOLYTICA
Descriptor:Phosphoserine aminotransferase, PYRIDOXAL-5'-PHOSPHATE, CHLORIDE ION
Authors:Singh, R.K., Gourinath, S.
Deposit date:2017-09-02
Release date:2018-10-31
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica.
Int.J.Biol.Macromol., 132, 2019
5YD2
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CRYSTAL STRUCTURE OF DELTA 4 MUTANT OF EHPSAT (PHOSPHOSERINE AMINOTRANSFERASE OF ENTAMOEBA HISTOLYTICA)
Descriptor:Phosphoserine aminotransferase, CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Singh, R.K., Gourinath, S.
Deposit date:2017-09-10
Release date:2018-10-31
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica.
Int.J.Biol.Macromol., 132, 2019
5YII
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CRYSTAL STRUCTURE OF 45 AMINO ACID DELETED FROM N-TERMINAL OF PHOSPHOSERINE AMINOTRANSFERASE (PSAT) OF ENTAMOEBA HISTOLYTICA
Descriptor:Phosphoserine aminotransferase, THIOCYANATE ION
Authors:Singh, R.K., Gourinath, S.
Deposit date:2017-10-04
Release date:2018-10-24
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica.
Int.J.Biol.Macromol., 132, 2019
6EMS
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CRYSTAL STRUCTURE OF DUAL SPECIFIC TRM10 CONSTRUCT FROM THERMOCOCCUS KODAKARAENSIS.
Descriptor:tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase
Authors:Singh, R.K., Versees, W.
Deposit date:2017-10-03
Release date:2018-06-13
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Structural and biochemical analysis of the dual-specificity Trm10 enzyme fromThermococcus kodakaraensisprompts reconsideration of its catalytic mechanism.
RNA, 24, 2018
6EMT
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CRYSTAL STRUCTURE OF DUAL SPECIFIC TRM10 CONSTRUCT FROM THERMOCOCCUS KODAKARAENSIS.
Descriptor:tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, ACETATE ION, GLYCEROL, ...
Authors:Singh, R.K., Versees, W.
Deposit date:2017-10-03
Release date:2018-06-13
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.794 Å)
Cite:Structural and biochemical analysis of the dual-specificity Trm10 enzyme fromThermococcus kodakaraensisprompts reconsideration of its catalytic mechanism.
RNA, 24, 2018
6EMU
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CRYSTAL STRUCTURE OF DUAL SPECIFIC TRM10 CONSTRUCT FROM THERMOCOCCUS KODAKARAENSIS.
Descriptor:tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, S-ADENOSYLMETHIONINE, GLYCEROL
Authors:Singh, R.K., Versees, W.
Deposit date:2017-10-03
Release date:2018-06-13
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.297454 Å)
Cite:Structural and biochemical analysis of the dual-specificity Trm10 enzyme fromThermococcus kodakaraensisprompts reconsideration of its catalytic mechanism.
RNA, 24, 2018
6EMV
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CRYSTAL STRUCTURE OF DUAL SPECIFIC TRM10 CONSTRUCT FROM THERMOCOCCUS KODAKARAENSIS.
Descriptor:tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Singh, R.K., Versees, W.
Deposit date:2017-10-03
Release date:2018-06-13
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.900014 Å)
Cite:Structural and biochemical analysis of the dual-specificity Trm10 enzyme fromThermococcus kodakaraensisprompts reconsideration of its catalytic mechanism.
RNA, 24, 2018
5MJ7
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STRUCTURE OF THE C. ELEGANS NUCLEOSIDE HYDROLASE
Descriptor:Uncharacterized protein, CALCIUM ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Versees, W., Singh, R.K.
Deposit date:2016-11-30
Release date:2017-03-08
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis.
Protein Sci., 26, 2017
1TD7
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INTERACTIONS OF A SPECIFIC NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) WITH GROUP I PHOSPHOLIPASE A2 (PLA2): CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN PLA2 AND NIFLUMIC ACID AT 2.5 A RESOLUTION
Descriptor:Phospholipase A2 isoform 3, CALCIUM ION, 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID
Authors:Jabeen, T., Singh, N., Singh, R.K., Sharma, S., Perbandt, M., Betzel, C., Singh, T.P.
Deposit date:2004-05-21
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution.
Acta Crystallogr.,Sect.D, 61, 2005
1S6B
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X-RAY CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN TWO HOMOLOGOUS ISOFORMS OF PHOSPHOLIPASE A2 FROM NAJA NAJA SAGITTIFERA: PRINCIPLE OF MOLECULAR ASSOCIATION AND INACTIVATION
Descriptor:Phospholipase A2 isoform 1, Phospholipase A2 isoform 2, CALCIUM ION, ...
Authors:Jabeen, T., Sharma, S., Singh, R.K., Kaur, P., Singh, T.P.
Deposit date:2004-01-23
Release date:2004-02-10
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a calcium-induced dimer of two isoforms of cobra phospholipase A2 at 1.6 A resolution.
Proteins, 59, 2005
1MH2
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CRYSTAL STRUCTURE OF A ZINC CONTAINING DIMER OF PHOSPHOLIPASE A2 FROM THE VENOM OF INDIAN COBRA (NAJA NAJA SAGITTIFERA)
Descriptor:PHOSPHOLIPASE A2, ZINC ION, ACETIC ACID
Authors:Jabeen, T., Varma, A.K., Paramasivam, M., Singh, N., Singh, R.K., Sharma, S., Srinivasan, A., Singh, T.P.
Deposit date:2002-08-19
Release date:2003-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of a Zinc Containing Dimer of Phospholipase A2 from the Venom of Indian cobra (Naja Naja Saggittifera)
To be Published