1T37

Design of specific inhibitors of phospholipase A2: Crystal structure of the complex formed between group I phospholipase A2 and a designed pentapeptide Leu-Ala-Ile-Tyr-Ser at 2.6A resolution

Summary for 1T37

• Entry DOI: 10.2210/pdb1t37/pdb
• Related: 1JQ9 1MF4 1SZ8
• Descriptor: Phospholipase A2 isoform 3, Synthetic peptide, ACETATE ION, ... (4 entities in total)
• Functional Keywords: phospholipase a2, complex, inhibition, hydrolase
• Biological source: Naja sagittifera
• Cellular location: Secreted: P60045
• Total number of polymer chains: 2
• Total formula weight: 13915.32

Authors

Singh, R.K.,Singh, N.,Jabeen, T.,Makker, J.,Sharma, S.,Dey, S.,Singh, T.P. (deposition date: 2004-04-25, release date: 2004-05-04, Last modification date: 2023-08-23)

• Primary citation: Singh, R.K.,Singh, N.,Jabeen, T.,Sharma, S.,Dey, S.,Singh, T.P.; Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution.; J.Drug Target., 13:367-374, 2005; PubMed: 16278156; DOI: 10.1080/10611860500254450

Experimental method

X-RAY DIFFRACTION (2.6 Å)