Design of specific inhibitors of phospholipase A2: Crystal structure of the complex formed between group I phospholipase A2 and a designed pentapeptide Leu-Ala-Ile-Tyr-Ser at 2.6A resolution

Summary for 1T37

Related1MF4 1JQ9 1SZ8
DescriptorPhospholipase A2 isoform 3, Synthetic peptide, ACETATE ION, ... (4 entities in total)
Functional Keywordsphospholipase a2, complex, inhibition, hydrolase
Biological sourceNaja sagittifera
Cellular locationSecreted P60045
Total number of polymer chains2
Total molecular weight13915.32
Singh, R.K.,Singh, N.,Jabeen, T.,Makker, J.,Sharma, S.,Dey, S.,Singh, T.P. (deposition date: 2004-04-25, release date: 2004-05-04, Last modification date: 2011-07-13)
Primary citation
Singh, R.K.,Singh, N.,Jabeen, T.,Sharma, S.,Dey, S.,Singh, T.P.
Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution.
J.Drug Target., 13:367-374, 2005
PubMed: 16278156 (PDB entries with the same primary citation)
DOI: 10.1080/10611860500254450
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers30 2.5% 5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02